personal care active mapping · glycation of proteins in the skin causes aging of the skin such as...

Personal Care Active Mapping

QD Permitted to be used as quasi-drugs in Japan. QD status is depending on products, contact us for details.QD* IECIC2015 Listed in the Inventory of Existing Cosmetic Ingredient in China 2015.

Anti-aging❶

StemCell

Sugar

Sugar

Tobacco Smoke UVVehicle

Emission

Collagen

TA-StemCell

TryptaseBasementMembrane

Mast Cell

AhR-CYP

Melanocyte

NoticeablePore

*AhR : Aryl hydrocarbon Receptor CYP : Cytochrome P450

Keratinocyte(Keratin)

Lymphatic capillary

Waste productsFluid retention

Draining disorder

PM 2.5

Blue LightKeratinocyte

DAMPsKeratinocyte(KC)

OUGON Liquid B/G<Scutellaria Baicalensis Root Extract>

PrincessCare /G<Geranium Robertianum Extract>

❻CUREPASSION /G<Passi�ora Edulis Fruit Extract>

❺ Lymphatic Care

Prevention of Environmental Pollution

❸ Minimizing Noticeable Pore

Protection of Basement Membrane

Absorage<Plantago Major Seed Extract>

Preventing glycation

IZAYOI /G<Rosa Roxburghii Fruit Extract>

Inhibiting DAMPs response on KC

Improving dermal lymphatic system

Inhibiting AhR-CYP

Inhibiting tryptase

Protection of Skin Protein❹

Biobene�ty /G/HS<Cynara Scolymus (Artichoke) Leaf Extract>

❶

Suppression of Erythema Caused by UV rays ❷Inhibiting NF- B κ

1

Inhibiting DAMPs response on KC

In the trial for smoker or passive smoker, OUGON Liquid B recovered wrinkles.

After the application of 3% PrincessCare solution for 12 weeks, the wrinkle signi�cantly diminished.

PrincessCare /G

PrincessCare inhibits tryptase activity and prevents extracellular matrix degradation as well as basement membrane damage leading to perfect anti-photoaging care.

<Geranium Robertianum Extract>

OUGON Liquid B/G

Inhibiting AhR-CYPPollutants, such as PM2.5 activates AhR-CYP signal which induces expression of collagenase MMP-1 and promotion of in�ammation mediator IL-8 (�gure to the right), and leads to skin wrinkles and pigmentation.

DAMPs (damage-associated molecular patterns) are released when cells are damaged by UV rays. DAMPs are involved in the uppermost stream of the skin aging route. DAMPs-like substance Poly (I:C) was added to cultured keratinocytes. IZAYOI suppressed the expression of IL-8 mRNA dose-dependently.

Inhibiting tryptase

Basement Membrane

Breakdown of the Basement Membrane by Tryptase

Protection of the Basement Membrane by PrincessCare

<Scutellaria Baicalensis Root Extract> <Rosa Roxburghii Fruit Extract>

50’s Smoking Female (Japanese) 2% OUGON Liquid B

❶ Prevention of Environmental Pollution ❷ Suppression of Erythema Caused by UV

❻ Protection of Basement Membrane

Before After 2 months

Before After 2months80

90

100

Ratio

of w

rinkl

e d

epth

(%)

Control

2% OUGON Liquid B

60

80

100

120

140

Before After 12weeks

Ratio

of w

rinkl

e ar

ea (%

)

3% PrincessCare

Control

IECIC2015

IECIC2015

IECIC2015

0 1 2 3 4

0 20 40 60 80 100

***

***

**

non-PM2.5

Control

0.01%OUGON Liquid B

0.2%OUGON Liquid B

Relative IL-8 mRNA Expression

*** : p<0.01, ** : p<0.05

***

*** : p<0.01 vs. Before

QD*


❸ Minimizing Noticeable Pore

NF-κB activation causes hyperproliferation of keratinocytes to enlarge pores and increases in the melanin production of melanocytes causing to darken pores.

Biobene�ty minimized noticeable pores through NF-κB inhibition.

20’s Female (Japanese)

After 2 months

N o t i c e a b l e pores indicated red dots were decreased.

Before

5% Biobene�ty

0 1 2400

500

600

Pore

num

ber

5% Biobene�ty

Control

Month

*** : p< 0.01 vs. 0 month

IECIC2015

QD*

Preventing glycation

Dihydroxyacetone(DHA) solution stains the skin by glycation. Absorage prevented skin browning by glycation of skin protein.

Plantagoside, the active compound of Absorage, prevented glycation of keratinocyte protein.

❹

Glycation of proteins in the skin causes aging of the skin such as loss in clarity, lowering of elasticity or resiliency and wrinkles.

Absorage<Plantago Major Seed Extract>

Protection of Skin Protein

Control

DHA Conc.

1%

0.5%

Absorage

40’s Male (Japanese)

Plantagoside 10 μmol/L

L-Lysine 100 μmol/L

Inhibition ratio of glycation (%)

GlycationInhibitors

Aminoguanidine Sulfate 100 μmol/L

Equivalent to Absorage 0.93%

QD IECIC2015 ❺

emImproving dermal lymphatic system

Main function of lymphatic vessel system is to collect wastes and excess water. But they are known to impair in their function by UV rays. CUREPASSION enhances lymphatic tube-like formation by lymphatic endothelial cells and improved of facial puffiness.

CUREPASSION /G<Passi�ora Edulis Fruit Extract>

Control

1% CUREPASSION1% CUREPASSION

Lymphatic Care

Lymphatic tube-like formation

IECIC2015


ControlThe white part shows the face line before.

After 8weeks

IZAYOI /G

Control0

1020304050

Rela

tive

IL-8

mRN

A

Expr

essi

on

IZAYOI0.04% 0.2% 1%Non

Poly(I:C)

Inhibition of DAMPs response on KC

*** : p<0.01 vs. Control

Addition of Poly(I:C)

******

******

Control 2% IZAYOI

24 hours after sunbathing

Erythema

After sunbathing 2% IZAYOI lotion were applied on the face for 7 days. Erythema was d e t e c t a b l e a t t h e control applied area, but was not at the IZAYOI applied area.40’s Male (Japanese)

QD*QD

** : p<0.05

**

Inhibiting NF- B κ

2


UV

BasementMembrane

TurnoverKeratinocyte(KC)

KeratinocyteEndothelin-1

Melanocyte Melanocyte

MelaninKinesin

Melanosome Transfer

Stagnant Melanin

Alpiniawhite /HS

Mediators for Melanogenesis

KIWI Liquid B<Actinidia Chinensis (Kiwi) Fruit Extract>

MandarinClear /HS<Citrus Reticulata (Tangerine) Peel Extract>

Melanin Synthesis Activation

<Alpinia Katsumadai Seed Extract>


❶ Inhibition of Melanogenesis Mediators

Brake on Melanin Production❷ Suppression of Melanin Transport❸CinderellaCare<Thymus Serpyllum Extract>

Rejection of Melanin❹Clairju<Hydrolyzed Prunus Domestica>

Melanosome Tranport in Cell

❺

Increase Clarity / Internal Re�ection❻

Dullness / Scattering Light

Discharge of Stagnant Melanin

Age Spots / Brightening / Clarity

3

IECIC2015

QD

QD

IECIC2015

QD IECIC2015

QD IECIC2015

IECIC2015 QD IECIC

2015

QD*

5% Alpiniawhite

Age spots are decreased !30’s Male (Japanese)

Before After (4 weeks)1% Alpiniawhite

Melanin particleswere accumulated

Clairju

Clear skin with smooth surface

Before

Control

1% CinderellaCare

Before

After (2 weeks)

30’s Female

After (4 weeks)

Fluorescent Particles (Pseudo melanin)

0.5% CinderellaCare

0 40 80 120 160Endothelin-1 production (pg/mL)

Non-UV

Control

***

***

Control

0 1 2 3150

200

250M

elan

in In

dex

Month

***

***

Whitening e�ect on human skin

*** : p<0.01 vs. 0 month

*** : p<0.01

** : p<0.05

5% Biobene�ty Control

Control

Before

After (4weeks)


"Frosted glass" like

"Transparent glass" like

1% MandarinClear1% MandarinClear

Reduction of Scattering

light

0.5%Biobene�ty

+1% KIWI Liquid B

0 50 100 150 200 250

KC intaked melanin

+2% KIWI Liquid B**

**

**

Acceleration ratio of cell division (%)

Normal KC


Age spots are decreased !

Before1% KIWI Liquid B

After (4 weeks)

❹

Biobene�ty /G/HS

Control of NF- B activity guardsskin against pigmentation

κ

Clarity and shine that comes from within the skin

<Cynara Scolymus (Artichoke) Leaf Extract>

❶ Inhibition of Melanogenesis Mediators

CinderellaCare<Thymus Serpyllum Extract>Suppression of melanin migration within melanocytes

❸ Supression of Melanin Transport

Rejection of Melanin

Alpiniawhite /HSThe new mechanism of whitening “Melanogenic Brake”

↑Decreased age spots after application of 1% Alpiniawhite for 4 weeks.

<Alpinia Katsumadai Seed Extract>

←Decreased melanin particles in stratum corneum after application of 5% Alpiniawhite for 42 days.

❷ Brake on Melanin Production

ClairjuThe new mechanism of whitening “Melanin Diet Theory”

Phagocytosis (eating of cells) of keratinocytes was observed with �uorescent beads (alternative to melanosomes). Clairju clearly inhibited keratinocytes ability to absorb the �uorescent beads.

<Hydrolyzed Prunus Domestica>KIWI Liquid B<Actinidia Chinensis (Kiwi) Fruit Extract>

❺

1% MandarinClear was applied on test subjects' cheeks twice a day for 4weeks, MandarinClear reduces scattering lights and improved light transparency (photo to the right), signi�cantly improved the brightness of skin (photo below) .

In melanocyte that CinderellaCare was added to, kinesins activities were suppressed so melanosomes were not carried (photo above).1% CinderellaCare was applied on one side each of the face of 21 male and female. In CinderellaCare applied area, the melanin index signi�cantly lowered and the number of dark spots reduced.

Biobene�ty inhibited the production of endothelin-1 which could mediate the melanogenesis (�gure to the left). After the application of lotion containing 5% of Biobene�ty, melanin index of skin were improved (�gure to the right).

MandarinClear /HS<Citrus Reticulata (Tangerine) Peel Extract>

Increase Clarity / Internal Re�ection❻

New whitening theory “Discharge of Stagnant Melanin”

Discharge of Stagnant Melanin

After the application of lotion containing 1% of K I W I L i q u i d B f o r 4 weeks, melanin index of skin were improved a n d p i g m e n t s p o t s were decreased.

K I W I L i q u i d B h a s b e e n con�rmed to have an e�ect to p r o m o t e t h e d i v i s i o n o f keratinocytes intaking melanin (melanin �lled basal cells).

4


Sensitive Skin Care / Soothing

Keratinocyte

IL-1α

NGF

Skin bacteria

Mastcell

Peripheral nerve

Environmentalpollution

Fibroblast

Langerhans cell

Corneocyte

Dry environmentMechanical stress

PAR2

HistamineTryptase, ..etc.

Barrier dysfunction

In�ammation

Irritation due to bacteria and its metabolites

Nerve stimulation factor(Mastcell)Conduction of impulse

(Itching)

❷Dermaveil<Salix Alba (Willow) Bark Extract>

Maturation of Skin Cells

COMFREY Liquid B<Symphytum O�cinale Leaf Extract>

BOTANPI Liquid B<Paeonia Su�ruticosa Root Extract>

Soapnut Extract Powder<Sapindus Trifoliatus Fruit Extract>

YUZU Ceramide B<Citrus Junos Fruit Extract>

Dyskeratosis

❻ Inhibiting Histamine Release

❹ Inhibiting Inflammatory MediatorSAKURA Extract B<Prunus Yedoensis Leaf Extract>

❺ Anti-Inflammation

Gentle Cleansing❸

In�ammatory mediator

❶ Improvement of Barrier Function

5

■

Ceramide from citrus fruit

Inhibiting Histamine Release❻

0 0.2 0.4 0.6 0.8 1.0

20

40

60

80

100

GK2

Comfrey extractComfrey extractBOTANPI

LiquidBOTANPI

Liquid

0

■■

▲▲▲▲

0 0.5 1.0 1.5 2.0

Standard hair color

Erythema index (point)

Reducing skin irritation

COMFREY Liquid B<Symphytum O�cinale Leaf Extract>

sePowerfully inhibiting histamine release and reducing chemical dermatitis

IInhi

bitio

n ra

tio o

f hi

stam

ine

rele

ase

(%)

Concentration (%)

Concentration (%)

IInhi

bitio

n ra

tio o

f hi

stam

ine

rele

ase

(%)

Hair color combined with1.5% COMFREY Liquid B

COMFREY Liquid B reduced contact dermatitis by hair color.

Comfrey extract suppressed histamine release strongly.

Suppressing histamine release very strongly

Cromolyn (Mast cell stabilizer)

Activation of PPAR-β/δthe latest strategy against dry skin

Dermaveil<Salix Alba (Willow) Bark Extract>

Maturation of Skin Cells❷

Abnormal keratinocyte maturation (corni�ca-tion) induces the dry skin or sensitive skin. Dermaveil activates the intranuclear receptor “PPAR-β/δ” which is one of the important key factors of corni�cation.Dermaveil enhanced CE production in keratino-cyte and improved the skin roughness induced by sodium lauryl sulfate (SDS) in human skin.

0.5%Dermaveil

Control

5% BOTANPILiquid

Control

1.0%Dermaveil

CE production (relative ratio)

***

**

0 1 2 3

*** : p<0.01, ** : p<0.05

Control

3% Dermaveil

SDS-damaged skin

Anti-Inflammation❺

SAKURA Extract B improved the erythema (skin redness) induced by 5% sodium lauryl sulfate (SDS) solution in human skin.

BOTANPI Liquid suppressed histamine release relatively strongly.

BOTANPI Liquid well suppressed the production of IL-1α from keratinocytes by ultraviolet light.

●●

●●●●●●●●● ●●●

0 10 12 14-5

-4

-3

-2

-1

0

1

VAS

itch

scal

e (c

m)

Day2 4 6 8

SAKURA Extract B decreased usually skin itchiness over time and it has also improved the state of the stratum corneum.

Decreasing itching over time

2% SAKURA Extract B

●

Improving erythema

SAKURA Extract B<Prunus Yedoensis Leaf Extract>

Suppressing erythema and itching by excellent anti-in�ammatory

Excellent anti-in�ammatory

ControlSAKURA Extract B

Gentle Cleansing❸

Gently cleanses the skin without damaging

<Sapindus Trifoliatus Fruit Extract>YUZU Ceramide B<Citrus Junos Fruit Extract>

QD QD

IECIC2015

IECIC2015

IECIC2015

BOTANPI Liquid B<Paeonia Su�ruticosa Root Extract>

QD IECIC2015

IECIC2015

Intercellular lipid(e.g. Ceramide)Water

Natural Moisturizing Factor (NMF)

Improvement of trans epidermal water loss (TEWL) caused by surfactant with YUZU Ceramide B

Control（10% SDS treatement）

YUZU Ceramide B

QD IECIC2015

derSoapnut Extract Powder

1.35% SLES

5% Soapnut Extract Powder

Repeated washing damaged skin

Less scales after repeated washing

Soapnut Extract Powder decontaminated Staphylococcus aureus (S. aureus) which worsens atopic dermatitis.Still, Soapnut Extract Powder was con�rmed to be a cleansing agent that is less damaging to the skin (photo to the right).

0.5

0.6

0.7

0.8

0.9

1.0

Ant

ibac

teria

l e�

cacy

(r

elat

ev v

alue

) **** : p<0.05

After 1st wash(Soap base)

After 2nd wash(+1% Soapnut Ext.)

Staphylococcus aureus

** : p<0.05

** : p<0.05

■

8

10

12

14

Damaged skin After treatment

■

TEW

L (g

/m2 h)

●

●

**YUZU Ceramide B

Control

❶ Improvement of Barrier Function

Non-UV

0 20 40 60 80 100IL-1α (ng/mL)

**

**

0

20

40

60

80

100

0 0.1 0.2 0.3 0.4 0.5

GK2

❹ Inhibiting Inflammatory Mediator

6


Moisturizing

Ceramide

Corneocyte

NMF

Aquaporin disorder

Decrease of ceramide

Epidermal cells

Tight Junction

Tight junction disorder

Troublous ridgesand furrows

Corni�cation disorderIncrease of watertranspiration rate

Decrease of NMF

BIO-PGA series Maple Water

MandarinClear /HS

YUZU Ceramide B

LEMONGRASS Liquid B CHRONO CHARDY /G

Improvement of Water Channel ❻

Natural Water Supply❷

Improvement of TJ Barrier❺

Film Formation / Increase NMF ❸

Ceramide Trans�er❹

Improvement of Barrier Function❶

<Acer Saccharum (Sugar Maple) Sap>

<Citrus Reticulata (Tangerine) Peel Extract>

<Citrus Junos Fruit Extract>

<Vitis Vinifera (Grape) Fruit Extract> <Cymbopogon Schoenanthus Leaf/Stem Extract>

<Polyglutamic Acid / Sodium Polygamma-Glutamate>

Natural polymer from fermentation

Promoting tight junction (TJ) Anti-aging by skin clock Promoting aquaporin

Ceramide from citrus fruit Life-invigorating water from the forests of quebec

7

Tight junction (TJ)

Stratumgranulosum

Stratumspinosum

Water TJ barrier2nd barrier

1st barrier(ceramide etc.)

Skin structure and barrier function

Tight junction (TJ) forms a second skin barrier by connecting cells.

Corneocyte

Externalirritant

T J i s a m e c h a n i s m tying cells, and it �lls the gaps among the c e l l s , c o n t r o l s t h e passage of water and ions, and regulates the function of corneocyte.

0.3% MandarinClear

Tight junction (red) Nuclear (blue)

Control

TJ formation at the cell

boundaries

N u c l e u s s t a i n i n g a n d i m m u n o s t a i n i n g w e r e performed by applying M a n d a r i n C l e a r t o t h e h u m a n e p i d e r m a l keratinocytes to observe TJ formation <2nd barrier>.

Intercellular lipid (e.g. Ceramide)

Water Natural Moisturizing Factor (NMF)

** : p<0.05

I m p r o v e m e n t o f t r a n s epidermal water loss (TEWL) caused by surfactant with YUZU Ceramide B

Control(10% SDS treatement)

YUZU Ceramide B

8

10

12

14

Damaged skin After treatment

**YUZU Ceramide B

Control

TEW

L (g

/m2 h)

BIO-PGA series

Promoting NMF (PCA) production

BIO-PGA series

Water

NMF (PCA etc.)

Wrapping from outside

PCA, lactic acid and urocanic acid, well known NMF (Natural Moisturiz ing Factor) were increased by BIO-PGA series.

Producing from inside

PCA

pro

duct

ion

(%)

14Day

2840

0

60

80

100

120

140 BIO-PGA Solution H

Sodium Hyaluronate

Control0

50

100

150

200

Ratio

of A

QP3

(%)

LEMONGRASS Liquid B

0.5% 0.7%

AQP3

LEMONGRASS Liquid B upregulated the level of aquaporin 3 in the keratinocytes.

Aquaporins (AQP) are porous proteins in the cell membrane, s e l e c t i v e l y a l l o w w a t e r molecules to pass through.

Water AQP3

Cellmembrane

Maple Water can moisturize the skin and boost the skin’s barrier function at the sometime, thus treating dry skin in winter.

e�ective

90

100

110

Elec

tric

al c

apac

itanc

e (%

)

Before After (14 days)Maple Water

TEW

L (%

)

80

90

100 e�ective

Before After (14 days)Maple Water

In cltured human epidermal cells CHRONO CHARDY increased the ABCA12 <night time barrier gene> and FLG <daytime moisturizing gene> mRNA expressions.

In the human monitor test, the application of CHRONO CHARDY signi�cantly increased the water c o n t e n t a n d i m p r o v e d t h e condition of the stratum corneum.

UP

Before After (4 weeks)

100

110

120

Rela

tive

elec

tric

al c

apac

itanc

e

**

** : p<0.05 vs. Before

*** : p<0.01, ** : p<0.05 vs. Each control

n.s.

Moisturizing Effect

1% CHRONOCHARDY

Control

**

Rela

tive

gene

exp

ress

ion

0

0.5

1.0

1.5

2.0

ABCA12 FLG

UP UP***

Cont

rol

Cont

rol

0.5%

CHR

ONO

CHA

RDY

0.5%

CHR

ONO

CHA

RDY

*excluding BIO-PGA Na Powder

Natural polymer from fermentation

Promoting tight junction (TJ) Anti-aging by skin clockPromoting aquaporin

Ceramide from citrus fruit Life-invigorating water from the forests of quebec

<Polyglutamic Acid / <Acer Saccharum (Sugar Maple) Sap>

<Citrus Reticulata (Tangerine) Peel Extract>

<Citrus Junos Fruit Extract> Sodium Polygamma-Glutamate>

<Vitis Vinifera (Grape) Fruit Extract> <Cymbopogon Schoenanthus Leaf/Stem Extract>

BIO-PGA series Maple Water

MandarinClear /HS

YUZU Ceramide B

LEMONGRASS Liquid B LEMONGRASS Liquid B CHRONO CHARDY /G

Film Formation / Increase NMF Improvement of Barrier Function

Improvement of TJ Barrier

Natural Water Supply

Ceramide Trans�er Improvement of Water Channel ❻

❷

❺

❸

❹

❶ QD IECIC2015

IECIC2015

IECIC2015 QD IECIC

2015IECIC2015QD

QD*

8


Anti-Acne

Neutrophil

Acne

Breeding of P.acnes

In�ammationOxidation

Bacteria( P.acnes)

Comedo

Androgenic hormone elution

Sebaceous elution promotionHyperkeratosis

Delaminated keratin

Promoting turnover

Fermentage PEAR B Inhibiting P. acnes

OUBAKU Liquid B

Inhibiting COX-2

NEEM Leaf Liquid B/G

Inhibiting 5 alpha-reductase

JIOU Liquid /B

Inhibiting lipase

CUREBERRY Biobene�ty /G/HS

Minimizing Pore❻

Anti-Sebum❸

Anti-In�ammation❹

Exfoliation❺

Anti-Free Fatty Acid❷

Anti-Bacteria❶

<Phellodendron Amurense Bark Extract>

<Vaccinium Myrtillus Leaf Extract>

<Rehmannia Chinensis Root Extract>

<Melia Azadirachta Leaf Extract>

<Lactobacillus/Pear Juice Ferment Filtrate>

<Cynara Scolymus (Artichoke) Leaf Extract>

Inhibiting NF- B κ

9

N

OCH3

+

OCH3

O

O 5 alpha-Reductase

Oily Skin DHT Testosterone Acne

Turnover helps anti-acne by inhibiting hyperkeratosis. Fermentage PEAR B promotes turnover on the skin tanned by DHA.

NF-κB

Melanocyteproliferation

Spread-Open(Corn-shaped Pores)

Blackhead

Virtually perceptiblepores

Biobene�tySuppression

κB

κB

Hyperkeratosis

Suppression

Control20’s Female

Fermentage PEAR B

5% Biobenefity

Skin browning was decreased

7 days

OUBAKU Liquid

P. acnes

2 months

Phellodendron bark is the source of alkaloids such as berberine.

OUBAKU Liquid series inhibits P. acnes which causes acne.

JIOU Liquid inhibits the enzyme which converts testosterone to DHT, t h e s t r o n g e s t m a l e hormone promoting sebum production.

Bacteria such as P. acnes makes lipase, and free fatty acid is released from triglyceride by lipase. The free fatty acid is causing in�ammation at acne.

In�ammation cytokines, prostaglandins are synthesized from arachidonic acid by the action of cyclooxygenase (COX). NEEM Leaf Liquid B inhibits COX-2, and has anti-in�ammation e�ect.

Biobene�ty inhibits abnormal keratinazation, which cause lager visible pores.

C U R E B E R R Y inhibiting the enzyme lipase, as a result free f a t t y a c i d i s inhibited.

7%JIOU Liquid

1.4%JIOU Liquid

0 10 20 30 40 50 60Inhibition rate of 5α-reductase (%)

0 10 20 30 40 50 60 70 80

3.08% CUREBERRY

1.4% CUREBERRY

0.14% CUREBERRY

Inhibition of lipase activity (%)

1%NEEM Leaf Liquid B

0.1%NEEM Leaf Liquid B

0 20 40 60 80Inhibition rate (%)

COX-1COX-2

Promoting turnover

Fermentage PEAR B

Inhibiting P. acnes

OUBAKU Liquid B

Inhibiting COX-2

NEEM Leaf Liquid B/G

Inhibiting 5 alpha-reductase

JIOU Liquid /B

Inhibiting lipase

CUREBERRY Biobene�ty /G/HS Minimizing Pore❻

Anti-Sebum❸

Anti-In�ammation❹

Exfoliation❺

Anti-Free Fatty Acid❷

Anti-Bacteria❶

<Phellodendron Amurense Bark Extract>

<Vaccinium Myrtillus Leaf Extract>

<Rehmannia Chinensis Root Extract>

<Melia Azadirachta Leaf Extract>

<Lactobacillus/Pear Juice Ferment Filtrate>

<Cynara Scolymus (Artichoke) Leaf Extract> Inhibiting NF- B κ

QD IECIC2015 QD IECIC

2015 QD IECIC2015

QD IECIC2015

IECIC2015

IECIC2015QD*QD*

10


Hair Care / Hair Growth

Treat Split End Film formation Moisturizing

Prevent Hair Damage

Protect Cuticle

Hair growth - Hair Papilla Cell - Blood circulation

UVNormal hair

Perming

Bleaching & coloring

PermingBleaching & coloring Blow-drying Brushing

Damage of cuticle

Residual hydrogen peroxide-induced damage

Split hair

Porphyran from seaweed (NORI)

ALGAE FILMER / IPF-100K

Chlorogenic acid from co�ee

Ca�enoage

Hydroxypropyl chitosan from crab shell

HPCH series

Increasing hair papilla cell

Biocellact CHAMOMILLA BD Ceramide from japanese citrus

YUZU Ceramide B

Increasing blood circulation

JIOU Liquid /B

Hair Thickening / Hair Growth ❻

Cuticle Restore❷

Hair Thickening / Treat Split End ❹

Hair Thickening / Hair Growth ❺

Film Formation / Moisturizing ❸

Prevention of Hair Damage ❶

<Chamomilla Recutita (Matricaria) Flower Extract>

<Porphyra Yezoensis Extract> <Hydroxypropyl Chitosan> <Rehmannia Chinensis Root Extract>

<Co�ea Arabica (Co�ee) Seed Extract> <Citrus Junos Fruit Extract>

11

QD IECIC2015 QD IECIC

2015 QD IECIC2015

QD IECIC2015

IECIC2015

IECIC2015QD QD

O

OH

OH

O

OOH

OH

O

O

O

OH

O

OH

OH

CH2OH

CH2

CH2OR

CH2

OSO3-

O

R : H, CH3

Apply & Dry for 30 times / Apply & Wash o� for 30 times

1% YUZU Ceramide B BleachedCa�enoage

JIOU Control JIOU Control JIOU Control

Before Test 5 min. later 0 min. later Bleached 5% ALGAE FILMER

①

②

③

④

⑤

⑥ALGAE

FILMER

60 80 100 120Hair strength (relative value)

Control

*** : p<0.01

***

0 2 4 6 8 10 12

PVP

PVA

Sodiumhyaluronate

ALGAEFILMER Holding water UP

Hair strength UP

Retained moisture content (%)

2 months

Cell number (a.u.) *** : p<0.01

***

0.3 0.4 0.5 0.6

Control

0.14% BiocellactCHAMOMILLA B

Hair papilla cell

Control

0.002% Biocellact CHAMOMILLA B

Senescent cell less

16 passagesSuppresion of TA-stem cell aging

Many senescent cell (green)

O

O

O

O O

n

CH2OR

CH2ORNR2

OR RO

NR2

R= or

H

H

m

CH2CHO

CH3

Damaged hair by Hair dyeControl

Ca�enoage contains about 0.1% of chlorogenic acid, con�rmed anti-oxidation e�ect.

Ca�enoage prevented damage of hair cuticles.

Hair cuticles are preserved

YUZU Ceramide B restored hair cuticles.

YUZU Ceramide B contains the ceramide which is very similar to human ceramide II and V existing in stratum corneum. It is reported that 20% of human skin ceramide is type-II, and human hair are made of ceramide type-II and V.

Biocellact CHAMOMILLA BD increases number of human hair papilla cells, which expects hair growth.

Porphyran is water soluble �ber, which constitutes cell w a l l t o p r o t e c t t h e c e l l s against harsh environment.

HPCH Liquid has strong a�nity to hair.

#1, 2 and 3 10% H2O2 + 10% NH3 for 30 minutes without HPCH

#4, 5 and 6 10% H2O2 + 10% NH3 for 30 minutes with HPCH Liquid 25%

<Chamomilla Recutita (Matricaria) Flower Extract>

<Porphyra Yezoensis Extract> <Hydroxypropyl Chitosan> <Rehmannia Chinensis Root Extract>

<Co�ea Arabica (Co�ee) Seed Extract> <Citrus Junos Fruit Extract>

Porphyran from seaweed (NORI)

ALGAE FILMER / IPF-100K

Chlorogenic acid from co�ee

Ca�enoage

Hydroxypropyl chitosanfrom crab shell

HPCH series

Increasing hair papilla cell

Biocellact CHAMOMILLA BD

Ceramide from japanese citrus

YUZU Ceramide B

Increasing blood circulation

JIOU Liquid /B Hair Thickening / Hair Growth ❻

Cuticle Restore❷

Hair Thickening / Treat Split End ❹

Hair Thickening / Hair Growth ❺

Film Formation / Moisturizing ❸

Prevention of Hair Damage ❶Hair Care Hair Growth

12

Recommended ProductsCategory Product Name Main Efficacy Common Name [INCI name]

(BG = Butylene Glycol, G = Glycerin, MP = Methylparaben)JP

QDCH

IECIC 2015

SKIN

Anti-aging

Anti-wrinkle

Biocellact CHAMOMILLA BD TA-stem cell longevity Matricaria [Chamomilla Recutita (Matricaria) Flower Extract, Water, BG] JSQI Y

CUREBERRY Promote GABA in skin by GAD Bilberry [Vaccinium Myrtillus Leaf Extract, Water, BG] IPS Y

Phyto Hyaluron B Promote hyaluronic acid in skin Okra [Hibiscus Esculentus Fruit Extract, Water, BG] JSQI Y

PrincessCare /G Protect basement membrane (Anti-tryptase) Mountain Geranium [Geranium Robertianum Extract, Water, BG/G] IPS / N Y

Anti-spotsClarity

Evening toneLuminousLightening Brightening Whitening

Alpiniawhite /HS Activating melanogenic-brake signal Alpinia Katsumadai [Alpinia Katsumadai Seed Extract, Water, BG] IPS Y

Biobenefity /G/HS Decrease excess melanocytes promotion Artichoke [Cynara Scolymus (Artichoke) Leaf Extract, Water, BG/G] IPS / N Y

CinderellaCare Inhibit melanosome transportation Wild Thyme [Thymus Serpyllum Extract, Water, BG] JSQI Y

Clairju Inhibit melanosome transfer Prune [Hydrolyzed Prunus Domestica, Water, BG] JSQI Y

KIWI Liquid B Discharge stagnant melanin Kiwi [Actinidia Chinensis (Kiwi) Fruit Extract, Water, BG] JSQI Y

MandarinClear /HS Luminosity improved by good reflection Tangerine [Citrus Reticulata (Tangerine) Peel Extract, Water, BG] JSQI Y

Sensitive skin

Anti-inflammation

Soothing

Biobenefity /G/HS Inhibit NF-kB transcription Artichoke [Cynara Scolymus (Artichoke) Leaf Extract, Water, BG/G] IPS / N Y

NEEM Leaf Liquid B/G Inhibit COX-2 Neem [Melia Azadirachta Leaf Extract, Water, BG/G] IPS / N Y

SAKURA Extract B Reduce erythema / Anti-histamin Sakura [Prunus Yedoensis Leaf Extract, Water, BG] IPS Y

Moisturizing

BIO-PGA series NMF enhancement [Polyglutamic Acid, Water, BG or Alcohol and MP] (Powder available) IPS / N Y

CHRONO CHARDY /G Skin clock enhancement Common Grape [Vitis Vinifera (Grape) Fruit Extract] N Y

LEMONGRASS Liquid B Promote aquaporins Lemongrass [Cymbopogon Schoenanthus Leaf/Stem Extract, Water, BG] IPS Y

Maple Water Natural maple sap Sugar maple [Acer Saccharum (Sugar Maple) Sap] N N

YUZU Ceramide B Promote collagen and HA Yuzu [Citrus Junos Fruit Extract, Water, BG] IPS Y

UV / Sun care IZAYOI /G Prevent sunburn (Inhibit DAMPs response) Rosa Roxburghii Fruit [Rosa Roxburghii Fruit Extract, Water, BG/G] JSQI / N Y

Puffiness

Sliming

AMACHA Liquid B(N) Inhibit maturity of pro-lipocyte Hortensia [Hydrangea Serrata Leaf Extract, Water, BG] JSQI Y

CUREPASSION /G Lymphatic vessel formation Passion Fruit [Passiflora Edulis Fruit Extract, Water, BG/G] N Y

JPQD : Quasi-Drugs in Japan, JSQI : The Japanese Standards of Quasi-Drug Ingredients, IPS : Individual Permitted Specification by IchimaruIECIC2015 : Inventory of Existing Cosmetic Ingredients in China 2015, Y : Listed, N : Not listed

13

SKIN

Dark-circleCUREPASSION /G Lymphatic vessel formation Passion Fruit [Passiflora Edulis Fruit Extract, Water, BG/G] N Y

JIOU Liquid /B Improve blood circulation [Rehmannia Chinensis Root Extract, Water, BG] JSQI Y

Oily-skinFLAVOSTERON SB Inhibit sebaceous gland Soybean [Glycine Soja (Soybean) Seed Extract, Water, BG] JSQI Y

JIOU Liquid /B Inhibit 5α-reductase [Rehmannia Chinensis Root Extract, Water, BG] JSQI Y

Anti-acne OUBAKU Liquid B Anti-bacteria [Phellodendron Amurense Bark Extract, Water, BG] JSQI Y

Deodorant SHAKUYAKU Liquid B Deodorize ammonia, Trimethylamine Chinease Peony [Paeonia Albiflora Root Extract, Water, BG] JSQI Y

Cleansing Soapnut Extract Powder Foaming, Remove make up, Deodorant Three-leaf Soapberry [Sapindus Trifoliatus Fruit Extract] N Y

Anti-glycation Absorage Glycation inhibitor [Plantago Major Seed Extract, Water, BG] IPS Y

Minimizing pore Biobenefity /G/HS Inhibit NF-kB transcription Artichoke [Cynara Scolymus (Artichoke) Leaf Extract, Water, BG/G] IPS / N Y

Anti-pollution OUGON Liquid B/G Inhibit environmental toxicity pathway (AhR) Scute [Scutellaria Baicalensis Root Extract, Water, BG/G] JSQI Y

HAIR

Hair care

ALGAE FILMER / IPF-100K Hydrophilic film form [Porphyra Yezoensis Extract, Water, Alcohol and MP/BG] JSQI Y

BIO-PGA series Protect cuticle / Film form [Polyglutamic Acid, Water, BG or Alcohol and MP] (Powder available) IPS / N Y

HPCH Liquid 10 Hair thickening / Split end care [Hydroxypropyl Chitosan, Water, Alcohol] JSQI Y

YUZU Ceramide B Treat damaged hair by fruit ceramide Yuzu [Citrus Junos Fruit Extract, Water, BG] IPS Y

Hair growth

Biocellact CHAMOMILLA BD Increase hair papilla cell Matricaria [Chamomilla Recutita (Matricaria) Flower Extract, Water, BG] JSQI Y

BOTANPI Liquid B Anti-inflamation for hair growth Mountain Peony [Paeonia Suffruticosa Root Extract, Water, BG] JSQI Y

JIOU Liquid /B Inhibit 5α-reductase / Improve blood circulation [Rehmannia Chinensis Root Extract, Water, BG] JSQI Y

ECO

Sustainability NEEM Leaf Liquid B/G Inhibit COX-2 Neem [Melia Azadirachta Leaf Extract, Water, BG/G] IPS / N Y

OrganicCUCUMBER Organic Moisturizing Cucumber [Cucumis Sativus (Cucumber) Fruit Extract, Water, BG] JSQI Y

Soapnut Extract Powder Cleansing, Foaming, Deodorant Three-leaf Soapberry [Sapindus Trifoliatus Fruit Extract] N Y

Ecocert ecofarm series (see ->)ecofarm BILBERRY LEAF-E, G / CRATAEGUS-E, B / CUCUMBER-E, G / LAVENDER-E, B / ROSE HIPS-E, B / ROSEMARY-E, B / SAGE-E, B / THYME-E, B / YARROW-E, B [E = Ethanol, G = Glycerin, B = Natural BG made from sugarcane]

JSQI/ N Y

No BGPowder items (see->) Bio-PGA Na Powder / OUGON Extract Powder / Soapnut Extract Powder JSQI

/ N YGlycerin items (see->) Biobenefity G / CHRONO CHARDY G / CUREPASSION G / IZAYOI G / NEEM Leaf Liquid G / OUGON Liqiud G / PrincessCare G

Natural BG HS series (see->) Alpiniawhite HS / Biobenefity HS / Biocellact ALOE VERA B(HS) / MandarinClear HS JSQI / IPS Y

14

PRINTED 2019.02.04 EN R7

○ Head Office318-1, Asagi, Motosu-shi, Gifu 501-0475 JAPANPhone: +81 (0) 58 320-1032Fax: +81 (0) 58 320-1039e-Mail : [email protected]

○ Tokyo BranchPhone: +81 (0) 3 3663-4447 Fax: +81 (0) 3 3663-4448

Any ingredient may cause irritation such as allergies. Please exercise enough caution when using it.

○ ICHIMARU PHARCOS CHINA (Shanghai)Phone: +86 (0) 21 6125-6821

*REQUESTS CONCERNING WITH INTELLECTUAL PROPERTY RIGHTS AND OTHERSWe have the following request to make regarding the handling of the catalog of our company’s products, technological materials, samples, photographs, etc. which we have presented to you. We presented these materials on the basis of our mutual trust, and do not allow any use of these for the sake of your company’s intellectual property rights (industrial property rights such as patents, trademarks, copyrights, etc.) However, if you wish to use entries in these materials in your in-company materials, we request that you exercise final judgment on this matter based on the position of your company, giving due consideration to intellectual property rights of other companies, the Pharmaceutical Affairs Act, the Act Against Unjustifiable Premiums and Misleading Representations, etc., and extending us your kind understanding and courtesy.

○ Osaka BranchPhone: +81 (0) 6 4706-3885 Fax: +81 (0) 6 4706-3886

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