8/17/2019 Peds-ID

1/4

T-Cell defects Both B & T-cell B-cell defects Phagocyte defects Complement sys Acquired

Thymic dysplasia(DiGeorge)

SCID X-linkedagammaglobulinemia

Leukocyte adhesiondeiciency

Congenital asplenia !I"

Deecti#e T cellreceptor 

Combinedimmunodeiciency

C"ID Chediak-!igashi Splenic dysunction(hemoglobinopathies)

$alignancies

Deecti#e cytokineproduction

%menn syndrome Selecti#e Ig&deiciency

$yelopero'idasedeiciency

Transplantation orimmunosuppression

T-cell acti#ationdeects

iskott-&ldrich IgG subclassdeiciency

CGD urns* malnutrition

CD+ lymphopenia &ta'ia-telangiectasia !yper-Ig$ syndrome Leukopenia Sickle cell

!yper-Ig, syndrome(ob syndrome)

Congenital neutropenia(.ostmann syndrome)

Cystic /ibrosis

Implanted oreign body

0hgocyte disorder bugs1 S2 aureus* pseudomonas* Clostridium perringens* candida* gram neg bacteria* serratia* aspergillus* burkholderia

Complement prob bugs1 streptococcus pneumonia* !2 inluen3a* Salmonella* 4eisseria meningitides

-cell deect bugs1 ater 5 mo o age

 S2 pneumonia* !i* persistent diarrhea rom rota#irus* disseminated entero#irus6 hyperIg$

 0nuemocystis 7iro#eci and cryptosporidium

T-cell bugs1 chronic mucocutaneous candidiasis* pneumonia* rhinitis* otitis media* chronic diarrhea

Combined 8T cell bugs1 irst 5 mo- disseminated candidiasis* chronic diarrhea* 027iro#eci pneumonitis* C$"6 ater 5 mo- both gram pos and neg*dissemination rom li#e #irus #accination* S2 pneumonia* !i* 027iro#eci* S2aureus abscesses

/ebrile neutropenia (single temp abo#e or e9ual to :+2: (;

8/17/2019 Peds-ID

2/4

8/17/2019 Peds-ID

3/4

8/17/2019 Peds-ID

4/4