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Paul M. Hassoun March 2013

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CURRICULUM VITAE PAUL M. HASSOUN, MD

_____________________________ March 22, 2013 Paul M. Hassoun DEMOGRAPHIC AND PERSONAL INFORMATION Current Appointment:

Professor of Medicine Division of Pulmonary and Critical Care Medicine The Johns Hopkins University Department of Medicine Personal Data Office Addresses: Division of Pulmonary and Critical Care Medicine

Johns Hopkins University Department of Medicine 1830 East Monument Street, Suite 530 Baltimore, Maryland 21287 Tel: 410-614-5158/Fax: 443-287-3349 Pager: 410-434-0155/e-mail: [email protected]

Education and Training 1974 American University of Beirut, Lebanon Biology 1981 Faculté de Médecine Lariboisière-Saint Louis MD Université de Paris VII, France Internship and Residency 11/80-3/81 Clinical Research at the Joslin Clinic, Boston.

Research on "Diabetic Renal-Retinal Syndrome," leading to publication of thesis for MD degree.

1981-1982 Brigham and Women's Hospital/Harvard Medical School Intern Boston, Massachusetts 1982-1984 Internal Medicine, Brigham and Women's Hospital/ Resident Harvard Medical School, Boston, Massachusetts 1984-1987 Clinical and Research Fellow in Medicine Fellowship Pulmonary Unit, Massachusetts General Hospital/

Harvard Medical School, Boston, Massachusetts 1987-1988 Pulmonary Division, New England Medical Center Research

Tufts University School of Medicine, Boston, Massachusetts Training Associate


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PROFESSIONAL EXPERIENCE Academic Appointments: 1988-1994 Assistant Professor of Medicine Tufts University School of Medicine Boston, Massachusetts 1995-2002 Associate Professor of Medicine Tufts University School of Medicine Boston, Massachusetts 2002-2007 Associate Professor of Medicine Johns Hopkins University School of Medicine, Baltimore, Maryland 2007-Present Professor of Medicine Johns Hopkins University School of Medicine, Baltimore, Maryland Hospital Appointments: 1988-1994 Assistant Physician Department of Medicine

Pulmonary and Critical Care Division New England Medical Center Boston, Massachusetts 1991-2002 Physician,Medicine Department Medicine Center and

New England Sinai Hospital Rehabilitation Center Stoughton, Massachusetts 1993-2002 Physician, Department of Medicine Winchester Hospital, Winchester, Massachusetts 1995-2002 Physician, Department of Medicine Pulmonary and Critical Care Division

New England Medical Center Boston, Massachusetts

2002-Present Physician, Department of Medicine Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital

Baltimore, Maryland 2002-Present Director, Division of Pulmonary and Critical Care Pulmonary Hypertension Program Medicine, Johns Hopkins University

Baltimore, Maryland


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RESEARCH ACTIVITIES Publications: Peer-reviewed Articles 1. Hassoun PM, Shepherd KE, Flotte TJ, Kazemi H. Erythema induratum and active pulmonary tuberculosis.

Am J Med 1988;84:784-785. 2. Hassoun PM, Thompson BT, Hales CA. Effect of heparin and warfarin on chronic hypoxic pulmonary

hypertension and vascular remodeling in the guinea pig. Am Rev Respir Dis 1989;139:763-768. 3. Thompson BT, Hassoun PM, Kradin RL, Hales CA. Acute and chronic hypoxic pulmonary hypertension in

guinea pigs. J Appl Physiol 1989;66(2):920-928. 4. Hassoun PM, Pasricha PJ, Teufel E, Lee SL, Fanburg BL. Hypoxia stimulates the release by bovine

pulmonary artery endothelial cells of an inhibitor of pulmonary artery smooth muscle cell growth. Am J Resp Cell Mol Biol 1990;1:377-384.

5. Hassoun PM, Thompson BT, Hales CA. Partial reversal of hypoxic pulmonary hypertension by heparin. Am

Rev Respir Dis 1992;145:193-196. 6. Pasricha PJ, Hassoun PM, Teufel E, Landman MJ, Fanburg BL. Prostaglandins E1 and E2 stimulate the

proliferation of pulmonary artery smooth muscle cells. Prostaglandins 1992;43(1):5-19. 7. Hassoun PM, Thappa V, Landman M, Fanburg BL. Endothelin-1: mitogenic activity on pulmonary artery

smooth muscle cells and release from hypoxic endothelial cells. PSEBM 1992;199:165-170. 8. Hassoun PM, Shedd AL, Lanzillo JJ, Thappa V, Landman MJ, Fanburg BL. Inhibition of pulmonary artery

smooth muscle cell growth by hypoxanthine, xanthine and uric acid. Am J Respir Cell Mol Biol 1992;6:617-624. 9. Thannickal VJ, Hassoun PM, White AC, Fanburg BL. Enhanced rate of H2O2 release from bovine pulmonary

artery endothelial cells induced by transforming growth factor-ß1. Am J Physiol 265 (Lung Cell Mol Physiol 9) 1993;L622-L626.

10. Hertig IA, Hassoun PM, Zulueta JJ, Thannickal VJ, Fanburg BL. Mechanism of basal and transforming

growth factor beta-1 stimulated H2O2 release by endothelial cells. Transactions of the Association of American Physicians 1994;Vol CVI:179-186.

11. Hassoun PM, Yu FS, Shedd AL, Zulueta JJ, Thannickal VT, Lanzillo JJ, Fanburg BL. Regulation of endothelial

cell xanthine dehydrogenase/xanthine oxidase gene expression by oxygen tension. Am J Physiol 266 (Lung Cell Mol Physiol 10) 1994;L163-L171.

12. Zulueta JJ, Yu FS, Hertig IA, Thannickal VT, Hassoun PM. Release of hydrogen peroxide in response to

hypoxia-reoxygenation: role of NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane. Am J Respir Cell Mol Biol 1995;12:41-49.

13. Hassoun PM, Yu FS, Zulueta JJ, White AC, Lanzillo JJ. Effect of nitric oxide and cell redox status on the

regulation of endothelial cell xanthine dehydrogenase. Am J Physiol 268 (Lung Cell Mol Physiol 12) 1995;L809-L817.


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14. White AC, Maloney EK, Boustani MR, Hassoun PM, Fanburg BL. Nitric oxide increases cellular glutathione levels in rat lung fibroblasts. Am J Respir Cell Mol Biol 1995;13:442-448.

15. Liao JK, Zulueta JJ, Yu FS, Peng HB, Cote CG, Hassoun PM. Regulation of bovine endothelial constitutive

nitric oxide synthase by oxygen. J Clin Invest 1995;96:2661-2666. 16. Martin A, Zulueta J, Hassoun P, Blumberg JB, Meydani M. Effect of vitamin E on hydrogen peroxide

production by human vascular endothelial cells after hypoxia/reoxygenation. Free Radical Biol Med 1996;20:99-105.

17. Stevens J, Yu FS, Hassoun PM, Lanzillo JJ. Quantification of polymerase chain reaction products: enzyme

immunoassay based systems for digoxigenin- and biotin-labeled products that quantify either total or specific amplicons. Mol Cell Probe 1996;10:31-41.

18. Cote CG, Yu FS, Zulueta JJ, Hassoun PM. Regulation of intracellular xanthine oxidase by endothelial-derived

nitric oxide. Am J Physiol 271 (Lung Cell Mol Physiol 15) 1996;L869-L874. 19. Lanzillo JJ, Yu FS, Stevens J, Hassoun PM. Determination of xanthine oxidase mRNA by a reverse

transcription coupled competitive quantitative polymerase chain reaction assay: upregulation in rat endothelial cells by hypoxia. Arch Biochem Biophys 1996;335:377-380.

20. Hassoun PM. Dog kissing, recurrent Pasteurella pneumonia, and degenerative lung disease. Infectious Diseases in

Clinical Practice 1996;5:79-80. 21. Soubani AO, Miller KB, Hassoun PM. Pulmonary complications of bone marrow transplantation. Chest

1996;109:1066-1077. 22. Zulueta JJ, Sawhney R, Yu FS, Cote CC, Hassoun PM. Intracellular generation of reactive oxygen species in

endothelial cells exposed to anoxia-reoxygenation. Am J Physiol 272 (Lung Cell Mol Physiol 16) 1997;L897-L902. 23. Vosatka RJ, Hassoun PM, Harvey-Wilkes KB. Dietary L-arginine prevents fetal growth restriction in rats. Am

J Obstet Gynecol 1998;178(2):242-246. 24. Hassoun PM, Yu FS, Cote CG, Zulueta JJ, Sawhney R, Skinner KA, Skinner HB, Parks DA, Lanzillo JJ.

Upregulation of xanthine oxidase by lipopoysaccharide, interleukin-1 and hypoxia: role in acute lung injury. Am J Respir Crit Care Med 1998;158:299-305.

25. Libby ED, Fawaz R, Leano AM and Hassoun PM. Airway complications of self-expandable metallic stents.

Gastrointest Endoscop 1999;49:136-137. 26. Hassoun PM, Celli BR. Bilateral diaphragm paralysis secondary to central von Recklinghausen’s disease. Chest

2000;117(4):1196-2000. 27. Merker MP, Pitt PR, Choi PM, Hassoun PM, Dawson CA and Fisher AB. Lung redox homeostasis: Emerging

concepts. Am J Physiol (Lung Cell Mol Physiol) 2000;279(3):L413-L417. 28. Tanios MA, Kogelman L, McGovern B, Hassoun PM. Acute respiratory distress syndrome complicating

Plasmodium vivax malaria. Crit Care Med 2001; 29:665-667. 29. Kayyali U, Donaldson C Huang H, Abdelnour R, Hassoun PM. Phosphorylation of xanthine

dehydrogenase/oxidase in hypoxia. J Biol Chem 2001;276(17):14359-14365.


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30. Zulueta JJ, Sawhney R, Lanzillo JJ, Yu FS, Kim A, Hassoun PM. Modulation of inducible nitric oxide synthase

by hypoxia in pulmonary microvascular endothelial cells. Am J Respir Cell Mol Biol 2002; 26(1):22-30. 31. Kayyali US, Pennella CM, Trujillo C, Villa O, Gaestel M, Hassoun PM. The role of MK2 in mediating

cytoskeletal changes in hypoxic pulmonary endothelial cells. J Biol Chem 2002; 188(1): 59-68. 32. Curley MJ, Hussein SA, and Hassoun PM. Disseminated herpes simplex and varicella zoster in a patient taking

thalidomide for relapsed multiple myeloma. J Clin Microbiol. 2002;40(6):2302-2304. 33. Girgis RE, Li D, Zhan X, Garcia JGN, Tuder RM, Hassoun PM, Johns RA. Attenuation of chronic hypoxic

pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol 2003 Sep;285(3):H938-945. 34. Budhiraja R, Kayyali, U, Fogel M, Karamsetty, Hill NS, and Hassoun PM. Estrogen modulates xanthine

dehydrogenase/xanthine oxidase activity by a receptor-independent mechanism. Antioxid Redox Signal 2003 Dec;5(6):705-711.

35. Budhiraja R, Hassoun PM. Portopulmonary hypertension: a tale of two circulations. Chest 2003;123(2):562-

576. 36. Budhiraja R, Tuder RM, Hassoun PM. Endothelial dysfunction in pulmonary hypertension. Circulation 2004

Jan 20;109(2):159-165. 37. Tanios MA, El Gamal H, Epstein SK, Hassoun PM. Severe respiratory muscle weakness related to chronic

colchicine therapy. Respir Care. 49(2):189-191. 2004. 38. Tanios MA, Hassoun PM. Can we still miss tetrachloroethylene-induced lung disease? The emperor returns in

new clothes. Respiration 71(6):642-645, 2004. 39. Peng X, Hassoun PM, Sammani S, McVerry BJ, Burne MJ, Rabb H, Pearse D, Tuder RM, and Garcia JGN.

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med 169(11):1245-1251, 2004.

40. Hassoun PM, Filippov G, Fogel M, Kayyali U, Bloch KD. Hypoxia decreases the expression of soluble

guanylate cyclase in cultured rat pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 30;(6):908-913, 2004.

41. Hassoun PM, Krishnan, JA. Pulmonary hypertension as a risk factor for death in patients with sickle cell

disease. N Engl J Med 10:350(24): 2521-2522, 2004. 42. Severgnini M, Takahashi S, Rozo LM, Homer RJ, Kuhn C, Jhung JW, Perides G, Steer M, Hassoun PM,

Fanburg BL, Cochran BH, Simon AR. Activation of the STAT pathway in acute lung injury. Am J Physiol Lung Cell Mol Physiol 286(6): L1282-;1292, 2004.

43. McVerry B, Peng X, Hassoun PM, Sammani S, Simon BA, Garcia JGN. Sphingosine-1 phosphate reduces

vascular leak in murine and canine models of acute lung injury. Am J Respir Crit Care Med Nov 1;170(9):987-93, 2004.

44. Raghu G, Brown KK, Bradford WZ, Starko K, Noble PL, Schwartz DA, King TE Jr. and the Ideopathic

Pulmonary Fibrosis Study Group [Hassoun, PM]. A placebo-controlled trial of interferon gamma 10b in patients with idiopathic pulmonary fibrosis. N Engl J Med Jan 8:350(2): 125-133, 2004.


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45. Hassoun PM. Deciphering the “matrix” in pulmonary vascular remodelling. Eur Respir J, 25(5): 778-779, 2005. 46. An SS, Pennella CM, Gonnabathula A, Chen J, Wang N, Gaestel M, Hassoun PM, Fredberg JJ, Kayyali US.

Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways. Am J Physiol Cell Physiol. 289(3):C521-C530, 2005.

47. Peng X, Abdulnour RE, Sammani S, Ma SF, Han EJ, Tuder RM, Garcia JGN, Hassoun PM. Inducible nitric

oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med. 172(4):470-479, 2005. 48. Girgis RE, Mathai SC, Krishnan JA, Wigley FM, Hassoun PM. Long-term outcome of bosentan treatment in

primary pulmonary hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases. J Heart Lung Transplant. 24:1626-1631, 2005.

49. Abdulnour RE, Peng X, Han EJ, Hasan EJ, Kayyali US, JGN Garcia JGN, Hassoun PM. Mechanical stress

activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol 2006, 291(3):L345-L353.2006.

50. Fisher MR, Mathai SC, Champion HC, Girgis RE, Housten-Harris T, Hummers L, Wigley F, Hassoun PM.

Clinical differences between idiopathic and scleroderma-related pulmonary hypertension. Arthritis Rheum 54(9):3043-3050, 2006.

51. Forfia, PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC,

Champion HC, Girgis RE, Hassoun PM. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med. 174(9):1034-1041, 2006.

52. Papaiahgari S, Yerrapureddy A, Hassoun PM, Garcia JG, Birukov KG, Reddy SP. EGFR-Activated signaling

and actin remodeling regulate cyclic stretch-induced Nrf2-ARE activation. Am J Respir Cell Mol Biol. 36(3):304-312, 2006.

53. Mathai SC, Girgis RE, Fisher MR, Champion HC, Housten-Harris T, Zaiman AL, Hassoun PM. Addition of

sildenafil to bosentan monotherapy in pulmonary arterial hypertension Eur Respir J, 29(3):469-475. 2007.

54. Girgis RE, Mozammel S, Champion HC, Li D, Peng X, Shimoda LA, Tuder RM, Johns RA, Hassoun PM. Regression of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Lung Cell Mol Physiol. 292(5):L1105-1110, 2007.

56. Nonas SA, Moreno Vinasco L, Ma SF, Jacobson JR, Dudek SM, Flores C, Hassoun PM, Ye SQ, Moitra J,

Barnard J, Grigoryev DN, Garcia JGN. Use of consomic rats to derive genomic insights into ventilated-induced lung injury. Am J Physiol Lung Cell Mol Physiol 293(3): L292-L302, 2007.

57. Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, Grigoryev DN, Barnes K,

Tuder RM, Yamamoto M, Kensler TW, Biswal S, Mitzner W, Hassoun PM, Reddy SP. Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med. 176(12):1222-35, 2007.

57. Grigoryev DN, Fisher MR, Mathai SC, Girgis RE, Zaiman AL, Housten-Harris T, Cheadle C, Hummers LK,

Champion HC, Garcia JGN, Barnes KC, Wigley FM, Tuder RM, Hassoun PM. Identification of candidate genes in scleroderma-related pulmonary arterial hypertension. Transl Res. 2008 Apr;151(4):197-207, 2008.


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58. Forfia P, Mathai SC, Fisher MR, Housten-Harris T, Hemnes AR, Champion HC, Girgis RE, Hassoun PM. Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med 177(12):1364-9, 2008.

59. Le A, Damarala M, Boueiz A, Pae HH, Skirball J, Hasan E, Peng X, Damico R, Chesley A, Crow MT, Reddy

SP, Tuder RM, Hassoun PM. Alveolar Cell Apoptosis is Dependent on p38-MAPK-Mediated Activation of Xanthine Oxidoreductase in Ventilator-Induced Lung Injury. J Appl Physiol 105(4):1282-1290, 2008.

60. Dodd-o J, Hristopoulos, Scharfstein D, Brower RG, Hassoun PM, King LS, Becker PM, Liu M, Wang W,

Hassoun HT, Rabb H. Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse model. Am J Physiol: Lung Cell Mol Physiol Oct 10. [Epub ahead of print]PMID: 18849441 2008.

61. Bierman A, Yerrapureddy A, Reddy NM, Hassoun PM, Reddy SP. Epidermal growth factory receptor

(EGFR) regulates mechanical ventilation-induced lung injury in mice. Transl Res 152(6): 265-272, 2008. 62. Schmidt EP, Damarla M, Rentsendorj O, Servinsky LE, Zhu P, Moldobaeva A, Gonzalez A, Hassoun PM,

Pearse DB. Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 295(6) L1056-l1065, 2008.

63. Fisher MR, Forfia PR, Chamera E, Housten-Harris T, Champion HC, Girgis RE, Corretti MC, Hassoun PM.

Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med 179(7):615-21, 2009.

64. Damarla M, Hasan E, Boueiz A, Le A, Pae HH, Montouchet C, Kolb T, Simms T, Myers A, Kayyali US,

Gaestel M, Peng X, Reddy SP, Damico R, Hassoun PM. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. PLoS ONE 4(2):E4600. Epub Feb 25, 2009.

65. Barnett CF, Bonura EJ, Nathan SD, Ahmad S, Shlobin OA, Osei K, Zaiman AL, Hassoun PM, Moller DR,

Barnett SD, Girgis RE. Treatment of sarcoidosis-associated pulmonary hypertension: A two-center experience. Chest 2009 135(6):1455-1461, 2009.

66. Finigan JH, Boueiz A, Wilkinson E, Damico R, Skirball J, Pae HH, Damarla N, Hasan E, Pearse DB, Reddy SP,

Grigoryev D, Cheadle C, Esmon CT, Garcia JGN, Hassoun PM. Activated Protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol Lung Cell Mol Physiol 296(6):L1002-L1011, 2009. PMID 19363121.

67. Mathai SC, Hummers LK, Champion HC, Wigley FM, Zaiman A, Hassoun PM, Girgis RE. Survival in

pulmonary hypertension associated with the scleroderma spectrum of diseases: Impact of interstitial lung disease. Arthritis Rheum 60(2):569-577, 2009. PMID 19180517.

68. Angelini DJ, Su Q. Yamaji-Kegan K, Fan C. Teng X, Hassoun PM, Yang SC, Champion HC, Tuder RM,

Johns RA. Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension. Am J Respir Cell Mol Biol 41(5): 553-561, 2009. PMID19251945.

69. Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Disruption of Nrf2 impairs

the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol 182(11):7264-71, 2009. PMID 19454723.


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70. Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med. 180(9):867-874, 2009. PMID: 19679692.

71. Hassoun PM. Pulmonary arterial hypertension complicating connective tissue disease. Semin Respir Crit Care

Med 30(4):429-439, 2009. 72. Mathai SC, Bueso M, Hummers LK, Boyce D, Lechtzin N, LePavec J, Ezquibela AC, Champion HC,

Housten T, Forfia PR, Zaiman AL, Wigley FM, Girgis RE, Hassoun PM. Disproportionate elevation of NT-proBNP in scleroderma-related pulmonary hypertension. Eur Respir J, 2009, July 30 [Epub ahead of print].

73. Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberg SR,

Reddy SP. Innate immunity against bacterial infection following Hyperoxia exposure is impaired in NRF2-deficient mice. J Immunol 183(87):4601-4608, 2009.

74. Champion HC, Michelakis ED, Hassoun PM. Comprehensive invasive and noninvasive approach to the

right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation. 2009 Sep 15;120(11):992-1007.

75. Mathai SC, Hassoun PM. Therapy for pulmonary arterial hypertension associated with systemic sclerosis.

Current Opin Rheumatol 2009 Nov;21(6):642-648. 76. Peng XQ, Damarla M, Skirball J, Nonas S, Wang XY, Han EJ, Hasan EJ, Cao X, Boueiz A, Damico R, Tuder

RM, Sciuto AM, Anderson DR, Garcia JG, Kass DA, Hassoun PM, Zhang JT. Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung. Acta Pharmacol Sin. 2010 Feb;31(2):175-83.

77. Le Pavec J, Humbert M, Mouthon L, Hassoun PM. Systemic sclerosis associated pulmonary arterial

hypertension. Am J Respir Crit Care Med. 2009; 181(12):1285-1293, PMCID PMC2894407. 78. Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW,

Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol 2010;177(3):1549-1561. PMCID PMC2928984.

79. Campo A, Mathai SC, Le Pavec J, Zaiman AL, Hummers LK, Boyce D, Housten T, Champion HC, Lechtzin

N, Wigley FN, Girgis RE, Hassoun PM. Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension. Am J Respir Crit Care Med 182(2):252-260, 2010. PMCID: PMC 2913238

80. Chung L, Liu J, Parsons L, Hassoun PM, McGoon M, Badesch D, Miller DP, Nicolls MR, Zamanian RT.

Characterization of connective tissue disease associated pulmonary arterial hypertension from the REVEAL Registry: Identifying systemic sclerosis as a unique phenotype. Chest 2010;138(6):1383-94.

81. Le Pavec J, Launay D, Mathai SC, Hassoun PM, Humbert M. Scleroderma lung disease. Clin Rev Allergy

Immunol. 2011 40(2): 104-116. 82. Shehata ML, Basha TA, Tantawy WH, Lima JA, Vogel-Claussen J, Bluemke DA, Hassoun PM, Osman NF.

Real-time single heartbeat fast strain-encoded imaging of right ventricular regional function: Normal versus chromic pulmonary hypertension. Magn Reson Med 2010; 64(1):98-106.


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83. Damico R, Simms T, Kim BS, Tekeste Z, Amankwan H, Damarla M. Hassoun PM. p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: Inhibitory effects of macrophage migration inhibitor factor. Am J Respir Cell Mol Biol 2011;44(3):323-332.

84. Vogel-Claussen J, Skrok J, Shehata ML, Singh S, Sibley CT, Boyce DM, Lechtzin N, Girgis RE, Mathai SC,

Goldstein TA, Zheng J, Lima JA, Bleumke DA, Hassoun PM. Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension. Radiology 2011; 258(1):119-127. PMCID: PMC3009386.

85. Shehata ML, Lossnitzer D, Skrork J, Boyce D, Lechtzin N, Mathai SC, Girgis RE, Osman N, Lima JA,

Bleumke DA, Hassoun PM, Vogel-Claussen J. Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling. Am J Roentgenol 2011; 196(1):87-94. PMCID: PMC3034131.

86. Hassoun PM, Damico R. Moving beyond the ‘Allegory of the Care” in the assessment of pulmonary arterial

hypertension. J Appl Physiol 2011; 110(4):871-2 87. Le Pavec J, Girgis RE, Lechtzin N, Mathai SC, Launay D, Hummers LK, Zaiman A, Sitbon O, Simonneau G,

HumBert M, Hassoun PM. Systemic sclerosis related pulmonary hypertension associatr3ed with interstitial lung disease: Impact of pulmonary arterial hypertension therapies. Arthritis Rheum 2011; 63:2456-64.

88. Kawut SM, Bagiella E, Lederer DH, Shimbo D, Horn EM, Roberts KE, Hill NS, Barr RG, Rosenzweig EB,

Post W, Tracy RP, Palevsky HI, Hassoun PM, Girgis RE on behalf of the ASA-STAT Study Group. Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension. Circulation 123(25): 2985-2993, 2011

89. Vogel-Claussen J, Shehata ML, Ossnitzer D, Skrok J, Sing S. Boyce D, Lechtzin N, Girgis RE, Mathai SC,

Lima JA, Bluemke DA, Hassoun PM. Increased right ventricular septomarginal trabeculation mass is a novel marker for pulmonary hypertension: Comparison with ventricular mass index and right ventricular mass. Invest Radiol 2011; 46:567-75.

90. Hassoun PM, Damico R. Moving beyond the ‘Allegory of the cave’ in the assessment of pulmonary arterial

hypertension. J Appl Physiol 110(4):871-872, 2011. 91. Campo A, Mathai SC, Le Pavec J, Zaiman AL, Hummers LK, Boyce D, Housten T, Lechtzin N, Chami H,

Girgis RE, Hassoun PM. Outcomes of hospitalisation for right heart failure in pulmonary arterial hypertension. Eur Respir J 2011 Aug;38(2):359-67.

92. Mathai SC, Sibley CT, Forfia PR, Mudd JO, Fisher MR, Tedford RJ, Lechtzin N, Boyce D, Hummers LK,

Housten T, Zaiman AL, Girgis RE, Hassoun PM. Tricuspid annular plane systolic excursion is a robust outcome measure in scleroderma-associated pulmonary arterial hypertension. J Rheum 2011; 38:2410-8.

93. Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers

AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, Kitsis RN, Crow MT. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 124(23): 2533-2542, 2011.

94. Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Mudd JO, Borlaug BA,

Redfield MM, Lederer DJ, Kass DA. Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation, 125(2) 289-297, 2012.


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95. Skrok J, Shehata ML, Mathai S, Girgis RE, Zaiman A, Mudd JO, Boyce D, Lechtzin N, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J. Pulmonary Arterial Hypertension: MR Imaging-derived First-Pass Bolus Kinetic Parameters Are Biomarkers for Pulmonary Hemodynamics, Cardiac Function, and Ventricular Remodeling. Radiology. 2012 Jun;263(3):678-87.

96. Cheadle C, Berger AE, Mathai SC, Grigoryev DN, Watkins TN, Sugawara Y, Barkataki S, Fan J, Boorgula M,

Hummers L, Zaiman AL, Girgis R, McDevitt MA, Johns RA, Wigley F, Barnes KC, Hassoun PM. Erythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients. PLoS One. 2012;7(4):e34951.

97. D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez

JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J. Immunol .2012 Sep 1;189(5):2234-45.

98. Shehata ML, Harouni AA, Skrok J, Basha TA, Boyce D, Lechtzin N, Mathai SC, Girgis R, Osman NF, Lima

JA, Bluemke DA, Hassoun PM, Vogel-Claussen J. Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study. Radiology. 2013 Jan;266(1):114-22.

99. Hassoun PM, Nikkho S, Rosenzweig EB, Moreschi G, Lawrence J, Teeter, J, Meier C, Ghofrani AH, Minai

O, Rinaldi P, Michelakis E, Outiz RJ. Updating clinical endpoint definitions. Pulm Circulation. 2013;3(1): 205-210.

100. Hoeper MM, Barst RJ, Bourge RC, Feldman J, Frost AE, Galié N, Gómez-Sánchez MA, Grimminger F,

Grünig E, Hassoun PM, Morrell NW, Peacock AJ, Satoh T, Simonneau G, Tapson VF, Torres F, Lawrence D, Quinn DA, Ghofrani HA. Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study. Circulation. 2013 Mar 12;127(10):1128-38.

101. Mahammedi A, Oshmyansky A, Hassoun PM, Thiemann DR, Siegelman SS. Pulmonary artery

measurements in pulmonary hypertension: the role of computed tomography. J Thorac Imaging. 2013 Mar;28(2):96-103

102. Kim BS, Serebreni L, Hamdan O, Wang L, Parniani A, Sussan T, Scott Stephens R, Boyer L, Damarla M,

Hassoun PM, Damico R. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free Radic Biol Med. 2013 Feb 4. [Epub ahead of print]

103. Meyer S, McLaughlin VV, Seyfarth HJ, Bull TM, Vizza CD, Gomberg-Maitland M, Preston IR, Barberà JA,

Hassoun PM, Halank M, Jaïs X, Nickel N, Hoeper MM, Humbert M. Outcome of non-cardiac, non-obstetric surgery in patients with pulmonary arterial hypertension: results from an international prospective survey. Eur Respir J. 2012 Nov 8. [Epub ahead of print]

104. Tedford RJ, Mudd JO, Girgis RE, Mathai SC, Zaiman AL, Housten T, Boyce D, Hummers LK, Wigley FM, Russell SD, Hassoun PM and Kass DA. The etiology of right ventricular dysfunction in systemic sclerosis associated pulmonary arterial hypertension. 2013 (Circ Heart Fail, in press)


11

Invited Reviews/Book Chapters/ Multicenter Studies/ and Case Reports: 1. Hassoun P, Hales C. Corticosteroids. In Current Respiratory Care Techniques and Therapy. Ed, RM

Kazcmarek, JK Stoller. BC Decker, Inc., Ontario Canada, pp 62-68, 1988. 2. Hassoun PM, Eichhorn JH. MGH Case Records (Case 45-1989): A 48-year-old woman with ARDS and

left flank pain. N Engl J Med 1989;321:1316-1329. 3. Hassoun PM, Fanburg BL, Junod AF. Endothelium: Metabolic functions. The Lung: Scientific

Foundations. Edited by RG Crystal, JB West et al, Raven Press Ltd, New York. Chap 3.2.2. pp 313-327, 1991.

4. Hassoun PM. Role of endothelial cells in the remodeling of pulmonary vessels. In: Proceedings of the

International Meetings on Pathophysiology of Pulmonary Cells. A. Junod, D. Olivieri, E. Pozzi, Eds. Endothelial and Mucus Secreting Cells. Masson Italia Publications, Milan, Italy, pp 19-31, 1991.

5. Hassoun PM, Mark EJ. MGH Case Records (Case 43-1991): A 27-year-old man with AIDS, a cough,

fever, and pulmonary infiltrates. N Engl J Med 1991;325:1228-1239. 6. Vosatka RJ, Hassoun PM, Yu FS, Harvey-Wilkes KB. Modulation of xanthine oxidase, plasma uric acid

and fetal growth by endogenous nitric oxide. Pediatrics 1996; 98(3S-II) (Supplement):581-582. 7. Cote CG, Cicchelli R, Hassoun PM. Hemoptysis and a lung mass in a 51-year-old patient with asthma.

Chest 1998;114:1465-1468. 8. Simon AR and Hassoun PM. Thromboembolic disease: diagnosis and management. Hospital Physician

1998;34(11) 21-37. 9. Hassoun P and Saltzman E. Clinical implications of Phen/Phen and other appetite suppressants. Annals

of Pharmacology in Anesthesiology Clinics 17:273-286, 1998. 10. Hassoun P and Simon A. Cigarette smoking and the risk of thromboembolic disease. Hospital Physician

1999;35[2]:7-8. 11. Hassoun PM, Fogel MA, Kayyali US. Role of xanthine oxidase and inducible nitric oxide synthase in acute

lung injury. In Proceedings of the XXXIVth Middle East Medical Assembly, American University of Beirut, May 1999.

12. Hassoun PM. Primary pulmonary hypertension: a century of knowledge. In Proceedings of the XXXIVth

Middle East Medical Assembly, American University of Beirut, May 1999. 13. Tanios MA, Simon AR, and Hassoun PM. Management of venous thromboembolic disease in the

chronically critically ill patient. Clin Chest Med 2001;22(1):105-22. 14. Saltzman E., Mogensen KM, and Hassoun PM. Malnutrition in the intensive care unit. In SA Shikora,

RG Martindale, SD Schwaitzberg (eds), Nutritional Consideration in the Intensive Care Unit. Science, Rationale, and Practice. A.S.P.E.N. Silver Spring, MD. 2002;1:1-10.

15. Grigoryev DN, Finigan JH, Hassoun PM, Garcia JGN. Searching for gene candidates in acute lung injury.

Crit Care 2004 8(6):440-447.


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16. Sukkar A, D Mollura D, King K, J Spivak J, Hassoun PM, McDyer JF. A case of pulmonary hypertension

associated with a rare congenital hemolytic anemia. (In press) Clinical Pulmonary Medicine 12:319-322, 2004. 17. Kayyali US and Hassoun PM. Endothelial xanthine oxidoreductase and vascular disease. In: Encyclopedia

of the Microvasculature. (D Shepro, Ed.) Elsevier Publishing, San Diego, CA 2005. 18. Fisher MR, Hassoun PM. Prediction of pulmonary artery pressure. Chest. 2005, 128(1):466-467. Author

Reply 467. 19. Girgis RE, Ma SF, Ye S, Grigoryev DN, Li D, Hassoun PM, Tuder RM, Johns RA, Garcia JG. Differential

gene expression in chronic hypoxic pulmonary hypertension: Effect of simvastatin treatment. Chest Dec 2005 128 (6 Suppl):579S.

20. Zaiman A, Fijalkowska I, Hassoun PM, Tuder RM. One hundred years of research in the pathogenesis of

pulmonary hypertension. Am J Respir Cell Mol Biol 2005 33(5):425-431. 21. Mathai SC, Hassoun PM. N-terminal brain natriuretic peptide in scleroderma-associated pulmonary

arterial hypertension. Eur Heart J 28(1):140-1; author reply 141, 2007. 22. Reddy SP, Hassoun PM and Brower R. Redox imbalance and ventilator induced lung injury Antioxidants

& Redox Signaling 9(11):2003-12. Review, 2007. 23. Boueiz A, Damarla M, Hassoun PM. Xanthine oxidoreductase in respiratory and cardiovascular disorders.

Am J Physiol:Lung. (Review) 294(5):L830-40, 2008. 24. Boueiz A, Hassoun PM. Regulation of endothelial barrier function by reactive oxygen and nitrogen

species. Review. Microvasc Res. 77(1):26-34., 2009 PMID 19041330. 25. Champion HC, Michelakis ED, Hassoun PM. A comprehensive invasive and non-invasive approach to

the right ventricle-pulmonary circulation unit. Circulation. 120 (11):992-1007, 2009. PMID 19752350. 26. Boueiz A, Mathai SC, Hummers LK, Hassoun PM. Cardiac complications of systemic sclerosis: Recent

progress in diagnosis. Current Opin Rheumatol 2010;22(6):696-703.

27. Girgis RE, Mathai SC, Wigley FM, Hassoun PM. Survival in systemic sclerosis-related pulmonary arterial hypertension. Author Reply. Am J Respir Crit Care Med l80(12):1280, 2009. PMID 19949241.

28. Hoeper MM, Barberà JA, Channick RN, Hassoun PM, et al. Diagnosis, assessment, and treatment of non-

pulmonary arterial hypertension. J Am Coll Cardiol 54: S85-S96, 2009. PMID 19555862. 29. Hassoun PM, Mouthon L, Barbera JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML,

Michelakis ED, Morrell N W, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan J X-J, Humber M. Inflammation, growth factors and pulmonary vascular remodeling. J Am Coll Cardiol 54:S10-S19, 2009. PMID 19555853.

30. Hassoun PM. Therapies for scleroderma-related pulmonary arterial hypertension. Expert Rev Respir Med (

3(3):187-196, 2009. PMID 19885388.

31. Hassoun PM. Role of inflammation in pulmonary arterial hypertension. PVRI Review, 2(1):2-4, 2010.


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32. Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer S, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn II,GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Marc Humbert M, Naftali Kaminski N, Kawut SK, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R,. Yoder MC, Zhao Y, Gail D, Moore TM. Strategic Plan for Lung Vascular Research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med 182(12):1554-62, 2011.

33. Hassoun PM. Lung involvement in systemic sclerosis. Presse Med 40 (1) e3-e17, 2011. PMID 20833821. 34. Mathai SC, Hassoun PM. Pulmonary arterial hypertension associated with systemic sclerosis. Expert Rev

Respir Med, 5(2):267-279, 2011. 35. El Chami H, Hassoun PM. Inflammatory mechanisms in the pathogenesis of pulmonary arterial

hypertension. Compr Physiol 1:1-13, 2011

36. Mathai SC, Hassoun PM. Pulmonary arterial hypertension in connective tissue diseases. Heart Fail Clin N Am 2012 Jul;8(3):413-25

37. Hassoun PM and Adnot S. Update in pulmonary vascular diseases 2011. Am J Respir Crit Care Med. 2012 Jun 1;185(11):1177-82.

38. El Chami H, Hassoun PM. Immune and inflammatory mechanisms in pulmonary arterial hypertension. Prog Cardiovasc Dis. 2012 Sep-Oct;55(2):218-28. doi: 10.1016/j.pcad.2012.07.006. Review.

39. Damico R, Zulueta JJ, Hassoun PM. Pulmonary endothelial cell NOX. Am J Respir Cell Mol Biol. 2012 Aug;47(2):129-39. Review.

40. Hassoun PM. Drumming up prognostic significance in a heartbeat in pulmonary arterial hypertension.

Am J Respir Crit Care Med. 2012 Feb 15;185(4):354-5.

41. Kolb TM, Hassoun PM. Right ventricular dysfunction in chronic lung disease. Cardiol Clin. 2012 May;30(2):243-56.

42. Chaisson NF, Hassoun PM. Systemic sclerosis associated pulmonary arterial hypertension. Chest.

Submitted 2013. Review. 43. Boileau C. Guo DC, Hanna; N, Regalado ES, Detaint D, et al (388 collaborators including Hassoun PM).

TGF Beta2 mutations cause familial thoracic aortic aneukrysms and dissections associated with mild systemic features of Marfan syndrome. Nat Genet 2012 Jul 8;44(8): 916-21.

44. Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, et al (393 collaborators including Hassoun PM).

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chromic Pseudomonas aseruginosa infection in cystic fibrosis. Nat Genet 2012 Jul 8; 44(8): 886-91.

45. Fu W, O’Connor TD, Jun G, Kang HM, Abecasis G, et al (396 collaborators including Hassoun PM).

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature 2013 Jan 19;493(7431):216-20.


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Letters 1. Campo A, Mathai SC, Girgis RE, Hassoun PM. Is pulmonary arterial hypertension really a late

complication of systemic sclerosis? Chest 2010; 138(2):461-462.

2. Mathai SC, Hassoun PM. Drs. Mathai and Hassoun reply. J Rheumatol. 2013 Jan;40(1):91. No abstract available.

Inventions, Patents, Copyrights None Extramural Sponsorship: Current Dates: 08/15/2012-05/31/2017 Title: Mechanisms of Right Ventricular Dysfunction with PAH ID Number: R01 HL114910 (Grant #113231) Sponsor: NIH/NHLBI Direct Costs: $434,806 current year PI: Hassoun 20%, and Kass 20% The goals of this project are to 1) derive optimal non-invasive measures of right ventricular (RV) performance based on cardiac magnetic resonance imaging to predict survival in both idiopathic (IPAH) and scleroderma-associated (SSc-PAH) pulmonary arterial hypertension (PAH); 2) determine RV function and PA interaction by invasive pressure-volume and right heart catheterization, using rate pacing and leg-exercise to assess reserve RV function; and 3) obtain RV biopsies to test the role of primary sarcomere dysfunction to reduced RV contractility in PAH, identify cytokine activation pathways linked to transforming growth factor-beta cascades and angiogenesis modulators, and assess the potential for associated serum biomarkers to reflect RV disease. Dates: 04/01/2010-03/31/2014 Type R01 Title: Role of xanthine oxidoreductase in acute lung injury ID Number HL 04944 Sponsor: NIH/NHLBI Total Direct $222,750 current year PI: Hassoun Role: Principal investigator, 25% This project will determine the contribution of XOR to increased permeability and oxidant injury in ventilator-associated lung injury (VALI). Project aims are to define the mechanisms and sites of XOR post-translational modification by the MAP kinase pathway, to determine the role of XOR and mechanisms involved in endothelial cell apoptosis in response to mechanical stress, and to define the contribution of XOR in mechanical stress mediated cytoskeletal rearrangement and capillary leakage. Dates: 01/12/2007-12/31/2013 (NCE) Type Specialized Center of Clinically Oriented Research in Pulmonary Vascular Disease (SCCOR). Title: Molecular determinants of pulmonary arterial hypertension. ID Number: P50 HL084946 Sponsor: NIH/NHLBI Direct Costs: $690,147


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PI: Hassoun Roles: Principal Investigator/SCCOR Director

Project 1 Leader, 25% Core A Co-Leader, 5%

This project will utilize state of the art physiological, molecular, genomic and proteomic approaches and novel phenotyping instrumentation to expand our understanding of the critical pathobiologic processes of right ventricle-pulmonary vascular dysfunction and uncoupling and define key genetic determinants of scleroderma-associated pulmonary arterial hypertension. Dates: 01/01/2010-12-31/2013 Title: Role of cGMP in ventilator-induced lung endothelial barrier dysfunction ID Number: R01 HL067189-05A1 Sponsor: NIH/NHLBI Direct Costs: $222,750/year PI: Pearse Role: Co-Investigator, 2% The goal of this project is to determine the role of the second messenger cyclic guanosine monophosphate in the endothelial barrier dysfunction caused by large tidal volume ventilation Dates 01/10/2009-12/31/2013 NCE Title: Exhaled nitric oxide and oxidative stress in PAH associated with systemic sclerosis ID Number: R01 HL092831 (Hassoun/Girgis) Sponsor: NIH/NHLBI Direct Costs: $173,250 PI: Hassoun/Girgis, 2% The major goals of this project are to assess exhaled nitric oxide and biomarkers of oxidative stress in patients with PAH associated with scleroderma and their relationship with disease severity and changes in response to therapy. Dates: 07/01/2012-06/30/2014 Title: A genome-wide methylation study of epigenetic contributions to PAH ID Number: 1 R03 HL114937 Sponsor: NIH/NHLBI Direct Costs: $100,000 (two years) PI: Gao Role: Co-investigator/mentor, 3% effort-no salary support This study will utilize integrative unbiased genome-wide approaches to determine the distinct genome-wide methylation and gene expression signatures in PAH patients compared to non-diseased control subjects, and validate metabolic signaling pathway molecules as biomarkers and novel therapeutic targets for PAH therapy. Extramural Sponsorship: Pending Dates: 09/01/2013-08/31/2018 Title: Role of Col18a1 in right ventricular remodeling and function ID Number: 1R21HL120765-01 Sponsor: NIH/NHLBI Direct Costs: $1,271,836. Co PD/PI: Damico/Hassoun Role: Co-PD/PI, 10%


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The goals of this project are to define the molecular and cellular effects of polymorphisms in the gene Col18a1 encoding endostatin on right ventricular adaptive remodeling in the context of pulmonary arterial hypertension. Dates: 09/01/2013-08/31/2018 Title: Role of ARC in pulmonary arterial hypertension ID Number: R01 HL121136 Sponsor: NIH/NHLBI Direct Costs: $250,000/year PI: Damico Role: Co-Investigator, 5% This project will focus on the molecular mechanism(s) responsible for the altered expression and pathologic function of Apoptosis Repressor with CARD (ARC) in pulmonary arterial hypertension Dates: 09/01/2013-08/31/2017 Title: Biomarkers of Pulmonary Hypertension ID Number: R01 HL121367 Sponsor: NIH/NHLBI Direct Costs $443,703/year PI: Everett, Allen Role: Co-Investigator, 2% The long-term goal of this study is to identify lung/vascular specific circulating, diagnostic and prognostic markers of PAH to improve long-term outcomes. Dates: 09/01/2013-08/31/2018 Title: The function of ATP8B4 mutations in scleroderma and pulmonary hypertension ID Number: R21/R33 HL120763 Sponsor: NIH Direct Costs: $150,000/year PI: Gao Role: Co-Investigator, 2% The goal of our phased (R21 to R33) innovation study is to provide the first evidence that ATP8B4 is a novel phospholipid transporter and defect in ATP8B4 play a critical role in regulating pathogenesis of diverse phenotypes, in particular, SSc and SSc-PAH. Extramural Sponsorship: Previous 5 years Dates: 12/01/2008-11/30/2012 Title: Exhaled nitric oxide and oxidative stress in pulmonary arterial hypertension associated with systemic

sclerosis ID Number: R01 HL092831 Sponsor: NIH/NHLBI Direct Costs: $237,431 PI: Girgis Role: Co-Investigator, 20% An ancillary study to a clinical trial in scleroderma associated pulmonary arterial hypertension. Extra Dates: 03/01/2006-02/28/2011 Title A clinical trial of aspirin and simvastatin in pulmonary arterial hypertension ID Number: Not known (R01-NIH/NHLBI) Sponsor: Columbia University (subcontract)


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Direct Costs: $608,588 PI: Kawut Role: Co-Investigator, 5% Dates: 09/30/2009 - 09/29/2011 Title: NHLBI Lung Cohorts Sequencing Project ID Number: RC2 HG005555 Sponsor: University of Washington (NIH) PI: Barnes Role: Co-Investigator, 0.6 calendar months Notes: The major goal of this proposal is to apply second generation re-sequencing technology to identify disease-causing variants influencing pediatric and adult lung diseases in a collection of seven population cohorts that have been well characterized for a comprehensive set of clinical lung diseases. Dates: 04/01/2008 - 03/31/2010 Title: Research on Ethical Issues in Human Subjects Research: Testing Modified Approaches to Informed

Consent ID Number: 1R21AI74005-01A1 Sponsor: NIH/NIAID PI: Kass Role: Co-Investigator (0.12 calendar months) Notes: The broad goals are to design simple informed consent interventions with an approach relevant to most types of trials; and then determine the feasibility of testing them in the context of six ongoing clinical trials at Johns Hopkins. Dates: 12/01/2003-09/30/2009 (NCE) Title: SCCOR: “Ventilation associated lung injury: molecular approaches” ID Number: P50 HL073944 Sponsor: NIH/NHLBI Specialized Centers of Clinically Oriented Research (SCCOR) Direct Costs: $13.7 million PIs: Brower and Hassoun Role: Co-Leader, Core A, Administrative, 5% Co-Leader, Project 6, Antioxidant regulators in VALI, 15% Notes: It is a thematic underpinning of this SCCOR application that advances in genomic technology provides the opportunity to not only characterize pulmonary responses to VALI with increased sensitivity and clarity, but to also identify new molecular targets for potential therapy. We propose to conduct comprehensive genomic and proteomic studies of human and animal models of acute lung injury (with rigorous phenotypic characterization) and characterize potentially important polymorphisms in a large cohort of well-phenotyped patients with ALI. Dates: 07/01/2004-06/30/2008 Title: “The regulation and role of xanthine oxidase in lung injury” ID Number: R01 HL 49441 Sponsor: NIH/NHLBI Direct Costs: $800,000 PI: Hassoun Role: Principal Investigator, 35% Notes: The major goal of this project is to explore the regulation of the enzyme xanthine oxidoreductase in ventilator-associated lung injury


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CLINICAL TRIALS, CURRENT Dates: 10/31/06-03/31/14 Title: Effects of Combination of Bosentan and Sildenfil vs Sildenafil ID Number: AC-052-414 (Zaiman) Sponsor: ACTELION, LTD Direct Costs: $216,000 PI: Zaiman/Hassoun, 1% A multi-center, double-blind, randomized, placebo-controlled parallel group, prospective, event-driven Phase IV study to determine the effects of the combination of bosentan and sildenafil versus sildenafil monotherapy on morbidity and mortality in symptomatic patients with pulmonary arterial hypertension. EDUCATIONAL ACTIVITIES: Teaching Activities: 1989-2000 Responsible for Weekly Pulmonary Clinical Conference for Fellowship Training, New

England Medical Center 1989-2002 Morning Report Residency Training Program, New England Medical Center 1989-2002 Director of Bronchoscopy Activities, New England Medical Center, Boston 1998-2002 Mentor, Summer Research Program for Undergraduate Minority Students (Tufts University,

Sackler School of Graduate Biomedical Sciences) 1988-2002 Lecturer - Pulmonary curriculum; Pulmonary Pathophysiology Course

Tufts University School of Medicine, Boston, Massachusetts 2000-2002 Chief Rounds

Tufts University School of Medicine, Boston, Massachusetts 1989-2002 Lecturer, NEMC Residency Training Program 2002-2012 Mentor, Summer Research Program for undergraduate, under-represented, minority

students, Johns Hopkins University Mentoring Former Trainees: NAME YEAR CURRENT POSITION Pankaj Jay Pasricha, M.D. 1989-1990 Professor of Medicine,

Director of Johns Hopkins Center for Motility Disorders and Digestive Diseases

Johns Hopkins University Michael Landman, M.D. 1989-1990 Private Practice


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Vivek Thappa, M.D. 1989-1990 Associate Professor of Medicine Pulmonary and Critical Care Medicine

University of Illinois Medical College Victor Thannickal, M.D. 1991-1992 Professor of Medicine and Pathology

Director, Division of Pulmonary and Critical Care University of Alabama at Birmingham

Birmingham, Alabama Isabelle Hertig, M.D. 1992-1993 Staff, Holy Cross Hospital Silver Spring, MD Claudia Cote, M.D. 1994-1997 Deceased (January 2010)

Former Director, MICU Pulmonary and Critical Care Division

Bay Pines Medical Center University of Florida Javier Zulueta, M.D. 1993-1997 Chief, Div of Respiratory Medicine

Clinica Universitaria de Navarra Universidad de Navarra Pamplona, Spain Ayman O. Soubani, M.D. 1993-1996 Professor of Medicine and Medical Director Pulmonary & Critical Care Division Wayne State University School of Medicine, Detroit, MI Michael Fogel 1997-1998 MD/PhD Program, TUSM Julian Sanchez 1998 MD/PhD Program, TUSM Janell Catlin 1999 Columbia University Department of Pharmacology Usamah Kayyali, Ph.D. 1999-2002 Associate Professor of Medicine Pulmonary and Critical Care Division

New England Medical Center Tufts University School of Medicine Cameron W. Donaldson 1999-2001 Clinical Associate, Internal Medicine, Tufts University School of Medicine Hai-Lu Huang, M.D. 2000-2001 Research Associate Pulmonary and Critical Care Division

New England Medical Center Tufts University School of Medicine

Besstina Lyles 6/01-8/01 Summer Research Program for

Undergraduate Minority Students


20

Tufts University, Sackler School of Graduate Biomedical Sciences)

Oscar Le, M.D. 7/01-8/02 Instructor Pulmonary and Critical Care Division

New England Medical Center Tufts University School of Medicine Rohit Budhiraja, MD 7/2001-8/2002 Assistant Professor of Medicine

Pulmonary and Critical Care Division University of Arizona

Micah Fisher, MD 7/2003-06/2005 Assistant Professor and

Director, Medical ICU Pulmonary and Critical Care Medicine

Emory University, Atlanta, Georgia Rachel L. Damico, MD, PhD 7/2005-Present K08 Award Assistant Professor of Medicine FAMRI Award Pulmonary & Critical Care Medicine CSA Award Johns Hopkins University DOM Stephanie Nonas, MD 7/2005-6/2007 Assistant Professor of Medicine

NRSA Award Pulmonary and Critical Care Medicine K-23 Award Oregon Health & Science University, Portland,

Oregon James H. Finigan, MD 7/2005-6/2007 Assistant Professor of Medicine

NRSA Award Pulmonary and Critical Care Medicine K08 Award National Jewish Health, Denver, Colorado Raja-Elie Abdulnour, MD 9/2003-06/2007 Postdoctoral Fellow Brigham & Women’s Hospital Harvard Medical School Quy Hoa (Anne) Le Thi, MD 02/2007-01/2008 Instructor of Medicine Division of Hematology Johns Hopkins University Xinqi Peng, MD, PhD 8/2002-05/2008 Government

AHA Award Stephen C. Mathai, MD 7/2004-Present Assistant Professor of Medicine

NRSA Award Pulmonary and Critical Care Medicine LRP Award Johns Hopkins University K23 Award Lynnette Brown, MD 7/2006-07/2008 Assistant Professor of Medicine Pulmonary and Critical Care Medicine University of Utah SOM


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Mahendra Damarla, MD 7/2006-Present Assistant Professor of Medicine NRSA Award Pulmonary and Critical Care Medicine K08 Award Johns Hopkins University JHU CSA Award

Adel El-Boueiz, MD 11/2006-06/2009 Postdoctoral Fellow Brigham & Women’s Hospital Harvard Medical School Arunzazu C.Ezquibela, MD 07/2008-05/2010 Division of Respiratory Medicien Clinica Universitaria de Navarra

Universidad de Navarra, Spain

Hala El Chami, MD 04/2010-04/2011 Resident St. Elizabeth Medical Center

Tufts University Monica Bueso, MD 07/2010-06/2011 Post-doctoral Fellow

Pulmonary and Critical Care Medicine Johns Hopkins University Laurent Boyer, MD 07/2011- 08/2012 Assistant Professor Physiologie Explorations Fonctionelles Hôpital Henri Mondor, Créteil, France Current Trainees Bo Kim, MD 07/2008-Present Post-doctoral Fellow FAMRI Award Pulmonary and Critical Care Medicine Johns Hopkins University Li Gao, PhD 07/2008-Present Assistant Professor of Medicine Allergy & Clinical Immunology Johns Hopkins University Todd Kolb, MD, PhD 07/2010-Present Post-doctoral Fellow NRSA Award Pulmonary and Critical Care Medicine ATS/PHA Award Johns Hopkins University Neal F. Chaisson, MD 07/2011-Present Post-doctoral Fellow Pulmonary and Critical Care Medicine Johns Hopkins University Training Program Participation 2005-present T32 HL007534 NIH/NHLBI Multidisciplinary Training Program in Lung Diseases PD: Robert A. Wise, MD Educational Program Building/Leadership


22

N/A Educational Extramural Funding N/A


23

CLINICAL ACTIVITIES: Licensure and Certification: 2002- Maryland Medical License D0059427 Year Organization Number 1981 ECFMG 51585 1981 Visa Qualifying Exam (VQE) Parts I & II 1982 Commonwealth of Massachusetts medical license 51585 1983 FLEX Board Certification 1984 American Board of Internal Medicine (permanent diploma) 97292 1986 ABIM, subspecialty in Pulmonary Diseases (permanent diploma) 97292 1991 ABIM, subspecialty in Critical Care Medicine 97292 2002 ABIM, subspecialty in Critical Care Medicine 97292 (re-certification, valid until 2012) Clinical Service Responsibilities: Assistant Physician, Department of Medicine 1988-1994 Pulmonary and Critical Care Division New England Medical Center, Boston, Massachusetts Physician, Medicine Department Medicine Center and New England Sinai Hospital 1991-2002 Rehabilitation Center Stoughton, Massachusetts Physician, Department of Medicine Winchester Hospital 1993-2002 Winchester, Massachusetts Physician, Department of Medicine Pulmonary and Critical Care Division 1995-2002 New England Medical Center, Boston, Massachusetts

Physician, Department of Medicine Division of Pulmonary and Critical Care Medicine 2002-Present Johns Hopkins Hospital, Baltimore, Maryland Director, Division of Pulmonary and Critical Care Medicine Pulmonary Hypertension Program Johns Hopkins University, Baltimore, Maryland 2002-Present Clinical Program Building/Leadership 2011-present Director Johns Hopkins University Pulmonary Hypertension Program Clinical Extramural Funding N/A


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SYSTEM INNOVATION AND QUALITY IMPROVEMENT ACTIVITIES System Innovation and Quality Improvement Publications System Innovation and Quality Improvement efforts within JHM System Innovation and Quality Improvement efforts outside of JHM Production of guidelines and/or protocols System Innovation and Quality Improvement Program Building/Leadership System Innovation and Quality Improvement Extramural Funding N/A ORGANIZATIONAL ACTIVITIES Institutional Administrative Appointments Physician, Department of Medicine Division of Pulmonary and Critical Care Medicine 2002-Present Johns Hopkins Hospital, Baltimore, Maryland Director, Division of Pulmonary and Critical Care Medicine 2002-Present Pulmonary Hypertension Program

Johns Hopkins University 2005-Present Faculty Recruitment Committee

Division of Pulmonary and Critical Care Medicine Johns Hopkins University

2009-Present David M. Levine Excellence in Mentoring Awards Selection Committee Johns Hopkins University New England Medical Center Committee Assignments: 1997-2000 Scientific Affairs Committee, Tufts University School of Medicine 1997-2002 Internship Selection Committee, New England Medical Center 2000-2003 Scientific Affairs Committee, Tufts University School of Medicine 2001 Member, subcommittee for TUSM Academic Promotions Committee 2001-2004 Clinical Faculty Appointments and Promotions Committee Tufts University School of Medicine 2001-2002 New England Medical Center Basic Research Funding Committee 2002 Chairman, subcommittee for Clinical Appointment and Promotions


25

Editorial Activities: Editorial Boards: 2006-Present Member, Editorial Board, CHEST 2008-Present Member, Editorial Board, European Respiratory Review 2010-Present Member, Editorial Board, American Journal of Respiratory and Critical Care Medicine 2013-Present Member, Editorial Board, Pulmonary Circulation 2013-Present Associate Editor, European Respiratory Journal Journal Peer Reviewer: 1992-present New England Journal of Medicine 1999-present American Journal of Respiratory and Critical Care Medicine 1992-present American Journal of Respiratory Cell and Molecular Biology 1992-present American Journal of Physiology: Lung Cellular and Molecular Physiology 1992-present American Journal of Physiology: Heart and Circulatory Physiology 2004-present European Respiratory Journal 2002-present Circulation Research 2003-present Circulation 1995-present Chest 2002-present Journal of Clinical Investigation 2001-present Microvascular Research 2002-present Molecular Medicine 2004-present Peptides 2003-present Pulmonary Circulation 2005-present Journal of Cellular Physiology 2005-present Infectious Diseases in Clinical Practice 2001-present Endothelium 2004-present Free Radical Biology Medicine Advisory Committees, Review Groups/Study Sections 2000-2003 American Heart Association (New England Affiliate) Research Grant Review Committee 2000-Present American Thoracic Society-Pulmonary Circulation Long Range Planning Committee 1995-1996 External Reviewer for the Quebec Lung Association Research Grant Program 1996 External examiner (fourth-year medical students) King Abdul Aziz University School of Medicine, Jeddah, Saudi Arabia Sponsor - Tufts University School of Medicine, Boston, Massachusetts 1996-1998 Member, American Thoracic Society Assembly on Pulmonary Circulation Program 1997-2001 Member, American Lung Association Research Fellowship Review Committee 1998-2000 Member, American Thoracic Society/American Lung Association Scientific Advisory Council 1997-1998 Member, American Heart Association Research Grant Review Committee 1998 Search Committee for a new Editor for the American Journal of Respiratory and Critical Care Medicine


26

2000 Member, External Reviewer for the Department of Veterans Affairs Research Program 2000 Member, American Thoracic Society Writing Committee on Recommendations for Inhaled Nitric

Oxide 2000 Member, External Reviewer for the Israeli Science Foundation (Israeli Academy of Sciences and

Humanities) 2000 Member of scientific committee, session Chairman, 2nd Mediterranean Congress of Thoracic

Diseases, Beirut, Lebanon 2001-2005 Member, American Lung Association Research Fellowship Review Committee 2001 Reviewer for the Israel Science Foundation (Israeli Academy of Sciences and Humanities) 2001 Member of the judging committee, New England Respiratory Research Competition and Awards

Program, Cambridge, MA 2002 Co-Chairman, American Heart Association Research Grant Review Committee (New England

Chapter) 2002 Member, Scientific Committee, 3rd Mediterranean Congress of Thoracic Diseases, Lisbon, Portugal 2002 Ad hoc member, National Heart Lung and Blood Institute of Scientific Counselors for Intramural

Research Program 2003-Present Member, American College of Chest Physician Vascular Steering Committee 2004-Present Member, Pulmonary Circulation Leadership Committee, American Thoracic Society 2004-Present Member, Pulmonary Circulation Assembly Planning Committee, American Thoracic Society 2004 Review of the Department of Medicine, American University of Beirut, Beirut, Lebanon (with the

Department of Medicine, Johns Hopkins University) 2004 Member (ad hoc) Lung Injury, Repair, and Remodeling Study Section, NIH/NHLBI 2006 Member (ad hoc) Program Project Study Section, Lung Injury, Repair and Remodeling NIH/NHLBI 2006 Founding Member and Senior Fellow, The Pulmonary Vascular Research Institute. (An independent

medical research organization and “think tank” devoted to increasing the awareness and knowledge of pulmonary vascular diseases and to facilitating advances in the treatment of affected people worldwide”. PVRI is a non-for profit organization registered in the United Kingdom.

2006 Member, Management of Pulmonary Hypertension in Developing Countries Group as part of the

WHO program entitled Global Alliance against Chronic Respiratory Diseases (GARD). 2009-Present Member, Grant Review Committee, Gilead PAH 2013-Present Chair, Grant Review Committee, Gilead PAH


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2011-2012 Chair, Pulmonary Circulation Assembly, American Thoracic Society 2009-Present Member, Pfizer Grant Review Committee Professional Societies: 1988-Present American Thoracic Society 1990-2002 Massachusetts Thoracic Society 1988-Present American Heart Association 1995-Present European Respiratory Society 1990-Present Physicians for Human Rights 2002-Present Fellow, American College of Chest Physicians 2003-Present Maryland Thoracic Society Conference Organizer/Session Chair

1998 Chairman of Poster Discussion Session, ALA/ATS International Conference 2001 Facilitator, Poster Discussion on Acute Lung Injury, American Thoracic Society International

Meeting, San Francisco, California. 2003 Facilitator, Poster Discussion on Pulmonary Vascular Biology: Endothelium, American Thoracic

Society International Meeting, Seattle, Washington. 2003 Facilitator, Poster Discussion on Mechanisms of Acute Lung Injury, American Thoracic Society

International Meeting, Seattle, Washington. 2004 Convention Chair: “Pulmonary Hypertension in the 21st Century: The Beginning of a New Era.”

Johns Hopkins University School of Medicine, Baltimore, Maryland. 2004 Session Chair (Grover Conference: Genetic and Environmental Determinants of Pulmonary

Endothelial Cell Function) 2005 Seminar Organizer/Chair: European Respiratory Society/ATS.

Research Seminar: “Molecular determinants of pulmonary vascular remodeling.” December 8-9. Paris, France

2005-2006 Chair: ATS/ERS Task Force on Pulmonary Circulation, San Diego, California American Thoracic Society 102nd International Annual Meeting 2006 ATS International Annual Meeting, San Diego, California, May 2006. Symposium entitled,

“Endothelial stress phenotypes in acute lung injury.” Title of lecture: ‘Sources and mechanisms of ROS production in ventilator-associated lung injury.”

2006 ERS International Annual Meeting, Munich, Germany, September 2006. Co-Chair Symposium

entitled, “Signalisation in the pulmonary vasculature: new pathways and wrong signals.” 2007 Pulmonary Vascular Research Institute, Valetta, Malta.


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2007 Course Director: “Emerging Concepts in Pulmonary Hypertension,” CME Course. Johns Hopkins University, Baltimore, Maryland. Lecture: “Unique challenges in scleroderma-related pulmonary arterial hypertension.”

2008 Chair, Task Force/Working Group, “Inflammation, Growth Factors and Pulmonary Vascular

Remodeling,” 4th World Symposium on PAH, Dana Point, Orange County, California 2008 Seminar Organizer and Co-Chair: European Respiratory Society. Research Seminar on The

Pulmonary Circulation. “Scleroderma-related pulmonary arterial hypertension,” April 14-15. Paris, France.

2008 Chair, Scientific Symposium entitled “Right ventricular-pulmonary vascular coupling in pulmonary

hypertension: Imaging, molecular basis and treatment.” ATS International Annual Meeting, Toronto, Canada, May 2008.

2008 Chair: Post-Graduate Course entitled “From genotype phenotype: Beyond traditional thinking.”

ATS Annual International Meeting, Toronto, Canada, May 2008. 2009 Chair: Scientific Symposium entitled “Scleroderma-related PAH: A paradigm for vascular

remodeling.” ATS Annual International Meeting, San Diego, CA, May 2009. 2010 Chair: Mini-Symposium entitled “Inflammation and bone marrow derived cells in pulmonary arterial

hypertension.” ATS Annual International Meeting, New Orleans, LA, May 2010. 2013 World Symposium on Pulmonary Hypertension. Scientific Session, Task Force 4 Co-Chair.

“Pathophysiology focusing on exercise and RV.” Nice, France, February 27-March 1, 2013.


29

RECOGNITION Awards/Honors: 1986 Recipient of the Winthrop-Breon/ACCP Scholar Award for Outstanding Original Scientific

Research, American Lung Association/American Thoracic Society 1988-1990 Recipient of Edward Livingston Trudeau Scholar Award: declined due to acceptance of

Clinical Investigator Award 2001 Oliver Smith Award (“Recognizing excellence, compassion, and extraordinary service and

caring at the New England Medical Center”) 2001 Tufts University School of Medicine, Third Year Clerkship, “Excellence in Teaching”

Award. 2002 Tufts University School of Medicine, Third Year Clerkship, “Excellence in Teaching”

Award. 2008 Chair, Program Committee, Pulmonary Circulation, American Thoracic Society 2008 The David M Levine Excellence in Mentoring Award, Johns Hopkins University

Department of Medicine 2011-2012 Chair, Pulmonary Circulation Assembly, American Thoracic Society Invited Talks: 1988 Medical Grand Rounds: "Diagnosis and Treatment of Thromboembolic Diseases" Whidden Hospital, Everett, Massachusetts 1989 Medical Grand Rounds: “Primary Pulmonary Hypertension” St. Luke's Hospital, New Bedford, Massachusetts Clinical Pathological Case Discussion Massachusetts General Hospital, Boston, Massachusetts

Pulmonary and Critical Care Board Review Course: “Diagnosis and Treatment of Thrombo-embolic Disease” New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts

1991 Clinical Pathological Case Discussion Massachusetts General Hospital, Boston, Massachusetts Research Seminar: "Regulation of Endothelial Xanthine Oxidase"

Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 1993 Pulmonary Lecture: "Deep Venous Thrombosis and Pulmonary Embolism: Diagnosis and

Treatment", Longwood Greenery Rehabilitation Center, Brighton, Massachusetts


30

Visiting Professor, Medical Grand Rounds, The American University of Beirut, Lebanon, Pulmonary Division and Intensive Care Unit

Medical Grand Rounds: "Diagnosis of Pulmonary Embolism: the P.I.O.P.E.D. study." Winchester

Hospital, Winchester, Massachusetts

Medical Grand Rounds: "Update on the Diagnosis and Treatment of Pulmonary Embolism." New England Medical Center, Boston, Massachusetts

Pulmonary and Critical Care Research Seminar: "Regulation of Xanthine Oxidase by Hypoxia." Massachusetts General Hospital, Boston, Massachusetts

Medical Grand Rounds: "Treatment of Venous Thromboembolism." Waltham-Weston Hospital, Waltham, Massachusetts 1996 Research Seminar: "Interaction between Xanthine Oxidase and iNOS in Acute Lung Injury." Rhode

Island Hospital, Providence, Brown Medical School, Rhode Island

Medical Grand Rounds: "Diagnosis and Treatment of Thromboembolic Diseases" Jordan Hospital, Plymouth, Massachusetts

Visiting Lecturer, Case Presentation, St. Luke’s Hospital, New Bedford, Massachusetts 1997 International Meeting of the American Thoracic Society, Symposium on Novel Signaling Pathways in Pulmonary Vascular Biology, “Xanthine Oxidase: Regulation by Endothelium-Derived Nitric Oxide.” San Francisco, California 1998 Pulmonary Grand Rounds Massachusetts General Hospital, Boston, Massachusetts

"Molecular Regulation of Endothelial Xanthine Dehydrogenase/Oxidase" Pulmonary Lecture: "Primary Pulmonary Hypertension" Lahey Clinic, Burlington, Massachusetts Medical Grand Rounds: "Pulmonary Hypertension: New Concepts and Treatment" St. Elizabeth’s Medical Center, Boston, Massachusetts

Medical Grand Rounds": Primary Pulmonary Hypertension" New England Medical Center, Boston, Massachusetts 1999 "Role of Xanthine Oxidase and Inducible Nitric Oxide Synthase" American University of Beirut/XXXIV Middle East Medical Assembly Beirut, Lebanon

"A Century of Pulmonary Hypertension" American University of Beirut/XXXIV Middle East Medical Assembly Beirut, Lebanon


31

Role of Xanthine Oxidase and Formation of Peroxynitrite in Acute Lung Injury. New England Free Radical/Oxygen Society-Symposium on Nitric Oxide Sackler School of Graduate Biomedical Sciences Tufts University School of Medicine, Boston, Massachusetts 2000 FASEB International Conference. American Physiological Society-Symposium on Emerging

Concepts in Lung Redox Homeostasis. "Regulation of Xanthine Oxidase and Role in Oxidative Lung Injury and Inflammation." San Diego, California.

"Regulation and Role of the Inducible Form of Nitric Oxide Synthase in Pulmonary Endothelium," Sackler School of Graduate Biomedical Sciences, Summer Minority Research Program, TUSM, Boston, Massachusetts. Visiting Professor, Lung Research Conference, Pulmonary and Critical Care Division, The Johns Hopkins Hospital, Baltimore, MD

Anesthesia Grand Rounds, NEMC, Boston: "New Developments in the Medical Treatment of

Pulmonary Hypertension."

2nd Mediterranean Congress of Thoracic Diseases (Beirut, Lebanon). I. Novel Therapy in the Adult Respiratory Distress Syndrome. II. New Modes of Mechanical Ventilation in ARDS.

2001 “Endothelial Sources of Reactive Oxygen Species: Role of Hypoxia.” Division of Pulmonary and

Critical Care Medicine, Johns Hopkins University, Baltimore, MD "Scleroderma and Pulmonary Hypertension." Clinical Pediatric Rounds, American Thoracic Society,

San Francisco, California. "The Pulmonary Endothelium: a Conductor with an Unusual Repertoire." Sackler School of

Graduate Biomedical Sciences, TUSM, Boston, Massachusetts

"Pulmonary Hypertension: from Vascular Tone to the Gene." Medical Grand Rounds, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan

“New Trends in the Treatment of Primary Pulmonary Hypertension.” Medical Grand Rounds,

Deaconess-Waltham Hospital, Waltham, Massachusetts 2002 “Hypoxia and Endothelial Signaling: Effect on NO Expression.” Pulmonary and Critical Care

Division, Brown Medical School, Rhode Island

“Update in Primary Pulmonary Hypertension.” Pulmonary and Critical Care Review Course. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Santa Fe, New Mexico

2003 “Pulmonary Hypertension: Current treatment and future directions.” DC Thoracic Society:

Washington, DC.

“Regulation of XOR in Hypoxia” Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland

“Pulmonary Hypertension: In Search of the Gene(s).” Medical Grand Rounds:


32

Hopkins-Pulmonary Hypertension, Baltimore, Maryland 2003 “Pulmonary Hypertension and Scleroderma: New and Emerging Therapies.” Scleroderma

Foundation’s National Conference, Washington, DC. “Case from the Wards.” Pulmonary and Critical Care Review Course. Division of Pulmonary and

Critical Care Medicine, Johns Hopkins University School of Medicine, Santa Fe, New Mexico

“The Spectrum of Pulmonary Hypertension.” Pulmonary and Critical Care Review Course. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Santa Fe, New Mexico

“The role of echocardiography in the diagnosis of pulmonary embolism.” VIIth Pan-Arab Thoracic Society Meeting, Beirut, Lebanon

“Medical Treatment of Chronic Thromboembolic Disease.” VIIth Pan-Arab Thoracic Society Meeting, Beirut, Lebanon

“Pulmonary Hypertension: Diagnosis and Treatment.” Innovations in Respiration. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

2004 “Right Ventricular Dysfunction in Pulmonary Hypertension.” Pulmonary Hypertension in the 21st

Century: The Beginning of a New Era. Johns Hopkins University School of Medicine, Baltimore, MD.

“Pulmonary Hypertension: In Search of a Cure.” Medical Grand Rounds: Union Memorial

Hospital, Baltimore, Maryland “Right Ventricular Function: the Right Target in Pulmonary Hypertension.” Hôpital Antoine-

Beclere, Clamart, France.

“Journee de l’Hypertension Arterielle Pulmonaire,” Paris, France. “Pulmonary Hypertension: The Hopkins Experience.”

2005 “Pulmonary hypertension: Pathophysiology, natural history and diagnosis.” Annual Meeting of the Lebanese Pulmonary Society, Beirut, Lebanon.

Pulmonary hypertension: Novel therapies. Annual Meeting of the Lebanese Pulmonary Society,

Beirut, Lebanon.

“Droit et valeurs humanitaires dans le conflits armés assymétriques et la protection des blessés et des civils.” International Conference on Ethics (Conférence International d’Ethiques), Saint-Cyr, Coetquidan, France.

2006 “A model of ventilator-induced acute lung injury : Evidence for oxidative stress.” Visiting Professor, University of Pennsylvania, Institute for Environment Medicine, Philadelphia, Pennsylvania.

“The role of imaging (echocardiogram and MRI) in the assessment of pulmonary arterial

hypertension.” 2006 International Functional Lung Imaging Workshop, University of Pennsylvania, Department of Radiology.


33

‘Molecular determinants of right ventricular failure in pulmonary arterial hypertension.” NIH

Symposium: From oxygen sensing to heart failure. October 12, 2006, Bethesda, Maryland “Evolution of pulmonary hypertension: Emerging diseases and novel therapeutics meeting.” Session

4: Research Opportunities. National Institutes of Health, December 7-8, Bethesda, Maryland. 2007 “Current concepts in pulmonary hypertension.” 52nd Annual Philip A. Tumulty Topics in Clinical

Medicine – 2007 Program, M7-11, 2007. Johns Hopkins University, Baltimore, Maryland.

“Phenotypic and molecular determinants of RV failure in pulmonary arterial hypertension.” Scientific Session B10: Molecular basis of right ventricular hypertrophy and failure. 2007 American Thoracic Society International Meeting, San Francisco, California. “Pulmonary hypertension in patients with scleroderma: Diagnosis and treatment.” Scientific Symposium B15-Therapeutic advances in pulmonary vascular disease. 2007 American Thoracic Society International Meeting, San Francisco, California. (Title). Visiting Professor, Yale University School of Medicine, New Haven, Connecticut. “Emerging treatment options for pulmonaty hypertension.” Updates in Pulmonary and Critical Care Medicine: The Best of 2006-2007. Johns Hopkins University CME Symposium, Williamsburg, Virginia. “Five recent papers you should know about in pulmonary vascular disease.” Updates in Pulmonary and Critical Care Medicine: The Best of 2006-2007. Johns Hopkins University CME Symposium, Williamsburg, Virginia. “Title” Visiting Professor, University of Chicago Pritzger School of Medicine, Chicago, Illinois. “Pulmonary arterial hypertension: Diagnosis and treatment.” Medical Grand Rounds, Harbor Hospital, Baltimore, Maryland.

2008 ‘The six-minute walk test—it is simple, interpretable and meets the need.” Session entitled: The

assessment of novel therapies in pulmonary arterial hypetension: A review of acceptable and informative endpoints. PVRI Winter Meeting, Marbella, Spain

“Mechanisms of Endothelial Permeability in Ventilator-Associated Lung Injury Stanford University School of Medicine “Scleroderma-Related Pulmonary Arterial Hypertension: Challenges and Hope”

The 8th Annual Evans Family Lecture, Stanford University School of Medicine Vera Moulton Wall Center, California

“Pulmonary hypertension in systemic sclerosis.” Case Western Reserve University/University

Hospitals of Cleveland Grand Rounds, Cleveland, Ohio

Speaker and Moderator: Cardiovascular Seminar entitled “Inflammation and Pulmonary Hypertension. Presentation: “The role of inflammation in the diagnosis, prognosis and management of PAH: An overview.” American Heart Association Scientific Sessions, New Orleans, 2008.


34

Discussant, American College of Chest Physicians Interactive Session entitled “Case studies in pulmonary vascular disease,” Philadelphia, 2008.

Pulmonary Grand Rounds, Massachusetts General Hospital, Boston MA: “Scleroderma-Related

PAH: Challenges and Hope.”

Research symposium, Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston MA: “P38 MAPK-XOR signaling in ventilator-associated lung injury.”

2009 Saudi Arabia Pulmonary Hypertension Association Annual Meeting, Casablanca, Morocco: “A role for inflammation in PAH.”

ATS International Meeting, San Diego, CA, Postgraduate Course PG9 entitled Diagnosis and Therapy of PAH: State of the Art: “RV Imaging in PAH.”

ATS International Meeting, San Diego, CA, Postgraduate Course 24 entitled Controversies in Pulmonary Hypertension Management Past, Imperfect, Future Continuous: “Clinical Trials in PAH: are we mixing apples and oranges?”

ATS International Meeting, San Diego, CA, Symposium: “Determinants of Outcomes in Scleroderma-Related PAH: Lessons from the Sickest.”

4eme Journée Française de la Sclérodermie Systémique, Paris, France. « L’Atteinte Pulmonaire Interstitielle chez le Patient Sclérodermique. »

35th Annual Topics in Gasrtroenterology and Hepatobiliary Update Conference, The Johns Hopkins School of Medicine”, Baltimore, MD: “Porto-pulmonary Hypertension and Hepatopulmonary syndrome.”

Pulmonary Hypertension Summit 2009, Cleveland Clinic, InterContinental Hotel & Bank of America Conference Center, Cleveland, Ohio: “Pulmonary Hypertension in Scleroderma.”

Pulmonary Grand Rounds, Tufts-New England Medical Center, Boston MA: “Scleroderma-Associated Pulmonary Arterial Hypertension.”

2010 The Alfred P. Fishman Symposium, University of Pennsylvania. Right Ventricular Structure and

Function in Health and Disease. “Unique RV features in scleroderma.” Meet the Professor Seminar, ATS International Meeting, New Orleans, LA. “Scleroderma associated

PAH: Bench to bedside.” Scientific Symposium, Epidemiology of Pulmonary Hypertension: Lessons from contemporary

registries. ATS International Meeting, New Orleans, LA. “Lessons from the PAH screening programs.” Scientific Symposium, Rescuing the right ventricle in pulmonary vascular disease, ATS International Meeting, New Orlenas, LA. “Unique features of the right ventricle in systemic sclerosis. NHLBI-ORD Lung Vascular Workshop, Bethesda, MD. “The pulmonary vascular-cardiac axis.”


35

DIA/FDA/PVRI Debate on Clinical Trial for Pulmonary Arterial Hypertension, Bethesda, MD,

Session 3. “Future trials need to identify specific etiologies of PAH and to power the trials sufficiently to know in which etiologies treatment is effective.” Pulmonary Hypertension Association Meeting, Anaheim, California. PHCR Dinner Forum. “Update on PAH SCCOR research.”

2011 44TH Middle East Medical Assembly, Beirut, Lebanon. First Khalil Abu Feisal Lecture, “Cardiovascular features of scleroderma-associated PAH.” “Cardiovascular Features of Scleroderma-Associated PAH, VU University Medical Center, Amsterdam, The Netherlands. “Idiopathic vs. Scleroderma-Associated PAH: Failure of Standard Therapies,” ASC01: Rituximab for Treatment of SSc-PAH, Investigator & Coordinator Meeting, Bethesda, MD “Molecular Determinants of PAH, NIH/NHLBI P01HL84946-01, Hopkins SCCOR Update,” ATS, Denver, Colorado “Assessment of the RV in PAH.” CMREF Research Planning Meeting, Chicago IL “The Right Ventricle in PAH.” The Saudi Association for Pulmonary Hypertension Eastern Mediterranean Region, Dubai Grand Hyatt “Scleroderma-Associated PAH.” United Therapeutics Corp. Durham, NC “Xanthine Oxidoreductase in Acute Lung Injury.” Research Seminar Series, Vascular Biology Center, Georgia Health Sciences University, Augusta, GA “RV Failure: Lessons Learned in the ICU-Treatment with Catecholamines?” SMP.701-PH and RV Failure: Emerging Concepts. AHA, Orlando, FL

2012 “Updating Clinical End-Point Definitions”. Pulmonary Hypertension Academic Research Consortium. Bethesda, MD.

“Challenges in Pulmonary Arterial Hypertension”. Fellows Track Symposium. ATS 2012, San

Francisco. CA. “Pulmonary Hypertension and Exercise”. D86. Impact of exercise on Cardiopulmonary Status.

Implications for Pulmonary Hypertension. ATS 2012. San Francisco, CA. “Inotropes are Useful in Resuscitating the Failing Right Ventricle: a pro argument.” RV

Pathobiology on Pulmonary Vascular Disease. PVRI Annual Meeting. Cape Town, Republic of South Africa.

“Cross-Talk between Macrophages, Granulocytes and Vascular Cells in Pulmonary Arterial

Hypertension” Keystone Symposia on Molecular and Cellular Biology. Pulmonary Vascular Disease and Right Ventricular Dysfunction: Current Concepts and Future Therapies. Monterey, CA.


36

“Cardiovascular features of scleroderma-associated pulmonary arterial hypertension.” 10th Annual Retreat-Molecular Biology and Medicine in the Lung, Universities of Giessen and

Marburg Lung Center, Rauischholzhausen, Germany.

“Polymorhisms of the ACE gene are associated with risk of development of and disease severity in scleroderma related PAH”. ERS 2012. Vienna, Asutria.

“Managing pulmonary arterial hypertension: Current treatment options and unmet challenges”. ERS

2012. Vienna, Austria. 2013 “Imaging is all you need for diagnosis, follow up and prognosis”. PVRI 7th Annual meeting,

Istanbul, Turkey. “Upating clinical end-points definitions in PAH”. PVRI 7th Annual meeting, Istanbul, Turkey. The 18th Congress of the Asian Pacific Society of Respirology (ASPR 2013). Scientific Session

Speaker, “New concepts of pathogenesis of pulmonary arterial hypertension.” Yokohama, Japan.

1

Curriculum Vitae -‐ Tim Lahm, M.D.

DEMOGRAPHIC AND PERSONAL INFORMATION

Current Appointment Assistant Professor of Medicine Department of Medicine; Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine Staff Physician Richard L. Roudebush V.A. Medical Center Personal Data Date of birth: August 6, 1972 Place of birth: Zweibruecken, Germany Citizenship: Germany Visa status: Permanent Resident Business address: 980 W. Walnut Street, R3/Walther Hall room C-‐400, Indianapolis, IN

46202, phone: 317.278.0413, fax: 317.278.7030 Email: [email protected] Education Oct. 2005 – Sept. 2008 Pulmonary and Critical Care Medicine Fellowship, Indiana

University School of Medicine, Indianapolis, Indiana Oct. 2002 – Sept. 2005 Internal Medicine Residency, Indiana University School of

Medicine, Indianapolis, Indiana Jan. – Sept. 2002 Internship, Department of Thoracic Surgery, Thoraxklinik-‐

Heidelberg GmbH, Heidelberg, Germany Jan. – Sept. 2001 Internship, Department of Anesthesia, University of Heidelberg

Medical School, Heidelberg, Germany Oct. 1993 – Dec. 2000 University of Heidelberg Medical School, Heidelberg, Germany (Undergraduate education in Germany is included in the first two years

of Medical School) Research Training Sept. 2006 – Sept. 2008 Research Fellow to Daniel R. Meldrum, MD, Section of

Cardiothoracic Surgery and Center for Immunobiology, Indiana University School of Medicine. Research: Effects of Estrogen on Pulmonary Artery Vasoreactivity and Acute Hypoxic Pulmonary Vasoconstriction.

November 2003 Research Resident to H.L. Twigg III, MD, Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Research: Effect of Highly Active Antiretroviral Therapy on BAL Immunoglobulin and Cytokine Levels in HIV positive Patients.

Jan. 1997 – Oct. 1999 Doctoral Thesis: Heart Rate Variability – an Independent Prognostic Factor in Patients with Congestive Heart Failure

Advisor: M. Haass, MD, Department of Cardiology, University of Heidelberg Medical School, Heidelberg, Germany

2

PROFESSIONAL EXPERIENCE

Academic Appointments October 2008 – present Assistant Professor of Medicine, Department of Medicine, Division

of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine and Richard L. Roudebush V.A. Medical Center

Hospital Appointments October 2008 – present Richard L. Roudebush V.A. Medical Center, Indiana University

Hospital, Methodist Hospital, Clarian West hospital, Clarian North Hospital, Wishard Memorial Hospital, Kindred Hospital (all in Indianapolis, IN)

Specialty Board Status August 2007 Internal Medicine November 2008 Pulmonary Medicine October 2009 Critical Care Medicine Licensure and Certification May 2008 -‐ present Indiana Physician License, License Number 01065261A May 2008 -‐ present DEA registration Number FL0894077 April 2008 USMLE step 3 June 2003 -‐ present ACLS and BLS certified June 2002 ECFMG certified Nov. 2001 USMLE step 1 Dec. 2001 USMLE step 2 Additional Qualifications: July 2009 Methods in Molecular Biology (3 week full day course), Indiana

University October 2009 American College of Chest Physicians Leadership Development

Course (Sponsored Attendee; full day course) 2009-‐2010 Indiana University Leadership in Academic Medicine Program (4

hrs/month over 1 year) 2011 Getting Started as a Successful Grant Writer & Academician; Grant

Writers’ Seminars & Workshops (1 day course; held at Indiana University)

2011 Write Winning Grants; Grant Writers’ Seminars & Workshops (1 day course; held at Indiana University)

2011 Critical Care Echocardiography Course, American College of Chest Physicians

2012 Short Course in Biostatistics (3 half days), Indiana University 2012 Scientific Writing from the Reader’s Perspective; Dr. C. Gopen, Duke

University (held at Indiana University; 2 day course and 60 min one-‐on-‐one session with Dr. Gopen)

Professional Societies 2005 -‐ present American College of Chest Physicians 2007 -‐ present American Thoracic Society 2009 – present Pulmonary Hypertension Association 2013 – present Pulmonary Vascular Research Institute

3

RESEARCH ACTIVITIES Peer-‐reviewed publications (in chronological order): Original research:

1. Krüger C, Lahm T, Zugck C, Kell R, Schellberg D, Schweizer MWF, Kübler W, Haass, M.

Heart rate variability enhances the prognostic value of established parameters in patients with congestive heart failure. Z Kardiol 91: 1003-‐12, 2002.

2. Markel TA. Crisostomo PR. Wang M. Herring CM. Lahm T. Meldrum KK. Meldrum DR. Iron

chelation stimulates fetal human intestinal cell production of IL-‐6 and VEGF while decreasing HGF: The roles of p38, ERK, and JNK MAPK signaling. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G958-‐63.

3. Tsai BM, Lahm T, Crisostomo PR, Markel T, Wang M, Meldrum DR. Ethyl pyruvate

inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression. J Surg Res. 2007 Jun 13; [Epub ahead of print].

4. Crisostomo PR. Markel TA. Wang M. Lahm T. Lillemoe KD. Meldrum DR. In the adult

mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power. Surgery. 2007 Aug;142(2):215-‐21.

5. Lahm T, Patel KM, Crisostomo PR, Markel TA, Wang M, Herring C, Meldrum DR.

Endogenous Estrogen Attenuates Pulmonary Artery Vasoconstriction and Hypoxic Pulmonary Vasoconstriction: The Effects of Sex and Menstrual Cycle. Am J Physiol Endo Metab 2007. Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E865-‐71.

6. Hui U. Wang M. Crisostomo PR. Markel TA. Lahm T. Meldrum KK. Lillemoe KD.

Meldrum DR. The effect of chronic exogenous androgen on myocardial function following acute ischemia-‐reperfusion in hosts with different baseline levels of sex steroids. J Surg Res. 2007 Sep;142(1):113-‐8.

7. Patel KM. Crisostomo P. Lahm T. Markel T. Herring C. Wang C. Meldrum KK. Meldrum DR.

Mesenchymal stem cells attenuate hypoxic pulmonary vasoconstriction by a paracrine mechanism. J Surg Res. 2007 Dec;143(2):281-‐5.

8. Crisostomo PR, Wang Y, Markel TA, Wang M, Lahm T, Meldrum DR. Human mesenchymal

stem cells stimulated by TNF, LPS, or hypoxia produce growth factors by an NFkB but not JNK dependent mechanism. Am J Physiol Cell Physiol. 2008 Mar;294(3):C675-‐82.

9. Markel TA, Crisostomo PR, Manukyan MC, Al-‐Azzawi D, Herring CM, Lahm T, Novotny NM,

Meldrum DR. Are Neonatal Stem Cells as Effective as Adult Stem Cells in Providing Ischemic Protection? J Surg Res. 2009 Apr;152(2):325-‐30. Epub 2008 Apr 28.

10. Patel KM, Lahm T, Herring C, Crisostomo PR, Markel T, Wang M, Meldrum DR. The

Effects Endogenous Sex Hormones and Acute Hypoxia on Vasoconstriction in Isolated Rat Pulmonary Artery Rings. J Surg Res. 2008 May 1;146(1):121-‐6.

11. Ray R, Herring CM, Markel TA, Crisostomo PR, Wang M, Weil BR, Lahm T, Meldrum DR.

The Deleterious Effects of Endogenous and Exogenous Testosterone on Mesenchymal Stem

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Cell VEGF Production. Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1498-‐503.

12. Lahm T, Crisostomo PR, Markel TA, Wang M, Wang Y, Weil BR, Meldrum DR. Exogenous

Estrogen Attenuates Pulmonary Artery Vasoreactivity and Acute Hypoxic Pulmonary Vasoconstriction. Shock. 2008 Dec;30(6):660-‐7.

13. Markel TA, Crisostomo PR, Wang M, Wang Y, Lahm T, Novotny NM, Tan J, Meldrum DR.

TNFR1 Signaling Resistance Associated with Female Stem Cell Cytokine Production is Independent of TNFR2 Mediated Pathways. Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1124-‐30.

14. Crisostomo PR, Abarbanell AM, Wang M, Lahm T, Wang Y, Meldrum DR. Embryonic Stem

Cells Attenuate Myocardial Dysfunction and Inflammation After Surgical Global Ischemia via Paracrine Actions. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1726-‐35.

15. Lahm T, Crisostomo PR, Markel TA, Wang M, Wang Y, Tan J, Meldrum DR. Selective

Estrogen Receptor-‐Alpha And Estrogen Receptor-‐Beta Agonists Rapidly Decrease Pulmonary Artery Vasoconstriction By A Nitric Oxide Dependent Mechanism. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1486-‐93.

16. Markel TA, Wang Y, Herrmann JL, Crisostomo PR, Wang M, Novotny NM, Herring CM, Tan

J, Lahm T, Meldrum DR. VEGF Is Critical for Stem Cell Mediated Cardioprotection and a Crucial Paracrine Factor for Defining the Age Threshold in Adult and Neonatal Stem Cell Function. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2308-‐14.

17. Bosslet GT, DeVito ML, Lahm T, Sheski FD, Mathur PN. Nurse-‐Administered Propofol

Sedation: Feasibility and Safety in Bronchoscopy. Respiration 2010;79(4):315-‐21.

18. Devlin CM, Lahm T, Hubbard WC, Van Demark M, Wang KC, Wu X, Bielawska A, Obeid LM, Ivan M, Petrache I. A Dihydroceramide-‐based Response to Hypoxia. J Biol Chem 2011 Nov 4;286(44):38069-‐78.

19. Lahm T (corresponding author), Albrecht M, Fisher AJ, Selej M, Patel N, Brown JA, Justice

MJ, Brown MB, Van Demark M, Trulock KM, Dieudonne D, Reddy JG, Presson RG, Petrache I. 17-‐Beta Estradiol Attenuates Hypoxic Pulmonary Hypertension Via Estrogen Receptor-‐Mediated Effects. American Journal of Respiratory and Critical Care Medicine 2012 May 1;185(9):965-‐80. Epub 2012 Mar 1.

20. Clinkenbeard EL, Farrow EG, Summers LJ, Cass TA, Roberts JL, Bayt CA, Lahm T, Albrecht

M, Allen MR, Peacock M, White KE. Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice. J Bone Miner Res. 2013 Jul 22. [Epub ahead of print].

21. Bitar A, Selej M, Bolad I, Lahm T. Poor Agreement Between Pulmonary Capillary Wedge

Pressure And Left Ventricular End-‐Diastolic Pressure In A Veteran Population. PLOS ONE 2014 Jan 31;9(1):e87304.

22. Toney B, Albrecht M, Fisher A, Lockett AD, Presson RG, Petrache I, Lahm T. Selective

Endothelin-‐A Receptor Blockade Attenuates Endotoxin-‐Induced Pulmonary Hypertension and Pulmonary Vascular Dysfunction. Pulmonary Circulation 2014 (in press).

5

Reviews, editorials and case reports:

1. Lahm T, Meldrum DR. Point:Counterpoint "Release of an endothelium-‐derived vasoconstrictor and RhoA/Rho kinase-‐mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction". J Appl Physiol. 2007 May;102(5):2077-‐8; discussion 2080.

2. Lahm T. Crisostomo PR. Markel TA. Wang M. Lillemoe KD. Meldrum DR. The Critical Role of Vascular Endothelial Growth Factor in Pulmonary Vascular Remodeling Following Lung Injury (Review). Shock. 2007 Jul;28(1):4-‐14.

3. Crisostomo PR, Wang M, Markel TA, Lahm T, Abarbanell AM, Herrmann JL, Meldrum DR.

Stem Cell Mechanisms and Paracrine Effects: Potential in Cardiac Surgery (Review). Shock. 2007 Oct;28(4):375-‐83.

4. Markel TA, Wairiuko GM, Lahm T, Crisostomo PR, Wang M, Herring CM, Meldrum DR. The

Right Heart and Its Distinct Mechanisms of Development, Function, and Failure (Review). J Surg Res. 2008 May 15;146(2):304-‐13.

5. Ray R, Novotny NM, Crisostomo PR, Lahm T, Abarbanell A, Meldrum DR. Sex Steroids and

Stem Cell Function (Review). Mol Med. 2008 Jul-‐Aug;14(7-‐8):493-‐501. 6. Lahm T, Wolf KM. Book Review: The ICU Book, 3rd edition. J Surg Res. 2008 May

1;146(1):159-‐160. 7. Lahm T. Book Review: The Elsevier Guide to Oncology Drugs and Regimens. J Surg Res.

2008 May 15;146(2):314-‐315. 8. Lahm T, Neese S, Thornburg AT, Ober MD, Sarosi GA, Hage CA. Corticosteroids for

Blastomycosis-‐Induced Acute Respiratory Distress Syndrome: A Report of Two Patients and Review of the Literature. Chest. 2008 Jun;133(6):1478-‐80.

9. Lahm T, Crisostomo PR, Markel TA, Wang M, Weil BR, Novotny NM, Meldrum DR. The

Effects of Estrogen on Pulmonary Artery Vasoreactivity and Hypoxic Pulmonary Vasoconstriction: Potential New Clinical Implications for an Old Hormone (Review). Crit Care Med. 2008 Jul;36(7):2174-‐83.

10. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, Ray R, Tan J, Al-‐

Azzawi D, Meldrum DR. Beta-‐Blockers in Sepsis: Reexamining the Evidence (Review). Shock. 2009 Feb;31(2):113-‐9. Epub 2008 Jul 16.

11. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, Tan J, Meldrum DR.

Angiopoietin in the Treatment of Ischemia and Sepsis (Review). Shock. 2009 Apr;31(4):335-‐41. Epub 2008 Sep 11.

12. Markel TA, Crisostomo PR, Lahm T, Novotny NM, Rescorla FJ, Tector J, Meldrum DR. Stem

cells as a potential future treatment of pediatric intestinal disorders (Review). J Pediatr Surg. 2008 Nov;43(11):1953-‐63.

13. Lahm T. Sex Differences in COPD (Brief communication). Eur Resp J 2009 Jul;34(1):288-‐9.

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14. Lahm T, Spartz HN, Hawley DA, Leland DS, Wolf KM, Twigg III HL, Ober MD. Fatal

Adenovirus Serotype 21 Infection Associated with Hemophagocytic Lymphohistiocytosis and Multiorgan Failure. Respiratory Medicine CME 2010;3(4):223-‐225.

15. Lahm T. Bradykinin and the Heart: Left, Right, or Both? (Invited commentary). J Surg Res

2011 May 15;167(2):216-‐9. Epub 2010 Jun 9. 16. Lahm T, McCaslin CA, Wozniak TC, Ghumman W, Fadl YF, Obeidat OS, Schwab K, Meldrum

DR. Medical and Surgical Treatment of Acute Right Ventricular Failure. J Am Coll Cardiol 2010 Oct 26;56(18):1435-‐46.

17. Selej M, Lahm T. Red Card for White Blood Cells: Leukocytapheresis In Sepsis (Invited

commentary). J Surg Res 2011 Jul;169(1):21-‐4. Epub 2010 Sep 21. 18. Sigua NL, Cummings OW, Lahm T. A 42-‐Year-‐Old Woman With Diffuse Pulmonary

Infiltrates and Bilateral Pneumothoraces. Chest 2011;140(2):550-‐553. 19. Najm S, Hajjar J, Nelson RP Jr, Moorthy RS, Wolf KM, Lahm T. Whipple’s Disease-‐

Associated Pulmonary Hypertension with Positive Vasodilator Response Despite Severe Hemodynamic Derangements. Can Resp J 2011 Sep;18(5):e70-‐2.

20. Toney BM, Lahm T. A Healthy Dose of Heavy Metal: Magnesium and Acute Lung Injury

(Editorial). J Surg Res 2012 Dec;178(2):614-‐7. 21. Lahm T. Large Animal Studies in Pulmonary Hypertension: What Phenotype do We Need to

Model? (Editorial). J Surg Res 2012 Nov;178(1):115-‐8. 22. Lim L T, Moorthy R, Najm S, Nelson R P, Wolf K M, Lahm T. A unique posterior segment

manifestation of Whipple’s disease. Retinal Cases and Brief Reports 2012;6(2):204–205.

23. Lahm T*, Wetsch WA*, Hinkelbein J, Happel CM, Padosch SA. Das akute Rechtsherz-‐versagen (Acute Right Heart Failure; German). Anaesthesiol Intensivmed Notfallmed Schmerzther 2011 Nov;46(11-‐12):718-‐25. *shared first authors

24. Lahm T, Petrache I. Autophagic Punctum: LC3 as a potential therapeutic target in hypoxia-‐

induced pulmonary hypertension. Autophagy 2012 Jul 1;8(7). [Epub ahead of print] 25. Lahm T. Calcium handling in the pressure overloaded right ventricle (Invited commentary).

J Surg Res 2012 Aug 1. [Epub ahead of print] 26. Cucci AR, Lahm T. Resynchronization therapy for right ventricular failure: restoring

harmony in left ventricular contractility (Invited commentary). J Surg Res 2012 Aug 29. [Epub ahead of print]

27. Serban K, Muzoora M, Hage CA, Lahm T. Distinct immunologic and radiographic patterns in

etanercept-‐induced lung injury. Respiratory Medicine Case Reports 2013 (8): 18-‐20. 28. Lahm T. Pulmonary Hypertension Update from Chest 2012. International Journal of Clinical

Practice (invited review). Int J Clin Pract Suppl. 2013 May;(179):2-‐4.

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29. Austin ED, Lahm T, Johansen AK, Alzoubi A, Tofovic SP, Oka M, West J, MacLean MR (invited review; equal contribution of all authors). Gender, Sex Hormones, and Pulmonary Hypertension. Pulmonary Circulation 2013 Apr;3(2):294-‐314.

30. Lahm T, Chakinala MM. WHO Group 5 Pulmonary Hypertension. Clinics in Chest Medicine.

2013 Dec;34(4):753-‐78.

31. Lahm T (corresponding author), Tuder RM, Petrache I. Progress towards solving the sex hormone paradox in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 May 9. [Epub ahead of print].

Book Chapters:

1. Lahm T and Sheski FD. Update on Cryotherapy, Brachytherapy and Photodynamic Therapy. In: Beamis J, Mathur PN and Mehta AC: Interventional Pulmonary Medicine, Second Edition. New York: Informa Healthcare, 2009.

2. Selej M and Lahm T. Epidemiology and Genetics of Pulmonary Arterial Hypertension. In:

Sood N: Clinical Focus On Pulmonary Hypertension (in press).

3. Cucci AR, Hadi MA, Lahm T. Right Heart Failure. In: Stergiopoulos K and Brown D: The Evidence-‐Based Cardiology Consult. London: Springer, 2014.

4. Goss KN and Lahm T. Hypoxic Pulmonary Hypertension. In: Klinger J and Frantz R:

Diagnosis and Management of Pulmonary Hypertension (in press).

5. Cucci AR, Kline JK, Lahm T. Acute Right Heart Failure. In: Voelkel NF and Schrantz D: Right Ventricle in Health and Disease (in press).

Non-‐peer reviewed publications 1. Lahm T. Research Corner: Estrogens in Pulmonary Hypertension. Advances In

Pulmonary Hypertension; Summer 2012 issue. Grants and funding

Current: 9/1/2011–8/31/2014: ATS Proof-‐of-‐Concept Grant: Clinical Investigation of a Daily

Walking Program plus L-‐Arginine Supplementation for the Treatment of Pulmonary Arterial Hypertension (role: co-‐investigator; PI: Mary Beth Brown, PhD)

1/1/2013 – 12/31/2014: Gilead Sciences Research Scholars Program in Pulmonary Arterial Hypertension: Sex differences in the right ventricular autophagy response to exercise in experimental pulmonary hypertension (role: PI; $130,000)

11/1/2012 – 10/30/2014: Indiana University School of Medicine Strategic Research Initiative (SRI)/Center of Excellence in Cardiovascular Research (CECARE): Sex

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differences in the right ventricular autophagy response to exercise in experimental pulmonary hypertension (role: PI; $40,000)

4/1/2013 – 3/31/2015: VA Young Investigator Award: Role of autophagy in right ventricular failure (role: mentor; awardee: Anthony Cucci, MD; $30,000)

11/1/2014 – 12/31/2017: VA Merit Review Award 1I01BX002042-‐01A2: Hypoxia-‐mediated protective estrogen receptor signaling in pulmonary hypertension (role: PI, $650,000)

6/1/2014 – 5/31/2015: Indiana University Simon Center Core Grant: Cigarette smoking (CS) is the primary risk factor for lung cancer (role: co-‐PI; other PI: Irina Petrache, MD; $20,000)

Completed: Feb. 2008 – Nov. 2008 Encysive Pharmaceuticals: Effects of Selective Endothelin-‐A

Receptor Antagonist Sitaxsentan on Pulmonary Artery Relaxation and Cytokine Expression Following Endotoxinemia (role: Co-‐PI; PI: Daniel R. Meldrum)

Nov. 2008 – March 2012: Pfizer: Effects of Selective Endothelin-‐A Receptor Antagonist Sitaxsentan on Pulmonary Artery Relaxation and Cytokine Expression Following Endotoxinemia (role: PI; $16,800)

March 2009 – June 2012: VA Young Investigator Award: Noncanonical Estrogen Mechanisms to Reverse Hypoxia-‐Induced Pulmonary Endothelial Cell Activation (role: PI; $30,000)

July 2009 – June 2010: Research Support Funds Grant, Indiana University/Purdue University Indianapolis: In vivo determination of the role of estrogen-‐receptor beta in estradiol-‐mediated protection from hypoxic pulmonary hypertension (role: PI; $35,000)

9/2010 – 8/2012 American Thoracic Society/Pulmonary Hypertension Association/Pfizer Research Fellowship in Pulmonary Arterial Hypertension: Estrogen Metabolism and Autophagy in Hypoxic Pulmonary Hypertension (role: PI; $100.000)

9/2010 ASPIRE Young Investigator Research Award: Estrogen Metabolism as a Therapeutic Target in Hypoxic Pulmonary Hypertension (role: PI; $100.000) – declined due to scientific overlap with a simultaneously awarded grant

7/1/2011 – 6/30/2012 Indiana Clinical and Translational Sciences Institute Core Pilot Grant: Microarray analysis of estradiol-‐mediated protection in rats with hypoxia-‐induced pulmonary hypertension (role: PI, $10,000)

7/1/2012-‐6/30/2013: IUPUI Research Support Funds Grant: Evaluation of efficacy and mechanisms of Exercise Training as Therapy for Hypoxia-‐Induced Pulmonary Hypertension in Rats (Two PI proposal; role: co-‐PI; other PI: Mary Beth Brown, PhD; $35,000)

7/1/2012-‐6/30/2013: IUPUI Biomedical Research Grant: Hypoxia-‐induced anti-‐proliferative estrogen receptor signaling in pulmonary hypertension (role: PI, $40,000)

9/1/2011 – 11/30/2013 ASPIRE Young Investigator Research Award: Compartment-‐specific and Estrogen Receptor-‐dependent Effects of 17-‐Estradiol on Pulmonary Vascular and Right Ventricular Remodeling in Angioproliferative Pulmonary Hypertension (role: PI, $100,000)

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Clinical Trials: 4/2012 – 1/2014: Investigation of Correlation between PCWP and LVEDP at the

Roudebush VAMC (role: PI; no external funding) 5/2013 – present Combined pulmonary fibrosis and emphysema in veterans (role: PI;

no external funding) Invited Talks/Presentations

1. The Critical Role of Inflammation in Pulmonary Dysfunction After Cardiopulmonary Bypass. 7th World Congress on Trauma, Shock, Inflammation and Sepsis. March 16, 2007. Munich, Germany.

2. Pulmonary Hypertension – What Do I Need To Know (Sunrise Seminar). 2009 American Thoracic Society International Conference, May 19, 2009. San Diego, California.

3. The Effects of Estrogen on the Pulmonary Vasculature. Stanford University, Pulmonary

Division Grand Rounds. May 22, 2009.

4. Emerging Concepts and Treatment Strategies in Pulmonary Hypertension. Krannert Institute of Cardiology Grand Rounds, Indiana University, September 22, 2009.

5. Private Practice vs Academic Medicine: Academic Medicine – A Physician Scientist’s

Perspective. American College of Chest Physicians Annual Meeting. San Diego, CA, Nov 3, 2009.

6. Normal Cellular Physiology and Development of the Right Ventricle. Kenneth Moser

Memorial Symposium, 2010 American Thoracic Society International Conference, May 17, 2010. New Orleans, Louisiana.

7. Hormones, Hypoxia and Inheritance: Mechanisms of Sex Differences in Pulmonary

Hypertension (Sunrise Seminar). 2010 American Thoracic Society International Conference, May 19, 2010. New Orleans, Louisiana.

8. Molecular Mechanisms and Therapeutic Strategies for Acute Right Ventricular Failure in the

ICU (Sunrise Seminar). American Thoracic Society International Conference, May 17, 2011. Denver, CO, USA.

9. Visiting Lecturer; Wright State University School of Medicine and Dayton VA Hospital;

Topic: Management of Acute Right Ventricular Failure (8/30 and 8/31/2011)

10. 17-‐Beta Estradiol Attenuates Hypoxic Pulmonary Hypertension Via Estrogen Receptor-‐Mediated Effects. Webinar; Pulmonary Hypertension Association On-‐line University; May 10; 2012 (http://www.phaonlineuniv.org/node/8209).

11. Chair and Presenter, Pulmonary Hypertension: Improving Diagnosis (Morning Education

Symposium at Chest 2012 International Conference; October 21, 2012. Atlanta, GA, USA). Title of presentation: Diagnostic Procedures in PAH: Echocardiography, Right Heart Catheterization, Vasodilator Challenge

12. Co-‐chair and presenter; Postgraduate Course “Under Pressure: The Right Ventricle In

Health, Exercise, And Disease” at American Thoracic Society International Conference (May

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17, 2013; Philadelphia, PA). Title of presentation: An Obstructive And Restrictive View: Pulmonary Hypertension In Lung Disease.

13. Invited Attendee, Penn Pulmonary Vascular Disease Symposium; May 18th, 2013, University

of Pennsylvania, Philadelphia, PA

14. Non-‐CME Symposium at ATS 2013 “Improving the Diagnosis and Individualized Treatment of Patients in Pulmonary Arterial Hypertension”, title of presentation: Treating and Monitoring Patients with PAH (May 19, 2013; Philadelphia, PA).

15. Scientific Symposium at American Thoracic Society International Conference: B6 -‐ Influence

of estrogens on the Pulmonary Circulation and Right Ventricle: From Bench to Bedside (May 20, 2013; Philadelphia, PA). Topic: Estrogen receptor mediated signaling in normoxia and hypoxia.

16. Symposium at American College of Chest Conference International Conference: Evaluation

and Treatment of Right-‐Sided Heart Function in Pulmonary vascular Disease (October 27, 2013; Chicago, IL). Topic: Pathophysiology of Right Ventricular Failure.

17. Symposium at American College of Chest Conference International Conference: Pulmonary

Vascular Disease in Pregnancy (October 28, 2013; Chicago, IL). Topic: Physiologic Circulatory Changes of Pregnancy.

18. Chair and discussant, Symposium at American College of Chest Conference International

Conference: Pulmonary Hypertension: A Case-‐Based And Interdisciplinary Approach To Patient Management (October 29, 2013; Chicago, IL).

19. Symposium at American College of Chest Conference International Conference: Chronic

Thromboembolic Disease (October 30, 2013; Chicago, IL). Topic: Diagnosis of Chronic Thromboembolic Pulmonary Hypertension.

20. Symposium at American College of Chest Conference International Conference: Women at

Risk (October 30, 2013; Chicago, IL). Topic: Hormonal Influence on Pulmonary Vascular Disease

21. Krannert Institute of Cardiology Grand Rounds, Indiana University, November, 2013. Topic:

Update in Pulmonary Arterial Hypertension.

22. Mexican Society of Cardiology Biannual Meeting (November 25, 2013; Leon, Mexico). Topic: Pathophysiology of Right Ventricular Failure.

23. Mexican Society of Cardiology Biannual Meeting (November 25, 2013; Leon, Mexico). Topic:

The Sugen/Hypoxia Model of Pulmonary Hypertension.

24. University of Colorado Translational Cardiovascular Biology Conference (April 22, 2014; Aurora, CO). Topic: Sex hormones in pulmonary hypertension: Has there been progress in solving the estrogen paradox?

25. Alfred P. Fishman Symposium on Pulmonary Vascular Disease at University of Pennsylvania

(April 26, 2014; Philadelphia, PA). Topic: Hormones: Helpful or Hurtful in PAH?

26. Co-‐chair and presenter; Postgraduate Course “The Right Ventricle In Health, Exercise, And Disease: What’s Now, What’s New?” at American Thoracic Society International Conference

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(May 16, 2014; San Diego, CA). Title of presentation: Beyond Obstruction And Restriction: Is There A Rationale For The Treatment Of Cor Pulmonale With Pulmonary Vasodilators?

Original research presentations

1. Lahm T, Day RB, Weyer P, Smith P, Twigg III HL. Effect of Highly Active Antiretroviral Therapy on Bronchoalveolar Lavage Immunoglobulin Levels. Oral presentation at Plenary Session, Combined Meeting of the Central Society for Clinical Research and Midwestern Section American Federation for Medical Research 2004. Chicago, Illinois.

2. Lahm T. Patel KM. Crisostomo PR. Markel T. Petrache I. Meldrum DR. Is there a sex

difference in hypoxic pulmonary vasoconstriction? 7th World Congress on Trauma, Shock, Inflammation and Sepsis (Poster). March 16, 2007. Munich, Germany.

3. Lahm T, Patel K, Crisostomo P, Markel T, Wang M, Petrache I, Meldrum DR. Endogenous

Estrogen Attenuates Pulmonary Artery Vasoreactivity and Hypoxic Pulmonary Vasoconstriction. Oral presentation, Indiana University School of Medicine Department of Medicine Research Contest. June 6, 2007. Indianapolis, Indiana.

4. Lahm T, Wang M, Herring C, Crisostomo P, Markel T, Petrache I, Meldrum DR. Endogenous

Estrogen Attenuates Pulmonary Artery Vasoconstriction (Poster). 30th Annual Conference on Shock. June 10, 2007. Baltimore, Maryland.

5. Lahm T, Neese S, Ober MD, Sarosi GA, Hage CA. Reversal of Refractory Blastomycosis-‐

Induced Acute Respiratory Distress Syndrome with Corticosteroids. Oral presentation, CHEST, Oct 23, 2007. Chicago, Illinois.

6. Lahm T, Crisostomo PR, Markel TA, Wang M, Novotny NM, Wang Y, Meldrum DR. Estrogen

Receptor-‐Alpha Agonist PPT Attenuates Acute Hypoxic Pulmonary Vasoconstriction (HPV). Oral presentation, Annual Meeting of the Surgical Infection Society, May 8, 2008. Hilton Head Island, North Carolina.

7. Lahm T, Crisostomo PR, Markel TA, Petrache I, Meldrum DR. Endogenous and Exogenous

Estrogen Attenuates Pulmonary Artery Vasoreactivity and Acute Hypoxic Vasoconstriction (Poster). 2008 American Thoracic Society International Conference, May 18, 2008. Toronto, Canada.

8. Lahm T, Crisostomo PR, Markel TA, Novotny NM, Meldrum DR. Selective Estrogen Receptor Agonists Attenuate Pulmonary Artery Vasoconstriction By A Nitric Oxide-‐Dependent Mechanism. Oral presentation, Indiana University School of Medicine Department of Medicine Research Contest. May 28, 2008. Indianapolis, Indiana.

9. Lahm T, Crisostomo PR, Markel TA, Wang M, Wang Y, Meldrum DR. Selective Estrogen Receptor Agonists Attenuate Pulmonary Artery Vasoconstriction By A Nitric Oxide-‐Dependent Mechanism. Oral presentation, CHEST, Oct 26, 2008. Philadelphia, Pennsylvania.

10. Lahm T, Neumann T, Wolf KM, Twigg III, HL, Ober MD. Adenovirus-‐Associated

Hemophagocytic Lymphohistiocytosis with Acute Respiratory Distress Syndrome and Multiorgan Failure. Oral presentation, CHEST, Oct 27, 2008. Philadelphia, Pennsylvannia.

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11. Lahm T, Tan J, Wang M, Wang, Y, Abarbanell AM, Herrmann JL, Weil BR, Meldrum DR. Selective Estrogen Receptor Agonists Rapidly Decrease Pulmonary Artery Vasoconstriction without Activating PI3K/Akt (Poster). 2009 American Thoracic Society International Conference, May 20, 2009. San Diego, CA, USA.

12. Lahm T, Albrecht M, Van Demark M, Adamowicz J, Devlin C, Ivan M, Petrache I. Effects of

17-‐beta estradiol on cultured hypoxic lung endothelial cells (Poster). Pittsburgh International Lung Conference, Oct 9, 2009. Pittsburgh, Pennsylvannia.

13. Lahm T, Albrecht M, Adamowicz J, Van Demark M, Devlin C, Ivan M, Presson RG, Petrache I. Effects of 17-‐beta estradiol on cultured hypoxic lung endothelial cells and hypoxic pulmonary hypertension (Poster). 2010 American Thoracic Society International Conference, May 18, 2010. New Orleans, LA, USA.

14. Lahm T, Albrecht M, Gao Y, Van Demark M, Fisher A, Presson RG, Petrache I. Treatment with 17-‐beta Estradiol Attenuates Chronic Hypoxic Pulmonary Hypertension in Male Rats (Poster). Pulmonary Hypertension Association International PH Conference and Scientific Sessions, June 26, 2010. Garden Grove, CA, USA.

15. Lahm T, Albrecht M, Justice M, Fisher A, Van Demark M, Patel N, Presson RG, Petrache I.

17-‐Beta Estradiol (E2) Attenuates Hypoxia-‐Induced Pulmonary Hypertension Through An Estrogen Receptor-‐Dependent, But E2 Metabolite-‐Independent Mechanism. Oral presentation, American Thoracic Society International Conference, May 16, 2011. Denver, CO, USA.


Compartment-‐Specific Effects Of Hypoxia And 17beta-‐Estradiol On Autophagy In The Pulmonary Vascular System (Poster). American Thoracic Society International Conference, May 17, 2011. Denver, CO, USA.

17. Lahm T, Albrecht M, Fisher A, Justice M, Presson RG, Petrache I. 17beta-‐Estradiol

Attenuates Hypoxia-‐Induced Pulmonary Hypertension by an Estrogen Receptor-‐dependent Mechanism that Involves Decreased ERK1/2 Activation (Poster). Grover Conference on Pulmonary Vascular Disease, Sep 10, 2011. Lost Valley Ranch, Sedalia, CO, USA.

18. Lahm T, Fisher A, Albrecht M, Presson RG, Petrache I. The Role Of Estrogen Receptor (ER) Alpha And ER Beta In 17beta-‐Estradiol Mediated Protection From Hypoxia-‐Induced Pulmonary Hypertension (Poster). American Thoracic Society International Conference, May 22, 2012. San Francisco, CA, USA.

19. Lahm T, Albrecht M, Fisher A, Selej M, Patel N, Brown J, Justice M, Brown M, Trulock K,

Dieudonne D, Reddy J, Presson R, Petrache I. Protective Effects of 17-‐Beta Estradiol (E2) in Hypoxic Pulmonary Hypertension are Mediated by Estrogen Receptors Alpha and Beta (Poster). Aspen Lung Conference, June 8, 2012, Aspen, CO, USA.

20. Lahm T, Albrecht M, Fisher A, Selej M, Patel N, Brown J, Justice M, Brown M, Trulock K, Dieudonne D, Reddy J, Presson R, Petrache I. Protective Effects of 17-‐Beta Estradiol (E2) in Hypoxic Pulmonary Hypertension are Mediated by Estrogen Receptors Alpha and Beta (Poster). Pulmonary Hypertension Association Scientific Sessions, June 22, 2012, Orlando, FL, USA.

21. Lahm T, Brown J, Albrecht M, Fisher A, Cucci A, Cook T, Van Demark M, Johnstone B, Presson R, Brown MB, Petrache I. Differential Effects of 17beta-‐Estradiol (E2) on Functional

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Endpoints and Lung and RV Cellular Survival Signaling in Su5416/Hypoxia (SuHx)-‐Induced Pulmonary Hypertension (Poster). 5th World Symposium on Pulmonary Hypertension, Feb 27, 2013, Nice, France.

22. Lahm T, Albrecht M, Wood J, Edenberg H, Petrache I, McClintick J. Receptor Mediated Effects Of 17beta-‐Estradiol (E2) On The Inflammatory And Proliferative Transcriptome In Hypoxia-‐Induced Pulmonary Hypertension (HPH) (Poster). American Thoracic Society International Conference, May 21, 2013. Philadelphia, PA, USA.

23. Lahm T, Brown J, Albrecht M, Fisher A, Cucci A, Cook T, Van Demark M, Johnstone B, Presson R, Brown MB, Petrache I. Molecular Mechanisms of 17beta estradiol-‐mediated protection in Sugen/hypoxia-‐mediated severe right ventricular failure (Poster). Grover Conference on Pulmonary Vascular Disease, September 7, 2013. Lost Valley Ranch, Sedalia, CO, USA.

PROFESSIONAL SERVICE

Editorial Boards: Oct 2008 -‐ present Journal of Surgical Research July 2012 – present PLoS ONE March 2013 – present Physiological Reports Reviewer activities: August 2009 – present ad hoc reviewer for J Surg Res (2007-‐2008), Respiration (2009 –

present), Stem Cells International (2010), Clinical Infectious Diseases (2010), Chest (2010 – present), Endocrine Research (2010), PLoS One (2011 -‐ present), Vascular Pharmacology (2011 -‐ present), Circulation (2011 -‐ present), European Respiratory Journal (2011 -‐ present), American Journal of Physiology Lung (2012 – present), J Exp Physiology (2012 – present), J Crit Care (2012 – present), Respiratory Research (2012 – present), Am J Nephrology (2012 – present), Journal of Steroid Biochemistry and Molecular Biology (2013 – present), American Journal of Physiology Heart and Circulatory Physiology (2013 – present)

Grant review activities: August 2012 – present Participant in Early Career Reviewer (ECR) program at the Center for

Scientific Review (CSR), National Institute of Health November 2012 Medical Research Council (UK) August 2013 – present ATS Foundation Research Awards Activities in Professional Societies and National Meetings:

a) Committees: Oct 2008 – Oct 2012 Affiliate Network Steering Committee, American College of Chest

Physicians (term ended in Oct 2012) September 2012 – present Chair; Pulmonary Hypertension Association Early Diagnosis

Campaign Education Committee October 2012 – October 2013 American College of Chest Physicians Scientific Program Committee March 2013 -‐ present Preceptorship Program Planning Committee, Pulmonary

Hypertension Association

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March 2013 -‐ present Scientific Sessions Program Planning Committee, Pulmonary Hypertension Association

May 2013 -‐ present Program Committee, American Thoracic Society Pulmonary Circulation Assembly

May 2013 -‐ present Planning Committee, American Thoracic Society Pulmonary Circulation Assembly

October 2013 – present Pregnancy in Pulmonary Hypertension Taskforce, Pulmonary Vascular Research Institute

b) Moderator, chair, and abstract reviewer activities:

May 2009 – present Case report abstract grader, American College of Chest Physicians Annual Meeting

November 2009 – present Case report moderator, American College of Chest Physicians Annual Meeting

November 2009 Expert, “Cardiovascular Curiosities” case report session, American College of Chest Physicians Annual Meeting, San Diego, CA; Nov 2, 2009.

November 2010 Session Chair, Critical Care Radiology: Indications, Interpretation, and Case Review for the Intensivist. American College of Chest Physicians Annual Meeting, Vancouver, BC, Canada; Nov 3, 2010.

May 2011 – present Research abstract grader, American College of Chest Physicians Annual Meeting

May 2011 – present Thematic Poster Session and Poster Discussion Session Facilitator/Moderator (Pulmonary Circulation and Respiratory Cell & Molecular Biology Assemblies), American Thoracic Society Annual Meeting

October 2011 – present Original investigation moderator, American College of Chest Physicians Annual Meeting

October 2012 Session Chair, PAH: Improving Diagnosis (Morning Education Symposium). American College of Chest Physicians Annual Meeting, Atlanta, GA, USA; Oct 21, 2012.

October 2012 Session Chair, What is the State-‐of-‐the-‐Art in Imaging for Pulmonary Vascular Disease. American College of Chest Physicians Annual Meeting, Atlanta, GA, USA; Oct 23, 2012.

October 2012 Contributor and moderator for PAH small interactive case discussion sessions. American College of Chest Physicians Annual Meeting, Atlanta, GA, USA; Oct 20-‐25, 2012.

October 2012 Faculty contributor for PAH self-‐study station. American College of Chest Physicians Annual Meeting, Atlanta, GA, USA; Oct 20-‐25, 2012.

May 2013 Co-‐chair; Postgraduate Course “Under Pressure: The Right Ventricle In Health, Exercise, And Disease” at American Thoracic Society International Conference (May 17; Philadelphia, PA).

October 2013 Contributor and moderator for PAH small interactive case discussion sessions. American College of Chest Physicians Annual Meeting, Chicago, IL, USA; Oct 26-‐31, 2012.

January 2014 Poster grader, ECCPS/PVRI 2014 meeting; Giessen, Germany; Jan 29, 2014.

May 2014 Co-‐chair; Postgraduate Course “The Right Ventricle In Health, Exercise, And Disease: What’s Now, What’s New?” at American Thoracic Society International Conference (May 16; San Diego, CA).

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c) Other activities: November 2009 – present Associate editor, American Thoracic Society Pulmonary Circulation

web-‐based journal club

Honors and Awards

Nov. 1999 – June 2000 Scholarship from the Deutscher Akademischer Auslandsdienst (DAAD) (=German Academic Society for Foreign Countries) for eight months‘ participation in the Senior Medical Student Elective Program at Indiana University School of Medicine, Indianapolis, USA

June 2003 Indiana University Award for Outstanding Achievement in Ambulatory Education

March 2007 Invited speaker, 7th World Summit on Trauma, Shock, Inflammation and Sepsis. Munich, Germany, March 13 – 17.

May 2007 Indiana University Department of Medicine Fellow Research Competition, Second Place

October 2007 Best Case Report in Infectious Diseases Category: Lahm T, Neese S, Ober MD, Sarosi GA, Hage CA. Reversal of Refractory Blastomycosis-‐Induced Acute Respiratory Distress Syndrome with Corticosteroids. CHEST 2007. Chicago, Illinois.

May 2008 First place, Indiana University Department of Medicine Fellow Research Competition

October 2009 Sponsored Attendee; American College of Chest Physicians Leadership Development Course. San Diego, CA; Oct 31, 2010.

April 2012 First place winner, Translational Research Posters. Richard L. Roudebush VAMC Research Day.

EDUCATION Research Mentoring July – August 2010 Vinayak Gupta (Carmel High School Student; FEED program

participant). Project: Effects of 17-‐beta estradiol and myriocin on cultured pulmonary artery cells

August 2010 – June 2012 Brent Toney, DO, Pulmonary/Critical Care Fellow. Project: Effect of selective endothelin receptor (A) antagonist on pulmonary artery vasomotor tone and hemodynamic parameters following endotoxemia

March 2011 Kevin M. Trulock, MS3. Project: Pulmonary Artery Remodeling in Hypoxic Pulmonary Hypertension

July 2011 – July 2013 Mona Selej, MD, Pulmonary/Critical Care Fellow. Project: Estrogen Receptors in Hypoxia-‐Induced Pulmonary Hypertension

June 2012 – May 2013 Vannessa Taylor, Bridges to Baccalaureate student. Project: Effects of estrogen on Glut1 expression in RV failure

July 2012 -‐ present Anthony Cucci, MD, Pulmonary/Critical Care Fellow. Project: Autophagy in Right Ventricular Failure

July 2012 – June 2012 Shikha Gupta, MD, Pulmonary/Critical Care Fellow. Project: Exercise and L-‐arginine supplementation in pulmonary arterial hypertension (co-‐mentoring with Dr. Mary B. Brown; Dept. of Physical Therapy)

August 2012 – January 2014 Abbas Bitar, MD, Internal Medicine Resident. Project: Investigation of Correlation between PCWP and LVEDP at the Roudebush VAMC

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September 2012 -‐ present Kara Goss, MD, Pulmonary/Critical Care Fellow. Project: Does prematurity predispose to adult onset pulmonary hypertension? (co-‐mentoring with Drs. Robert Tepper and Shawn Ahlfeld; Dept. of Pediatrics)

October 2012 – August 2013 John Fierst, Life Health Sciences Initiative student. Project: Effects of estrogen on pulmonary vascular remodeling in Sugen/hypoxia-‐induced pulmonary hypertension

July 2013 – present Sikandar Khan, MD, Internal Medicine Resident. Project: Pulmonary hypertension in combined pulmonary fibrosis and emphysema syndrome in a veteran population

July 2013 – present Jordan Whitson, MD, Internal Medicine Resident. Project: Sex hormone levels in the rat model of sugen/hypoxia-‐induced pulmonary hypertension

August 2013 -‐ present Roziya Tursunova, Life Health Sciences Initiative student. Project: Effects of estrogen on right ventricular remodeling in Sugen/hypoxia-‐induced pulmonary hypertension

February 2014 – present Andrea Frump, PhD, post-‐doctoral research fellow. Project: Hypoxia-‐mediated protective estrogen receptor signaling in pulmonary hypertension

Research mentee honors and awards May 2012 Brent Toney: Winner of 2012 IU Department of Medicine Fellows

Research Contest April 2012 Mona Selej: Scholarship for attendance of 2012 Pulmonary

Hypertension Association Meeting March 2013 Anthony Cucci: VA Young Investigator Award ($30,000): Role of

autophagy in right ventricular failure May 2013 Abbas Bitar: Winner of 2013 IU Department of Medicine Resident

Research Contest May 2013 Anthony Cucci: Winner of 2013 IU Department of Medicine Fellows

Research Contest May 2013 Mona Selej: Second place, 2013 IU Department of Medicine Fellows

Research Contest May 2013 Anthony Cucci: Travel Award at American Thoracic Society

International Conference (Abstract: Evidence Of Impaired Autophagic Flux In Experimental Severe Right Ventricular Failure)

June 2013 John Fierst: Alpha Lambda Delta scholarship (one of 35 recipients nationwide)

September 2013 Anthony Cucci: Young Investigator Award at Grover Conference on Pulmonary Vascular Disease (Abstract: Impaired Autophagy in Right Ventricular Failure (RVF))

January 2014 Roziya Tursunova: IUPUI Undergraduate Research Opportunities Program (UROP) Project Grant. Title: Estrogen Receptor Effects on Right Ventricular and Pulmonary Vascular Remodeling in Rats with Pulmonary Hypertension

May 2014 Andrea Frump: Scholarship for attendance of 2014 Pulmonary Hypertension Association Meeting

May 2014 Kara Goss: Scholarship for attendance of 2014 Pulmonary Hypertension Association Meeting

May 2014 Sikandar Khan: Scholarship for attendance of 2014 Pulmonary Hypertension Association Meeting

May 2014 Jordan Whitson: Winner of 2013 IU Department of Medicine Resident Research Contest

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May 2014 Kara Goss: Winner of 2013 IU Department of Medicine Fellows Research Contest

Teaching Assignments

October 2008 – present Presenter, Pulmonary Division Chest Conference (30 min lecture; twice/year)

February 2008 Introduction into Clinical Medicine II: Pulmonary Arterial Hypertension (lecture, 1hr)

February 2008 Fourth year student interactive group: Pulmonary module (seminar, 3 hrs)

October 2008 – present I am spending two to three months per year on the inpatient critical care and pulmonary consultation service at the Richard L. Roudebush V.A. Medical Center. During these rotations, I actively teach fellows, residents and students. In addition, I have one half-‐day of clinic per week, and I supervise two fellows in this clinic (current fellows: Dr. Labib Debiane and Dr. Anthony Cucci). I attend and actively participate in the weekly fellows conference and the weekly interdisciplinary chest conference (1 hour per conference). I give two chest conference presentations per year (30 min each).

November 2009 Introduction into Clinical Medicine II: Pulmonary Arterial Hypertension (lecture, 1 hr)

February 2009 Pulmonary Arterial Hypertension and Pulmonary Hypertension for Fellows (lecture for pulmonary fellows, 1hr, 2/18/09)

February 2009 Advisor for Rayan Ihle, MD (Internal Medicine/Pediatrics Resident) – Senior Resident Lecture Series: Pulmonary Arterial Hypertension, 2/19/09

February 2009 Moderator, MSII TBL group on chronic obstructive lung disease and asthma (2hrs, 2/20/09)

May 2009 Department of Medicine Grand Rounds, Title: Current and Novel Treatment Strategies for Pulmonary Arterial Hypertension. May 1, 2009.

August 2009 Pulmonary Division Research Grand Rounds, Title: Sex, Drugs, and Hypoxia: Estrogen Effects on the Pulmonary Vasculature. August 17, 2009.

August 2009 Richard L. Roudebush VA Medical Center Noon Conference, Title: Pulmonary Hypertension and Pulmonary Arterial Hypertension. August 25, 2009.

October 2009 Advisor for Charles McCaslin, MD (Internal Medicine/Pediatrics Resident) – Senior Resident Lecture Series: Right Heart Failure in the Intensive Care Unit, 10/8/09

December 2009 Hemodynamics for Fellows (lecture for pulmonary fellows, 1hr, 12/9/09)

February 2010 Introduction into Clinical Medicine II: Pulmonary Arterial Hypertension (lecture, 1 hr)

September 2010 Pulmonary Division Research Grand Rounds, Title: “Estrogen Receptors and Estrogen Metabolism in Hypoxia-‐Induced Pulmonary Hypertension” (Oct 11, 2010)

November 2010 Pulmonary Arterial Hypertension and Pulmonary Hypertension for Fellows (lecture for pulmonary fellows, 1hr, 11/17/10)

January 2011 VA Research Conference, Title: “Estrogen Receptors and Estrogen Metabolism in Hypoxia-‐Induced Pulmonary Hypertension” (Jan 13, 2011)

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February 2011 Introduction into Clinical Medicine II: Pulmonary Arterial Hypertension (lecture, 1 hr; 2/2/2011)

February 2011 ARDS and ALI (lecture for pulmonary fellows, 1hr, 2/16/2011) March 2011 Advisor for Kruti Joshi, MD (Internal Medicine Resident) – Senior

Resident Lecture Series: Evaluation of Suspected Pulmonary Hypertension, 3/21/2011

June 2011 Wishard Hospitalist Seminar Series, Title: “Pulmonary Hypertension for the Hospitalist” (1hr, 6/9/2011)

July 2011 Pulmonary Arterial Hypertension and Pulmonary Hypertension for Fellows (lecture for pulmonary fellows, 1hr, 7/5/2011)

July 2011 Hemodynamics for Fellows (lecture for pulmonary fellows, 1hr, 7/7/2011)

August 2011 Update in ARDS and ALI (lecture for pulmonary fellows, 1hr, 8/17/2011)

February 2012 Pulmonary Division Research Grand Rounds,17-‐Beta Estradiol Attenuates Hypoxic Pulmonary Hypertension Via Estrogen Receptor-‐Mediated Effects. (1 hr; 2/6/2012)

February 2012 Introduction into Clinical Medicine II: Pulmonary Arterial Hypertension (lecture, 1 hr; 2/8/2012)

June 2012 Department of Medicine Grand Rounds, Title: Right Ventricular Failure: Pathophysiologic Mechanisms and Therapeutic Strategies. June 29, 2012.



November 2012 Pulmonary Hypertension in Pregnancy (lecture for Maternal Fetal Medicine, 1hr, 11/14/2012)

December 2012 Pulmonary Division Research Grand Rounds, Estrogen Effects on the Pulmonary Vasculature and Right Ventricle: Hypoxia and Beyond (1 hr, 12/4/2012)

December 2012 In-‐Depth Review of Pulmonary Hypertension Subtypes (lecture for pulmonary fellows, 1hr, 12/19/2012

January 2013 Introduction into Clinical Medicine II: Hemodynamics (lecture, 1 hr; 1/24/2013)



September 2013 Pulmonary Division Research Grand Rounds, Title: “Sex and the heart: Estrogen effects on the failing right ventricle” (1 hr; 9/3/2013)

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UNIVERSITY SERVICE

Committees and reviewer activities October 2008 -‐ present Fellowship Committee, Department of Medicine, Division of

Pulmonary, Allergy, Critical Care and Occupational Medicine January 2009 – present Interviewer for pulmonary/critical care fellowship applicants March 2009 – March 2010 VA committee for compliance improvement for treatment of

inpatients with community-‐acquired pneumonia July 2010 – March 2013 VA laboratory expert system committee December 2011 -‐ present Research Committee, Indiana University Department of Medicine January 2013 Reviewer for VA Young Investigator Awards August 2013 Reviewer for CECARE proposals December 2013 – Feb 2014 Reviewer for Indiana CTSI “Pilot Funding for Research Use of Indiana

Biobank (IB) Samples” proposals July 2014 -‐ Biomedical Research Committee Leadership and program building March 2014 – Director for Pulmonary Hypertension Research, Indiana

University/Indiana University Health Pulmonary Vascular Disease Program (one of three co-‐directors of program)

Conference organization May 2011 – present Organizer, monthly multidisciplinary Pulmonary Vascular Disease

Conference (CME credit since July 2012) July 2012 – present Organizer, biweekly Pulmonary Research Conference (CME credited) Resident advising July 2009 – June 2012 Faculty Advisor for Brian Middleton, MD (Internal Medicine

Resident) July 2013 – present Faculty Advisor for Philip Hanneman, MD (Internal Medicine

Resident)

OTHER INFORMATION Published Abstracts

1. Lahm T, Day RB, Weyer P, Smith P, Twigg III HL. Effect of Highly Active Antiretroviral Therapy on Bronchoalveolar Lavage Immunoglobulin Levels. J Investig Med 52(S2): S358, 2004.

2. Markel T, Crisostomo PR, Lahm T, Wang M, Meldrum DR. TNF-‐alpha preconditioning of

Human Bone Marrow Mesenchymal Stem Cells Does Not Improve Stem Cell Acute Myocardial Protection After Ischemia/Reperfusion. Inflammation Research. 2007 (56). Suppl. 2: S168.

3. Lahm T, Patel K, Crisotomo PR, Markel TA, Petrache I, Meldrum DR. Is There a Sex

Difference in Hypoxic Pulmonary Vasoconstriction? Inflammation Research. 2007 (56). Suppl. 2: S267.

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4. Meldrum DR, Lahm T, Markel TA, Crisostomo PR, Herring C, Wang M. Myocardial Ischemia-‐Reperfusion Injury During Cardiopulmonary Bypass. Inflammation Research. 2007 (56). Suppl. 2: S319.

5. Lahm T, Markel TA, Crisostomo PR, Herring C, Wang M, Meldrum DR. The Critical Role

of Inflammation in Pulmonary Dysfunction After Cardiopulmonary Bypass. Inflammation Research. 2007 (56). Suppl. 2: S320.

6. Markel TA, Lahm T, Crisostomo PR, Herring C, Wang M, Meldrum DR. Aprotinin

Attenuates the Incidence of Stroke During the Perioperative Period of Cardiopulmonary Bypass. Inflammation Research. 2007 (56). Suppl. 2: S320.

7. Lahm T, Wang M, Herring C, Crisostomo P, Markel T, Petrache I, Meldrum DR.

Endogenous Estrogen Attenuates Pulmonary Artery Vasoconstriction. Shock 2007 (27), Suppl.1: P69.

8. Crisostomo P, Wang M, Markel T, Lahm T, Meldrum DR. The Superiority of Embryonic

Stem Cell Paracrine Protective Mechanisms Against Ischemia. Shock 2007 (27), Suppl.1: A1.

9. Markel T, Crisostomo P, Wang M, Lahm T, Meldrum DR. Engineering “Smart” Stem Cells

for Maximum Benefit in Shock and Tissue Injury. Shock 2007 (27), Suppl.1: A31.

10. Patel K, Markel T, Crisostomo P, Wang M, Lahm T, Meldrum DR. Testosterone Elicits a Biphasic Depression in Fetal Human Intestinal Cell Growth Factor Production During Iron Chelation Induced Inflammation. Shock 2007 (27), Suppl.1: P51.

11. Markel TA, Crisostomo PR, Lahm T, Wang M, Herring C, Meldrum DR. Deferoxamine

stimulates fetal human intestinal cell production of IGF-‐1 and GM-‐CSF: The roles of P38, ERK, and JNK intracellular signaling. Surg Infect. 2007 Apr; 8(2): 290.

12. Lahm T, Neese S, Ober MD, Sarosi GA, Hage CA. Reversal of Refractory Blastomycosis-‐

Induced Acute Respiratory Distress Syndrome with Corticosteroids. Chest 2007, 132: 699S.

13. Lahm T, Crisostomo PR, Markel TA, Wang M, Novotny NM, Wang Y, Meldrum DR. Estrogen Receptor-‐Alpha Agonist PPT Attenuates Acute Hypoxic Pulmonary Vasoconstriction (HPV). Surgical Infections 2008 April;9(2):252.

14. Markel TA, Crisostomo PR, Wang M, Wang Y, Lahm T, Novotny NM, Meldrum DR. How Old

is Old Enough: In the Adult Stem Cell Population, is there an Age Limit for Optimum Functionality? Surgical Infections 2008 April;9(2):244.

15. Novotny NM, Markel TA, Crisostomo PR, Wang M, Herring CM, Lahm T, Wang Y, Meldrum

DR. Neonatal Mesenchymal Stem Cells Produce IL16 but not VEGF through NFκB while Adults Utilize NFκB for Both. Surgical Infections 2008 April;9(2):265.

16. Crisostomo PR, Markel TA, Lahm T, Novotny NM, Wang M, Wang Y, Meldrum DR. The

Acute Paracrine Effects of Stem Cell May not be Mediated by VEGF. Surgical Infections 2008 April;9(2):268.

17. Guzman M, Crisostomo PR, Markel TA, Lahm T, Wang M, Wang Y, Novotny NM, Meldrum

DR. VEGF Administration Increases Anti-‐inflammatory and decreases Proinflammatory Tissue Cytokine Production after Ischemia. Surgical Infections 2008 April;9(2):268.

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18. Lahm T, Crisostomo PR, Markel TA, Petrache I, Meldrum DR. Endogenous and Exogenous

Estrogen Attenuates Pulmonary Artery Vasoreactivity and Acute Hypoxic Vasoconstriction. Am J Resp Crit Care Med. 2008 April;177:A254.

19. Lahm T, Crisostomo PR, Markel TA, Wang M, Wang Y, Meldrum DR. Selective Estrogen Receptor Agonists Attenuate Pulmonary Artery Vasoconstriction By A Nitric Oxide-‐Dependent Mechanism. Chest Meeting Abstracts 2008 134: s25003.

20. Lahm T, Neumann T, Wolf KM, Twigg III, HL, Ober MD. Adenovirus-‐Associated Hemophagocytic Lymphohistiocytosis with Acute Respiratory Distress Syndrome and Multiorgan Failure. Chest Meeting Abstracts 2008 134: c22002.

21. Lahm T, Tan J, Wang M, Wang, Y, Abarbanell AM, Herrmann JL, Weil BR, Meldrum DR. Selective Estrogen Receptor Agonists Rapidly Decrease Pulmonary Artery Vasoconstriction without Activating PI3K/Akt. Am J Respir Crit Care Med 179;2009:A6239.

22. Bosslet GT, DeVito ML, Lahm T, Sheski FD, Mathur PN. Nurse-‐Administered Propofol

Sedation: Utility and Safety in Bronchoscopy. Am J Respir Crit Care Med 179;2009:A6151.

23. Wang M, Crisostomo PR, Markel TA, Wang Y, Lahm T, Tan J, Novotny N, Meldrum DR. Estrogen Receptor Beta Mediates Increased Activation of PI3k/Akt, Decreased Expression of Caspase-‐3, -‐8, Up-‐Regulation of Bcl-‐2, and Improved Myocardial Function in Female Hearts following Ischemia. Circulation. 2008;118:S_706.

24. Najm S., Wolf K., Larsson L., Lahm T. Pulmonary Hypertension Associated with Whipple’s

Disease: An Unusual Cause for a Common Clinical Condition. Chest Meeting Abstracts 2009; 136: 57S-‐57S.

25. Lahm T, Albrecht M, Adamowicz J, Van Demark M, Devlin C, Ivan M, Presson RG, Petrache I. Effects of 17-‐beta estradiol on cultured hypoxic lung endothelial cells and hypoxic pulmonary hypertension. Am J Resp Crit Care Med 181;2010:A5227.

26. Dutkiewicz RM, Cleveland K, Das M, Lahm T. Phrenic nerve paralysis after radiofrequency ablation for atrial fibrillation. Am J Resp Crit Care Med 181;2010:A5836.

27. Reddy J, Lahm T. Intravenous Lipid Emulsion Rescue for Severe Central Nervous System Local Anesthetic Toxicity. Chest Meeting Abstracts 2010; 138:76A.

28. Lahm T, Albrecht M, Justice M, Fisher A, Van Demark M, Patel N, Presson RG, Petrache I. 17-‐Beta Estradiol (E2) Attenuates Hypoxia-‐Induced Pulmonary Hypertension Through An Estrogen Receptor-‐Dependent, But E2 Metabolite-‐Independent Mechanism. Am J Resp Crit Care Med 183;2011:A2521.


Compartment-‐Specific Effects Of Hypoxia And 17beta-‐Estradiol On Autophagy In The Pulmonary Vascular System. Am J Resp Crit Care Med 183;2011:A4957.

30. Toney B, Fisher A, Albrecht M, Patel N, Presson RG, Petrache I, Lahm T. Endothelin-‐A Receptor Blockade Attenuates Pulmonary Vascular Dysfunction Following Experimental Endotoxemia. Am J Resp Crit Care Med 183;2011:A6408.

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31. Lahm T, Albrecht M, Fisher A, Justice M, Presson RG, Petrache I. 17beta-‐Estradiol Attenuates Hypoxia-‐Induced Pulmonary Hypertension by an Estrogen Receptor-‐dependent Mechanism that Involves Decreased ERK1/2 Activation. Pulmonary Circulation (in press).

32. Cucci AR, Miller M, Lahm T, Noor A. An Asthma Exacerbation That Blows Your Mind: A Case Report Of Asthma Induced Cerebral Edema. Am J Resp Crit Care Med 185;2012:A4613.

33. Lahm T, Fisher A, Albrecht M, Presson RG, Petrache I. The Role Of Estrogen Receptor (ER) Alpha And ER Beta In 17beta-‐Estradiol Mediated Protection From Hypoxia-‐Induced Pulmonary Hypertension. Am J Resp Crit Care Med 185;2012:A4751.

34. Toney B, Fisher A, Lockett A, Presson RG, Petrache I, Lahm T. Endothelin-‐A Receptor Blockade Attenuates Endotoxin-‐Induced Pulmonary Hypertension Without Affecting Blood Pressure And Oxygenation. Am J Resp Crit Care Med 185;2012:A4751.

35. Selej M, Lockett AD, Albrecht M, Petrache I, Lahm T. Hypoxia Increases Estrogen Receptor Beta Expression In Cultured Rat Pulmonary Artery Endothelial Cells. Am J Resp Crit Care Med 185;2012:A4817.

36. Brown MB, Reddy J, Chingombe TJ, Fisher A, Presson RG, Lahm T, Petrache I. Effect Of Treadmill Running On Cardiac And Skeletal Muscle Metabolism And Right Ventricular Inflammation In Rats With Monocrotaline-‐Induced Pulmonary Arterial Hypertension (PAH). Am J Resp Crit Care Med 185;2012:A6230.

37. Lahm T, Albrecht M, Fisher A, Selej M, Patel N, Brown J, Justice M, Brown M, Trulock K,

Dieudonne D, Reddy J, Presson R, Petrache I. Protective Effects of 17-‐Beta Estradiol (E2) in Hypoxic Pulmonary Hypertension are Mediated by Estrogen Receptors Alpha and Beta. Pulmonary Circulation 2013; 3:196.

38. Smith J, Lahm T. Septic Embolism From Atrial Pacer Wire Resulting In Complete Obstruction Of Right Pulmonary Artery. J Resp Crit Care Med 187;2013:A4603

39. Bittar A, Williams V, Bolad I, Lahm T. Poor Agreement Between Pulmonary Capillary Wedge Pressure (PCWP) And Left Ventricular End-‐Diastolic Pressure (LVEDP) In A Veteran Population. Resp Crit Care Med 187;2013:A4675

40. Lahm T, Albrecht M, Wood J, Edenberg H, Petrache I, McClintick J. Receptor Mediated Effects Of 17beta-‐Estradiol (E2) On The Inflammatory And Proliferative Transcriptome In Hypoxia-‐Induced Pulmonary Hypertension (HPH). Am J Resp Crit Care Med 187;2013:A4639

41. Selej M, Wood J, Lockett A, Albrecht M, Schweitzer K, Petrache I, Lahm T, Hypoxia Increases Expression Of Estrogen Receptor (ER)-‐Beta In Vivo And In Vitro. Am J Resp Crit Care Med 187;2013:A2257

42. Cucci A, Wood J, Albrecht M, Van Denmark M, Sorg C, Cook T, Petrache I, Lahm T. Evidence Of Impaired Autophagic Flux In Experimental Severe Right Ventricular Failure. Am J Resp Crit Care Med 187;2013:A5168

43. Clauss M, Lahm T, Albrecht M, Wood J, Fisher A, Presson R, Petrache I, Voswinckel R, Weissmann N. Endothelial-‐Monocyte-‐Activating Polypeptide II (EMAPII) Is Involved In Pulmonary Hypertension. Am J Resp Crit Care Med 187;2013:A1775

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44. Serban K, Winer-‐Muram H, Serban R, Lahm T. Characteristics Of Pulmonary Hypertension (PH) In A Cohort Of VA Patients With Combined Pulmonary Fibrosis And Emphysema (CPFE) Syndrome. Am J Resp Crit Care Med 187;2013:A2271

45. Brown M, Crist J, Little N, Gaidoo R, Chingombe T, Fisher A, Presson R, Lahm T, Petrache I. Exercise Training At Mild Relative Intensity Ameliorates Cardiac And Skeletal Muscle "Glycolytic Switch" And Improves Aerobic Capacity In Rats With Monocrotaline-‐Induced Pulmonary Arterial Hypertension. Am J Resp Crit Care Med 187;2013:A4658

46. Wood J, Albrecht M, Fisher A, Cucci A, Sorg C, Cook T, Johnstone B, Presson R, Brown M, Petrache I, Lahm T. 17beta-‐Estradiol (E2) Improves Right Ventricular (RV) Function And Exercise Capacity In Su5416/Hypoxia (SuHx)-‐Induced Pulmonary Hypertension. Am J Resp Crit Care Med 187;2013:A1028

47. Lahm T, Brown J, Albrecht M, Fisher A, Cucci A, Cook T, Van Demark M, Johnstone B, Presson R, Brown MB, Petrache I. Molecular Mechanisms of 17beta estradiol-‐mediated protection in Sugen/hypoxia-‐mediated severe right ventricular failure. Pulmonary Circulation (in press)

48. Brown M, Crist J, Chingombe T, Novack R, Cooney S, Wood J, Fisher A, Presson R, Cucci A, Petrache I, Lahm T. Aerobic Exercise Training Ameliorates RV Cardiomyocyte 'Glycolytic Switch' And Improves Aerobic Capacity In Rats With Hypoxic Pulmonary Hypertension. Am J Resp Crit Care Med 189;2014:A2634

49. Khan S, Serban K, Winer-‐Muram H, Lahm T. Clinical Characteristics And Outcomes In Veterans With Combined Pulmonary Fibrosis And Emphysema (CPFE) With And Without Concomitant Pulmonary Hypertension. Am J Resp Crit Care Med 189;2014:A1883

50. Pandya, P, Guindon L, Weber D, Fisher A, Albrecht M, Lahm T, Blum J, Wilkes D. HIF-‐1α Regulates CD55 And CRRY Expression In Hypoxic Airway Epithelium. Am J Resp Crit Care Med 189;2014:A1073

51. Kline J, Lahm T, Russell F. High Rate Of Right Ventricular Dysfunction After Negative Computed Tomographic Pulmonary Angiography. Am J Resp Crit Care Med 189;2014:A4739

52. Goss K, Ahlfeld S, Cucci A, Albrecht M, Fisher A, Wood J, Tursunova R, Brown M, Petrache I, Tepper R, Lahm T. Postnatal Hyperoxic Lung Injury Alters Adult Right Ventricular Remodeling Responses To Hypoxia Exposure In Rats. Am J Resp Crit Care Med 189;2014:A2352

53. Wood J, Cucci A, Albrecht M, Fisher A, Goss K, Cook T, Vandemark M, Whitson J, Tursunova R, Presson R, Brown M, Petrache I, Lahm T. The Effect Of Endogenous Sex Hormones On Hemodynamics, Exercise Capacity And Right Ventricular (RV) Pro-‐Apoptotic Signaling In Su5416/Hypoxia-‐Induced Pulmonary Hypertension (SuHx-‐PH). Am J Resp Crit Care Med 189;2014:A3301

54. Cucci A, Wood J, Albrecht M, Fisher A, Van Demark M, Goss K, Cook T, Brown M, Yin X, Petrache I, Lahm T. Worsening Right Ventricular Dysfunction By Fueling An Impaired Autophagic Flux With Rapamycin. Am J Resp Crit Care Med 189;2014:A2342

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