PATOBIOLOGI PENYAKIT

PERIODONTAL

Bakteri periodontopatogen

Faktor-faktor virulensi

Mekanisme kerusakan jaringan periodontal akibat bakteri

Respon imun terhadap bakteri periodontopatogen

Mekanisme kerusakan jaringan periodontal akibat respon imun

OVERVIEW

Oral Microbiota

Bacteria Fungi Mycoplasma Virus Protozoa

Gram-postive cocci (S. mutans group, S. salivarius group, S. anginosus group, S. mitis group, Enterococcus, Staphylococcus, Micrococcus, Stomatococcus)

Gram-positive rods & filaments (Actinomyces, Eubacterium, lactobacillus, Propioni bacterium)

Gram-negative cocci (Nisseria & Moraxella, Veilonella)

Gram-negative rods (Facultatively anaerobic & Capnophilic genera, obligately anaerobic gram-negative rods)

Aspergillus Geotrichium Mucor spp. Candida sp

C. glabrata, C. tropicalis, C. krusei, C. parapsilosis, C. guiliermoni, Rhodotorula, Saccharomyces spp

Saliva: M. salivarium, M. pneumoniae, M. hominis

Oral mucosa: M. buccale, M. orale, M. pneumoniae

Dental plaque: M. pneumoniae, M. buccale, M. orale

Herpes simplex type 1 and 2 Cytomegalovirus Coxsackie virus A2, 4, 5, 6, 8,

9, 10, 16 HIV

Entamoeba gingivalis

Trichomonas tenax

Giardia lamblia

Anaerob bacteria

Porphyromonas gingivalis

Fimbriae

Capsular polysaccharide

Lipopolysaccharide

Enzymes

Protein antigens

Agregatibacter actinomycetemcomitans

Serotype-specific carbohydrates

LPS

Leukotoxin

GroEL-like protein (64 kDa protein)

Fimbriae

Protein antigens

Referensi

Page RC, Kornman KS., Tonetti MS., 1997. The host response to microbial challenge in periodontitis: assembling the players. Periodontol 2000. 14: 33-53.

Samaranayake LP, 2002, Essential Microbiology for Dentistry, Churchill Livingstone, Toronto.

Marsh P and Martin MV, Oral Microbiology, MPG Books Ltd, Cornwall.