pathophysiology of hemorrhoids varut lohsiriwat md. phd. · 2019-06-13 · external hemorrhoids...
TRANSCRIPT
Pathophysiology of Hemorrhoids
Varut Lohsiriwat MD. PhD. Associate Professor of Surgery
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, Thailand
Outline
• Applied anatomy of hemorrhoids
• Pathophysiology of hemorrhoids
• Symptoms & clinical evaluation
Applied Anatomy of Hemorrhoids
Blood Supply to Anorectal Region
Lohsiriwat V. Common anorectal diseases, 1st Ed. Siriraj Publisher, Bangkok 2015
Superior rectal (hemorrhoidal) artery
Inferior rectal (hemorrhoidal) artery
Middle rectal artery
From internal iliac artery
From internal pudendal artery
To internal iliac vein
To internal pudendal vein
Anal Cushions & Hemorrhoids
Lohsiriwat V. World J Gastroenterol 2012
Types of hemorrhoids
Internal hemorrhoids Located above the dentate line Covered by mucosa
External hemorrhoids Located distal to the dentate line Covered by skin
Lohsiriwat V.
cc
Fragmented subepithelial
smooth muscle (Trietz’s muscle or mucosal suspensory ligament)
Markedly dilated vascular channels 5 mm
Lohsiriwat V. World J Gastroenterol 2012
Histology of Hemorrhoids
Pathohysiology of Hemorrhoids
Theory of Hemorrhoid Formation
1. Sliding anal cushions/ Loss of fixation
Presenting symptom: Prolapse
2. Rectal redundancy/ Internal rectal prolapse
Presenting symptom: Circumferential prolapse
3. Vascular abnormalities
Presenting symptom: Bleeding
Lohsiriwat V. World J Gastroenterol 2012
(1) Theory of ‘Sliding Anal Cushions’
Destructive changes in the supporting connective tissue of anal cushion
Distal displacement of anal cushion
+
Abnormal vascular dilatation
(2) Theory of ‘Rectal Redundancy’
• Some clinicians postulated a redundant rectal mucosa as a primary alteration of hemorrhoids.
• This theory proposes that prolapsed hemorrhoids is always associated with an internal rectal prolapse.
(3) Theory of ‘Vascular Abnormalities’
3.1 Increased anorectal blood flow
3.2 Vascular hyperplasia
3.3 Dysregulation of the vascular tone
(i.e. ↑ vasodilator)
3.4 Inflammatory reaction involving the
vascular wall and surrounding tissue
Chung et al. Eur J Clin Invest 2004
Han et al. Chinese J Gastrointest Surg 2005
Aigner et al. J Gastrointest Surg 2006
Lohsiriwat et al. Current Vascular
Pharmacology 2018 (next slide)
Risk Factors for Hemorrhoids Strong risk factors (OR >2)
Constipation
Diarrhea
Modest risk factors (OR 1.1-2.0)
A history of childbirth
Depression
Low fiber intake
Obesity
Non-sedentary behavior
Pregnancy
ANAL CUSHIONS
Mechanical injury
Aging
(degenerative change)
Straining Increased anorectal blood flow
Venous stasis
Tissue inflammation
HEMORRHOIDS
Loss of fixation Disruption of supporting tissue in anal cushions
Abnormal venodilation Engorged and tortuous veins
in hemorrhoidal plexus
Pathophysiology & Risk Factors
Symptoms & Clinical Evaluation
Presenting Symptoms
• Bleeding
– Bright-red blood (due to direct arteriovenous communication in the anal cushion)
– Blood seen on the surface of stool, or dripping in the bowl, or on tissue paper during anal cleansing (if blood is mixed in stool, it suggests bleeding from GI tract elsewhere)
• Prolapse (depending on grade of hemorrhoids)
• Pain (if thrombosed or strangulated)
Clinical Evaluation
• Inspection
• Digital rectal examination
– In general, internal hemorrhoids should be palpable unless they are large or thrombosed
– Differential diagnosis of palpable intra-anal canal lesion includes anal malignancy and neoplasms
• Proctoscopy
– Number of lesion, location, grading, and any bleeding stigmata should be noted
Goligher’s Classification of Internal Hemorrhoids
1st degree (Grade I): no prolapse
2nd degree (Grade II): prolapse through the anus on straining but reduce spontaneously
3rd degree (Grade III): prolapse through the anus on straining and require manual reduction
4th degree (Grade IV): prolapse stays out at all times and is irreducible
Hemorrhoidectomy
Non-excisional Operation
Sclerotherapy
Dietary and Lifestyle Modification
Rubber Band Ligation
Medication - Venotonics
Grade 1 Grade 2 Grade 3 Grade 4
Modification from Lohsiriwat V. Approach to Hemorrhoids. Curr Gastroenterol Rep 2013;15:332-6
Approaches to Hemorrhoids (Based on Goligher’s Classification)
Approaches to Hemorrhoids (Based on Pathophysiology)
Sliding anal cushions (CC: Prolapse)
Rx: banding, sclerotherapy, plication, hemorrhoidectomy
Rectal redundancy (CC: Circumferential Prolapse)
Rx: stapled hemorrhoidopexy
Vascular abnormality (CC: Bleeding)
Rx: phlebotonic (venotonic), vasoconstrictor, anti-inflammatory, hemorrhoid artery ligation
Lohsiriwat V. World J Gastroenterol 2012
CONCLUSIONS
• Exact pathophysiology of hemorrhoids
Unknown (likely to be multi-factorial)
- Sliding anal cushions/ Loss of fixation
- Rectal redundancy/ Internal rectal prolapse
- Vascular abnormalities
• Different philosophy Different approach