pathology2 bfinalspart1
DESCRIPTION
FInals PPT from Arianne\'s USBTRANSCRIPT
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Final Examination Review Slides
liezl_emdi
Pathology 2B
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Diseases of the Endocrine Glands
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Acute Pancreatitis, Pancreas
Enzymatic Fat Necrosis Gland can return to
Normal if the cause is remove
Sequelae: sterile pancreatic abscess, pseudocyst
Causes: Alcoholism- Male Biliary Tract Disease-
Female
Hemorrhage
Acini
Necr
oti
c A
cini
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Hemorrhage
Saponified fat cells
Necrotic Acini with Neutrophilic Infiltrates
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Kimmelstiel-Wilson nodule
Afferent arteriole
Kimmelstiel-Wilson nodule/ nodular diabetic glomerulosclerosis
Diffuse mesangial sclerosis
Diffuse mesangial sclerosis
Capillary Basement Membrane (thickened)
Capillary Basement Membrane (thickened)
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Acute Pyelonephritis, Kidney
One of the forms of Renal Lesions secondary to DM
Begins in the interstitium tubules
Formation of cystic cavity containing purulent fluid
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Neutrophils
Abscess formation
Neutrophils
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Irregular shapes and sizes of follicles
Colloid/ Non-Toxic (Simple) Goiter, Thyroid Gland
Diffuse involvement without nodularity
Not associated with hypo/hyperfunctioning
Can be Endemic or Sporadic Endemic- low level of
Iodine in soil, water and food supply
Sporadic- ingestion of substance that interferes with thyroid hormone synthesis or enzymatic defects
Thyroid follicles are lined by flattened epithelium
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Flattening of
epitheliu
m
colloid
colloid
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Colloid/ Non-Toxic (Simple) Goiter, Thyroid Gland
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Grave’s Disease (Thyrotoxicosis), Thyroid Gland
Most common cause of endogenous hyperthyroidism
Hypertrophy of the Thyroid Follicles + Epithelium
Antibodies to TSH Receptor, TSI, TGI, TSH-BII
Triad Hyperthyroidism Exopthalmos Pretibial Myxedema
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Scallop appearance of Thyroid follicles
papilla
Tall epithelial cells
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Hashimoto’s Thyroiditis, Thyroid Gland
Chronic Lymphocytic Thyroiditis
Struma lymphomatosa Lymphadenoid Goiter Most common cause
of Goitrous Hypothroidism in areas that have sufficient Iodine
Major cause of Non-Endemic Goiter in Children
Long Term Complication- NHL
GC
GC
GC
GC
Lymphoid follicles
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GC
GCA
A
A
GC
A- Acini GC- Germinal Center L- Lymphocytic infiltration
LL
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GC
Atrophic thyroid Follicles/ Acini
fibrosis
GC
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Hurthle cells- lines residual thyroid follicles
**Eosinopilic in Staining, granular cytoplasm, enlarged nuclei, squamous epithelial cells
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Papillary CA, Thyroid Gland
papilla
Most common morphologic form of Thyroid CA (75-85%)
Risk Factor: Irradiation of the head and neck area during the first two decades
Most significant diagnostic basis is the presence of nuclear grooving
Pattern of Spread: Lymphatics
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s
s
s
s
papilla
Thyroid follicles
s- stroma Orphan Annie Eye- nuclei of cells (clear)
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Parathyroid Adenoma
Cause of 75-80% of Hyperparathyroidism Hypercalcemia
Solitary Capsulated
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Proliferating chief cells
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Hemorrhage, Adrenal Gland
Blood vessel
Area of hemorrhage
Area of hemorrhage