Pathogenesis of DKA and HHSStress,infectionand/or Insufficient Insulin intake

Pathogenesis of DKA and HHSStress,infectionand/or Insufficient Insulin intake

Absolute insulin deficiency INCLUDEPICTURE "http://www.diabetesindia.com/diabetes/images/arrow_top.gif" \* MERGEFORMATINET

GlucogonCatecholaminesCortisolGrowth HormoneRelative insulin deficiency

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LipolisisProcolisisProtein synthesisAbsent or minimal ketogeneses

FFA to Liver

Ketogenesis

GluconcogenicSubstrates

Alkali Reserve

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Glucose UtilizationGluconcogenicGluconcogenic

Ketoacidosis

Triacylglycerol

Hyperglycemia

Glucosuria(osmotic diuresis)

Hyperlipidemia

Loss of water and Electrolytes

Dehydration

Impaired Renal FunctionDeceased

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HHS

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DKA

http://www.diabetesindia.com/diabetes/diabetic_ketoacidosis.htmThe management of type 2 diabetes, The Indian Consensus 2002