pascal gagneux, ph. d. -...

Pascal GAGNEUX, Ph. D.

CURRICULUM VITAE CURRENT ADDRESS Glycobiology Research and Training Center Biomedical Research Facility 2 (BRF II) Room 4124 University of California San Diego 9500 Gilman Drive La Jolla, Ca 92093-0687, U. S. A. Phone (858) 822 4030 Fax (858) 534 5611 e-mail: [email protected] Webpage: Gagneux Laboratory PERSONAL INFORMATION Born in Basel, Switzerland. Citizenship: American / Swiss Languages: French, German, English, Spanish, Japanese, Chinese (Mandarin)

EDUCATION

Basel University, Switzerland Ph.D. (summa cum laude) 1998 Zoology

Basel University, Switzerland Diplom (Master's) 1993 Population Biology

PRESENT Associate Professor of Pathology, Division of Comparative Pathology and Medicine Concurrent: Associate Director of The Center for Academic Research and Training in Anthropogeny (CARTA). Member of Center for Immunity, Infection and Inflammation Investigator; Glycobiology Research and Training Center, Member of Faculty of Biomedical Sciences and Faculty of Neuroscience, Affiliate Faculty of Human Development, University of California, San Diego.

2011-2014 Associate Professor of Cellular and Molecular Medicine, and Glycobiology Research and Training Center, University of California, San Diego. Concurrent: Associate Director of The Center for Academic Research and Training in Anthropogeny (CARTA).

2007-2011 Assistant Professor of Cellular and Molecular Medicine, and Glycobiology Research and Training Center, University of California, San Diego. Concurrent: Associate Director of The Center for Academic Research and Training in Anthropogeny (CARTA).

2006-2007 Assistant Project Scientist at the Glycobiology Research and Training Center, Department of Cellular and Molecular Medicine, University of California San Diego.

2003-2006 Scientist with the Division of Ecology and Evolution at the Center for Reproduction of Endangered Species (CRES), Zoological Society of San Diego. Comparative studies of primate sperm energetics and surface molecules in species with different mating systems (chimpanzee, bonobo, and human). Other projects included: population genetics of Aotus azarai in Northern Argentina, development of interpretation for primate exhibit “Monkey Trails” and concept for a new elephant exhibit at the San Diego Zoo.

DOCTORAL AND POST-DOCTORAL EXPERIENCE 1998-2003 Postdoctoral fellow in Dr. Ajit Varki's laboratory at the University of California San Diego, Glycobiology Research and Training Center / Cancer Center. Main focus: comparative glycobiology of humans and chimpanzees.

1994-1998 Basel University. Ph.D. project on population genetics of West African chimpanzees under supervision of Dr, Stephen Stearns. Visiting student with Dr. David Woodruff at UCSD. Two sample-collecting expeditions to West Africa (Côte d'Ivoire and Mali) in 1995 and 1997.

MASTER'S COURSE 1990-1993 Masters program at Basel University in population biology. Topic: behavioral ecology of wild chimpanzees. Project directed by Dr. Christophe Boesch and included one year of field work in the Taï Forest National Park, Côte d'Ivoire (Ivory Coast), West Africa.

http://pathology.ucsd.edu/faculty/labs/gagneux/Gagneux_Lab_UCSD.html

P.Gagneux Curriculum Vitae

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TEACHING EXPERIENCE

2000 / 2001 Visiting lecturer, Anthropology Department UCSD: developed and taught upper division course on “DNA and Human Evolution” (Molecular approaches to human evolution, Winter 2000 and Fall 2001).

2003 / 2004 Teaching (in Spanish) of the theoretical and practical molecular genetics part of the First and Second Latin American Courses on Primate Conservation Biology in Formosa, Argentina.

2006-present Glycobiology Journal Club “Current Literature in Glycobiology” MED246/CMM246/BIOM246 2007 & 2009 Reading group for medical students on glycobiology: “Evolving Glycans – Glycosylation in Health and

Disease”, SOM 204. 2008/2010/ 2012 Co-teaching of Essentials of Glycobiology MED 225/CHEM 237/BIOM 222/BGGN 236/CMM 225. 1999-2014 Guest lecturer in Human Genetics, BIOM 252, Evolutionary Biology, BIOM 200, and Conservation

Biology, ANBI 132 and Glycobiology of HIV, Cognitive Science COGS 260, Human Developemnt, Advanced Principals of Human Evolution, ANBI 111.

2008-present Teaching of Course BIOM 218 “Current Topic in Anthropgeny” 2011 Co-Teaching of Field Course in Anthropogeny in Ethiopia and Tanzania, August 1st to 20th. 2011 /2013/ 2014/2015 Teaching and coordination of BIOM 225 “Introduction to Anthropogeny” 2012/2014/ 2015 Teaching and coordination of BIOM 229 “Advanced Anthropogeny” 2012 Co-Teaching of Field Course in Anthropogeny in Ethiopia and Tanzania, August 2nd to 24th 2013 Co-Teaching of Field Course in Anthropogeny in Ethiopia and Tanzania, August 5th to 27th

2014 Teaching of Field Course in Anthropogeny in Ethiopia and Tanzania, August 17th to September 6th SYNERGISTIC ACTIVITIES

i) Member of Conservation and Research committee, Zoological Society of San Diego 2000-2003. ii) Field work in Africa: Training of African assistants in canopy access: workshop in Côte D’Ivoire, tracking and

observing wild chimpanzees; running of field research station and collaboration with local technical staff. iii) Member of the interpretation strategic plan implementation team of the Zoological Society of San Diego: produced

interpretive graphics and displays on primate biology and conservation, themed new elephant exhibit and coordinated collaboration with Southern California Natural History museums and African elephant conservation organization.

iv) Associate Director of the Center for Academic Research and Training in Anthropogeny (CARTA) an Official Research Unit established between UC San Diego and the Salk Institute for Biological Studies (January 2008).

v) Spearheaded the establishment of a new elective graduate specialization track in Anthropogeny at UCSD including the establishment of a Faculty of Anthropogeny with members representing seven different graduate programs (February 2010).

vi) Facilitated the application by the Visual Arts Graduate Program for joining the Anthropogeny Graduate Specialization (Spring 2012).

vii) Ambassador for the Society for Glycobiology for Reproduction http://www.glycobiology.org/ambassadors.php Ix) Board Member of Wild Chimpanzee Foundation US www.wildchimps.org ACADEMIC HONORS

2009 Kavli Fellow, Kavli Frontiers of Science program, German-American frontiers

COLLABORATORS IN THE LAST 4 YEARS Dr. Ajit Varki, UCSD (Sailic acids and human evolution), Dr. Michael Berns, UCSD (sperm motility); Dr. Steven Lindheim, University of Cincinnati (Sialic acid in human assited reproduction); Dr Paolo Rinaudo, UC San Francisco (IVF and unintended effects developemnt and health); Dr. Robert Schooley, UCSD and Dr. Walter Boyce, UC Davis (Influenza A and sialic acids); Dr Kamil Godula, UC San Diego Biochemistry (biomimetic mucins and virus interactions); Drt. Colin Parrish, Cornell (Mcucus droplet and viral infections); Dr. Elina Zuniga, UCSD (in vitro LCMV and mouse anti-glycan antibodies). Dr Estella Poloni, University of Geneva (Worldwide distribution of human N-acetyltransferase 1 (NAT1) diversity and interspecies comparison with chimpanzees). Dr Evan Eichler, University of Washington, Dr, Tomas Marques-Bonet, Universitad Pompeu Fabra, Barcelona (genome sequences of wild great apes). Dr Ed Green, UC Santa Cruz and Dr Alysson Muotri, Sanford Consortium for Regenerative Medicine (establishing cell lines from hybrid apes).


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GRANTS AND FELLOWSHIPS

• NIH, NCI Training grant 5T32CA09523 May 1998 through May 1999. • American Lung Association Research Training Fellowship Award, June 1999 to June 2001. • NIH Training Grant in Gastroenterology,5T32DK07202, June 2001 through June 2002. • University of California Lab Fees Research Program, July 2009 through June 2012. • G. Harold and Leila Y. Mathers Charitable Foundation Research Grant, February 1 1 2016 through January 31, 2019. • NIH 1R01GM095882-01A1, July 2011 through April 2016. PROFESSIONAL ASSOCIATION

Member of Sigma Xi, San Diego Chapter, American Association for the Advancement of Science, Union of Concerned Scientists, American Association for Biochemitry and Molecular Biology. EDITORIAL BOARD MEMBERSHIP

Member of the Editorial Board of “The Open Evolution Journal”, Bentham Science Publishers. Member of the Editorial Board Matrix of Comparative Anthropogeny (MOCA). REVIEWED MANUSCRIPTS AND PROPOSALS FOR

Agence Narionale de La Recherche (France), Behavioral Ecology and Sociobiology, Comparative Biochemistry and Physiology, Folia Primatologica, Genome Research, Molecular Biology and Evolution, Molecular Ecology, Molecular Reproduction and Development, Nature, Nature Reviews Genetics, Plos Pathogens, Proceedings of the National Academy of Sciences USA, Science, Genetics, The Journal of Cell Biology, Journal of General Virology, Journal of Heredity, Journal of Nutrition, Journal of Human Evolution, Journal of Molecular Evolution, , Journal of Theoretical Biology, Trends in Genetics, University of California Press, University of Chicago Press, Garland Science, National Science Foundation (USA), Leakey Foundation. ADVISOR FOR

Master’s Thesis. Shannon Chapman, Title: Sperm Competition and Mitochondrial Loading: A Comparative Analysis of Pan troglodytes and Homo sapiens. Master of Arts in Anthropology, San Diego State University, 2006

Ph.D. Thesis Committee for Leela Davies Biomedical Sciences, UCSD, Title: Anomalous expression of Neu5Gc in the Vertebrate CNS. 2013.

Ph.D. Thesis Committee for Jonathan Okerblom, Biomedical Sciences, UCSD, Title: Human loss of Neu5Gc: Impact on receptor signaling, sialidase action and muscle pathology, ongoing

Ph.D. Thesis Committee for Andrew Schork, Cognitive Sciences, UCSD, Title: Characterization of the genetic architecture underlying individual variability in cognition, ongoing

Ph.D. Thesis Committee for Camille Toarmino, Psychology, UCSD, Title: Neuroimaging of vocal communication in captive marmosets, ongoing

Ph.D. Thesis Committee for Michael Vail, Biomedical Sciences, UCSD, Title: Polysialic acid synthesis enzymes in the brain, ongoing

Ph.D. Thesis Committee for Emily Little, Psychology, UCSD, Title: Culture and infant-caregiver interaction: The role of physical contact in early social development, ongoing Post Doctoral Advisory Committee for Dr. Apuã Paquola, in Dr Muotri’s laboratory at UCSD. Project: Comparison of gene expression profiles of human, chimpanzee and bonobo iPS-derived neurons, ongoing.

Hosted Saul Propp. High Tech High High School student intern in the Gagneux Lab in May and June 2010.

Danjuma Quarless: Minor Proposition Committee Member for this Biomedical Science Graduate Student, Winter 2011.

Maya Remington, ISP committee member, Purification of anti-Neu5Gc-Sialyl-Tn antibodies, 2011

Janell Bryant, BISP 199 committee member, Immunohistochemical Staining of Von Willebrand Factor and Vimentin, 2012

Corey Jefferson, Masters Student at New Mexico Sytate University Las Cruces witrh Dr Kathy Hanley. Bird mucin sialic acids and influenza A viruses.


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Ph.D. Thesis Advisor for Sequoyah Reynoso, Neuroscience Program UCSD, Title: Sperm sialic acids and and Sperm function in the face of female immune factors. 2013 – ongoing. Anthropogeny Graduate Specialization Advisor for: Hope Morgan, Lingusitics, Leela Davies, Rachel Zarndt, and Robert Thomas, Biomedical Sciences, Ben Cipollini, Daniel Frysinger, Whitney Friedman, Andrew Schork, and Jeremy Karnowski, Cognitive Sciences, Melanie Beasley, Kari Hanson, Corinna Most, Caroline Horton, Ian Parker Anthropology, Heidi Sharipov, Sequoyah Reynoso, Landon Klein, Stephen Johnston, Kyle Fisher, Laura Sancho, Matthew Boisvert, Neuroscience, Jordan Comins, Emily Little, Camille Toarmino, Hans Peterson, Haleh Yazdi, Psychology, Emily Bovino, Vizual Arts. PUBLICATIONS RESEARCH ARTICLES Gagneux, P. 1997. Sampling rapidly dwindling chimpanzee populations. Pan Africa News. 4, 12-15. Gagneux, P., Woodruff. D.S., Boesch, C. 1997. Microsatellite Scoring errors associated with noninvasive genotyping

based on nuclear DNA amplified from shed hair. Molecular Ecology 6, 861-868. Gagneux, P., Wills, C., Gerloff, U., Tautz, D., Morin, P.A., Boesch, C., Fruth, B., Hohmann, G., Ryder, O., Woodruff,

D.S. 1999. Mitochondrial sequences show diverse evolutionary histories of African hominoids. Proc. Natl. Acad. Sci. USA 96:5077-5082.

Gagneux, P., Woodruff. D.S., Boesch, C. 1999. Female reproductive strategies, paternity and community structure in

a community of wild West African chimpanzees Animal Behaviour 57, 19-32. Gagneux, P. and Varki, A. 1999. Evolutionary considerations in relating oligosaccharide diversity to biological function.

Glycobiology 9:747-755. Gagneux, P. and Varki, A. 2000. What Is the Meaningful Number for the Difference? In: Varki, A, A Chimpanzee

Genome Project is a Biomedical Imperative. Genome Research 10: 1065-1070. Edwin H. McConkey and Ajit Varki, cosignatories: Allman, J., Benirschke, K., Crick F., Deacon T.W., de Waal, F.,

Dugaiczyk,A., Gagneux, P., Goodman,M., Grossman L.I., Gumucio, D., Insel,T., Kidd,K.K., King M.-C., Krauter, K., Kucherlapati, R., Motulsky, A.G., Nelson,D., Oefner, P., Palade, G., Ruvolo,M., Ryder,O.A., Sikela,J., Stewart C.-B. A., Woodruff, D.S., 2000. A Primate Genome Project Deserves High Priority. Science 25: 1295.

Hayakawa, T., Satta, Y., Gagneux, P., Varki, A., Takahata, N. 2001. Alu-mediated inactivation of the human CMP- N-

acetylneuraminic acid hydroxylase gene. Proc. Natl. Acad. Sci. USA 98:11399-11404. Gagneux, P. and Varki, A. 2001 . Genetic differences between humans and the great apes. Mol. Phyl. Evol. 18:2-13. Gagneux, P., Gonder, M.K., Goldberg, T. A. and Morin P.A., 2001. Gene flow in wild chimpanzees. What genetic data

tell us about chimpanzee movements over space and time. Phil. Trans. R. Soc. London B. 356:889-897. Gagneux, P., Amess, B., Diaz, S., Moore, S., Thakor, P., Dillmann, W.,Parekh, R.,& Varki, A. 2001. Proteomic

Comparison of Human and Great Ape Blood Plasma Points to Highly Conserved Glycosylation and Differences in Thyroid Hormone Metabolism. Am. J. Phys. Anthropol. 115:99-109.

Hu, XL, Javadian, A., Gagneux, P., Robertson BH. 2001. Genetic Clusters of chimpanzee HBV correlate with

geographically distinct chimpanzee species based upon mtDNA sequencing. Virus Research 79:103-108. Gagneux, P. and Varki, A. 2002. Reply to comments by Previc: Endocrine differences between humans and great

apes - Did environmental factors provide genetic opportunities? Am. J. Phys. Anthropol. 118:404-405. Gagneux, P. 2002. The genus Pan: Population Genetics of An Endangered Outgroup. Trends in Genetics 7:327-30. De Groot, N.G. Otting, N., Doxiadis, GGM., Balla-Jhagjhoorsingh, S.S.,Heeney, J.L., Gagneux, P. & Bontrop. R.E.

2002. Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees. Proc. Natl. Acad. Sci. USA 99:11748-11753.


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Gagneux P., Cheriyan M., Hurtado-Ziola, N., Brinkman Van Der Linden, E.C., Anderson, D., McClure, H., Varki, A., Varki, N.M. 2003. Human-specific regulation of Alpha2-6 linked sialic acids. Journal of Biological Chemistry 278:48245-48250.

Tangvoranuntakul, P., Gagneux, P., Diaz, S., Varki, N., Varki, A., and Muchmore, E. 2003. Human Uptake and

Incorporation of an Immunogenic Non-human Dietary Sialic Acid. Proc. Natl. Acad. Sci. USA 100:12045-50. Gagneux P. 2004. A Pan-oramic view – insights into hominoid evolution through the chimpanzee genome. Trends in

Ecology and Evolution 19 (11):571-576. Ely, J.J., Dye, B., Frels, W.I., Fritz, J., Gagneux ,P., Khun, H.H., Switzer, W.M., Lee, D.R. 2005. Subspecies composition and founder contribution of the captive U.S. chimpanzee (Pan troglodytes) population. Am. J. Primatol. 67 (2):223-41. Gagneux, P., Moore, J., Varki, A. 2005. Great Apes in Captivity: Ethical and Scientific Challenges. Nature

437(7055):27-9. Martin, M.J., Rayner, J.C., Gagneux, P., Barnwell, J., Varki. 2005. Evolution of human-chimpanzee differences in

malaria susceptibility: Relationship to human genetic loss of N-glycolylneuraminic acid. Proc. Natl. Acad. Sci. USA 102 (36):12819-24.

Nguyen, D.H., Hurtado-Ziola, N., Gagneux, P., Varki. 2006. Loss of Siglec expression on T-lymphocytes during

human evolution. Proc. Natl. Acad. Sci. USA 103 (20):7765-7770. Bishop., J., Gagneux, P. 2007 Evolution of carbohydrate antigens - microbial forces shaping host glycomes?

Glycobiology 17 (5):23-34. Anderson, M., Chapman, S., Videan, E., Fritz, J., Stoinski, T., Dixson, A.F., and Gagneux, P. 2007. Sperm

Bioenergetics in Humans and Chimpanzees – Functional Evidence for Sperm Competition. Am. J. Phys. Anthropol. 134 (2):274-80.

Baena, A., Falvo, J.V., Mootnick, A.R., Tsytskova, A.V., Ligeiro, F., DIOP, M.O., Brieva, C., Gagneux, P. O’Brien, S.J.,

Ryder, O.A. & Goldfeld, A.E. 2007. TNF Promoter Comparative Genomics Reveals Markers of Phylogeny and Evolution of Innate Immunity in Primates. PlosOne 2(7):e621 Published online July 2007, doi:10.1371/ journal.pone.0000621.

Schrenzel M., Snook, E., Gagneux, P. 2007. Molecular Assays for Detection of Falcon Adenovirus. J. Vet. Diag.

Invest. 19 (5):479-85. Nascimento, J.M, Shi, L.Z., Meyers, S., Gagneux, P., Loskutoff, N.M., Botvinick, E. L., Berns, M.W. 2008. The use of

optical tweezers to study sperm competition and motility in primates. J.R. Soc. Interface. 5 (20):297-302. Lewis, A.L., Desaa, N., Hansen, E.E., Knirel, Y., Gordon, J.I., Gagneux, P., Nizet, V., and Varki, A. 2009. Innovations

in Host and Microbial Sialic Acid Biosynthesis Revealed by Phylogenomic Prediction of Nonulosonic Acid Structure. Proc. Natl. Acad. Sci. USA. 106 (32):13552-13557.

Varki, A and Gagneux, P. 2009. Human-Specific Evolution of Sialic Acid Targets: Explaining the Malignant Malaria

Mystery? Proc. Natl. Acad. Sci. USA. 106 (35) :14739-14740. Adibekian, A, Stallforth, P., Hecht, M., Werz, D.B., Gagneux, P., and Seeberger, P.H. 2011. Comparative

bioinformatics analysis of the mammalian and bacterial glycomes. Chemical Science. 2:337-344. Dall'Olio, GM., Jassal, B., Montanucci, L., Gagneux, P., Bertranpetit, J.,and Laayouni, H. 2011. The annotation of the

N-linked Glycosylation pathway in the Reactome pathways database. Glycobiology. 21(11):1395-400. Tao, N., Wu, S., Kim, J., Hinde, K., Powers, M., Gagneux, P., German, JB. and Lebrilla, CB. 2011. Evolutionary

Glycomics: Characterization of the Milk Oligosaccharides in Primates. J. Proteome Research 10: 1548-1557. Babb, P.,L., Fernandez-Duque, E., Gagneux, P., Schurre,T.G. 2011. Phylogeography and Population Structure of

mtDNA Diversity in Azara’s owl monkeys (Aotus azarai azarai) of the Argentinean Chaco. Am. J. Phys. Anthropol. 146 (2):209-24.


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Ghaderi, D., Springer, S., Ma, F., Cohen, M., Secrest, P. ,Taylor, R., Varki, A., and Gagneux, P. 2011. Sexual selection by female immunity against paternal antigens can fix loss of function alleles. Proc. Natl. Acad. Sci. USA. 108 (43):17743-8.

Varki, A. and Gagneux, P. 2012. Multifarious Roles of sialic acids in immunity. An. Acad., Sci. New York.1253:16-36. Davies, L.R., Pearce, O.M., Tessier, M.B., Assar, S., Smutova, V., Pajunen, M., Sumida, M., Sato, C., Kitajima, K.,

Finne, J., Gagneux, P., Pshezhetsky, A., Woods, R., Varki, A. 2012. Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups: Resistance of alpha2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage. J Biol Chem. 34:28917-31.

Ma, F., Wu, D., Deng, L., Secrest, P., Zhao, J., Varki, N., Lindheim, S and Gagneux, P. 2012 Sialidases on

Mammalian Sperm Mediate Deciduous Sialylation During Capacitation. J Biol Chem. 287(45):38073-9. Cohen. M. Yankowski, M.D., Varki, N, Gagneux, P. 2012. Frozen tissues use for natural mucin distribution. 2012.

JOVE. J Vis Exp. (67):e3928. doi: 10.3791/3928. O’Bleness, M., Searles, V., Varki, A., Gagneux, P. and Sikela, J. 2012. Genetic and Genomic Features Unique to the

Human Lineage. Nature Reviews Genetics 13, 853-866. Springer, S.A. and Gagneux. P. 2013 Glycan Evolution in Response to Collaboration, Conflict, and Constraint J Biol

Chem. 288 (10):6904-11. Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor

TD, Santpere G, Cagan A, Theunert C, Casals F, Laayouni H, Munch K, Hobolth A, Halager AE, Malig M, Hernandez-Rodriguez J, Hernando-Herraez I, Prüfer K, Pybus M, Johnstone L, Lachmann M, Alkan C, Twigg D, Petit N, Baker C, Hormozdiari F, Fernandez-Callejo M, Dabad M, Wilson ML, Stevison L, Camprubí C, Carvalho T, Ruiz-Herrera A, Vives L, Mele M, Abello T, Kondova I, Bontrop RE, Pusey A, Lankester F, Kiyang JA, Bergl RA, Lonsdorf E, Myers S, Ventura M, Gagneux P, Comas D, Siegismund H, Blanc J, Agueda-Calpena L, Gut M, Fulton L, Tishkoff SA, Mullikin JC, Wilson RK, Gut IG, Gonder MK, Ryder OA, Hahn BH, Navarro A, Akey JM, Bertranpetit J, Reich D, Mailund T, Schierup MH, Hvilsom C, Andrés AM, Wall JD, Bustamante CD, Hammer MF, Eichler EE, Marques-Bonet T. 2013. Great ape genetic diversity and population history. Nature. 499 (7459):471-5.

Cohen M., Zhang XQ., Senaati HP., Chen HW., Varki N. Schooley, RT., Gagneux P. 2013. Influenza A penetrates

host mucus by cleaving sialic acids with neuraminidase. Virology Journal 10:321. Springer, SA. Diaz, S., Gagneux, P. Independent Inactivation of Cmah and Loss of Neu5Gc in New World Primates.

2014. Immunogenetics. 66 (11):671-4. Niv, Y., Boltin, D., Halpern, M., Cohen, M., Levi, Z., Vilkin, A., Morgenstern, S., Manugian, V., St Lawrence, E.,

Gagneux, P., Kaur, S., Sharma, P., Batra, S.K., Ho, S.B. 2014. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. World J Gastroenterol. 20 (40):14913-20.

Huang, M. L., Miriam, C., Fisher, C.J., Schooley, R. T., Pascal, P., and Godula, K. 2015. Determination of receptor

specificities for whole influenza viruses using multivalent glycan arrays Chem. Comm. 51, 5326-5329. Schwarz, F., Pearce, O.M., Wang, X. Samraj, A.N., Läubli, H., Garcia, J.O., Lin, HQ, Fu, X.M., Garcia-Bingman, A.,

Secrest, P., Romanoski, C., Heyser, C., Glass, C., Hazen, S.L.,Varki, N., Varki, A., and Gagneux, P. 2015. Siglec Receptors Impact Mammalian Lifespan by Modulating Oxidative Stress. eLife; 4:e06184.

Nam K, Munch K, Hobolth A, Dutheil JY, Veeramah KR, Woerner AE, Hammer MF, Mailund T, Schierup MH and

; Great Ape Genome Diversity Project: Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor TD, Santpere G, Cagan A,Theunert C, Casals F, Laayouni H, Munch K, Hobolth A, Halager AE, Malig M, Hernandez-Rodriguez J, Hernando-Herraez I, Prüfer K, Pybus M,Johnstone L, Lachmann M, Alkan C, Twigg D, Petit N, Baker C, Hormozdiari F, Fernandez-Callejo M, Dabad M, Wilson ML, Stevison L, Camprubí C,Carvalho T, Ruiz-Herrera A, Vives L, Mele M, Abello T, Kondova I, Bontrop RE, Pusey A, Lankester F, Kiyang JA, Bergl RA, Lonsdorf E, Myers S,Ventura M, Gagneux P, Comas D, Siegismund H, Blanc J, Agueda-Calpena L, Gut M, Fulton L, Tishkoff SA, Mullikin JC, Wilson RK, Gut IG, Gonder MK, Ryder OA, Hahn BH, Navarro A, Akey JM, Bertranpetit J, Reich D, Mailund T, Schierup MH, Hvilsom C, Andrés AM, Wall


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JD, Bustamante CD,Hammer MF, Eichler EE, Marques-Bonet T. 2015. Extreme selective sweeps independently targeted the X chromosomes of the great apes. Proc Natl Acad Sci U S A. . 112 (20) 6413–6418.

Tecle, E. & Gagneux, P. 2015. Glycosylation and Sperm Function. invited Review Molecular Reproduction and

Development. 82 (9):635-50. Lindheim, S. R, & Gagneux P. 2015. A Sweet View of Reproduction. Fertility and Sterility. Fertility and Sterility. 104

(3):533. Schwarz, F., Springer, SA., Altheide, T., Varki, N., Gagneux, P. and Varki, A. 2015. Human-specific Derived Alleles of

CD33 and Other Genes Protect Against Cognitive Deterioration in Post-Reproductive Individuals. Proc. Natl. Acad. Sci. USA. 113 (1):74-9.

Sroga, J.M. Wu, D.H., Ma, F., Tecle,E., Reynoso, H.S., Ressler, I.B., Maxwell, R., Ferrari, R., Whigham, L., Gagneux,

P. and Lindheim. S.R. 2015. Detection of the dietary xenoglycan N-glycolylneuraminic acid (Neu5Gc) and anti-Neu5Gc antibodies within reproductive tracts of male and female infertility subjects. Clin. Obstet. Gynecol.Reprod. Med. 1 (3): 72-78.

Springer, S.A., Gagneux, P. 2015. Glycomics: Revealing the Dynamic Ecology and Evolution of Sugar Molecules J.

Proteomics S1874-3919 (15):30194-9 Springer, SA., Schwarz, F., Altheide, T., Varki, N., Varki and Gagneux, P. 2016 A Reply to Liu and Jiang:

Maintenance of Postreproductive Cognitive Capacity by Inclusive Fitness Proc. Natl. Acad. Sci. USA. Online Cohen, M., Fisher, C.J., Huang, M.L. Lindsay, L.L., Boyce, W.M., Godula, K., and Gagneux. P. 2016. Capture and

characterization of influenza A virus from primary samples using glycan bead arrays. Virology.493:128-135. Ma, X., Pan, Q.,Feng, Y., Ma, Q., Gagneux, P., Ma, F. 2016. Sialylation Facilitates the Maturation of Mammalian

Sperm and Affects Its Survival in Female Uterus. Biology of Reproduction. DOI:10.1095/biolreprod.115.137810. SUBMITTED Springer, SA and Gagneux, P. submitted. New genetic variants to protect old minds, Des variations génétiques

nouvelles préservent l'esprit des personnes âgées. Médecine et Sciences. Vohr, S.H., O’Connell, B. Freitas, B. Ollivet-Courtois, F. Gagneux,P. Muotri, A.R., and Richard E. Green. (submitted)

Genomic evidence for lack of pre-zygotic species barrier between chimpanzees and bonobos. BOOK CHAPTERS Gagneux, P. 2001. The structure of primate families. International Encyclopedia Of The Social & Behavioral

Sciences. Ed. Neil J. Smelser & Paul B. Baltes, Pergamon. Gagneux, P. 2003. Genetic Differences between Humans and the Great Apes. Encyclopedia of the Human

Genome, Ed. David Cooper. Nature Publishing Group, Macmillan Publishers Ltd. London. Gagneux, P. and Muchmore, E.A. 2004. The chimpanzee model: contributions and considerations for studies of HBV.

Hepatitis B and D Protocols Volume 2: Immunology, Model Systems, and Clinical Studies Edited by R. Hamatake. Humana Press, pps. 289-318.

Di Fiore, A. Gagneux, P. 2006. Molecular Primatology, in Primates in Perspectives, Edited by Christina J. Campbell,

Augustín Fuentes, Katherine C. MacKinnon, Melissa Panger and Simon K. Bearder, Oxford University Press, pps 369-393.

Varki, A., Freeze, H., Gagneux, P. 2008. Evolution of Glycan Diversity. In: Essentials of Glycobiology. Second

Edition, Cold Spring Harbor Press. Cold Spring Harbor.


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Di Fiore, A., Disotell, T., Gagneux, P., Ayala, F. 2009. Primate Malarias. In: Primate Parasite Ecology: Dynamics and Study of Host-Parasite Relationships. M.A. Huffman and C.A. Chapman, eds. Cambridge University Press.pps 141-182.

Di Fiore, A., Lawler, R.R., Gagneux, P. 2011. Molecular Primatology, in Primates in Perspectives, Second Edition.

Edited by Christina J. Campbell, Augustín Fuentes, Katherine C. MacKinnon, Melissa Panger and Simon K. Bearder, Rebecca M. Stumpf. Oxford University Press, pps 390-416.

Gagneux, P. Primate Groups and their Correlates. 2015. International Encyclopedia Of The Social & Behavioral

Sciences 2nd Edition. James Wright editor. Gagneux, P. Sweetness in Human Evolution. 2015. Oxford Companion to Sweets. Oxford University Press. Darra

Goldstein Editor. Varki, A. and Gagneux. P. in press. How Different are Humans and “Great Apes”? A Matrix of Comparative

Anthropogeny. in ON HUMAN NATURE: EVOLUTION, DIVERSITY, PSYCHOLOGY, ETHICS, POLITICS AND RELIGION. Edited by Michel Tibayrenc and Francisco J. Ayala, Springer.

Gagneux, P. Flow Cytometry in press. Encyclopedia of Primatology. Anthony Di Fiore Editor, Wiley Blackwell Gagneux, P. Anthropogeny. In press. Evolution of the Human Genome II. Naruya Saitou Editor, Springer BOOK REVIEWS Gagneux, P., 2011.The biodiversity crisis in our midst. Review of The Hygiene Hypothesis and Darwinian Medicine,

(G.A.W. Rook Ed) Birkhäuser. Quarterly Review of Biology. 87:173-175. Gagneux, P., 2004. Gorilla Biology (Taylor and Goldsmith Eds), Cambridge University Press. Journal of Human

Evolution. 47:479-480. Gagneux, P., 2004. Protein Structure and Function. By Gregory A. Petsko and Dagmar Ringe, New Science Press

2004, Journal of Heredity. 95:274. Gagneux, P., 2003. Gene Regulations 4th Edition by David Latchman, Nelson Thornes, 2002, Journal of Heredity

94:528-529. Gagneux, P., 2002. The Evolution of Evolutionary Pathways. By Adam S. Wilkins, Journal of Heredity. 93:460-461. Gagneux, P., 1991. The Behavioural Biology of Aggression by J. Archer, Cambridge Studies in Behavioural Biology.

Journal of Evolutionary Biology 4:515-516. INVITED PRESENTATIONS August 1996 International Primatological Society in Madison, Wisconsin. February 1997 Morrison Institute for population and resource studies. Stanford University, Palo Alto, California. April 1997 American Association of Physical Anthropologists (AAPA). St. Louis, Missouri. May 1997 Seventh Annual Spring Symposium. Santa Fe Institute, Santa Fe, New Mexico. July 1997 Kyoto University, Zoology Department, Kyoto, Japan. November 1997 University of Southern California, Southern California Primate Research Forum October 1997 Meeting on Human Evolution. Cold Spring Harbor Laboratory, New York. October 1998 Seminar in Physical Anthropology department. Harvard University. Boston, Massachusetts. January 1999 Seminar on Conservation Genetics. Universitad Autonoma de Baja California. Ensenada,

Mexico. September 1999 Seminar on comparative studies of cell surface glycoconjugates in chimpanzees and humans.

San Diego Zoological Society, Pathology Department. San Diego, California. December 1999 Bronowski Forum Art&Science Forum, Salk Institute for Biological Sciences. La Jolla, California. August 2000 Symposium on “Explaining Humans.” Salk Institute for Biological Sciences. La Jolla, California. June 2000 Symposium on Molecular Variation of Chimpanzees. Max Planck Institut for Evolutionary

Anthropology. Leipzig, Germany. February 2001 Colloquium of the anthropology department. University of California, Los Angeles. Los Angeles,


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California. April 2001 7th Annual Kurt Benirschke Lecture in Pediatrics. University of California, San Diego. La Jolla,

California. November 2001 Center for the Study of Evolution and the Origin of Life (CSEOL). University of California, Los

Angeles. Los Angeles, California. February 2002 Scripps Institute of Oceanography, University of California, San Diego. La Jolla, California. April 2002 Center for the Reproduction of Endangered Species (CRES). San Diego, California. April 2002 University of California, Riverside, Biology Department. Riverside, California. May 2002 Hubbs Research Institute, Seaworld San Diego. San Diego, California. July 16, 2002 Consorci Universitat International Menendez Pelayo de Barcelona. Barcelona, Spain. June 2003 First Latin American Course in Primate Conservation Biology. Formosa, Argentina. March 2004 Symposium on Sequencing the Chimpanzee Genome, UCSD Medical School June 2004 Latin American Course in Primate Conservation Biology, Formosa, Argentina December 2004 Center for DNA Fingerprinting and Diagnostics, Hyderabad, India January 2005 San Diego Glycobiology Symposium August 2005 Project for Explaining The Origin of Humans, Salk Institute for Biological Studies October 2005 Loma Linda University, California November 2005 University of California, San Diego, Southern California Primate Research Forum January 2006 San Diego Glycobiology Symposium March 2006 UC San Diego Comparative Pathology April 2006 UC San Diego Pathology Department July 2006 Symposium on “Comparative Anthropogeny” Salk Institute for Biological Sciences. La Jolla,

California. November 2006 “The New Comparative Biology of Human Nature”, National Academy of Science, Irvine, California March 2007 UC San Diego Kavli Institute for Brain and Mind February 2008 San Diego Glycobiology Symposium April 2008 European Federation of Immunology, Toulouse, France April 2008 University of Geneva, Switzerland April 2008 Southern California Primate Research Forum, Cal State Fullerton January 2009 University of California, Darwin’s Bicentennial Lecture Series February 2009 San Diego Glycobiology Symposium June 2009 Kavli Frontiers of Science, Irvine, California November 2009 Palomar College, San Marcos, California March 2010 Symposium on “The Evolution of Human Biodiversity” UCSD and Salk Institute for Biological

Sciences. La Jolla, California. September 2010 Symposium on Gene Loss in Primate Evolution, International Primatological Society, Kyoto, Japan November 2010 Palomar College, San Marcos, California December 2010 San Diego Museum of Man February 2011 University of Cincinnati, Gynecology and Obstetrics Grand Rounds April 2011 University of California San Diego, Neonatology June 2011 ETH Zurich, Switzerland June 2011 Swiss Tropical Institute, Basel, Switzerland September 2011 University of California San Diego, Pediatrics Grand Rounds November 2011 Society for Glycobiology, Seattle March 2012 San Diego Glycobiology Symposium June 2012 Cornell University, Reproductive and Developmental Genomics Retreat September 2012 University of Southern California, Biological Sciences Seminar November 2012 University of California, San Diego, Oceanids January 2013 San Diego Glycobiology Symposium March 2013 San Diego Breast Feeding Coalition, Scripps Memorial Hospital, la Jolla, CA July 2013 Gordon Research Conference on Fertilization and Activation of Development, Holderness School,

New Hampshire October 2013 Osher Center for Life long Learning, UCSD Extension March 2014 University of Chicago, Department of Human Genetics April 2014 Leicester University, UK, Human evolution in the genomic era - Events - EMBO April 2014 June 2014

Radcliffe Institute for advanced study, Harvard University Technical University of Denmark, Lyngby, Denmark

June 2014 AAAS Pacific Division,University of California Riverside, CA


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July 2014 International Lactation Consultant Association, Pheonix, AZ October 2014 Palomar College, SDan Marcos , CA January 2015 San Diego Glycobiology Symposium January 2015 UC San Diego Hillcrest Seminar Series, San Diego, CA March 2015 Gordon Research Seminars, Lucca, Italy March 2015 Gordon Research Conference, Lucca, Italy March 2015 University of Ferrara, Ferrara, Italy March 2015 Evolutionary Medicine, University of Arizona Tuscon May 2015 Evolution of Human Milk, La Leche League, Newport Beach, CA May 2015 Placer Lactation Conferences, Roseville, CA May 2015 UC San Diego Neuroscience Program Annual Retreat, Lake Arrowhead, CA July 2015 Universidad Pompeu Fabra, Barcelona August 2015 Emerging Viruses, NIH, Washington DC September 2015 Glyco 23 Split, Coratia January 2016 Physics seminar, UC San Diego January 2016 Emerginf Infectious Diseases, 50th Japanese American Joint Medical Scences Program,

Washington. DC February 2016 CARTA Symposium, Salk Institute, La Jolla, CA February 2016 AAAS, Evolutionary Medicine, Washington. DC February 2016 Virology Seminar, Cornell University March 2016 San Diego Glycobiology Symposium

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