part 7 of 8 - evexia diagnostics · urine amino acid testing is valuable for assessing...
TRANSCRIPT
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Dr. Wayne Sodano, DC, DABCI, DACBN, CIHP, BCTNDirector of Clinical Support & Education, Evexia Diagnostics, Inc.
8 PART SERIES
Part 7 of 8 The ‘Must Know’ advanced laboratory tests for a successful treatment outcome
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D: DigestiveI: Inflammation/immune system
G: Gastrointestinal microbiome
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Integrative and Functional Medicine Stool Analysis
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• Gastroesophageal reflux (GERD)• Irritable bowel syndrome• Inflammatory bowel disease• Non-alcoholic steatohepatitis• Colorectal cancer• Allergy and asthma• Autism• Autoimmune disorders: type 1 diabetes, and• Hashimoto’s thyroiditis
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Some Diseases Associated with GI Dysfunction
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ClinicalMicrobiology:Bacteriology, Parasitology,Virology
viaPCRtesting
• BacterialPathogens• ParasiticPathogens• Viral Pathogens
H. pylori • H. pyloriandVirulenceFactor
Normal BacteriaFlora
• Bacteroidesfragilis• Biffidobacterium species• Enterococcusspecies• Lactobaccillus species• Clostridiumspecies• Enterbacter species
PhylaMicrobiotia• Bacteroidetes• Firmicutese• Firmicutes:Bacteroidetes Ratio
OpportunisticBacteria(dysbiosis/overgrowth)
• Bacillusspecies• Enterococcus faecalis• Enterococcusfaecium• Morganella species• Pseudomonasspecies• Pseudomonasaeruginosa• Staphylococcusspecies• Staphylococcusaureus• Streptococcusspecies
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Opportunistic Bacteria
PotentialAutoimmuneTriggers
• Citrobacter species• Citerbacter freudii• Klebseilla pneumoniae• M.avium subsp.paratuberculosis• Prevotella copri• Proteusspecies• Proteusmirabilis
Fungi/Yeast
• Candida species• Candidaalbicans• Geotrichum species• Microsporidium species• Rodotoula speccies
Viruses • Cytomegalovirus• EpsteinBarrVirus
Parasites • Protozoa• Worms
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GutImmunology/InflammationMarkers
• Calprotectin• SecretoryIgA• Anti-gliadin IgA
DigestionandGIMarkers
• OccultBlood–FecalImmunochemicalTest• Beta-Glucuronidase• Elastase-1• Steatocrit
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Beneficial Bacteria: Health promoting bacteria - Controls potentially pathogenic organism and opportunistic organisms, synthesize vitamins, aids in digestion of protein and carbohydrates, removal of toxins, stimulates the intestinal immune system and produces of short chain fatty acids (e.g. butyrate – fuel for the colonocytes and reduces DNA damage). Dysbiotic Bacteria: Known pathogenic bacteria and/or overgrowth of certain commensal bacteria.Commensal/Imbalanced Bacteria: Bacteria that are part of the normal flora (co-evolved). Imbalances (e.g. overgrowth) can occur when there are insufficient levels of beneficial bacteria, resulting in dysbiosis and opportunistic infection.Yeast (Mycology): Yeast is normally found in small numbers as a part of the colonic flora. Over growth of yeast can infect virtually every organ system, leading to an extensive array of clinical manifestations.
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Clinical Microbiology: Bacteriology and Mycology
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• Traditionally, a one-sample stool is collected for examination of parasites.
• Most integrative and functional medicine labs use three stool samples generally collected on consecutive days.
• Laboratory techniques used for identifying parasites and ova can vary among labs.
• It is generally recognized that stained fecal films are a productive means of stool examination for intestinal protozoa.
• PCR testing and Antigen Detection Testing
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Parasitology
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• Medical History: antibiotic use; NSAIDs; antacids, acid-blocking medication
• Associated Conditions: hypochlorhydria; pancreatic insufficiency; Standard American Diet; exposures to pathogens (esp. water and food), inflammatory bowel disease, oxidative stress, emotional stress, depressed immune system (e.g. low secretory IgA)
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General Considerations for Abnormal GI Microbiology
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Conditions PotentialEtiology
Lowbeneficialbacteria • Antibioticuse• Poordiet
Abnormallyhighcountofsomebeneficialbacteria
• Poordiet• Maldigestion• Malabsorption• Foodintolerance
PresenceofPotentialBacterialPathogens(opportunistic)(Especiallywithhighcounts/growth)
• Lowbeneficialbacteria• Poordiet• Antibioticuse• Lowgutimmunity
Pathogenicbacteria • Well-recognizedpathogensofconcern
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Conditions PotentialEtiology
Yeast/Fungi
(CandidaarenormalinhabitantstheGItractwhenpresentinsmallnumbers.Theymaybecomepotentialpathogenswhentheintestinalbarrieriscompromisedand/orwithovergrowth.)
• Antibioticuse• Hypochlorhydria• Foodallergies• Alteredintestinalflora• Poordietwithhighintakeof
carbohydratesanddairy• Depressedimmunesystem
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Conditions PotentialEtiology
Parasiticinfection
Suspicionofparasiticinfection
• Skinirritationanditching• Analorrectalitching• Lowlactobacillusonstoolanalysis• Bloodinstool• Unexplainedanemia• Abdominaldiscomfortespeciallyrightlower
quadrant• Lowbloodaminoacidassayandlowprotein• Unexplainednutritionaldeficiencies(e.g.iron,
zinc,selenium)• ContinuedGIsymptomsaftertreatmentfor
yeastand/orbacterialinfection.
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Marker Explanation
Pancreaticelastase
Digestiveenzymeproducedbythepancreas.Lowlevelssuggest:
• Pancreaticinsufficiency• Gallstonesorpost-cholecystectomy• Chronicpancreatitis• Diabetes• Hypochlorhydria• Cysticfibrosis• Chronicinflammatoryboweldisease
Iflow,considerdigestiveenzymesupportandtreattheunderlyingcause
Digestion and Absorption Markers
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Marker ExplanationFecalfats-Steatocrit:Triglycerides,longchainfattyacids,cholesterol,phospholipids
Increasedlevelsareassociatedwithfatmalabsorption• Pancreaticinsufficiency• Cholestasis• Celiacdisease• Shortbowelsyndrome• Post-cholecystectomy
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Marker Explanation
Lactoferrin
Lactoferrinisaniron-bindingglycoproteinthatservesasamarkerforleukocytesactivityIn theGItract,itservesasanon-specificmarkerofinflammation.
Elevatedlevelsasassociatedwith:• Entericinfection• IBD• Colorectalcancer
CalprotectinCalprotectinisacalcium-bindingneutrophilderivedprotein.ElevatedlevelsofcalprotectinareassociatedwithIBD.
Gastrointestinal Immunology and Inflammatory Markers
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Marker Explanation
Secretory IgA
sIgAisthefirstlineofdefenseoftheGImucosa.
ElevatedsIgA potentialcauses:• Normalimmuneresponsetopathogenicorganism• Chronicelevationshavebeenfoundinintractable
(stubborn)GIinfections,atopicdermatitisandcolorectalcancer.
DepressedsIgApotentialcauses:• Immunocompromised• Dysbiosis• PartialorprimaryselectiveIgAdeficiency• Chronicstress
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Marker Explanation
OccultBlood
(Fecal ImmunochemicalTest)
Hiddenbloodinthestool.• Colorectalcancer• Inflammatoryboweldisease• Pepticulcer• Polyps• Diverticulosis• OthercancersoftheGItractoraccessoryorgans(ConsiderFITtest– Insure Test- andcolonoscopy)
Beta-Glucuronidase
Beta-glucuronidase isaninducibleenzymeelaboratedbyanaerobicintestinalbacteria.Increasedactivityofthisenzymehasbeenimplicatedinincreasedenterohepaticrecirculationoftoxins,steroidshormones,drugsandcarcinogens.
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GI-MAP DIAGNOSTIC(MULTIPLEX PCR)
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GI-MAP INTERPRETIVE GUIDE
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GI-MAP
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GI-MAP
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GI-MAP
SESSION 1SESSION 2
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GI-MAP
SESSION 1SESSION 2
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GI-MAP
SESSION 2
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GI-MAP
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GI-MAP
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GI-MAP
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NutrEval Test = Nutritional testing tool for complex chronic illness as well for those seeking to improve health
Targeted personalized nutrition (biochemical individuality)that provides the framework of core nutrients in 5 key areas:
1. Antioxidants2. B-vitamins3. Minerals4. Essential Fatty Acids5. Digestive support (pancreatic/need for probiotics)
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Most Comprehensive
ü NutrEval Plasma ü NutrEval FMV (first morning void)
- both require urine and blood
Genomic testing can be added to both tests to assess for SNPs
Shorter version with no EFA testing
ü ONE-FMV – urine only (Optimal Nutritional Evaluation)
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Why use the NutrEval Profile?
NutrEval Profile is an advanced nutritional analysis designed to reveal nutritional imbalances or inadequacies.
Evaluates the functional need for antioxidants, B-vitamins, minerals, essential fatty acids, amino acids, digestive support, and other select nutrients.
Provides insight into nutrient status and allows you to provide targeted treatment (i.e. personalized nutrition) for the particular needs of each patient, often augmenting and speeding recovery of complex chronic conditions.
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Effective for individuals experiencing the following conditions
● Mood disorders (e.g. depression, anxiety)
● Fatigue
● Digestive Complaints
● Chronic Pain/Inflammatory Conditions (e.g. migraine, musculoskeletal)
● Cardiovascular Risk
● Weight Issues
● Dietary Guidance
● General Health
● Sports Fitness Optimization
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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NutrEval FMV Profile and NutrEval Plasma Profile (FMV = first morning void)
NutrEval FMV Profile ● Metabolic Analysis (urine organic acids)● Urine Amino Acid Analysis (essential and non-essential amino acids,
plus intermediary metabolites)● Essential and Metabolic Fatty Acids (red blood cell essential and non-
essential fatty acids, including Omega-3 and Omega-6 fatty acids)● Oxidative Stress Analysis (blood and urine biomarkers indicative of
oxidative stress)● Elemental Markers (both nutrient and toxic elements)
NutrEval Plasma Profile• Urine Amino Acid Analysis is replaced with Plasma Amino Acid
Analysis (essential and non-essential amino acids, plus intermediary metabolites)
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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What’s the difference between the two tests?
NutrEval FMV Profile
Urine amino acid testing is valuable for assessing vitamin/mineral cofactors that affect amino acid metabolism and provide insight into protein digestion.
NutrEval Plasma Profile
A fasting plasma amino acid highlights the dynamic balance of the amino acid pool, independent of recent dietary intake. Plasma amino acid analysis is favored when the primary clinical consideration are conditions in which the supply of essential amino acid precursors is critical, such as in mood and neurobehavioral disorders.
Select genomics biomarkers may be added to the profile for enhanced personalization of therapies such as MTHFR, COMT, TNF-alpha and APOE.
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Biomarkers on the NutrEval Profile
● Metabolic Analysis Markers (urine organic acids)○ Malabsorption and Dysbiosis Markers
■ Malabsorption Markers■ Bacterial Dysbiosis Markers■ Yeast/Fungal Dysbiosis Markers
○ Cellular Energy & Mitochondrial Metabolites■ Carbohydrate Metabolism■ Energy Metabolism■ Fatty Acid Metabolism
○ Neurotransmitter Metabolites○ Vitamin Markers○ Toxin & Detoxification Markers○ Tyrosine Metabolism
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Biomarkers on the NutrEval Profile (continued)
● Urine Amino Acid Analysis (FMV)
○ Nutritionally Essential Amino Acids
○ Nonessential Protein Amino Acids
○ Intermediary Metabolites
○ Dietary Peptide Related Markers
● Plasma Amino Acid Analysis (Plasma)
○ Nutritionally Essential Amino Acids
○ Nonessential Protein Amino Acids
○ Intermediary Metabolites
○ Dietary Peptide Related Markers
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Biomarkers on the NutrEval Profile (continuted)
● Essential and Metabolic Fatty Acids○ Omega 3 Fatty Acids○ Omega 6 Fatty Acids○ Omega 9 Fatty Acids○ Saturated Fatty Acids○ Monounsaturated Fats
■ Omega 7 Fats■ Trans Fat
○ Delta-6 Desaturase Activity○ Cardiovascular Risk – featuring key ratios: Omega 6/Omega 3,
AA/EPA, and the Omega 3 Index
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Info@ evexiadiagnostics.com www.evexiadiagnostics.com
Sources: Macadamia oil and sea buckthorn oil
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Biomarkers on the NutrEval Profile (continuted)
Oxidative Stress Markers
○ Glutathione (whole blood)○ Lipid Peroxides (urine)○ 8-OHdG (urine – 8-hydroxy-2-deoxyguanosine)○ Coenzyme Q10 (plasma)
Elemental Markers○ Nutrient Elements
■ Copper■ Magnesium■ Manganese■ Potassium■ Selenium■ Zinc
○ Toxic Elements■ Lead■ Mercury■ Antimony■ Arsenic■ Cadmium■ Tin
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Advantages of the NutrEval Tests
● Identification of imbalances that may precede abnormal findings on standard laboratory panels
● Comprehensive nutritional assessment indicating the functional need for specific nutrients, diet modification, antioxidant protection, detoxification and other therapies
● Personalized nutrient recommendations based on biochemical individuality
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Applying the NutrEval In Clinical Practice
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Applying the NutrEval In Clinical Practice
Green = normalYellow = borderlineRed = high need
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Applying the NutrEval In Clinical Process
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Applying the NutrEval In Clinical Practice
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FunctionCause of DeficiencyComplications of DeficiencyFood sources
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Applying the NutrEval In Clinical Practice
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Applying the NutrEval In Clinical Practice
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Applying the NutrEval In Clinical Practice
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Applying the NutrEval In Clinical Practice
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Applying the NutrEval In Clinical Process
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Applying the NutrEval In Clinical Practice
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Applying the NutrEval In Clinical Practice
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Applying the NutrEval In Clinical Practice
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Applying the NutrEval In Clinical Practice
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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Applying the NutrEval In Clinical Practice
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
OMEGA 7
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Applying the NutrEval In Clinical Practice
Info@ evexiadiagnostics.com www.evexiadiagnostics.com
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ORGANIC ACID TESTIndications & Clinical Interpretation
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Organic Acids
• Family of compounds that are intermediates in a variety of metabolic pathways.
• Normally found in the urine of health individuals
• Increased levels of specific organic acids or elevations of combinations of specific organic acids are often seen in metabolic disorders in which there is a blockage or blockages in certain metabolic pathways.
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• Abnormal urinary organic acids, organic aciduria, is seen genetic disorders of amino acid metabolism, mitochondrial fatty acid beta-oxidation metabolism, and of mitochondrial oxidative phosphorylation metabolism.
• Inborn errors of metabolism such as phenylketonuria and methylmalonic aciduria
Key test in evaluation of individuals with suspected genetic disorders of organic
acid metabolism.
Organic Acids
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Organic Acids
Genetic disorders detected by urinary acid analysis present at
some time during infancy or childhood
Significant catabolic stresses such as illness with vomiting, diarrhea
and/or fever or fasting.
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Most laboratories only test for genetic inborn errors of metabolism via urinary organic acid
evaluation.
However, there are labs that analysis the urine for organic acid abnormalities from a
pathological/non-genetic perspective.
Many of the blocked metabolic pathways can be treated nutritionally once they have
been identified.
Organic Acids
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Common Clinical Laboratory and Patient Assessment Indications for Ordering a Urinary Organic Acid Test
Patient Assessment Indications
• Neonates and infants with unexplained life-threatening phenotype
• Infants, children and selected adults with unexplained cognitive or developmental regression
• Infants, children and selected adults with unexplained epilepsy
• Any age individual with unexplained encephalopathy• Infants, children and selected adults with two or
more unexplained CNS peoblems• Infants, children and selected adults with
unexplained growth retardation or failure to thrive• Any age individual with unexplained fasting
intolerance• Any age individual with exercise intolerance
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LaboratoryIndications
● Neonates with unexplained moderate or marked ketouria
● Neonates, infants, children and selected adults with unexplained anion gap acidosis.
● Neonates, infants, children and selected adults with unexplained hyperammonemia
● Neonates, infants, children and selected adults with unexplained hypoglycemia
● Neonates, infants, children and selected adults with unexplained lactic acidemia
Common Clinical Laboratory and Patient Assessment Indications for Ordering a Urinary Organic Acid Test
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Non-Genetic Pathologic/Functional Conditions
Common Clinical Laboratory and Patient Assessment Indications for Ordering a Urinary Organic Acid Test
● Fatigue/Weakness (decreased energy production –Krebs cycle, fatty acid metabolism, carbohydrate metabolism)
● Fibromyalgia/chronic fatigue● Chemical Sensitivity: detoxification /dysfunction
markers● Neurological Signs and Symptoms: cognitive
impairment, headaches, irritability and motor impairment. Assess for nutritional deficiencies esp. B-vitamins and neurotransmitter metabolism dysfunction
● Candida/GI dysbiosis: dysbiosis markers● Oxidative Stress: Oxidative damage marker and
antioxidant levels
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The information content of an organic acid profile is high, but the interpretation is simplified by keeping in mind that the results supplies answers to a few clinically relevant questions
Organic Acid Laboratory Interpretation
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• Are there signs of inborn errors of metabolism?• Is mitochondrial energy production adversely affected?
(Mitochondrial Function Assessment)• Are functional nutrient deficiencies present? (B-complex
Vitamin Markers)• Does altered neurotransmitter turnover reveal symptom
origins? (Neurotransmitter Metabolism Markers)
Clinically Relevant Questions (page 1 of 2)
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• Are antioxidants nutrients protecting against oxidative stress? (Oxidative Damage and Antioxidant Markers)
• Is there a high toxin load and is this adversely affecting detoxification capacity? (Detoxification Markers)
• Are symptoms related to excessive growth of bacteria and fungi in the gut? (Intestinal Dysbiosis Markers)
Clinically Relevant Questions (page 2 0f 2)
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Reprinted with permission: Laboratory Evaluations for Integrative and Functional Medicine, 2nd Ed.
Mitochondrial Functional Assessment
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Sample Report
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Sample Report
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Sample Report
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Reprinted with permission: Laboratory Evaluations for Integrative and Functional Medicine, 2nd Ed.
Mitochondrial Functional Assessment
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Reprinted with permission: Laboratory Evaluations for Integrative and Functional Medicine, 2nd Ed.
Mitochondrial Functional Assessment
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Reprinted with permission: Laboratory Evaluations for Integrative and Functional Medicine, 2nd Ed.
Mitochondrial Functional Assessment
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• The degrading of amino acids requires many vitamin cofactors.
• During degradation intermediate acids are formed, which require these cofactors for continued catabolism.
Nutritional Markers
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Nutritional deficiencies can block the metabolism of the intermediate acids causing them to spilling in to the urine
Reprinted with permission: Laboratory Evaluations for Integrative and Functional Medicine, 2nd Ed.
Nutritional Markers
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• Neurotransmitter Metabolism Markers (Metabolites)
• Neurotransmitters: include biogenic amines, amino acids, purines, and neuropeptides that are released from the neurons and change the electrical activity of other neurons and myocytes.
• Neurotransmitter disorders represent as enigmatic and enlarging group of neurometabolic conditions.
Neurotransmitters Markers
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• Primary defects of neurotransmitter metabolism and transport. • Include defects of catecholamine, serotonin, biopterin, glycine, pyridoxine
and gamma amino butyric acid (GABA) metabolism.
• Defects of catecholamine (dopamine, epinephrine and norepinephrine) and serotonin metabolism, also called monoamine or biogenic amine metabolism, are the most widely known and investigated group of neurotransmitter disorders.
Inherited Neurotransmitter Disorders
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Neurotransmitter
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Reprinted with permission: Laboratory Evaluations for Integrative and Functional Medicine, 2nd Ed.
Neurotransmitter
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• Urinary organic acid testing provides significant insight about DNA oxidative damage, detoxification, and gastrointestinal dysbiosis
• 8-hydroxy-2’-deoxyguanosine (8-OHdG) Marker of DNA Damage
• Exogenous toxin accumulation and endogenous detoxification
• Metabolic products of bacterial and yeast infections
DNA Damage, Detoxification and Intestinal Dysbiosis Markers
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Reprinted with permission: Laboratory Evaluations for Integrative and Functional Medicine, 2nd Ed
Intestinal Dysbiosis Markers
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• Organic acid testing provides valuable insight to the functioning of many biochemical processes in the body via spillage of organic acid end products into the urine.
• Aside from assessing for inborn errors of metabolism, organic acid testing at its very basic level provides urinary markers of nutritional deficiencies of many pathways including central energy pathways.
Summary
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Dr. Wayne L. SodanoDC, DABCI, DACBN, CFMP, CIHP, BCTN
Next lesson: Part 8 of 8 Laboratory Test Interpretation with Case Presetntations