papers prof. simioni paolo simioni p simioni p · 33. bulato c, radu cm, campello e, gavasso s,...

PAPERS – PROF. SIMIONI PAOLO

1. Russo FP, Zanetto A, Campello E, Bulato C, Shalaby S, Spiezia L, Gavasso S,

Franceschet E, Radu C, Senzolo M, Burra P, Lisman T, Simioni P. Reversal of

hypercoagulability in patients with HCV-related cirrhosis after treatment with direct

acting antivirals. Liver Int. 2018 May 8. doi: 10.1111/liv.13873. PMID: 29738632

2. Bulato C, Novembrino C, Anzoletti MB, Spiezia L, Gavasso S, Berbenni C, Tagariello

G, Farina C, Nardini I, Campello E, Peyvandi F, Simioni P. "In vitro" correction of

the severe factor V deficiency-related coagulopathy by a novel plasma-derived factor

V concentrate. Haemophilia. 2018 Mar 26. doi: 10.1111/hae.13465. PMID: 29578313

3. Spiezia L, Al Mamary A, Campello E, Piazza D, Maggiolo S, Dalla Valle F, Napodano

M, Simioni P. On-treatment platelet reactivity in peripheral and coronary blood in

patients undergoing primary PCI for ST-segment elevation myocardial infarction

(STEMI). Scand J Clin Lab Invest. 2018 Mar 26:1-6. doi:

10.1080/00365513.2018.1455220. PMID: 29575927

4. Mattia E, Tonello M, Del Ross T, Zerbinati P, Campello E, Simioni P, Ruffatti A.

Clinical and laboratory characteristics of isolated lupus anticoagulants. Thromb Res.

2018 May;165:51-53. doi: 10.1016/j.thromres.2018.03.008. Epub 2018 Mar 13.

PMID: 29567587

5. Bulato C, Campello E, Gavasso S, Maggiolo S, Tormene D, Simioni P. Peculiar

laboratory phenotype/ genotype relationship due to compound inherited protein C

defects in a child with severe venous thromboembolism. Hamostaseologie. 2018

Feb;38(1):33-38. doi: 10.5482/HAMO-17-03-0013. Epub 2018 Feb 26. PMID:

29536478

6. Zoia A, Drigo M, Piek CJ, Simioni P, Caldin M. Hemostatic findings of pleural fluid

in dogs and the association between pleural effusions and primary

hyperfibrino(geno)lysis: A cohort study of 99 dogs. PLoS One. 2018 Feb

20;13(2):e0192371. doi: 10.1371/journal.pone.0192371. eCollection 2018. PMID:

29462172

7. Spiezia L, Campello E, Valle FD, Simion C, Colpo A, Simioni P. ABO blood group

and the risk of post-thrombotic syndrome. Ann Hematol. 2018 Jun;97(6):1057-1060.

doi: 10.1007/s00277-018-3255-3. Epub 2018 Feb 1. PMID: 29387976

8. Campello E, Henderson MW, Noubouossie DF, Simioni P, Key NS. Contact System

Activation and Cancer: New Insights in the Pathophysiology of Cancer-Associated

Thrombosis. Thromb Haemost. 2018 Feb;118(2):251-265. doi: 10.1160/TH17-08-

0596. Epub 2018 Jan 29. PMID: 29378353

9. Campello E, Radu CM, Tonello M, Kuzenko A, Bulato C, Hoxha A, Mattia E, Spiezia

L, Ruffatti A, Simioni P. Circulating microparticles in pregnant patients with primary

anti-phospholipid syndrome: an exploratory study. Scand J Rheumatol. 2018 Jan 8:1-

4. doi: 10.1080/03009742.2017.1372518. [Epub ahead of print] No abstract available.

PMID: 29308695

10. Gianesello L, Priante G, Ceol M, Radu CM, Saleem MA, Simioni P, Terrin L, Anglani

F, Del Prete D. Albumin uptake in human podocytes: a possible role for the cubilin-

amnionless (CUBAM) complex. Sci Rep. 2017 Oct 20;7(1):13705. doi:

10.1038/s41598-017-13789-z. PMID: 29057905

11. Ceolotto G, Giannella A, Albiero M, Kuppusamy M, Radu C, Simioni P, Garlaschelli

K, Baragetti A, Catapano AL, Iori E, Fadini GP, Avogaro A, Vigili de Kreutzenberg

S. miR-30c-5p regulates macrophage-mediated inflammation and pro-atherosclerosis

pathways. Cardiovasc Res. 2017 Aug 14. doi: 10.1093/cvr/cvx157. PMID: 29016810

12. Giannella A, Radu CM, Franco L, Campello E, Simioni P, Avogaro A, de

Kreutzenberg SV, Ceolotto G. Circulating levels and characterization of

microparticles in patients with different degrees of glucose tolerance. Cardiovasc

Diabetol. 2017 Sep 19;16(1):118. doi: 10.1186/s12933-017-0600-0. PMID: 28927403

13. Carron M, Bertini D, Prandini T, Fanton F, Foletto M, Ori C, Perissinotto E, Simioni

P. Effect of sugammadex on coagulation as detected by rotational thromboelastometry

in morbidly obese patients. Minerva Anestesiol. 2017 Jul 13. doi: 10.23736/S0375-

9393.17.11856-0. PMID: 28714298

14. Giordano P, Grassi M, Saracco P, Molinari AC, Gentilomo C, Suppiej A, Indolfi G,

Lasagni D, Luciani M, Piersigilli F, Putti MC, Rota LL, Sartori S, Simioni P;

Paediatric Thrombosis Working Group of the RITI (see Appendix I). Paediatric

venous thromboembolism: a report from the Italian Registry of Thrombosis in

Children (RITI). Blood Transfus. 2017 Jun 30:1-8. doi: 10.2450/2017.0075-17. PMID:

28686155

15. Zoia A, Drigo M, Simioni P, Caldin M, Piek CJ. Association between ascites and

primary hyperfibrinolysis: A cohort study in 210 dogs. Vet J. 2017 May;223:12-20.

doi: 10.1016/j.tvjl.2017.03.008. Epub 2017 Mar 31. PMID: 28671065

16. Campello E, Spiezia L, Dalla Valle F, Tormene D, Simioni P. Factor V Leiden

paradox and the occurrence of distal vein thrombosis in a large cohort of thrombotic

patients. Thromb Res. 2017 Aug;156:20-22. doi: 10.1016/j.thromres.2017.05.025.

Epub 2017 May 26. PMID: 28577389

17. Giordano S, Spiezia L, Campello E, Simioni P. The current understanding of trauma-

induced coagulopathy (TIC): a focused review on pathophysiology. Intern Emerg

Med. 2017 May 5. doi: 10.1007/s11739-017-1674-0. Review. PMID: 28477287

18. Spiezia L, Di Gregorio G, Campello E, Maggiolo S, Bortolussi G, Stellin G, Simioni

P, Vida V. Predictors of postoperative bleeding in children undergoing

cardiopulmonary bypass: A preliminary Italian study. Thromb Res. 2017 May;153:85-

89. doi: 10.1016/j.thromres.2017.03.021. Epub 2017 Mar 22. PMID: 28359027

19. Bazzan E, Turato G, Tinè M, Radu CM, Balestro E, Rigobello C, Biondini D, Schiavon

M, Lunardi F, Baraldo S, Rea F, Simioni P, Calabrese F, Saetta M, Cosio MG. Dual

polarization of human alveolar macrophages progressively increases with smoking

and COPD severity. Respir Res. 2017 Feb 23;18(1):40. doi: 10.1186/s12931-017-

0522-0. PMID: 28231829

20. Alshaikh NA, Rosing J, Thomassen MCLGD, Castoldi E, Simioni P, Hackeng TM.

New functional assays to selectively quantify the activated protein C- and tissue factor

https://www.ncbi.nlm.nih.gov/pubmed/28477287








pathway inhibitor-cofactor activities of protein S in plasma. J Thromb Haemost. 2017

May;15(5):950-960. doi: 10.1111/jth.13657. Epub 2017 Mar 20. PMID: 28211163

21. Zanetto A, Senzolo M, Vitale A, Cillo U, Radu C, Sartorello F, Spiezia L, Campello

E, Rodriguez-Castro K, Ferrarese A, Farinati F, Burra P, Simioni P.

Thromboelastometry hypercoagulable profiles and portal vein thrombosis in cirrhotic

patients with hepatocellular carcinoma. Dig Liver Dis. 2017 Apr;49(4):440-445. doi:

10.1016/j.dld.2016.12.019. Epub 2016 Dec 26. PMID: 28109767

22. Senzolo M, Simioni P, Andriulli A. Screening and treatment of portal vein thrombosis

in cirrhosis. Dig Liver Dis. 2017 Feb;49(2):228-229. doi: 10.1016/j.dld.2016.12.015.

Epub 2016 Dec 21. PMID: 28081904

23. Campello E, Radu CM, Duner E, Lombardi AM, Spiezia L, Bendo R, Ferrari

S, Simioni P, Fabris F. Activated platelet-derived and leukocyte-derived circulating

microparticles and the risk of thrombosis in heparin-induced thrombocytopenia: A

role for pf4-bearing microparticles? Cytometry B Clin Cytom. 2017 Jan 3. doi:

10.1002/cyto.b.21507. PMID: 28052584

24. Mallett S, Simioni P, Görlinger K, Fenger-Eriksen C. Thrombin generation tests and

viscoelastic testing in cirrhosis: comparing apples and oranges? Eur J Anaesthesiol.

2017 Jan;34(1):36-37. PMID: 27898482

25. Zoia A, Drigo M, Piek CJ, Simioni P, Caldin M. Hemostatic Findings in Ascitic Fluid:

A Cross-Sectional Study in 70 Dogs. J Vet Intern Med. 2017 Jan;31(1):43-50. doi:

10.1111/jvim.14610. Epub 2016 Nov 16. PMID: 27862300

26. Campello E, Radu CM, Spiezia L, Simioni P. Modulating thrombotic diathesis in

hereditary thrombophilia and antiphospholipid antibody syndrome: a role for

circulating microparticles? Clin Chem Lab Med. 2016 Nov 7. pii: /j/cclm.ahead-of-

print/cclm-2016-0562/cclm-2016-0562.xml. doi: 10.1515/cclm-2016-0562. PMID:

27816948

27. Campello E, Spiezia L, Simioni P. Diagnosis and management of factor V Leiden.

Expert Rev Hematol. 2016 Dec;9(12):1139-1149. Epub 2016 Oct 31. PMID:

27797270

28. Radu CM, Spiezia L, Bulato C, Gavasso S, Campello E, Sartorello F, Castoldi

E, Simioni P. Endocytosis of exogenous factor V by ex-vivo differentiated

megakaryocytes from patients with severe parahaemophilia. Br J Haematol. 2016

Nov;175(3):517-524. doi: 10.1111/bjh.14262. Epub 2016 Jul 22. PMID: 27443583

29. Vasques F, Spiezia L, Manfrini A, Tarzia V, Fichera D, Simioni P, Gerosa G, Ori C,

Di Gregorio G. Thromboelastometry guided fibrinogen replacement therapy in

cardiac surgery: a retrospective observational study. J Anesth. 2017 Apr;31(2):286-

290. doi: 10.1007/s00540-016-2271-5. Epub 2016 Oct 18. PMID: 27757554

30. Spiezia L, Campello E, Valle FD, Woodhams B, Simioni P. Factor VIIa-antithrombin

complex: a possible new biomarker for activated coagulation. Clin Chem Lab Med.

2017 Mar 1;55(4):484-488. doi: 10.1515/cclm-2016-0399. Review. PMID: 27522621























31. Campello E, Spiezia L, Radu CM, Simioni P. Microparticles as biomarkers of venous

thromboembolic events. Biomark Med. 2016 Jul;10(7):743-55. doi: 10.2217/bmm-

2015-0063. Epub 2016 Jun 24. PMID: 27338783

32. Campello E, Zanetto A, Spiezia L, Radu CM, Gavasso S, Ferrarese A, Farinati F,

Senzolo M, Simioni P. Hypercoagulability detected by circulating microparticles in

patients with hepatocellular carcinoma and cirrhosis. Thromb Res. 2016 Jul;143:118-

21. doi: 10.1016/j.thromres.2016.05.021. Epub 2016 May 20. PMID: 27236709

33. Bulato C, Radu CM, Campello E, Gavasso S, Spiezia L, Tormene D, Simioni P. New

Prothrombin Mutation (Arg596Trp, Prothrombin Padua 2) Associated With Venous

Thromboembolism. Arterioscler Thromb Vasc Biol. 2016 Mar 24. pii:

ATVBAHA.115.306914. [Epub ahead of print] PMID: 27013614

34. Spiezia L, Vasques F, Behr A, Campello E, Maggiolo S, Berizzi A, Gavasso S,

Woodhams B, Biancari F, Simioni P. Perioperative coagulation assessment of

patients undergoing major elective orthopedic surgery. Intern Emerg Med. 2016 Mar

7. [Epub ahead of print] PMID: 26951189

35. Campello E, Farina F, Spiezia L, Maggiolo S, Palmieri A, Sartorello F, Baracchini C,

Simioni P. Thromboelastometry profiles in patients undergoing thrombolytic therapy

for acute ischaemic stroke. Thromb Haemost. 2016 Feb 11;115(6). [Epub ahead of

print] PMID: 26864700

36. Campello E, Zabeo E, Radu CM, Spiezia L, Foletto M, Prevedello L, Gavasso S,

Bulato C, Vettor R, Simioni P. Dynamics of circulating microparticles in obesity after

weight loss. Intern Emerg Med. 2016 Feb 2. [Epub ahead of print] PMID: 26837209

37. Saracco P, Bagna R, Gentilomo C, Magarotto M, Viano A, Magnetti F, Giordano P,

Luciani M, Molinari AC, Suppiej A, Ramenghi LA, Simioni P; Neonatal Working

Group of the Registro Italiano Trombosi Infantili (RITI). Clinical Data of Neonatal

Systemic Thrombosis. J Pediatr. 2016 Apr;171:60-66.e1. doi:

10.1016/j.jpeds.2015.12.035. Epub 2016 Jan 16. PMID: 26787378

38. Lim MY, Deal AM, Kim S, Musty MD, Conard J, Simioni P, Dutrillaux F, Eid SS,

Middeldorp S, Halbmayer WM, Boneu B, Moia M, Moll S. Thrombophilic Risk of

Individuals with Rare Compound Factor V Leiden and Prothrombin G20210A

Polymorphisms: An International Case-Series of 100 Individuals. Eur J Haematol.

2016 Jan 16. doi: 10.1111/ejh.12738. [Epub ahead of print] PMID: 26773706

39. Aron Badin R, Vadori M, Vanhove B, Nerriere-Daguin V, Naveilhan P, Neveu I, Jan

C, Lévèque X, Venturi E, Mermillod P, Van Camp N, Dollé F, Guillermier M, Denaro

L, Manara R, Citton V, Simioni P, Zampieri P, D'avella D, Rubello D, Fante F, Boldrin

M, De Benedictis GM, Cavicchioli L, Sgarabotto D, Plebani M, Stefani AL, Brachet

P, Blancho G, Soulillou JP, Hantraye P, Cozzi E. Cell therapy for Parkinson's disease:

A translational approach to assess the role of local and systemic immunosuppression.

Am J Transplant. 2016 Jan 8. doi: 10.1111/ajt.13704. [Epub ahead of print] PMID:

26749114

40. Spiezia L, Campello E, Maggiolo S, Tormene D, Simioni P. Short-term exposure to

high levels of air pollution (nickel) and the risk of acute unprovoked proximal deep

vein thrombosis in the legs. Intern Emerg Med. 2015 Dec 8. [Epub ahead of print].

PMID: 26645216

41. Vida VL, Spiezia L, Bortolussi G, Marchetti ME, Campello E, Pittarello D, Gregori

D, Stellin G, Simioni P. The Coagulative Profile of Cyanotic Children Undergoing

Cardiac Surgery: The Role of Whole Blood Preoperative Thromboelastometry on

Postoperative Transfusion Requirement. Artif Organs. 2015 Nov 27. doi:

10.1111/aor.12629. [Epub ahead of print] PMID: 26611664

42. Campello E, Spiezia L, Radu CM, Bulato C, Gavasso S, Tormene D, Woodhams B,

Dalla Valle F, Simioni P. Circulating microparticles and the risk of thrombosis in

inherited deficiencies of antithrombin, protein C and protein S. Thromb Haemost.

2015 Dec 22;115(1):81-8. doi: 10.1160/TH15-04-0286. Epub 2015 Sep 10. PMID:

26354831

43. Bertazza L, Barollo S, Radu CM, Cavedon E, Simioni P, Faggian D, Plebani M,

Pelizzo MR, Rubin B, Boscaro M, Pezzani R, Mian C. Synergistic antitumour activity

of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells. J Cell Mol

Med. 2015 Jun 17. doi: 10.1111/jcmm.12612. [Epub ahead of print] PMID: 26081844

44. Radu CM, Campello E, Spiezia L, Dhima S, Visentin S, Gavasso S, Woodhams B,

Cosmi E, Simioni P. Origin and levels of circulating microparticles in normal

pregnancy: A longitudinal observation in healthy women. Scand J Clin Lab Invest.

2015 Oct;75(6):487-95. doi: 10.3109/00365513.2015.1052551. Epub 2015 Jun 12.

PMID: 26067611

45. Campello E, Spiezia L, Radu CM, Dhima S, Visentin S, Valle FD, Tormene D,

Woodhams B, Cosmi E, Simioni P. Circulating microparticles in umbilical cord

blood in normal pregnancy and pregnancy with preeclampsia. Thromb Res. 2015

Aug;136(2):427-31. doi: 10.1016/j.thromres.2015.05.029. Epub 2015 May 28. PMID:

26037284

46. Meneghel L, Ruffatti A, Gavasso S, Tonello M, Mattia E, Spiezia L, Tormene D,

Hoxha A, Fedrigo M, Simioni P. Detection of IgG anti-Domain I beta2 Glycoprotein

I antibodies by chemiluminescence immunoassay in primary antiphospholipid

syndrome. Clin Chim Acta. 2015 Jun 15;446:201-5. doi: 10.1016/j.cca.2015.04.033.

Epub 2015 Apr 30. PMID: 25935129

47. Haas T, Görlinger K, Grassetto A, Agostini V, Simioni P, Nardi G, Ranucci M. Rotem

and transfusion protocols: not yet time to give recommendations - Authors' reply.

Minerva Anestesiol. 2015 Apr 28. [Epub ahead of print]. PMID: 25918276

48. Spiezia L, Bogana G, Campello E, Maggiolo S, Pelizzaro E, Carbonare CD, Gervasi

MT, Simioni P. Whole blood thromboelastometry profiles in women with

preeclampsia. Clin Chem Lab Med. 2015 Mar 18. pii: /j/cclm.ahead-of-print/cclm-

2014-1128/cclm-2014-1128.xml. doi: 10.1515/cclm-2014-1128. [Epub ahead of print]

PMID: 25803079

49. Suppiej A, Gentilomo C, Saracco P, Sartori S, Agostini M, Bagna R, Bassi B,

Giordano P, Grassi M, Guzzetta A, Lasagni D, Luciani M, Molinari AC, Palmieri A,

Putti MC, Ramenghi LA, Rota LL, Sperlì D, Laverda AM, Simioni P; Stroke working

group of the Italian Registry of Pediatric Thrombosis. Paediatric arterial ischaemic

stroke and cerebral sinovenous thrombosis. First report from the Italian Registry of

Pediatric Thrombosis (R. I. T. I., Registro Italiano Trombosi Infantili). Thromb

Haemost. 2015 Jun;113(6):1270-7. doi: 10.1160/TH14-05-0431. Epub 2015 Mar 12.

PMID: 25761414

50. Meneghel L, Ruffatti A, Gavasso S, Tonello M, Mattia E, Spiezia L, Campello E,

Hoxha A, Fedrigo M, Punzi L, Simioni P. The clinical performance of a

chemiluminescent immunoassay in detecting anti-cardiolipin and anti-β2 glycoprotein

I antibodies. A comparison with a homemade ELISA method. Clin Chem Lab Med.

2015 Jun;53(7):1083-9. doi: 10.1515/cclm-2014-0925. PMID: 25720075

51. Ferrazzi EM, Gervasi MT, Simioni P. Dalteparin for pregnant women with

thrombophilia. Lancet. 2015 Feb 21;385(9969):688-9. doi: 10.1016/S0140-

6736(15)60284-7. Epub 2015 Feb 20. PMID: 25706212

52. Le Bas-Bernardet S, Tillou X, Branchereau J, Dilek N, Poirier N, Châtelais M,

Charreau B, Minault D, Hervouet J, Renaudin K, Crossan C, Scobie L, Takeuchi Y,

Diswall M, Breimer ME, Klar N, Daha MR, Simioni P, Robson SC, Nottle MB,

Salvaris EJ, Cowan PJ, d'Apice AJ, Sachs DH, Yamada K, Lagutina I, Duchi R, Perota

A, Lazzari G, Galli C, Cozzi E, Soulillou JP, Vanhove B, Blancho G. Bortezomib, C1-

Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic

GalT-KO Pig Kidney Xenografts in Baboons. Am J Transplant. 2015 Feb;15(2):358-

70. doi: 10.1111/ajt.12988. PMID: 25612490 [PubMed - in process]

53. Campello E, Spiezia L, Zabeo E, Maggiolo S, Vettor R, Simioni P. Hypercoagulability

detected by whole blood thromboelastometry (ROTEM®) and impedance

aggregometry (MULTIPLATE®) in obese patients. Thromb Res. 2015 Jan 7. pii:

S0049-3848(15)00005-5. doi: 10.1016/j.thromres.2015.01.003. [Epub ahead of print]

PMID: 25592651 [PubMed - as supplied by publisher]

54. Spiezia L, Vasques F, Bovo R, Martini A, Simioni P. Role of factor V Leiden

polymorphism or G20210A prothrombin variant in patients with sudden sensorineural

hearing loss: A meta-analysis of the literature. Thromb Res. 2014 Dec 13. pii: S0049-

3848(14)00667-7. doi: 10.1016/j.thromres.2014.12.011. [Epub ahead of print] PMID:

25538030 [PubMed - as supplied by publisher]

55. Nuzzo F, Bulato C, Nielsen BI, Lee K, Wielders SJ, Simioni P, Key NS, Castoldi E.

Characterization of an apparently synonymous F5 mutation causing aberrant splicing

and factor V deficiency. Haemophilia. 2014 Dec 3. doi: 10.1111/hae.12554. [Epub

ahead of print] PMID: 25470420 [PubMed - as supplied by publisher]

56. Alkozai EM, Porte RJ, Adelmeijer J, Zanetto A, Simioni P, Senzolo M, Lisman T. No

evidence for increased platelet activation in patients with hepatitis B- or C-related

cirrhosis and hepatocellular carcinoma. Thromb Res. 2014 Nov 23. pii: S0049-

3848(14)00625-2. doi: 10.1016/j.thromres.2014.11.016. [Epub ahead of print] PMID:


57. Spiezia L, Mazza A, Pelizzaro E, Campello E, Messina C, Pettenazzo A, Simioni P.

Thromboelastometry-guided therapy of massive gastrointestinal bleeding in a 12-year

old boy with severe Graft-versus-Host Disease. Blood Transfus. 2014 Sep 12:1-3. doi:

10.2450/2014.0031-14. [Epub ahead of print]. PMID: 25369597 [PubMed - as

supplied by publisher]

58. Campello E, Zabeo E, Radu CM, Spiezia L, Gavasso S, Fadin M, Woodhams B, Vettor

R, Simioni P. Hypercoagulability in overweight and obese subjects who are

asymptomatic for thrombotic events. Thromb Haemost. 2014 Oct 16;113(1). [Epub

ahead of print] PMID: 25318550 [PubMed - as supplied by publisher]

59. Alkozai EM, Porte RJ, Adelmeijer J, Zanetto A, Simioni P, Senzolo M, Lisman T.

Levels of angiogenic proteins in plasma and platelets are not different between

patients with hepatitis B/C-related cirrhosis and patients with cirrhosis and

hepatocellular carcinoma. Platelets. 2014 Oct 2:1-6. [Epub ahead of print] PMID:


60. Omarova F, Uitte de Willige S, Simioni P, Ariëns RA, Bertina RM, Rosing J, Castoldi

E. Fibrinogen γ' increases the sensitivity to activated protein C in normal and factor

V Leiden plasma. Blood. 2014 Jun 20. pii: blood-2014-02-554055. [Epub ahead of

print] PMID: 24951429 [PubMed - as supplied by publisher]

61. Spiezia L, Campello E, Bon M, Maggiolo S, Pelizzaro E, Simioni P. Short-term

exposure to high levels of air pollution as a risk factor for acute isolated pulmonary

embolism. Thromb Res. 2014 May 14. pii: S0049-3848(14)00276-X. doi:

10.1016/j.thromres.2014.05.011. [Epub ahead of print] PMID: 24909892 [PubMed -

as supplied by publisher]

62. Campello E, Spiezia L, Radu CM, Gavasso S, Zerbinati P, Woodhams B, Simioni P.

Circulating microparticles in carriers of prothrombin G20210A mutation. Thromb

Haemost. 2014 May 8;112(3). [Epub ahead of print] PMID: 24816676 [PubMed - as

supplied by publisher]

63. Rossitto G, Piano S, Rosi S, Simioni P, Angeli P. Life-threatening coagulopathy and

hypofibrinogenaemia induced by tigecycline in a patient with advanced liver cirrhosis.

Eur J Gastroenterol Hepatol. 2014 Mar 24. [Epub ahead of print] PubMed PMID:

24667348

64. Haas T, Görlinger K, Grassetto A, Agostini V, Simioni P, Nardi G, Ranucci M.

Thromboelastometry for Guiding Bleeding Management of the Critically Ill Patient:

A Systematic Review of the Literature. Minerva Anestesiol. 2014 Feb 11. [Epub ahead

of print] PubMed PMID: 24518216

65. Campello E, Spiezia L, Radu CM, Gavasso S, Woodhams B, Simioni P. Evaluation

of a procoagulant phospholipid functional assay as a routine test for measuring

circulating microparticle activity. Blood Coagul Fibrinolysis. 2014 Jan 10. [Epub

ahead of print] PubMed PMID: 24418946

66. Grassetto A, Fullin G, Cerri G, Simioni P, Spiezia L, Maggiolo C. Management of

severe bleeding in a ruptured extrauterine pregnancy: a theragnostic approach. Blood

Coagul Fibrinolysis. 2014 Mar;25(2):176-9. doi: 10.1097/MBC.0000000000000010.

PubMed PMID: 24253241

67. Segers O, Simioni P, Tormene D, Castoldi E. Influence of single nucleotide

polymorphisms on thrombin generation in factor V Leiden heterozygotes. Thromb

Haemost. 2014 Mar 3;111(3):438-46. doi: 10.1160/TH13-05-0360. Epub 2013 Nov

14. PubMed PMID: 24226152

http://www.ncbi.nlm.nih.gov/pubmed/24816676

68. Pezzani R, Rubin B, Redaelli M, Radu C, Barollo S, Cicala MV, Salvà M, Mian C,

Mucignat-Caretta C,Simioni P, Iacobone M, Mantero F. The antiproliferative effects

of ouabain and everolimus on adrenocortical tumor cells. Endocr J. 2014;61(1):41-

53. Epub 2013 Oct 24. PubMed PMID: 24153038

69. Ammollo CT, Semeraro F, Colucci M, Simioni P. Factor IX-Padua enhances the

fibrinolytic resistance of plasma clots.Thromb Haemost. 2014 Feb;111(2):226-32. doi:

10.1160/TH13-06-0489. Epub 2013 Oct 17. PubMed PMID: 24136406

70. Nuzzo F, Radu C, Baralle M, Spiezia L, Hackeng TM, Simioni P, Castoldi E.

Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a

F5 deep-intronic splicing mutation. Blood. 2013 Nov 28;122(23):3825-31. doi:

10.1182/blood-2013-04-499657. Epub 2013 Oct 1. PubMed PMID: 24085767

71. Radu CM, Spiezia L, Campello E, Gavasso S, Woodhams B, Simioni P. Thrombin

activatable fibrinolysis inhibitor in cancer patients with and without venous

thromboembolism. Thromb Res. 2013 Oct;132(4):484-6. doi:

10.1016/j.thromres.2013.06.018. Epub 2013 Sep 9. PubMed PMID: 24028756

72. Bucciarelli P, De Stefano V, Passamonti SM, Tormene D, Legnani C, Rossi E,

Castaman G, Simioni P, Cini M, Martinelli I. Influence of proband's characteristics

on the risk for venous thromboembolism in relatives with factor V Leiden or

prothrombin G20210A polymorphisms. Blood. 2013 Oct 10;122(15):2555-61. doi:

10.1182/blood-2013-05-503649. Epub 2013 Aug 2. PubMed PMID: 23913469

73. Manara R, Sartori S, Nosadini M, Baracchini C, Citton V, Toldo I, Simioni P,

Gentilomo C, Milanese L, Suppiej A. Secondary parenchymal and vascular changes

after middle cerebral artery stroke in children. Neuroradiology. 2013

Oct;55(10):1259-66. doi: 10.1007/s00234-013-1248-4. Epub 2013 Aug 3. PubMed

PMID: 23913014

74. Rossetto V, Spiezia L, Senzolo M, Rodriguez-Castro KI, Maggiolo S, Simioni P.

Whole blood rotation thromboelastometry (ROTEM®) profiles in subjects with non-

neoplastic portal vein thrombosis. Thromb Res. 2013 Aug;132(2):e131-4. doi:

10.1016/j.thromres.2013.06.009. Epub 2013 Jun 28. PubMed PMID: 23810655

75. Sartori MT, Della Puppa A, Ballin A, Campello E, Radu CM, Saggiorato G, d'Avella

D, Scienza R, Cella G, Simioni P. Circulating microparticles of glial origin and tissue

factor bearing in high-grade glioma: a potential prothrombotic role. Thromb

Haemost. 2013 Aug;110(2):378-85. doi: 10.1160/TH12-12-0957. Epub 2013 Jun 27.


76. Spiezia L, Campello E, Simioni P. "Hypocoagulable" thromboelastography profiles

in patients with cyanotic congenital heart disease: facts or technical artifacts? Int J

Cardiol. 2013 Oct 3;168(3):2914. doi: 10.1016/j.ijcard.2013.03.105. Epub 2013 Apr


77. Rossetto V, Spiezia L, Senzolo M, Rodriguez-Castro KI, Gavasso S, Woodhams

B, Simioni P. Does decreased fibrinolysis have a role to play in the development of

non-neoplastic portal vein thrombosis in patients with hepatic cirrhosis? Intern

Emerg Med. 2013 Mar 17. [Epub ahead of print] PubMed PMID: 23504244

78. Spiezia L, Visentin S, Radu C, Bon M, Woodhams B, Cosmi E, Simioni P.

Association between increased FVIIa-antithrombin complex/FVIIa ratio and pre-

eclampsia. J Matern Fetal Neonatal Med. 2013 Sep;26(13):1352-4. doi:

10.3109/14767058.2013.784265. Epub 2013 Apr 16. PubMed PMID: 23488878

79. Campello E, Spiezia L, Bulato C, Gavasso S, Woodhams B, Simioni P. Factor IX

activity/antigen ratio and the risk of first unprovoked venous thromboembolism.

Thromb Haemost. 2013 Apr;109(4):755-6. doi: 10.1160/TH12-12-0954. Epub 2013

Feb 28. PubMed PMID: 23446552

80. Bulato C, Tognin G, Spiezia L, Fadin M, Gavasso S, Simioni P. Identification of a

novel frameshift mutation causing a premature stop codon in a young Nigerian man

with type I antithrombin deficiency. Thromb Res. 2013 May;131(5):463-5. doi:

10.1016/j.thromres.2013.01.032. Epub 2013 Feb 18. PubMed PMID: 23427904

81. Koutroumpi S, Spiezia L, Albiger N, Barbot M, Bon M, Maggiolo S, Gavasso

S, Simioni P, Frigo A, Mantero F, Scaroni C. Thrombin generation in Cushing's

Syndrome: do the conventional clotting indices tell the whole truth? Pituitary. 2014

Feb;17(1):68-75. doi: 10.1007/s11102-013-0467-3. PubMed PMID: 23408210

82. Spiezia L, Boldrin M, Radu C, Bulato C, Bertini D, Bon M, Campello E, Vadori M,

Galli C, Gavasso S, Nottle MB, Cowan PJ, Cozzi E, Simioni P.

Thromboelastographic evaluation of coagulative profiles in pig-to-monkey kidney

xenotransplantation. Xenotransplantation. 2013 Mar-Apr;20(2):89-99. doi:

10.1111/xen.12024. Epub 2013 Feb 14. PubMed PMID: 23406330

83. Spiezia L, Campello E, Bon M, Tison T, Milan M, Simioni P, Prandoni P. ABO blood

groups and the risk of venous thrombosis in patients with inherited thrombophilia.

Blood Transfus. 2013 Apr;11(2):250-3. doi: 10.2450/2012.0060-12. Epub 2012 Oct


84. Zanon E, Milan M, Brandolin B, Barbar S, Spiezia L, Saggiorato G, Simioni P, Baudo

F. High dose of human plasma-derived FVIII-VWF as first-line therapy in patients

affected by acquired haemophilia A and concomitant cardiovascular disease: four

case reports and a literature review. Haemophilia. 2013 Jan;19(1):e50-3. doi:

10.1111/hae.12033. Epub 2012 Oct 11. Review. PubMed PMID: 23051581

85. Simioni P, Campello E, Spiezia L. Prothrombin mutation conveying antithrombin

resistance. N Engl J Med. 2012 Sep 13;367(11):1069; author reply 1069-70. doi:

10.1056/NEJMc1208510#SA2. PubMed PMID: 22970963

86. Rossetto V, Spiezia L, Senzolo M, Rodriguez K, Gavasso S, Woodhams B, Simioni

P. Factor VIIa-antithrombin complexes in patients with non-neoplastic portal vein

thrombosis with and without cirrhosis. Int J Lab Hematol. 2013 Feb;35(1):101-5. doi:

10.1111/ijlh.12003. Epub 2012 Sep 10. PubMed PMID: 22958499

87. Finn JD, Nichols TC, Svoronos N, Merricks EP, Bellenger DA, Zhou S, Simioni P,

High KA, Arruda VR. The efficacy and the risk of immunogenicity of FIX Padua

(R338L) in hemophilia B dogs treated by AAV muscle gene therapy. Blood. 2012 Nov

29;120(23):4521-3. doi: 10.1182/blood-2012-06-440123. Epub 2012 Aug 23. PubMed

PMID: 22919027

88. Simioni P, Spiezia L. Reprint of: Factor VIIa-AT complex plasma levels and arterial

thrombosis. Thromb Res. 2012 Aug;130(2):141. doi: 10.1016/j.thromres.2012.07.003.


89. Campello E, Spiezia L, Radu CM, Bon M, Gavasso S, Zerbinati P, Woodhams B,

Tormene D, Prandoni P, Simioni P. Circulating microparticles in carriers of factor V

Leiden with and without a history of venous thrombosis. Thromb Haemost. 2012

Oct;108(4):633-9. Epub 2012 Jul 26. PubMed PMID: 22836806

90. Rodriguez-Castro KI, Simioni P, Burra P, Senzolo M. Anticoagulation for the

treatment of thrombotic complications in patients with cirrhosis. Liver Int. 2012

Nov;32(10):1465-76. doi: 10.1111/j.1478-3231.2012.02839.x. Epub 2012 Jun 27.

Review. PubMed PMID: 22734713

91. Senzolo M, Rodriguez-Castro KI, Rossetto V, Radu C, Gavasso S, Carraro P, Zerbinati

P, Sartori MT,Simioni P. Increased anticoagulant response to low-molecular-weight

heparin in plasma from patients with advanced cirrhosis. J Thromb Haemost. 2012

Sep;10(9):1823-9. doi: 10.1111/j.1538-7836.2012.04824.x. PubMed PMID:

22712870

92. Rossetto V, Spiezia L, Dabrilli P, Gavasso S, Simioni P. Effect on thrombin

generation of the "in vitro" addition of low-dose LMWH to plasma of healthy pregnant

and nonpregnant women. Clin Appl Thromb Hemost. 2012 Jun;18(3):331-3. doi:

10.1177/1076029611429787. PubMed PMID: 22566703

93. Bulato C, Radu C, Simioni P. Studies on coagulation incompatibilities for

xenotransplantation. Methods Mol Biol. 2012;885:71-89. doi: 10.1007/978-1-61779-

845-0_6. PubMed PMID: 22565991

94. Spiezia L, Campello E, Bon M, Gavasso S, Woodhams B, Simioni P. Factor VIIa-

antithrombin complexes plasma levels in cancer patients with and without thrombosis.

Thromb Res. 2012 Jun;129(6):818-9. doi: 10.1016/j.thromres.2012.02.046. Epub

2012 Mar 22. PubMed PMID: 22444156

95. Senzolo M, M Sartori T, Rossetto V, Burra P, Cillo U, Boccagni P, Gasparini D,

Miotto D, Simioni P, Tsochatzis E, A Burroughs K. Prospective evaluation of

anticoagulation and transjugular intrahepatic portosystemic shunt for the

management of portal vein thrombosis in cirrhosis. Liver Int. 2012 Jul;32(6):919-27.

doi: 10.1111/j.1478-3231.2012.02785.x. Epub 2012 Mar 21. PubMed PMID:

22435854

96. Simioni P. Thrombosis risk in purely obstetric APS. Blood. 2012 Mar

15;119(11):2435-6. doi: 10.1182/blood-2012-01-398735. PubMed PMID: 22422812

97. Tormene D, Grandone E, De Stefano V, Tosetto A, Palareti G, Margaglione M,

Castaman G, Rossi E, Ciminello A, Valdrè L, Legnani C, Tiscia GL, Bafunno V,

Carraro S, Rodeghiero F, Simioni P. Obstetric complications and pregnancy-related

venous thromboembolism: the effect of low-molecular-weight heparin on their

prevention in carriers of factor V Leiden or prothrombin G20210A mutation. Thromb

Haemost. 2012 Mar;107(3):477-84. doi: 10.1160/TH11-07-0470. Epub 2012 Jan 25.


98. Kenet G, Aronis S, Berkun Y, Bonduel M, Chan A, Goldenberg NA, Holzhauer S,

Iorio A, Journeycake J, Junker R, Male C, Manco-Johnson M, Massicotte P, Mesters

R, Monagle P, van Ommen H, Rafini L,Simioni P, Young G, Nowak-Göttl U. Impact

of persistent antiphospholipid antibodies on risk of incident symptomatic

thromboembolism in children: a systematic review and meta-analysis. Semin Thromb

Hemost. 2011 Oct;37(7):802-9. doi: 10.1055/s-0031-1297171. Epub 2011 Dec 20.

Review. PubMed PMID: 22187403

99. Spiezia L, Radu C, Bulato C, Tognin G, Gavasso S, Barillari G, Pradella P, De Angelis

V, Simioni P. Platelet factor V levels in moderate to severe congenital factor V

deficiency. Haemophilia. 2012 Mar;18(2):e53-5. doi: 10.1111/j.1365-

2516.2011.02717.x. Epub 2011 Dec 19. PubMed PMID: 22176589

100. Spiezia L, Radu C, Campello E, Bulato C, Bertini D, Barillari G, De Angelis V,

Pradella P, Zanon E,Simioni P. Whole blood rotation thromboelastometry

(ROTEM(®)) in nine severe factor V deficient patients and evaluation of the role of

intraplatelets factor V. Haemophilia. 2012 May;18(3):463-8. doi: 10.1111/j.1365-


101. Tarzia V, Bottio T, Buratto E, Spiezia L, Simioni P, Gerosa G. The hazard of

comparing apples and oranges: the proper indication for the use of recombinant

activated clotting factor VII in cardiac surgery. J Thorac Cardiovasc Surg. 2011

Dec;142(6):1588-9; author reply 1589. doi: 10.1016/j.jtcvs.2011.08.028. PubMed

PMID: 22093717

102. Tarzia V, Bottio T, Buratto E, Spiezia L, Simioni P, Gerosa G. Freedom solo stentless

aortic valve: quantitative and qualitative assessment of thrombocytopenia. Ann

Thorac Surg. 2011 Nov;92(5):1935. doi: 10.1016/j.athoracsur.2011.06.040. Epub

2011 Oct 31. PubMed PMID: 22051309

103. Segers O, Simioni P, Tormene D, Bulato C, Gavasso S, Rosing J, Castoldi E. Genetic

modulation of the FV(Leiden)/normal FV ratio and risk of venous thrombosis in factor

V Leiden heterozygotes. J Thromb Haemost. 2012 Jan;10(1):73-80. doi:

10.1111/j.1538-7836.2011.04546.x. PubMed PMID: 22044617

104. Simioni P, Spiezia L. Factor VIIa-AT complex plasma levels and arterial thrombosis.

Thromb Res. 2011 Dec;128(6):507. doi: 10.1016/j.thromres.2011.09.020. Epub 2011

Oct 11. PubMed PMID: 21995975

105. Spiezia L, Campello E, Gentilomo C, Gavasso S, Woodhams B, Laverda AM, Simioni

P. Factor VIIa-antithrombin complexes in children with ischemic stroke. Thromb Res.

2011 Sep;128(3):303-4. doi: 10.1016/j.thromres.2011.05.020. Epub 2011 Jun 25.


106. Tormene D, Ferri V, Carraro S, Simioni P. Gender and the risk of venous

thromboembolism. Semin Thromb Hemost. 2011 Apr;37(3):193-8. doi: 10.1055/s-

0031-1273083. Epub 2011 Mar 31. Review. PubMed PMID: 21455853

107. Senzolo M, Sartori MT, Rodriguez-Castro K, Simioni P, Rossetto V. Increased

thrombin generation in liver transplant recipients: does immunosuppressive therapy

play a role? Liver Transpl. 2011 Mar;17(3):347-8. doi: 10.1002/lt.22229. PubMed

PMID: 21384519

108. Castoldi E, Duckers C, Radu C, Spiezia L, Rossetto V, Tagariello G, Rosing J, Simioni

P. Homozygous F5 deep-intronic splicing mutation resulting in severe factor V

deficiency and undetectable thrombin generation in platelet-rich plasma. J Thromb

Haemost. 2011 May;9(5):959-68. doi: 10.1111/j.1538-7836.2011.04237.x. PubMed

PMID: 21320286

109. Campello E, Spiezia L, Radu CM, Bulato C, Castelli M, Gavasso S, Simioni P.

Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with

and without venous thromboembolism. Thromb Res. 2011 May;127(5):473-7. doi:

10.1016/j.thromres.2011.01.002. Epub 2011 Jan 22. PubMed PMID: 21256535

110. Duckers C, Simioni P, Tormene D, Carraro S, Rosing J, Castoldi E. Factor V Leiden

pseudo-homozygotes have a more pronounced hypercoagulable state than factor V

Leiden homozygotes. J Thromb Haemost. 2011 Apr;9(4):864-7. doi: 10.1111/j.1538-

7836.2011.04205.x. PubMed PMID: 21251207

111. Dragoni F, Chiarotti F, Rosano G, Simioni P, Tormene D, Mazzucconi MG, Cafolla

A, Avvisati G. Thrombophilic screening in young patients (< 40 years) with idiopathic

ischemic stroke: a controlled study. Thromb Res. 2011 Feb;127(2):85-90. doi:

10.1016/j.thromres.2010.11.013. Epub 2010 Dec 18. PubMed PMID: 21172722

112. Bartolini L, Gentilomo C, Sartori S, Calderone M, Simioni P, Laverda AM. Varicella

and stroke in children: good outcome without steroids. Clin Appl Thromb Hemost.

2011 Nov-Dec;17(6):E127-30. doi: 10.1177/1076029610389025. Epub 2010 Dec 15.


113. Simioni P, Boldrin M, Gavasso S, Seveso M, Radu C, Bulato C, Calabrese F,

Cavicchioli L, Bertini D, De Benedictis GM, Besenzon F, Baldan N, Spiezia L, Plebani

M, Ancona E, Cozzi E. Effects of long-term administration of recombinant human

protein C in xenografted primates. Transplantation. 2011 Jan 27;91(2):161-8. doi:

10.1097/TP.0b013e318200ba0e. PubMed PMID: 21088649

114. Zanon E, Sartori MT, Spiezia L, Brandolin B, Simioni P, Manara R. Outcome of long-

term prophylaxis after cerebral hemorrhage in a patient with severe hemophilia B.

Clin Appl Thromb Hemost. 2011 Oct;17(5):535-8. doi: 10.1177/1076029610384110.

Epub 2010 Nov 15. PubMed PMID: 21078618

115. Spiezia L, Bertini D, Boldrin M, Radu C, Bulato C, Gavasso S, Cozzi E, Simioni P.

Reference values for thromboelastometry (ROTEM®) in cynomolgus monkeys

(Macaca fascicularis). Thromb Res. 2010 Oct;126(4):e294-7. doi:

10.1016/j.thromres.2010.07.016. Epub 2010 Aug 11. PubMed PMID: 20705332

116. Rizzardi E, Tagliaferro T, Snijders D, Bertuola F, Spolaore F, Simioni P, Maimone P,

Pinello L, Mazzarolo M, Barbato A. D-dimer evaluation of hemorrhagic orbital

lymphangioma. J Pediatr Ophthalmol Strabismus. 2010 May-Jun;47(3):174-7.


117. Spiezia L, Rossetto V, Campello E, Gavasso S, Woodhams B, Tormene D, Simioni P.

Factor VIIa-antithrombin complexes in patients with arterial and venous thrombosis.

Thromb Haemost. 2010 Jun;103(6):1188-92. doi: 10.1160/TH09-08-0606. Epub 2010

Apr 29. PubMed PMID: 20431847

118. Castoldi E, Maurissen LF, Tormene D, Spiezia L, Gavasso S, Radu C, Hackeng TM,

Rosing J, Simioni P. Similar hypercoagulable state and thrombosis risk in type I and

type III protein S-deficient individuals from families with mixed type I/III protein S

deficiency. Haematologica. 2010 Sep;95(9):1563-71. doi:

10.3324/haematol.2010.021923. Epub 2010 Apr 26. PubMed PMID: 20421270

119. Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S,

Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther

G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K,

Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH,

Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U. Impact of

thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis

in neonates and children: a systematic review and meta-analysis of observational

studies. Circulation. 2010 Apr 27;121(16):1838-47. doi:

10.1161/CIRCULATIONAHA.109.913673. Epub 2010 Apr 12. Review. PubMed

PMID: 20385928

120. Castoldi E, Maurissen LF, Tormene D, Spiezia L, Gavasso S, Radu C, Hackeng TM,

Rosing J,Simioni P. Similar hypercoagulable state and thrombosis risk in type I and

type III protein S-deficient individuals from mixed type I/III families. Haematologica.

2010 Apr 7. doi: 10.3324/haematol.2009.021923. Epub 2010 Apr 7. PubMed PMID:

20378562

121. Maurissen LF, Castoldi E, Simioni P, Rosing J, Hackeng TM. Thrombin generation-

based assays to measure the activity of the TFPI-protein S pathway in plasma from

normal and protein S-deficient individuals. J Thromb Haemost. 2010 Apr;8(4):750-8.

doi: 10.1111/j.1538-7836.2010.03743.x. Epub 2010 Jan 17. PubMed PMID:

20088940

122. Castoldi E, Simioni P, Tormene D, Rosing J, Hackeng TM. Hereditary and acquired

protein S deficiencies are associated with low TFPI levels in plasma. J Thromb

Haemost. 2010 Feb;8(2):294-300. doi: 10.1111/j.1538-7836.2009.03712.x. Epub

2009 Nov 30. PubMed PMID: 20002538

123. Duckers C, Simioni P, Spiezia L, Radu C, Dabrilli P, Gavasso S, Rosing J, Castoldi

E. Residual platelet factor V ensures thrombin generation in patients with severe

congenital factor V deficiency and mild bleeding symptoms. Blood. 2010 Jan

28;115(4):879-86. doi: 10.1182/blood-2009-08-237719. Epub 2009 Oct 27. PubMed

PMID: 19861681

124. Simioni P, Tormene D, Tognin G, Gavasso S, Bulato C, Iacobelli NP, Finn JD, Spiezia

L, Radu C, Arruda VR. X-linked thrombophilia with a mutant factor IX (factor IX

Padua). N Engl J Med. 2009 Oct 22;361(17):1671-5. doi: 10.1056/NEJMoa0904377.


125. Spiezia L, Simioni P. Upper extremity deep vein thrombosis. Intern Emerg Med. 2010

Apr;5(2):103-9. doi: 10.1007/s11739-009-0320-x. Epub 2009 Sep 26. Review.


126. Lussana F, Dentali F, Abbate R, d'Aloja E, D'Angelo A, De Stefano V, Faioni EM,

Grandone E, Legnani C, Martinelli I, Simioni P, Tormene D; Italian Society for

Haemostasis and Thrombosis. Screening for thrombophilia and antithrombotic

prophylaxis in pregnancy: Guidelines of the Italian Society for Haemostasis and

Thrombosis (SISET). Thromb Res. 2009 Nov;124(5):e19-25. doi:

10.1016/j.thromres.2009.06.031. Epub 2009 Aug 11. PubMed PMID: 19671474

127. Tormene D, Barbar S, Perlati M, Brandolin B, Simioni P. Sex-related type of venous

thromboembolism in patients with and without thrombophilia. Thromb Haemost. 2009

Jul;102(1):177-8. doi: 10.1160/TH09-02-0116. PMID: 19572085

128. Rossetto V, Spiezia L, Franz F, Salmaso L, Pozza LV, Gavasso S, Simioni P. The role

of antiphospholipid antibodies toward the protein C/protein S system in venous

thromboembolic disease. Am J Hematol. 2009 Sep;84(9):594-6. doi:

10.1002/ajh.21466. PubMed PMID: 19565645

129. Duckers C, Simioni P, Rosing J, Castoldi E. Advances in understanding the bleeding

diathesis in factor V deficiency. Br J Haematol. 2009 Jun;146(1):17-26. doi:

10.1111/j.1365-2141.2009.07708.x. Epub 2009 Apr 27. Review. PubMed PMID:

19438479

130. Prandoni P, Prins MH, Lensing AW, Ghirarduzzi A, Ageno W, Imberti D,

Scannapieco G, Ambrosio GB, Pesavento R, Cuppini S, Quintavalla R, Agnelli G;

AESOPUS Investigators. Residual thrombosis on ultrasonography to guide the

duration of anticoagulation in patients with deep venous thrombosis: a randomized

trial. Ann Intern Med. 2009 May 5;150(9):577-85. PubMed PMID: 19414836

131. Vadori M, Seveso M, Besenzon F, Bosio E, Tognato E, Fante F, Boldrin M, Gavasso

S, Ravarotto L, Mann BE, Simioni P, Ancona E, Motterlini R, Cozzi E. In vitro and

in vivo effects of the carbon monoxide-releasing molecule, CORM-3, in the xenogeneic

pig-to-primate context. Xenotransplantation. 2009 Mar-Apr;16(2):99-114. doi:

10.1111/j.1399-3089.2009.00521.x. PubMed PMID: 19392725

132. Simioni P. Thrombophilia and gestational VTE. Thromb Res. 2009;123 Suppl 2:S41-

4. doi: 10.1016/S0049-3848(09)70009-X. PubMed PMID: 19217475

133. Spiezia L, Radu C, Marchioro P, Bertini D, Rossetto V, Castelli M, Pagnan A,

Sørensen B, Simioni P. Peculiar whole blood rotation thromboelastometry (Rotem)

profile in 40 sideropenic anaemia patients. Thromb Haemost. 2008 Dec;100(6):1106-


134. Prandoni P, Tormene D, Spiezia L, Pesavento R, Simioni P. Duration of

anticoagulation and risk of recurrent thromboembolism in carriers of factor V Leiden

or prothrombin mutation. J Thromb Haemost. 2008 Dec;6(12):2223-4. doi:

10.1111/j.1538-7836.2008.03173.x. Epub 2008 Oct 1. PubMed PMID: 18983490

135. Spiezia L, Meneghetti L, Dalla Valle F, Tognin G, Radu C, Saggiorato G, Fadin M,

Zanon E, Simioni P. Potential role of thrombelastography in the monitoring of

acquired factor VIII inhibitor hemophilia A: report on a 78-year-old woman with life-

threatening bleedings. Clin Appl Thromb Hemost. 2009 Jul-Aug;15(4):470-6. doi:

10.1177/1076029608326167. Epub 2008 Oct 16. PubMed PMID: 18930953

136. Young G, Albisetti M, Bonduel M, Brandao L, Chan A, Friedrichs F, Goldenberg NA,

Grabowski E, Heller C, Journeycake J, Kenet G, Krümpel A, Kurnik K, Lubetsky A,

Male C, Manco-Johnson M, Mathew P, Monagle P, van Ommen H, Simioni P, Svirin

P, Tormene D, Nowak-Göttl U. Impact of inherited thrombophilia on venous

thromboembolism in children: a systematic review and meta-analysis of observational

studies. Circulation. 2008 Sep 23;118(13):1373-82. doi:

10.1161/CIRCULATIONAHA.108.789008. Epub 2008 Sep 8. Review. PubMed

PMID: 18779442

137. Duckers C, Simioni P, Spiezia L, Radu C, Gavasso S, Rosing J, Castoldi E. Low

plasma levels of tissue factor pathway inhibitor in patients with congenital factor V

deficiency. Blood. 2008 Nov 1;112(9):3615-23. doi: 10.1182/blood-2008-06-162453.

Epub 2008 Aug 11. PubMed PMID: 18695002

138. Camporese G, Bernardi E, Prandoni P, Noventa F, Verlato F, Simioni P, Ntita K,

Salmistraro G, Frangos C, Rossi F, Cordova R, Franz F, Zucchetta P, Kontothanassis

D, Andreozzi GM; KANT (Knee Arthroscopy Nadroparin Thromboprophylaxis)

Study Group. Low-molecular-weight heparin versus compression stockings for

thromboprophylaxis after knee arthroscopy: a randomized trial. Ann Intern Med.

2008 Jul 15;149(2):73-82. PubMed PMID: 18626046

139. Spiezia L, Marchioro P, Radu C, Rossetto V, Tognin G, Monica C, Salmaso

L, Simioni P. Whole blood coagulation assessment using rotation thrombelastogram

thromboelastometry in patients with acute deep vein thrombosis. Blood Coagul

Fibrinolysis. 2008 Jul;19(5):355-60. doi: 10.1097/MBC.0b013e328309044b. PubMed

PMID: 18600082

140. Tormene D, Beltramello P, Perlati M, Brandolin B, Barbar S, De Toffoli G, Simioni

P. The risk of cancer progression in women with gynecological malignancies and

thrombophilic polymorphisms: a pilot case-control study. Clin Appl Thromb Hemost.

2009 Oct;15(5):535-9. doi: 10.1177/1076029608317941. Epub 2008 Jun 29. PubMed

PMID: 18591179

141. Zanon E, Gentilomo C, Laverda A, Suppiej A, Saggiorato G, Manara R, Simioni P.

Cerebral sinus venous thrombosis with parenchymal infarcts in a newborn with severe

haemophilia A and subdural haematomas. Haemophilia. 2008 Sep;14(5):1117-21. doi:

10.1111/j.1365-2516.2008.01794.x. Epub 2008 Jul 8. PubMed PMID: 18582228

142. Spiezia L, Bertini D, Salmaso L, Simioni P. Whole blood rotation thrombelastometry

in subjects undergoing vitamin K antagonist treatment: hypo- or hypercoagulable

profiles? Thromb Res. 2008;122(4):568-9. doi: 10.1016/j.thromres.2008.04.006. Epub

2008 Jun 4. PubMed PMID: 18534666

143. Michelin E, Snijders D, Conte S, Dalla Via P, Tagliaferro T, Da Dalt L, Monciotti

CM, Simioni P, Stefanutti G, Ghirardo V, Gamba P, Barbato A. Procoagulant activity

in children with community acquired pneumonia, pleural effusion and empyema.

Pediatr Pulmonol. 2008 May;43(5):472-5. doi: 10.1002/ppul.20795. PubMed PMID:

18383331

144. Spiezia L, Tormene D, Pesavento R, Salmaso L, Simioni P, Prandoni P.

Thrombophilia as a predictor of persistent residual vein thrombosis. Haematologica.

2008 Mar;93(3):479-80. doi: 10.3324/haematol.12205. PubMed PMID: 18310547

145. Huisman MV, Klok FA, Karami Djurabi R, Tormene D, Simioni P, Prandoni P.

Factor V Leiden is associated with more distal location of deep vein thrombosis of the

leg. J Thromb Haemost. 2008 Mar;6(3):544-5. doi: 10.1111/j.1538-


146. Suppiej A, Franzoi M, Gentilomo C, Battistella PA, Drigo P, Gavasso S, Laverda

AM, Simioni P. High prevalence of inherited thrombophilia in 'presumed peri-

neonatal' ischemic stroke. Eur J Haematol. 2008 Jan;80(1):71-5. Epub 2007 Nov 19.


147. Tormene D, De Stefano V, Grandone E, Za T, Perlati M, Rossi E, Margaglione

M, Simioni P. The G20210A prothrombin variant and the risk of venous

thromboembolism or fetal loss in pregnant women: a family study. J Thromb Haemost.

2007 Nov;5(11):2193-6. PubMed PMID: 17958738

148. Spiezia L, Rossetto V, Zuin A, Pagnan A, Simioni P. Acute oppressive chest pain in

a 66-year-old woman with a recent Amplatzer device closure of patent foramen ovale.

Intern Emerg Med. 2007 Oct;2(3):229-30. Epub 2007 Oct 1. PubMed PMID:

17912492

149. Gentilomo C, Franzoi M, Laverda AM, Suppiej A, Battistella PA, Simioni P. Cerebral

sinovenous thrombosis in children: thrombophilia and clinical outcome. Thromb Res.

2008;121(4):589-91. Epub 2007 Aug 1. PubMed PMID: 17675220

150. Castoldi E, Simioni P, Tormene D, Thomassen MC, Spiezia L, Gavasso S, Rosing J.

Differential effects of high prothrombin levels on thrombin generation depending on

the cause of the hyperprothrombinemia. J Thromb Haemost. 2007 May;5(5):971-9.


151. Prandoni P, Noventa F, Ghirarduzzi A, Pengo V, Bernardi E, Pesavento R, Iotti M,

Tormene D,Simioni P, Pagnan A. The risk of recurrent venous thromboembolism after

discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or

pulmonary embolism. A prospective cohort study in 1,626 patients. Haematologica.

2007 Feb;92(2):199-205. PubMed PMID: 17296569

152. Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, Simioni P, Ottaviano F, Damasceno

BP, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Promoter polymorphisms in the

plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic

stroke among young adults and children. Stroke. 2007 Jan;38(1):41-9. Epub 2006 Nov


153. Tormene D, Gavasso S, Rossetto V, Simioni P. Thrombosis and thrombophilia in

children: a systematic review. Semin Thromb Hemost. 2006 Oct;32(7):724-8. Review.


154. Simioni P, Tormene D, Spiezia L, Tognin G, Rossetto V, Radu C, Prandoni P.

Inherited thrombophilia and venous thromboembolism. Semin Thromb Hemost. 2006

Oct;32(7):700-8. Review. PubMed PMID: 17024597

155. Simioni P. Who should be tested for thrombophilia? Curr Opin Hematol. 2006

Sep;13(5):337-43. Review. PubMed PMID: 16888438

156. De Stefano V, Simioni P, Rossi E, Tormene D, Za T, Pagnan A, Leone G. The risk of

recurrent venous thromboembolism in patients with inherited deficiency of natural

anticoagulants antithrombin, protein C and protein S. Haematologica. 2006

May;91(5):695-8. PubMed PMID: 16670075

157. Brugge JM, Simioni P, Bernardi F, Tormene D, Lunghi B, Tans G, Pagnan A, Rosing

J, Castoldi E. Expression of the normal factor V allele modulates the APC resistance

phenotype in heterozygous carriers of the factor V Leiden mutation. J Thromb

Haemost. 2005 Dec;3(12):2695-702. PubMed PMID: 16359508

158. Cozzi E, Simioni P, Boldrin M, Seveso M, Calabrese F, Baldan N, Busetto R,

Tormene D, Gavasso S, Castagnaro M, Echelard Y, Rice T, Plebani M, Carraro P,

Bosio E, Valente M, Pagnan A, Thiene G, Ancona E. Effects of long-term

administration of high-dose recombinant human antithrombin in immunosuppressed

primate recipients of porcine xenografts. Transplantation. 2005 Nov 27;80(10):1501-


159. Tormene D, Fortuna S, Tognin G, Gavasso S, Pagnan A, Prandoni P, Simioni P. The

incidence of venous thromboembolism in carriers of antithrombin, protein C or

protein S deficiency associated with the HR2 haplotype of factor V: a family cohort

study. J Thromb Haemost. 2005 Jul;3(7):1414-20. PubMed PMID: 15978097

160. Simioni P, Castoldi E, Lunghi B, Tormene D, Rosing J, Bernardi F. An underestimated

combination of opposites resulting in enhanced thrombotic tendency. Blood. 2005 Oct

1;106(7):2363-5. Epub 2005 Jun 16. PubMed PMID: 15961511

161. Simioni P, Morboeuf O, Tognin G, Gavasso S, Tormene D, Woodhams B, Pagnan A.

Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism

in carriers of two dysfunctional protein C variants. Thromb Res. 2006;117(5):523-8.


162. Zanardo V, Savio V, Sabrina G, Franzoi M, Zerbinati P, Fadin M, Tognin G, Tormene

D, Pagnan A,Simioni P. The effect of pre-eclampsia on the levels of coagulation and

fibrinolysis factors in umbilical cord blood of newborns. Blood Coagul Fibrinolysis.

2005 Apr;16(3):177-81. PubMed PMID: 15795535

163. Gould WR, Simioni P, Silveira JR, Tormene D, Kalafatis M, Tracy PB.

Megakaryocytes endocytose and subsequently modify human factor V in vivo to form

the entire pool of a unique platelet-derived cofactor. J Thromb Haemost. 2005

Mar;3(3):450-6. PubMed PMID: 15748232

164. Mazzoleni S, Putti MC, Simioni P, Sainati L, Tormene D, Manara R, Carli M. Early

cerebral sinovenous thrombosis in a child with acute lymphoblastic leukemia carrying

the prothrombin G20210A variant: a case report and review of the literature. Blood

Coagul Fibrinolysis. 2005 Jan;16(1):43-9. PubMed PMID: 15650545

165. Preston RJ, Villegas-Mendez A, Sun YH, Hermida J, Simioni P, Philippou H,

Dahlbäck B, Lane DA. Selective modulation of protein C affinity for EPCR and

phospholipids by Gla domain mutation. FEBS J. 2005 Jan;272(1):97-108. PubMed

PMID: 15634335

166. Tormene D, Simioni P, Pagnan A, Prandoni P. The G20210A prothrombin gene

mutation: is there room for screening families? J Thromb Haemost. 2004

Aug;2(8):1487-8. PubMed PMID: 15304069

167. Prandoni P, Bernardi E, Marchiori A, Lensing AW, Prins MH, Villalta S, Bagatella P,

Sartor D, Piccioli A, Simioni P, Pagnan A, Girolami A. The long term clinical course

of acute deep vein thrombosis of the arm: prospective cohort study. BMJ. 2004 Aug

28;329(7464):484-5. Epub 2004 Jul 15. PubMed PMID: 15256419

168. Tormene D, Pagnan A, Prandoni P, Simioni P. Screening for thrombophilia in

children: a puzzling decision with unclear implications. J Thromb Haemost. 2004

Jul;2(7):1193-4. PubMed PMID: 15219210

169. Bernardi E, Bagatella P, Frulla M, Simioni P, Prandoni P. Postthrombotic syndrome:

incidence, prevention, and management. Semin Vasc Med. 2001;1(1):71-80. Review.


170. Cozzi E, Simioni P, Boldrin M, Seveso M, Calabrese F, Baldan N, Castagnaro M,

Gavasso S, Fadin M, Zerbinati P, Tormene D, Tognin G, Thiene G, Pagnan A, Ancona

E. Alterations in the coagulation profile in renal pig-to-monkey xenotransplantation.

Am J Transplant. 2004 Mar;4(3):335-45. PubMed PMID: 14961985

171. Colucci M, Simioni P, Piro D, Prandoni P, Pagnan A, Semeraro N. An antifibrinolytic

effect associated with an anti-factor V antibody in a patient with severe thrombophilia.

Haematologica. 2003 Dec;88(12):1383-9. PubMed PMID: 14687992

172. Sartori MT, Danesin C, Saggiorato G, Tormene D, Simioni P, Spiezia L, Patrassi

GM, Girolami A. The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis

in patients with inherited thrombophilia. Clin Appl Thromb Hemost. 2003

Oct;9(4):299-307. PubMed PMID: 14653439

173. Spiezia L, Bernardi E, Tormene D, Simioni P, Girolami A, Prandoni P. Recurrent

thromboembolism in fertile women with venous thrombosis: incidence and risk

factors. Thromb Haemost. 2003 Nov;90(5):964-6. PubMed PMID: 14597998

174. Prandoni P, Simioni P, Pagnan A. [Therapeutic indications for acute venous

thromboembolism. Current status and future perspectives]. Minerva Cardioangiol.

2003 Aug;51(4):361-71. Italian. PubMed PMID: 12900718

175. Simioni P. Risk of recurrent venous thromboembolism and thrombophilia: does

discrepancy make complexity or vice versa? J Thromb Haemost. 2003 Jan;1(1):16-8.


176. Carraro P, Simioni P. Appropriateness of choice and interpretation of tests for

thrombophilic defects: a practical experience. Clin Chim Acta. 2003 Jul

15;333(2):191-3. PubMed PMID: 12849904

177. Cafolla A, Dragoni F, Puopolo M, Ruzzi L, Chiarotti F, Silvestri L, Bongarzoni

V, Simioni P. Folate status and homocysteine level in Italian patients aged under 60

on oral anticoagulant therapy. Ann Med. 2003;35(2):140-4. PubMed PMID:

12795342

178. Paternoster DM, Stella A, Simioni P, Girolami A, Snijders D. Activated protein C

resistance in normal and pre-eclamptic pregnancies. Gynecol Obstet Invest.

2002;54(3):145-9. PubMed PMID: 12571435

179. Prandoni P, Lensing AW, Prins MH, Bernardi E, Marchiori A, Bagatella P, Frulla M,

Mosena L, Tormene D, Piccioli A, Simioni P, Girolami A. Residual venous

thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern

Med. 2002 Dec 17;137(12):955-60. PubMed PMID: 12484710

180. Prandoni P, Lensing AW, Piccioli A, Bernardi E, Simioni P, Girolami B, Marchiori

A, Sabbion P, Prins MH, Noventa F, Girolami A. Recurrent venous thromboembolism

and bleeding complications during anticoagulant treatment in patients with cancer

and venous thrombosis. Blood. 2002 Nov 15;100(10):3484-8. Epub 2002 Jul 12.


181. Bilora F, Boccioletti V, Manfredini E, Petrobelli F, Tormene D, Simioni P, Girolami

A. Seasonal variation in the incidence of deep vein thrombosis in patients with

deficiency of protein C or protein S. Clin Appl Thromb Hemost. 2002 Jul;8(3):231-7.


182. Tormene D, Simioni P, Prandoni P, Franz F, Zerbinati P, Tognin G, Girolami A. The

incidence of venous thromboembolism in thrombophilic children: a prospective cohort

study. Blood. 2002 Oct 1;100(7):2403-5. PubMed PMID: 12239149

183. Kalafatis M, Simioni P, Tormene D, Beck DO, Luni S, Girolami A. Isolation and

characterization of an antifactor V antibody causing activated protein C resistance

from a patient with severe thrombotic manifestations. Blood. 2002 Jun 1;99(11):3985-


184. Hung K, Sun X, Ding H, Kalafatis M, Simioni P, Guo B. A matrix-assisted laser

desorption/ionization time-of-flight based method for screening the 1691G --> A

mutation in the factor V gene. Blood Coagul Fibrinolysis. 2002 Mar;13(2):117-22.


185. Simioni P, Tormene D, Prandoni P, Zerbinati P, Gavasso S, Cefalo P, Girolami A.

Incidence of venous thromboembolism in asymptomatic family members who are

carriers of factor V Leiden: a prospective cohort study. Blood. 2002 Mar

15;99(6):1938-42. PubMed PMID: 11877263

186. Franzoi M, Simioni P, Luni S, Zerbinati P, Girolami A, Zanardo V. Effect of delivery

modalities on the physiologic inhibition system of coagulation of the neonate. Thromb

Res. 2002 Jan 1;105(1):15-8. PubMed PMID: 11864701

187. Turri D, Rosselli M, Simioni P, Tormene D, Grimaudo S, Martorana G, Siragusa S,

Mariani G, Cottone M. Factor V Leiden and prothrombin gene mutation in

inflammatory bowel disease in a Mediterranean area. Dig Liver Dis. 2001

Oct;33(7):559-62. Erratum in: Dig Liver Dis 2002 Mar;34(3):212. Siracusa S

[corrected to Siragusa S]. PubMed PMID: 11816544

188. Tormene D, Simioni P, Prandoni P, Luni S, Zerbinati P, Sartor D, Franz F, Girolami

A. Factor V Leiden mutation and the risk of venous thromboembolism in pregnant

women. Haematologica. 2001 Dec;86(12):1305-9. PubMed PMID: 11726323

189. Dragoni F, Tormene D, Simioni P, Arcieri P, Avvisati G, Girolami A. ProC global: a

new automated screening assay for the evaluation of total function of the protein C

system. Clin Appl Thromb Hemost. 2001 Oct;7(4):351-5. PubMed PMID: 11697723

190. Simioni P, Kalafatis M, Tormene D, Luni S, Zerbinati P, Barzon L, Palù G, Girolami

A. Abnormal propeptide processing resulting in the presence of two abnormal species

of protein C in plasma: characterization of the dysfunctional protein C Padua3

(protein C(R-1L/propeptide)). Thromb Haemost. 2001 Oct;86(4):1017-22. PubMed

PMID: 11686318

191. Simioni P, Tormene D, Prandoni P, Girolami A. Pregnancy-related recurrent events

in thrombophilic women with previous venous thromboembolism. Thromb Haemost.

2001 Sep;86(3):929. PubMed PMID: 11583329

192. Kalafatis M, Simioni P, Bernardi F. Phenotype and genotype expression in

pseudohomozygous R2 factor V. Blood. 2001 Sep 15;98(6):1988-9. PubMed PMID:

11565539

193. Castoldi E, Lunghi B, Mingozzi F, Simioni P, Girolami A, Bernardi F. A highly

polymorphic microsatellite in the factor V gene is an informative tool for the study of

factor V-related disorders. Br J Haematol. 2001 Sep;114(4):868-70. PubMed PMID:

11564076

194. Girolami A, Tormene D, Simioni P, Zanon E. Long-term use of oral contraceptive

therapy in women with the prothrombin 20210 G-A polymorphism without thrombotic

complications: a study of 13 women (12 heterozygotes and 1 homozygote). Thromb

Res. 2001 May 1;102(3):205-10. PubMed PMID: 11369413

195. Tormene D, Simioni P, Sartori MT, Girolami A. Heterozygous carrier of G20210A

prothrombin mutation used oral contraceptive treatment for 23 years without

thrombotic events, and developed cerebral venous thrombosis 1 month after

resumption of the medication at the age of 50. Blood Coagul Fibrinolysis. 2001

Mar;12(2):161-2. PubMed PMID: 11302480

196. Prandoni P, Tormene D, Simioni P, Girolami A. Venous thromboembolism, fetal loss

and preeclampsia in pregnant women with congenital thrombophilia. Clin Lab.

2001;47(3-4):155-9. Review. PubMed PMID: 11294579

197. Simioni P, Vianello F, Kalafatis M, Barzon L, Ladogana S, Paolucci P, Carotenuto M,

Dal Bello F, Palù G, Girolami A. A dysfunctional factor X (factor X San Giovanni

Rotondo) present at homozygous and double heterozygous level: identification of a

novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor

X gene. A study of an Italian family. Thromb Res. 2001 Feb 15;101(4):219-30.


198. Simioni P, Prandoni P, Lensing AW, Manfrin D, Tormene D, Gavasso S, Girolami B,

Sardella C, Prins M, Girolami A. Risk for subsequent venous thromboembolic

complications in carriers of the prothrombin or the factor V gene mutation with a first

episode of deep-vein thrombosis. Blood. 2000 Nov 15;96(10):3329-33. PubMed

PMID: 11071624

199. Castoldi E, Simioni P, Kalafatis M, Lunghi B, Tormene D, Girelli D, Girolami A,

Bernardi F. Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT

20210G/A) affecting the prothrombinase complex in a thrombophilic family. Blood.

2000 Aug 15;96(4):1443-8. PubMed PMID: 10942390

200. Girolami A, Simioni P, Girolami B, Scarano L. G to A 20210 prothrombin

polymorphism and venous thrombosis: simple association or causal relationship? Clin

Appl Thromb Hemost. 2000 Jul;6(3):135-8. Review. PubMed PMID: 10898272

201. Simioni P. The molecular genetics of familial venous thrombosis. Baillieres Best Pract

Res Clin Haematol. 1999 Sep;12(3):479-503. Review. PubMed PMID: 10856982

202. Simioni P, Tormene D, Luni S, Caldato M, Girolami A. Clinical and laboratory

expression of associated thrombophilic conditions (homozygous/heterozygous factor

V Leiden mutation and heterozygous prothrombin variant 20210A) in an Italian

family. Blood Coagul Fibrinolysis. 2000 Jun;11(4):379-84. PubMed PMID: 10847426

203. Girolami B, Bernardi E, Prins MH, ten Cate JW, Prandoni P, Simioni P, Andreozzi

GM, Girolami A, Büller HR. Antiplatelet therapy and other interventions after

revascularisation procedures in patients with peripheral arterial disease: a meta-

analysis. Eur J Vasc Endovasc Surg. 2000 Apr;19(4):370-80. PubMed PMID:

10801370

204. Girolami A, Simioni P, Scarano L, Carraro G. Prothrombin and the prothrombin

20210 G to A polymorphism: their relationship with hypercoagulability and

thrombosis. Blood Rev. 1999 Dec;13(4):205-10. Review. PubMed PMID: 10741896

205. Girolami A, Simioni P, Scarano L, Girolami B, Zerbinati P. Symptomatic combined

homozygous factor XII deficiency and heterozygous factor V Leiden. [email protected].

J Thromb Thrombolysis. 2000 Apr;9(3):271-5. PubMed PMID: 10728027

206. Sartori MT, Simioni P, Patrassi GM, Theodoridis P, Tormene D, Girolami A.

Combined heterozygous plasminogen deficiency and factor V Leiden defect in the

same kindred. Clin Appl Thromb Hemost. 2000 Jan;6(1):36-40. PubMed PMID:

10726047

207. Girolami A, Simioni P, Manfrin D, Tormene D, Luni S. Asymptomatic homozygous

nt 20210 G to A prothrombin polymorphism in two blood donors belonging to two

different kindreds. Clin Appl Thromb Hemost. 1999 Jan;5(1):48-51. PubMed PMID:

10725983

208. Girolami A, Simioni P, Girolami B, Zanon E. Low incidence of venous thrombosis in

homozygous patients with NT 20210 G to a prothrombin polymorphism. Clin Appl

Thromb Hemost. 1999 Oct;5(4):205-7. Review. PubMed PMID: 10726011

209. Girolami A, Simioni P, Tormene D. APC resistance, oral contraceptive therapy and

deep vein thrombosis: settled and unsettled problems. Haematologica. 2000

Mar;85(3):225-6. PubMed PMID: 10702806

210. Girolami A, Simioni P, Tormene D, Scarano L. Two additional homozygous patients

for the 20210 prothrombin polymorphism with no venous thrombosis. Thromb Res.

1999 Dec 1;96(5):415-7. PubMed PMID: 10605957

211. Sanson BJ, Simioni P, Tormene D, Moia M, Friederich PW, Huisman MV, Prandoni

P, Bura A, Rejto L, Wells P, Mannucci PM, Girolami A, Büller HR, Prins MH. The

incidence of venous thromboembolism in asymptomatic carriers of a deficiency of

antithrombin, protein C, or protein S: a prospective cohort study. Blood. 1999 Dec

1;94(11):3702-6. PubMed PMID: 10572082

212. Tormene D, Simioni P, Prandoni P, Luni S, Innella B, Sabbion P, Girolami A. The

risk of fetal loss in family members of probands with factor V Leiden mutation. Thromb

Haemost. 1999 Oct;82(4):1237-9. PubMed PMID: 10544905

213. Prandoni P, Lensing AW, Bagatella P, Simioni P, Girolami A. Low rate of warfarin-

related major bleeding in patients with recurrent venous thromboembolism. Thromb

Haemost. 1999 Jul;82(1):158-9. PubMed PMID: 10456478

214. Paternoster DM, Rodi J, Santarossa C, Vanin M, Simioni P, Girolami A. Acute

pancreatitis and deep vein thrombosis associated with HELLP syndrome. Minerva

Ginecol. 1999 Jan-Feb;51(1-2):31-3. PubMed PMID: 10230242

215. Simioni P, Prandoni P, Girolami A. Low rate of venous thromboembolism in

asymptomatic relatives of probands with factor V Leiden mutation. Ann Intern Med.

1999 Mar 16;130(6):538. PubMed PMID: 10075628

216. Simioni P, Sanson BJ, Prandoni P, Tormene D, Friederich PW, Girolami B, Gavasso

S, Huisman MV, Büller HR, Wouter ten Cate J, Girolami A, Prins MH. Incidence of

venous thromboembolism in families with inherited thrombophilia. Thromb Haemost.

1999 Feb;81(2):198-202. PubMed PMID: 10063991

217. Kalafatis M, Bernardi F, Simioni P, Lunghi B, Girolami A, Mann KG. Phenotype and

genotype expression in pseudohomozygous factor VLEIDEN : the need for phenotype

analysis. Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):336-42. PubMed PMID:

9974416

218. Simioni P, Tormene D, Manfrin D, Gavasso S, Luni S, Stocco D, Girolami A.

Prothrombin antigen levels in symptomatic and asymptomatic carriers of the 20210A

prothrombin variant. Br J Haematol. 1998 Dec;103(4):1045-50. PubMed PMID:

9886317

219. Simioni P, Kalafatis M, Manfrin D, Tormene D, Girolami A. Factor V variants,

activated protein C resistance and venous thromboembolism. Blood Coagul

Fibrinolysis. 1998 Oct;9(7):661-2. PubMed PMID: 9863717

220. Castoldi E, Kalafatis M, Lunghi B, Simioni P, Ioannou PA, Petio M, Girolami A,

Mann KG, Bernardi F. Molecular bases of pseudo-homozygous APC resistance: the

compound heterozygosity for FV R506Q and a FV null mutation results in the

exclusive presence of FV Leiden molecules in plasma. Thromb Haemost. 1998

Sep;80(3):403-6. PubMed PMID: 9759618

221. Girolami A, Simioni P, Scarano L, Girolami B, Marchiori A. Hemorrhagic and

thrombotic disorders due to factor V deficiencies and abnormalities: an updated

classification. Blood Rev. 1998 Mar;12(1):45-51. Review. PubMed PMID: 9597197

222. Girolami A, Simioni P, Zanon E, Girolami B, Marchiori A. Factor V Leiden

(activated protein C resistance) versus factor V deficiency in Padua, Italy. Clin Appl

Thrombosis and Haemostasis 1998; 4: 201-204

223. Camire RM, Kalafatis M, Simioni P, Girolami A, Tracy PB. Platelet-derived factor

Va/Va Leiden cofactor activities are sustained on the surface of activated platelets

despite the presence of activated protein C. Blood. 1998 Apr 15;91(8):2818-29.


224. Paternoster DM, Simioni P, Girolami A. Protein S deficiency and pregnancy: is there

a case for ylaxis? Minerva Ginecol. 1997 Oct;49(10):447-8. PubMed PMID: 9450361

225. van 't Veer C, Golden NJ, Kalafatis M, Simioni P, Bertina RM, Mann KG. An in vitro

analysis of the combination of hemophilia A and factor V(LEIDEN). Blood. 1997 Oct

15;90(8):3067-72. PubMed PMID: 9376587

226. Zanon E, Simioni P, Saracino MA, Prandoni P, Girolami B, Sardella C, Girolami A.

Antiphospholipid antibodies do not seem to be associated with deep vein thrombosis:

a case control study. Clinical and Applied Thrombosis and Haemostasis 1997, 3:165-

7. Lippincott-Raven Publishers, Philadelphia, USA, 1997

227. van den Belt AG, Sanson BJ, Simioni P, Prandoni P, Büller HR, Girolami A, Prins

MH. Recurrence of venous thromboembolism in patients with familial thrombophilia.

Arch Intern Med. 1997 Oct 27;157(19):2227-32. Review. PubMed PMID: 9342999

228. van 't Veer C, Kalafatis M, Bertina RM, Simioni P, Mann KG. Increased tissue factor-

initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor

VLEIDEN. J Biol Chem. 1997 Aug 15;272(33):20721-9. PubMed PMID: 9252393

229. Paternoster D, Girolami B, Grella P, Dalla Pria S, Simioni P, Girolami A. Sindrome

HELLP ed implicazioni genetiche: caso clinico. Medicina Fetale, 1997; 268-270

230. Prandoni P, Villalta S, Bagatella P, Rossi L, Marchiori A, Piccioli A, Bernardi E,

Girolami B, Simioni P, Girolami A. The clinical course of deep-vein thrombosis.

Prospective long-term follow-up of 528 symptomatic patients. Haematologica. 1997

Jul-Aug;82(4):423-8. PubMed PMID: 9299855

231. Girolami A, Simioni P, Venturelli U, Girolami B, Zanon E. Factor V antigen levels in

APC resistance, in factor V deficiency and in combined APC resistance and factor V

deficiency (pseudohomozygosis for APC resistance). Blood Coagul Fibrinolysis. 1997

Jun;8(4):245-8. PubMed PMID: 9199822

232. Scarano L, Bernardi E, Prandoni P, Sardella C, Rossi L, Carraro P, Simioni P,

Girolami A. Accuracy of two newly described D-dimer tests in patients with suspected

deep venous thrombosis. Thromb Res. 1997 Apr 15;86(2):93-9. PubMed PMID:

9175231

233. Simioni P, Scalia D, Tormene D, Bongiovi S, Sardella C, Girolami A. Intra-atrial

thrombosis and homozygous factor V Leiden mutation. Clinical and Applied

Thrombosis and Haemostasis 1997, 3: 215-7. Lippincott-Raven Publishers,

Philadelphia, USA, 1997

234. Simioni P, Prandoni P, Lensing AW, Scudeller A, Sardella C, Prins MH, Villalta S,

Dazzi F, Girolami A. The risk of recurrent venous thromboembolism in patients with

an Arg506-->Gln mutation in the gene for factor V (factor V Leiden). N Engl J Med.

1997 Feb 6;336(6):399-403. PubMed PMID: 9010145

235. Prandoni P, Polistena P, Bernardi E, Cogo A, Casara D, Verlato F, Angelini F, Simioni

P, Signorini GP, Benedetti L, Girolami A. Upper-extremity deep vein thrombosis. Risk

factors, diagnosis, and complications. Arch Intern Med. 1997 Jan 13;157(1):57-62.


236. Girolami A, Simioni P, Scarano L, Girolami B. Venous and arterial thrombophilia.

Haematologica. 1997 Jan-Feb;82(1):96-100. Review. PubMed PMID: 9107094

237. Friederich PW, Sanson BJ, Simioni P, Zanardi S, Huisman MV, Kindt I, Prandoni P,

Büller HR, Girolami A, Prins MH. Frequency of pregnancy-related venous

thromboembolism in anticoagulant factor-deficient women: implications for

prophylaxis. Ann Intern Med. 1996 Dec 15;125(12):955-60. Erratum in: Ann Intern

Med 1997 May 15;126(10):835. Ann Intern Med 1997 Dec 15;127(12):1138. PubMed

PMID: 8967705

238. Vergani L, Angelini C, Pegoraro E, Cadaldini M, Simioni P, Girolami A. Turnbull

DM. Hereditary protein C deficiency associated with riboflavin-responsive lipid

storage myopathy. European Journal of Neurology 1996, 3:61-65. Rapid Science

Publishers, LTD, Oxford and New York, 1996

239. Paternoster DM, Stella A, Simioni P, Girolami A, Plebani M. Fibronectin and

antithrombin as markers of pre-eclampsia in pregnancy. Eur J Obstet Gynecol

Reprod Biol. 1996 Dec;70(1):33-9. PubMed PMID: 9031918

240. Simioni P, Prandoni P, Burlina A, Tormene D, Sardella C, Ferrari V, Benedetti L,

Girolami A. Hyperhomocysteinemia and deep-vein thrombosis. A case-control study.

Thromb Haemost. 1996 Dec;76(6):883-6. PubMed PMID: 8972005

241. Girolami A, Simioni P, Tormene D, Vianello F. Pitfalls of protein C assays in patients

with activated protein C resistance. Blood Coagul Fibrinolysis. 1996 Oct;7(7):712-5.


242. Bajzar L, Kalafatis M, Simioni P, Tracy PB. An antifibrinolytic mechanism describing

the prothrombotic effect associated with factor V Leiden. J Biol Chem. 1996 Sep

20;271(38):22949-52. PubMed PMID: 8798478

243. Simioni P, Kalafatis M, Millar DS, Henderson SC, Luni S, Cooper DN, Girolami A.

Compound heterozygous protein C deficiency resulting in the presence of only the

beta-form of protein C in plasma. Blood. 1996 Sep 15;88(6):2101-8. PubMed PMID:

8822929

244. Girolami A, Simioni P, Girolami B, Radossi P. Homozygous patients with APC

resistance may remain paucisymptomatic or asymptomatic during oral contraception.

Blood Coagul Fibrinolysis. 1996 Sep;7(6):590-4. PubMed PMID: 8899147

245. Simioni P, Prandoni P, Zanon E, Saracino MA, Scudeller A, Villalta S, Scarano L,

Girolami B, Benedetti L, Girolami A. Deep venous thrombosis and lupus

anticoagulant. A case-control study. Thromb Haemost. 1996 Aug;76(2):187-9.


246. Girolami A, Zanon E, Zanardi S, Saracino MA, Simioni P. Thromboembolic disease

developing during oral contraceptive therapy in young females with antiphospholipid

antibodies. Blood Coagul Fibrinolysis. 1996 Jun;7(4):497-501. PubMed PMID:

8840004

247. Zanon E, Saracino MA, Simioni P, Cogo A, Fadin MA, Gavasso S, Girolami A.

Prevalence of antiphospholipid antibodies and lupus anticoagulant in juvenile patients

with objectively documented deep-vein thrombosis. Clinical and Applied Thrombosis

and Hemostasis 1996, 2: 69-73

248. Preda L, Simioni P, Legnani C, Palareti G, Poggio M, Rossi E, Girolami A. A new

global test for the evaluation of the protein C-protein S system. Blood Coagul

Fibrinolysis. 1996 Jun;7(4):465-9. PubMed PMID: 8839999

249. Simioni P, Prandoni P, Girolami A. Frequency of resistance to activated protein C

due to factor V mutation in young patients with ischemic stroke. Response. Stroke

1996, 27:767. American Heart Association, Dallas, TX, USA, 1996

250. Prandoni P, Simioni P, Girolami A. Antiphospholipid antibodies, recurrent

thromboembolism, and intensity of warfarin anticoagulation. Thromb Haemost. 1996

May;75(5):859. PubMed PMID: 8725737

251. Simioni P, Scudeller A, Radossi P, Gavasso S, Girolami B, Tormene D, Girolami A.

"Pseudo homozygous" activated protein C resistance due to double heterozygous

factor V defects (factor V Leiden mutation and type I quantitative factor V defect)

associated with thrombosis: report of two cases belonging to two unrelated kindreds.

Thromb Haemost. 1996 Mar;75(3):422-6. PubMed PMID: 8701401

252. Sanson BJ, Friederich PW, Simioni P, Zanardi S, Hilsman MV, Girolami A, ten Cate

JW, Prins MH. The risk of abortion and stillbirth in antithrombin-, protein C-, and

protein S-deficient women. Thromb Haemost. 1996 Mar;75(3):387-8. PubMed PMID:

8701393

253. Cogo A, Lensing AWA, Prandoni P, Simioni P, Bernardi E, Girolami B, Piccioli A,

Villalta S, ten Cate JW, Girolami A. Relevance of inherited risk factors in young

patients with deep-vein thrombosis. Clinical and Applied Thrombosis and Hemostasis

1996, 2(1): 55-59. Lippincott-Raven Publishers, Philadelphia, USA, 1996

254. Simioni P, Scarano L, Gavasso S, Sardella C, Girolami B, Scudeller A, Girolami A.

Prothrombin fragment 1+2 and thrombin-antithrombin complex levels in patients with

inherited APC resistance due to factor V Leiden mutation. Br J Haematol. 1996

Feb;92(2):435-41. PubMed PMID: 8603014

255. Wojcik EG, Simioni P, d Berg M, Girolami A, Bertina RM. Mutations which

introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins

result in the formation of complexes with alpha 1-microglobulin. Thromb Haemost.

1996 Jan;75(1):70-5. PubMed PMID: 8713782

256. Girolami A, Simioni P, Zanardi S, Scarano L, Girolami B. Patients with APC

resistance compared with those with other clotting inhibitor deficiencies show later

onset of venous thrombosis during oral contraception. Clinical and Applied

Thrombosis and Hemostasis 1995, 1(4): 274-276. Lippincott-Raven Publishers,

Philadelphia, USA, 1995

257. Formstone CJ, Wacey AI, Berg LP, Rahman S, Bevan D, Rowley M, Voke J, Bernardi

F, Legnani C, Simioni P, Girolami A, Tuddenham EG, Kakkar VV, Cooper DN.

Detection and characterization of seven novel protein S (PROS) gene lesions:

evaluation of reverse transcript-polymerase chain reaction as a mutation screening

strategy. Blood. 1995 Oct 1;86(7):2632-41. PubMed PMID: 7545463

258. Zanon E, Saracino MA, Simioni P, Scarano L, Girolami B, Girolami A. Recombinant

thromboplastin inhibition assay for the detection of lupus anticoagulant. Clin Lab

Haematol. 1995 Sep;17(3):231-5. PubMed PMID: 8719896

259. Paternoster DM, Stella A, Simioni P, Mussap M, Plebani M. Coagulation and plasma

fibronectin parameters in HELLP syndrome. Int J Gynaecol Obstet. 1995

Sep;50(3):263-8. PubMed PMID: 8543109

260. Simioni P, Scudeller A, Girolami A. Factor V Leiden and thrombophilia. N Engl J

Med. 1995 May 18;332(20):1382. PubMed PMID: 7715653

261. Simioni P, de Ronde H, Prandoni P, Saladini M, Bertina RM, Girolami A. Ischemic

stroke in young patients with activated protein C resistance. A report of three cases

belonging to three different kindreds. Stroke. 1995 May;26(5):885-90. PubMed

PMID: 7740584

262. Simioni P, Gavasso S, Luni S, Invidiato S, Girolami A. A protein S functional assay

yields unsatisfactory results in patients with activated protein C resistance. Blood

Coagul Fibrinolysis. 1995 May;6(3):286-7. PubMed PMID: 7654942

263. Girolami A, Simioni P, Girolami B, Scarano L, Paolo S [corrected to Simioni P],

Bruno G [corrected to Girolami B], Luigi S [corrected to Scarano L]. Oral

contraceptive therapy causes an increased and not a decreased resistance to APC.

Blood Coagul Fibrinolysis. 1995 Apr;6(2):143-4. Erratum in: Blood Coagul

Fibrinolysis 1995 May;6(3):285. PubMed PMID: 7605882

264. Villalta S, Prandoni P, Cogo A, Bagatella P, Piccioli A, Bernardi E, Simioni P,

Scarano L, Girolami A. The utility of non-invasive tests for detection of previous

proximal-vein thrombosis. Thromb Haemost. 1995 Apr;73(4):592-6. PubMed PMID:

7495064

265. Girolami A, Prandoni P, Simioni P, Girolami B, Scarano L, Zanon E. The

pathogenesis of venous thromboembolism. Haematologica. 1995 Mar-Apr;80(2

Suppl):25-35. Review. PubMed PMID: 7628768

266. Ruffatti A, DiLenardo L, Simioni P, Tonetto S, Girolami A, Grella P, Todesco S.

Anticardiolipin antibodies, functional protein S deficiency, and fetal loss. Am J

Hematol. 1995 Jan;48(1):65-6. PubMed PMID: 7832202

267. Girolami A, Prandoni P, Simioni P, Bernardi E, Cella G, Cogo A, Girolami B,

Polistena P, Scarano L, Villalta S, Zanardi S, Zanon E. La malattia tromboembolica

venosa. Luigi Pozzi Editore, Roma, 1994

268. Simioni P, Scarano L, Zanardi S, Scudeller A, Gavasso S, Sardella C, Girolami A. La

valutazione degli stati di ipercoagulabilità. Da Atti del 27° Corso CEFAR:

Aggiornamenti in Coagulazione, Cortina D'Ampezzo 1994

269. Paternoster DM, Stella A, Trovò S, Simioni P, Girolami A, Grella PV. Studio delle

concentrazioni plasmatiche dell' AT III nelle ipertensioni pregravidiche e nell' EPH

gestosi. Da Medicina Fetale. Monduzzi Editore, Bologna, 1994,pag 11-15

270. Paternoster DM, Stella A, Trovo' S, Simioni P, Scarano G, Girolami A, Plebani M,

Grella PV. Fibronectina e fattori della coagulazione: markers precoci di EPH gestosi.

Da Medicina Fetale. Monduzzi Editore, Bologna, 1994, pag 27-35

271. Paternoster D, Stella A, Simioni P, Trovò S, Plebani P, Girolami A. Clotting inhibitors

and fibronectin as potential markers in preeclampsia. Int J Gynaecol Obstet. 1994

Dec;47(3):215-21. PubMed PMID: 7705525

272. Simioni P, Girolami A. Homozygous factor V-deficient patients show resistance to

activated protein C whereas heterozygotes do not. Blood Coagul Fibrinolysis. 1994

Oct;5(5):825-7. PubMed PMID: 7865690

273. Simioni P, Prandoni P, Girolami A. Patients with AT III, protein C or protein S defects

show no associated hereditary APC-resistance. Thromb Haemost. 1994

Sep;72(3):481-2. PubMed PMID: 7855802

274. Girolami A, Simioni P, Scarano L. Evaluation of activated protein C resistance in

stored plasma. Lancet. 1994 May 21;343(8908):1288-90. PubMed PMID: 7910292

275. Cogo A, Prandoni P, Villalta S, Polistena P, Bernardi E, Simioni P, Vigo M, Benedetti

L, Girolami A. Changing features of proximal vein thrombosis over time. Angiology.

1994 May;45(5):377-82. PubMed PMID: 8172385

276. Simioni P, Battistella PA, Drigo P, Carollo C, Girolami A. Childhood stroke

associated with familial protein S deficiency. Brain Dev. 1994 May-Jun;16(3):241-5.


277. Girolami A, Zanardi S, Simioni P, Tormene D. Prolonged oral contraceptive therapy

in a woman with an antithrombin III abnormality involving heparin binding (type IIc)

without thromboembolic complications. Blood Coagul Fibrinolysis. 1994

Apr;5(2):313-4. PubMed PMID: 8054465

278. Cogo A, Bernardi E, Prandoni P, Girolami B, Noventa F, Simioni P, Girolami A.

Acquired risk factors for deep-vein thrombosis in symptomatic outpatients. Arch Intern

Med. 1994 Jan 24;154(2):164-8. PubMed PMID: 8285811

279. Simioni P, Girolami B, Scarano L, Scudeller A, Gavasso S, Cogo A, Prandoni P,

Girolami A. Indicazioni cliniche all'uso dei concentrati di AT III. Valenti S, Gallo F,

Giron GP eds, Sangue ed emoderivati nel perioperatorio. San Marco Editrice 1993

280. Paternoster D, Simioni P, Tambuscio B, Valentich F, Quintieri F, Grella PV.

Descrizione di un caso clinico di trombosi venosa profonda (TVP) in gravidanza e

revisione della letteratura. Risveglio Ostetrico 1993, 65: 17-20

281. Carta M, Villalta S, Cogo A, Girolami B, Polistena P, Simioni P, Prandoni P. Efficacia

delle calze elastiche nella sindrome post-tromboflebitica. Topic Medical News 1993,

1:7-9. Rotoweb, Castel Maggiore, BO, 1993

282. Simioni P, Marchiori A, Zanardi S, Scudeller A, Bagatella P, Rossi L, Sardella C,

Girolami A. Il sistema della proteina C / proteina S. Da "Nuove prospettive nello

studio dello stato ipercoagulabile" Atti del Seminario di Coagulazione, Padova Ottobre

1993, pag. 24-28

283. Prandoni P, Simioni P, Cogo A, Bagatella P, Piccioli A, Scudeller A, Rossi L,

Girolami A. Rilevanza clinica degli stati trombofilici. Da "Nuove prospettive nello

studio dello stato ipercoagulabile" Atti del Seminario di Coagulazione, Padova Ottobre

1993, pag.7-9

284. Prandoni P, Cogo A, Simioni P, Pietrogrande F, Polistena P, Villalta S, Girolami A.

Terapia e prevenzione della malattia tromboembolica venosa. Trombosi ed

arteriosclerosi 1993,4:235-44. Piccin Editore, Padova, 1993

285. Prandoni P, Cogo A, Villalta S, Simioni P, Sgarabotto D, Girolami A. Le eparine a

basso peso molecolare nella prevenzione e nel trattamento della trombosi venosa

profonda. Trombosi ed arteriosclerosi 1993,4:165-70. Piccin Editore, Padova, 1993

286. Zanardi S, Simioni P, Girolami B, Zanon E, Scarano L, Gavasso S, Scudeller A, Rossi

L, Girolami A. Le alterazioni congenite dell' antitrombina III: studio di 78 pazienti.

Trombosi ed Arteriosclerosi 1993, 4:248-70. Piccin Editore, Padova, 1993

287. Patrassi GM, Sartori MT, Viero M, Boeri G, Simioni P, Bassi N, Piccinni P, Girolami

A. Protein C, factor VII and prothrombin time as early markers of liver function

recovery or failure after liver transplantation. Blood Coagul Fibrinolysis. 1993

Dec;4(6):863-7. PubMed PMID: 8148479

288. Girolami A, Simioni P, Scudeller A, Girolami B, Zanon E, Tormene D, Rossi L. The

hereditary thrombosis (Los trastornos tromboembolicos hereditarios). Da: Atti del XI

Congreso Argentino de Hematologia. Rosario, Ottobre 1993

289. Girolami A, Sartori MT, Simioni P, Zanon E, Gavasso S, Fadin M. El uso de

substratos cromogenicos en coagulacion. Revista Iberoamericana de trombosis y

hemostasia 1993, 6: 128-30. Editorial Garsi, S.A., Madrid, 1993

290. Girolami A, Prandoni P, Simioni P. Relevance of thrombophilic states: an

introduction. In ETRO, 5th advanced research meeting, worksheets:

Pathophysiological and clinical research in thromboembolic disease. Bologna , Italy,

1993

291. Girolami A, Simioni P, Girolami B, Marchiori A, Millar DS, Bignell P, Kakkar VV,

Cooper DN. A novel dysfunctional protein C (protein C Padua 2) associated with a

thrombotic tendency: substitution of Cys for Arg-1 results in a strongly reduced affinity

for binding of Ca++. Br J Haematol. 1993 Nov;85(3):521-7. PubMed PMID: 8136274

292. Prandoni P, Cogo A, Bernardi E, Villalta S, Polistena P, Simioni P, Noventa F,

Benedetti L, Girolami A. A simple ultrasound approach for detection of recurrent

proximal-vein thrombosis. Circulation. 1993 Oct;88(4 Pt 1):1730-5. PubMed PMID:

8403319

293. Girolami A, Zanardi S, Simioni P, Polistena P, Villalta S. Are oral contraceptives a

more important risk factor than pregnancy in women with congenital antithrombin III

deficiency? Blood Coagul Fibrinolysis. 1993 Oct;4(5):841-2. PubMed PMID:

8292733

294. Girolami A, Simioni P, Lazzaro AR, Girolami B, Prandoni P. A family with an

abnormal protein C and a thrombotic tendency. Haematologia (Budap).

1993;25(1):25-33. PubMed PMID: 8339996

295. Girolami A, Simioni P, Zanardi S, Girolami B, Scarano L, Saracino MA, Prandoni P.

The hereditary thrombosis. Revista Iberoamericana de trombosis y hemostasia 1993,

6: 113-117. (Editorial Garsi, S.A., Madrid, 1993)

296. Girolami A, Simioni P, Sartori MT, Caenazzo A. Intra-cardial thrombosis with

systemic and pulmonary embolism as main symptoms in a patient with protein S

deficiency. Blood Coagul Fibrinolysis. 1992 Aug;3(4):485-8. PubMed PMID:

1420826

297. Simioni P, Zanardi S, Prandoni P, Girolami A. Combined inherited protein S and

heparin co-factor II deficiency in a patient with upper limb thrombosis: a family study.

Thromb Res. 1992 Jul 1;67(1):23-30. PubMed PMID: 1440513

298. Girolami A, Simioni P, Sartori MT, Zanardi S. Oral contraceptives caused thrombosis

in a monoovular twin with protein C deficiency, while the other, without medication,

remained asymptomatic. Blood Coagul Fibrinolysis. 1992 Feb;3(1):119-20. PubMed

PMID: 1623113

299. Paternoster D, Trovo' S, Dal Maso J, Stella A, Simioni P, Grella PV. Nuovi parametri

coagulatori nelle gravidanze fisiologiche, a rischio,e complicate da gestosi. Da:

Gruppo di studio e ricerca in medicina fetale 1992. Monduzzi Editore, Bologna, 1992

300. Scarano L, Paternoster D, Simioni P, Quintieri F, Zanon E, Stella A, Grella PV,

Girolami A. Livelli di F1+2 e TAT nelle gestosi. Da: Gruppo di studio e ricerca in

medicina fetale 1992. Monduzzi Editore, Bologna, 1992

301. Paternoster D, Simioni P, Rinaldo M, Quintieri F, Marinangeli S, Grella PV.

Alterazione dei parametri coagulatori nella sindrome HELLP. Da: Gruppo di studio e

ricerca in medicina fetale 1992. Monduzzi Editore, Bologna, 1992

302. Grella PV, Paternoster D, Simioni P, Marinangeli S, Cataldi A, Quintieri F, Girolami

A. Sindrome H.E.L.L.P.: descrizione di due casi clinici. Trombosi & Aterosclerosi,

1992, 4:221-226. Piccin Editore, Padova, 1992

303. Girolami B, Simioni P, Saracino MA, Zanon E, Gavasso S, Fadin MA, Girolami A.

La deficienza di proteina C: studio di 71 pazienti con difetto congenito. Trombosi &

Aterosclerosi, 1992, 3:267-284. Piccin Editore, Padova, 1992

304. Simioni P, Girolami B, Zanardi S, Saracino MA, Marchiori A, Girolami A. Difetti

ereditari di proteina S: studio in 52 pazienti. Trombosi & Aterosclerosi 1992,3:1-14.

Piccin Editore, Padova, 1992

305. Simioni P, Girolami B, Saracino MA, Zanardi S, Gavasso S, Zanolli FA, Girolami A.

I deficit degli inibitori della coagulazione: inquadramento nosologico e diagnostica.

Da: "Plasma, Derivati e Sostituti: uso razionale e pratica clinica", 1992

306. Paternoster D, Simioni P. Deep vein thrombosis in pregnancy. Journal of Foetal

Medicine 1992, XII, 42-46. S.O.G S.r.l., Padova, 1992

307. Simioni P, Zanardi S, Saracino A, Girolami A. Occurrence of arterial thrombosis in

a cohort of patients with hereditary deficiency of clotting inhibitors. J Med.

1992;23(1):61-74. PubMed PMID: 1533414

308. Girolami A, Sartori MT, Simioni P. The biological inertia of coumarin-induced pre-

factors (so called PIVKAs). Thromb Res. 1991 Dec 1;64(5):627-8. PubMed PMID:

1822984

309. Girolami A, Simioni P, Girolami B, Zanardi S. The role of drugs, particularly oral

contraceptives, in triggering thrombosis in congenital defects of coagulation

inhibitors: a study of six patients. Blood Coagul Fibrinolysis. 1991 Oct;2(5):673-8.


310. Girolami A, Simioni P, Zanardi S, Coser E, Signora S. [The genetics of thrombosis].

Haematologica. 1991 Jun;76 Suppl 3:249-60. Review. Italian. PubMed PMID:

1836447

311. Simioni P, Zanon G, Lazzaro AR, Patrassi GM, Girolami A. Heterozygous protein

C deficiency associated with multiple congenital hemangiomas--a case report.

Angiology. 1991 Apr;42(4):337-42. PubMed PMID: 2014924

312. Simioni P, Lazzaro A, Zanardi S, Girolami A. Spurious protein C deficiency due to

antiphospholipid antibodies. Am J Hematol. 1991 Apr;36(4):299-301. PubMed

PMID: 2012079

313. Girolami A, Sartori MT, Simioni P. An updated classification of factor XIII defect. Br

J Haematol. 1991 Apr;77(4):565-6. PubMed PMID: 1673865

314. Girolami A, Simioni P, Ruzza G. The classification of congenital factor X deficiency

and abnormalities. Annals of Saudi Medicine 1990,10(2):218-220. King Saud

University Press, Riyadh, Saudi Arabia, 1990

315. Girolami A, Simioni P, Steffan A. Factor VII and haemostasis: interaction between

abnormal factors VII and tissue thromboplastins. Blood Coagul Fibrinolysis. 1990

Dec;1(6):749-50. PubMed PMID: 2133255

316. Simioni P, Lazzaro AR, Coser E, Salmistraro G, Girolami A. Hereditary heparin

cofactor II deficiency and thrombosis: report of six patients belonging to two separate

kindreds. Blood Coagul Fibrinolysis. 1990 Oct;1(4-5):351-6. PubMed PMID:

2133211

317. Girolami A, Simioni P, Lazzaro AR. Discrepancies between clotting and amidolytic

assay in congenital clotting disorders. Thromb Res. 1990 Aug 1;59(3):701-2.


318. Girolami A, Simioni P, Lazzaro AR, Pontara E, Ruzza G. Heterozygous protein-S

deficiency: a study of a large kindred. Acta Haematol. 1990;84(3):162-8. PubMed

PMID: 2147089

319. Girolami A, Simioni P, Lazzaro AR. Peculiar rocket profile in the

electroimmunoassay of protein-S-deficient plasma: a clue to diagnosis? Clin Lab

Haematol. 1990;12(1):109-11. PubMed PMID: 2140544

320. Simioni P, Lazzaro AR, Girolami A. Deep vein thrombophlebitis of a leg in a young

female with heterozygous protein C deficiency taking oral contraceptives. Folia

Haematol Int Mag Klin Morphol Blutforsch. 1990;117(3):443-5. PubMed PMID:

1703114

321. Cella G, Prosdocimi M, Zatta A, Luzzatto G, Simioni P, Stevanato F, Sasahara AA.

Kinetics of human platelet factor 4 in rabbits: effect of glycosaminoglycans and

protamine sulfate. Annals of New York Academy of Sciences 1989,556:429-431. The

New York Academy of Sciences, New York, NY, 1989

322. Bernardi F, Marchetti G, Patracchini P, Volinia S, Gemmati D, Simioni P, Girolami

A. Partial gene deletion in a family with factor X deficiency. Blood. 1989

Jun;73(8):2123-7. PubMed PMID: 2567188

323. Luzzatto G, Paolini R, Stevanato F, Simioni P, Cella G. Effects of glycosaminoglycans

and protamine chloridrate on platelet aggregation induced by collagen and thrombin.

Angiology. 1989 Mar;40(3):170-4. PubMed PMID: 2916768

324. Girolami A, Simioni P, Lazzaro AR, Cordiano I. Severe arterial cerebral thrombosis

in a patient with protein S deficiency (moderately reduced total and markedly reduced

free protein S): a family study. Thromb Haemost. 1989 Feb 28;61(1):144-7. PubMed

PMID: 2526383

325. Girolami A, Lazzaro A, Simioni P. Thrombotic manifestations in plasminogen

deficiency and in plasminogen abnormalities. Thromb Haemost. 1988 Dec

22;60(3):528. PubMed PMID: 3238658

326. Mozzanega B, Marchesoni D, Lazzaro AR, Simioni P, Girolami A. Complesso

protrombinico e fattore VIII nella menopausa recente: effetti del

medrossiprogesterone acetato in monoterapia ed in associazione sequenziale agli

estrogeni coniugati. Il climaterio femminile: esperienze italiane di un decennio.

Monduzzi Editore, Bologna, 1988

327. Girolami A, Simioni P, Lazzaro AR. Importanza delle coagulopatie congenite rare.

Progressi in Ematologia Clinica. C Bernasconi 1988,7:85-95

328. Stevanato F, Paolini R, Sgarbossa G, Simioni P, Cella G. Heparin-induced platelet

factor 4 release by serial heparin injections. J Nucl Med Allied Sci. 1988 Apr-

Jun;32(2):106-9. PubMed PMID: 3171705

329. Girolami A, Lazzaro AR, Simioni P. The relationship between defective heparin

cofactor activities and thrombotic phenomena in AT III abnormalities. Thromb

Haemost. 1988 Feb 25;59(1):121. PubMed PMID: 3363528

330. Cella G, Prosdocimi M, Stevanato F, Simioni P, Sasahara AA. Interaction between

human platelet factor 4 and protamine sulfate in the presence of a low molecular

weight heparin in the rabbit. J Nucl Med Allied Sci. 1988 Jan-Mar;32(1):54-7.


331. Girolami A, Cappellato MG, Lazzaro AR, Simioni P, Boscaro M. The report of an

Italian family with heterozygous protein C deficiency. Folia Haematol Int Mag Klin

Morphol Blutforsch. 1988;115(6):859-68. PubMed PMID: 2467857

332. Girolami A, Cappellato MG, Lazzaro AR, Simioni P. Factor X antigen--factor X

activity discrepancy in coumarin treated patients. No relationship with dilution curve.

Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(1):126-33. PubMed

PMID: 2439413

333. Randi ML, Fabris F, Varotto L, Simioni P, Girolami A. Acute coronary disease in

polycytemia vera and in essential thrombocytosis. Atherosclerosis and Cardiovascular

diseases - Vol 3.Lenzi S and Descovich GC. Editors, Editrice Compositori, Bologna

1987

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