PATHOLOGY– 1T&DJUNE2020PaperDiscussionDR. DEEPAKMARWAH

1.15-year-oldboyishavingcirrhosisofliverleadingtorecurrentascites.Hehasdevelopedbehaviouralproblems,dystonia,rigidityandKFringisnotedintheeyesofpatient.Whichstainwillbeusedtodemonstratecoppertoxicity?a.Hemosiderinb.Sudanblackc.Vonkossad.Rubeanicacid

2.Cholesterolembolismoccursdueto?a.Traumaleadingtofractureoflongbonesb.Worminfestationinlymphaticsblockingchylec.Endothelialcellinjuryd.Fissureofatheroscleroticplaque

3.Donovanbodiesareseenin?a.LeishmaniaDonovanib.Granulomainguinalec.LymphomaHodgkinsd.LymphomaNon- Hodgkins

4.WhichstainisusedforGbandinginchromosomestaining?a.Congoredb.ThioflavinTc.Giemsad.Quinacrine

5.Corallinethrombusisseenin?a.Arterialthrombosisb.Venousthrombosisc.Postmortemthrombosisd.Superficialthrombophlebitis

6.Whichofthefollowingcellsismostresistanttoischemiccells?a.Cardiacmyocyteb.Neuronc.Nephrond.Fibroblast

7.Brownindurationoflungsisseenin?a.Rightheartfailureb.Leftheartfailurec.Anthracosisd.Berylliosis

8.WhichofthefollowingisincorrectaboutAmyloidosis?a.Xraycrystallographyshowsabetacrosspleatedsheathb.Nephroticrangeproteinuriac.Sagospleenshowstapiocalikegranulesd.ApplegreenbirefringenceonlightmicroscopywithSchiff’sreagent

9.CorrectaboutMalloryHyalinebodies?a.Aggregatesofintermediatecytokeratinfilamentsincytoplasmofhepatocytesb.AggregatesofCytokeratinfilamentsinnucleusofhepatocytesc.AggregatesofintermediatecytokeratinfilamentsincytoplasmofKupffercellsd.AggregatesofCytokeratinfilamentsinnucleusofKupffercells

10.CorrectaboutItocellinliver?a.Responsibleforphagocytosisb.StorageofvitaminAc.Foamymacrophageinfattyliverd.Linesintrahepaticbileducts

11.Extrinsicpathwayofclottinginvolvesa.FactorVb.Factor8c.Caspase8d.Caspase9

12.Stellategranulomaisseenduetoinfectionwithwhichofthefollowing?a.Nocardiab.Treponemapertenuec.BartonellaHenslaed.Actinomyces

13.Michealis gutman bodiesareseenin:a.Erthyroplakiab.Leukoplakiac.Malakoplakiad.Reyesyndrome

14.Namethefixativeusedinroutinehistopathology?a.Glutaraldehydeb.Neutralbufferedformalinc.Hematoxylin eosinstaind.Toluidinebluestain

15.Asteroidbodiesareseenin?a.Silicosisb.Anthracosisc.Sarcoidosisd.Coalworkers’pneumoconiosis

16.Globi arefoundin?a.TBb.Leprosyc.Yawsd.Infectiousmononucleosis

17.WhatisthefunctionofWiebel palade bodies?a.ProductionofVonWilebrand factorb.Productionofclottingfactorsbyhepatocytesc.Productionofbilebyintrahepaticcholangiocytesd.ProductionofclottingfactorbyStellatecells

18.A20-year-oldboyssaysthatheisverythinandhasbeenlosingweight.Hehasbulkyfoul-smellinggreasystoolsaftereverymeal.SmallintestinalmucosalbiopsyshowsPeriodicacidSchiff’reagentpositiveintracellularbacteriavisualizedinlaminapropria.Whatisthediagnosis?a.Pepticulcerdiseaseb.Bacterialovergrowthsyndromec.Whipplediseased.Celiacsprue

19.Prussianbluestainisusedtodemonstratea.Lipofuschinb.Copperc.Irond.Melanin

20.Emperipolesisis?a.Activepenetrationofonecellbyanotherwhichremainsintactb.Programmedcelldeathc.Migrationofleukocytesfromthebloodcirculationtositesofinflammationd.Ingestionofmicrobesintophagosomes

21.Monckebergarteriosclerosisoccursin?a.Tunicaintimab.Tunicamediac.Tunicaadventitiad.Internalelasticlamina

22.Whichofthefollowingisanexampleofmetastaticcalcification?a.PostMIscarb.Cysticercosisc.HypervitaminosisDd.Monckeberg sclerosis

23.Whichofthefollowingdoesnotexhibitphysiologicalatrophy?a.Thymusb.Adrenalc.Gonadsd.Brain

24.Alphafetoproteinisatumourmarkerfor?a.Seminomaoftestisb.Non-seminomatous germcelltumouroftestisc.Trisomy21d.Trisomy18

25.Acuteauto-graftrejectionoccurswithin?a.Fewhoursb.<1monthc.<6monthsd.6-12months

26.Tigered patternofmyocardiumisfoundin?a.Fattychangesinheartb.Hibernatingmyocardiumc.Rheumaticheartdiseased.Hypercoagulablestate

27.Antibodymediatedcellcytotoxicityismediatedby?a.Monocyteb.Giantcellsc.T- suppressorcellsd.NKcell

28.PredominantTcellis?a.CD4+b.CD8+c.NKcellsd.Plasmacell

29.A30-year-oldpatientisadmittedfromruralindia withsymptomsofabdominalpainandfeverforlast2weeks.Hisbloodcultureisdrawnwithcompletebloodcountandintravenousceftriaxonewithofloxacinwasstartedinthepatient.Immediatelythepatientturnedblueandhaddifficultyinbreathing.Whichofthefollowingcellsisresponsibleforthefollowingpresentation?

a.Eosinophilb.Basophilc.Monocyted.Macrophage

30.GeneforHLAislocatedon?a.6pb.6qc.9pd.9q

31.Whichofthefollowingisresponsibleforgraftversushostreaction?a.RecipientBlymphocytesb.DonorT8lymphocytesc.Immunecomplexesd.Recipienteosinophils

32.Geneforbloodgroupislocatedat?a.6pb.6qc.9pd.9q

33.Amyloidaccumulationinbetacellsofpancreasisafeatureof?a.ChronicalcoholisminducedChronicpancreatitisb.Type2diabetesmellitusc.Maturityonsetdiabetesd.Type1diabetesmellitus

34.Microangiopathichaemolyticanemia isseenin?a.Henochscholein purpurab.Haemolyticuraemic syndromec.Hereditaryspherocytosisd.Favism

35.A75year- oldmanhasdevelopedAmnesia,apraxiaandanosoagnosia.Whichofthefollowingwouldbefoundonpostmortem?a.ATTRdepositioninneuronsb.Aβdepositioninter-neuronalc.Aprocalcitonindepositionintra-neuronald.Aβ2 depositioninsynoviumandtendonsheath

36.Contractionofendothelialcellsoccursduetoincreasedvascularpermeability.Whichbloodvesselsareinvolvedinthisleakiness?a.Arteriolesb.Capillariesc.Venulesd.Alloftheabove

37.CD62is?a.P- selectinb.PECAMc.ICAMd.Integrin

38.Fentonreactionoccursinpresenceof?a.Fe++

b.Superoxideradicalc.Myeloperoxidased.Cobalt

39.WhichoftheseisaFeatureofcancercellsis?a.Pleomorphismb.Prominentnucleolic.Aisonucleosisd.Allofthese

40.Retproto-oncogenene leadsto?a.Glioblastomab.Sipple syndromec.Carcinomabreastd.CML

41.MHCantigenisabsentin?a.Neutrophilb.Epithelialcellc.RBCd.Thrombocyte

42.Mostreactivefreeradical?a.Hydrogenperoxideb.Hydroxylfreeradicalc.Peroxidefreeradicald.SuperoxideAnion

43.ABObloodgroupisanexampleof?a.XlinkedInheritanceb.Autosomalrecessivec.MitochondrialInheritanced.Codominance

44.Anticipationisseenin?a.FragileXsyndromeb.Praderwili syndromec.Angelmansyndromed.TaySach disease

45.Virchowcellsareseenin?a.Leprosyb.TBc.Malignancyd.Catscratchdisease

46.Immuno-stainforneuraltumoursa.NSEb.HMB-45c.Epithelialmembraneantigend.GFAP

47.HTLV-1leadsto?a.Tropicalspasticparaparesisb.B-cellALLc.MantleCelllymphomad.Follicularlymphoma

48.Endometriosisisanexampleof?a.Choriostomab.Hamartomac.Desmoplasiad.Anaplasia

49.Mostlethalofthesehemoglobinopathiesis?a.HbH diseaseb.HbBartsc.HbEdiseased.Thalassemiamajor

50.Besttodifferentiatebetweenintravascularandextravascularhemolysis?a.Ferritinb.Hepcidinc.Transferrind.Haptoglobin

51.Mostreliablefeatureofmalignancy?a.Pleomorphiccellsb.Intensebasophiliac.Lossofpolarityd.Breakofbasementmembraneandcelldissemination

52.Mostcommontypeofmetaplasia?a.Columnartosquamousb.Squamoustocolumnarc.Squamoustopseudostratifiedcolumnard.Columnartopseudostratifiedsquamous

53.Calcificationoftunicaintimaisafeatureof?a.Atherosclerosisb.Arteriosclerosisc.Monckeberg arteriosclerosisd.Hyalinearteriosclerosis

54.WhichofthefollowingdoesnotcontributetocellularSenescence?a.Telomereattritionb.Cellcyclearrestc.Activationoftumoursuppressorgenesd.Respiratoryburst

55.Diapedesisismediatedby?a.CD21b.CD30c.CD31d.CD45

56.Executionerphaseofcaspaseismediatedby?a.Caspase3andcaspase6b.Caspase3andcaspase8c.Caspase8andcaspase9d.Caspase8andcaspase10

57.Modeofdeathinreperfusioninjuryis?a.Apoptosisb.Necroptosisc.Pyroptosisd.Autophagy

58.Painismediatedvia?a.Histamineb.Lymphotactinc.Leukotrienesd.Prostaglandin

59.Anticipationisseenin?a.FragileXsyndromeb.Praderwili syndromec.Angelmansyndromed.TaySach disease

60.Largegranularlymphocytesare?a.Dendriticcellsb.Naturalkillercellsc.CytotoxicTlymphocytesd.RegulatoryTlymphocytes

61.MostorganinvolvementinAmyloidosisleadsto?a.Nephroticrangeproteinuriab.Nephriticsyndromec.Restrictivecardiomyopathyd.Seniledementia

62.HighN:Cratioandhyperchromasia isafeatureof?a.Anaplasiab.Metaplasiac.Dysplasiad.Malakoplakia

63.Mostcommoncancerinthedevelopedworldinmenis?a.Prostateb.Lungc.Colorectald.Skin

64.CommonestpresentationofAIDSincaseofcART notbeinginitiated?a.Orophyrangeal candidiasisb.P.Jirovecic.Bacterialpneumoniad.Tuberculosis

65.Whichofthefollowingisnotahypercoagulablestate?a.Antiphospholipidsyndromeb.FactorVleiden mutationc.Nephroticsyndromed.Hepaticfibrosis

66.Trinucleotiderepeatswithlossoffunctionisseenin?a.FragileXsyndromeb.Huntingtondiseasec.Klinefeltersyndromed.Spinocerebellarataxia

67.Virchowrobinspacesarefoundin?a.Brainb.Lymphnodesc.Heartd.Thymus

68.TypeIIHypersensitivityisseenin?a.Serumsicknessb.Arthus phenomenonc.Pathergyphenomenond.Perniciousanaemia

69.WhichchromosomaltranslocationleadstoAcutelymphoblasticLeukemia?a.t(9:22)b.t(8:14)c.Trisomy21d.t(15:17)

70.Consanguinityseenwithpatternofinheritance?a.ARb.ADc.XLRd.XLD

71.Leadingtumourofspleenis?a.MALTomab.GISTc.Lymphomad.Angiosarcoma

72.Whichiscorrectaboutmatchingofcarcinogenicagentwithdevelopmentofaparticularmalignancy?a.Hepatocellularcarcinoma:polycyclicaromatichydrocarbonsb.Stomachcancer:Nitrosaminesc.Lungcancer:AflatoxinBd.Bladdercancer:β-napthylamine

73.Triphenyltetrazolium chlorideisusedtostudydamagetoheartduetoMI.Whichiscorrectaboutthishistochemicalstaining?a.Redbrowncolourtotheinfarcttissueb.Bluecolourtoinfarcttissuec.Failuretouptakestaind.Concentriccirclesofuptake

74.Classicalpathwaybeginswith?a.C3ab.C3bc.C5ad.AgandAbcomplex

75.Allarehighlypremalignantconditionsoforalcavityexcept?a.Chronichyperplasticcandidiasisb.Oralsubmucosalfibrosisc.Orallichenplanusd.Leukoplakia

76.“Owleyeappearanceofcells”notedinlungbiopsyspecimenisindicativeofdiagnosisof?a.Non-Hodgkinlymphomab.MixedcellularitysubtypeofHodgkins lymphomac.Histoplasmosisd.CMVinfection