pamela lovern, ph.d.vetmed.okstate.edu/site-files/docs/faculty-staff-cv/pamela-lovern-cv.… ·...

Pamela Lovern, Ph.D. (formerly Pamela G. Lloyd)

Contact Information Dept. of Physiological Sciences Email: [email protected] 264 McElroy Hall Office Phone: (405) 744-9019 Oklahoma State University Cell Phone: (405) 269-9536 Stillwater, OK 74078 FAX: (405) 744-8263 Positions Held 2013- Graduate Program Coordinator, Veterinary Biomedical Sciences

Oklahoma State University College of Veterinary Medicine, Stillwater, OK

2012- Associate Professor (with tenure), Department of Physiological Sciences Oklahoma State University College of Veterinary Medicine, Stillwater, OK

2006-2012 Assistant Professor (tenure-track), Department of Physiological Sciences Oklahoma State University College of Veterinary Medicine, Stillwater, OK

2004-2006 Assistant Research Professor, Department of Cellular & Integrative Physiology Indiana University School of Medicine, Indianapolis, IN

2003-2004 Research Assistant Professor, Department of Medical Pharmacology and Physiology University of Missouri School of Medicine, Columbia, MO

Education 2000-2003 Postdoctoral Fellow

University of Missouri College of Veterinary Medicine, Columbia, MO

2000 Ph.D., Physiology Department of Physiology, University of Missouri School of Medicine, Columbia, MO

1992-1995 Post-baccalaureate studies, Biological Sciences University of Missouri, Columbia, MO

1991 B.A. (summa cum laude), Russian Area Studies University of Missouri, Columbia, MO

1990-1991 Study abroad University of Manchester, Manchester, United Kingdom

Research Interests Regulation of arteriogenesis (collateral artery enlargement); mechanisms by which diabetes inhibits arteriogenesis; mechanisms regulating placenta growth factor (PLGF) expression; regulation of arteriogenic signaling by biomechanical forces (stretch, shear stress) and reactive oxygen species; crosstalk between VEGF family growth factors and receptors; crosstalk between pulmonary epithelial and endothelial cells; stem cell therapy for vascular repair in COPD. Professional Memberships American Physiological Society, American Heart Association, Microcirculatory Society, Sigma Xi, Phi Zeta (honorary member)

Pamela Lovern, Ph.D. /13, 19 September 2019

Fellowships, Scholarships, And Honors 2015 Zoetis Award for Research Excellence 2013 Charter member, Gamma of Oklahoma chapter of Phi Beta Kappa 2012 Regents Distinguished Research Award, OSU 2009 Big 12 Faculty Fellowship (to visit Texas A&M University) 2009 J. Wiley Wolfe Award 2001 Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award 2000-2003 NIH National Research Service Award Postdoctoral Fellowship 2000 Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award 1999 First Prize, School of Medicine Research Day, University of Missouri 1999-2000 American Heart Association Predoctoral Fellowship 1999 Second Prize, University of Missouri Research and Creative Activities Forum 1997-1999 NIH Training Grant Fellowship 1995-1999 G. Ellsworth Huggins Doctoral Fellowship 1991- Phi Beta Kappa 1988-1991 National Merit Scholar

Research Funding Active “Role of advanced glycation end products (AGE) in angiogenic growth factor signaling.” Bridge grant,

Research Advisory Committee, OSU CVM (10/2018-9/2019). Role: PI. Direct costs: $15,000.

Completed “Regulation of placenta growth factor by hemodynamics and reactive oxygen species.” NIH 2R56

HL084494-06A1 (09/15/2016-08/31/2017). Role: PI. Annual direct costs: $250,000. Total costs: $361,738. No-cost extension until 8/31/2018.

“A novel tissue-equivalent respiratory model to study airway reactivity to infectious agents.” NIH P20 GM103648 (09/01/2013-08/31/2017). NIH COBRE (“Oklahoma Center for Respiratory & Infectious Diseases”) Role: Project Mentor for Project 2 (Project PI: Heather Fahlenkamp; COBRE PI: Lin Liu).

“Regulation of placenta growth factor by hemodynamics and reactive oxygen species.” NIH R01 HL-084494 (07/17/2009-06/30/2014). Role: PI. Annual direct costs: $250,000. Total costs: $1,811,587. No-cost extension until 6/30/2015.

“Mechanisms for fluid shear stress and metabolic dysfunction-mediated regulation of PLGF.” Research Advisory Committee, OSU CVM (10/2015-9/2016). Role: PI. Direct costs: $15,000.

“Adult stem cells to enhance repair of lung vasculature in chronic obstructive pulmonary disease.” Oklahoma Center for Adult Stem Cell Research (07/01/2014-06/30/2015). Role: PI. Total costs, $111,571.

“Acquisition of a BD FACSAria cell sorter to expand the capabilities of OSU’s Flow Cytometry Core Facility.” OSU Vice-President for Research & Technology Transfer’s Core Facility Support Program (11/20/2013-12/31/2014). Role: PI. Total costs: $466,766.

“An acquisition for a SELDI ProteinChip reader.” NSF Major Research Instrumentation grant (11/1/2010-10/31/2013). Role: PI (transfer from original PI - Wei Yin). No-cost extension until 10/31/2014.


“Mesenchymal stem cells and inflammatory signaling in COPD.” Oklahoma Center for Adult Stem Cell Research (01/01/2013-12/31/2013). Role: PI. Total costs: $112,000.

“Mesenchymal stem cell therapy to support maintenance and repair of lung vasculature in experimental COPD.” Oklahoma Center for Adult Stem Cell Research (01/01/2012-12/31/2012). Role: PI. Total costs: $72,800.

“Shared equipment for creating a lung disease model to test efficacy of adult stem cell therapy.” Oklahoma Center for Adult Stem Cell Research (01/01/2012-06/01/2012). Total costs, $21,280 (1:1 match by OSU). Role: Co-I (PI: Lin Liu).

“Endothelial progenitor cell survival and function in emphysema: role of VEGF-A/PLGF signaling.” Oklahoma Center for Adult Stem Cell Research (09/01/2010-12/31/2011). Role: PI. Total costs: $72,800.

“Effect of hyperlipidemia on signaling pathways mediating exercise-induced vascular remodeling.” Research Advisory Committee, OSU CVM (01/01/2010-12/31/2010). Role: Mentor (PI: Jennifer Shaw, postdoctoral fellow). Total costs: $9,947.

“VEGF and PLGF expression in hyperoxic lung and cultured pulmonary cells.” Research Advisory Committee, OSU CVM (02/13/2009-02/28/2010). Role: PI. Total costs: $20,000.

“PLGF expression in mouse models of hyperlipidemia and hyperglycemia.” Seed grant proposal. Research Advisory Committee, OSU CVM (08/1/2007-09/30/2008). Total costs: $18,500.

“Exercise, diabetes, and coronary smooth muscle Ca2+.” NIH R01 HL62552 (09/01/2004-08/31/2006). Role: Co-I (PI: Michael Sturek).

“Angiogenic growth factors in exercising skeletal muscle.” NIH National Research Service Award 1 F32 HL10406 (07/01/2000-06/30/2003). Direct costs: $105,944.

“Cytoplasmic organization of carbohydrate metabolism in vascular smooth muscle cells.” American Heart Association Heartland Affiliate Pre-Doctoral Fellowship 9910198Z (1999-2001). Direct costs: $32,000.

“Changes in angiogenic growth factor content and expression in skeletal muscle in response to exercise.” American Heart Association Postdoctoral Fellowship (2000-2002). Direct costs: $56,000. Awarded but declined to accept NRSA.

Manuscript Review Service (Ad Hoc) Microcirculation, Cardiovascular Research, Microvascular Research, American Journal of Physiology: Heart and Circulatory Physiology, American Journal of Physiology: Cell Physiology, Circulation Research, Journal of Applied Physiology, Journal of Vascular Research, Vascular Pharmacology, Pflugers Archiv – European Journal of Physiology, Physiological Research, International Journal of Physiology Pathophysiology and Pharmacology, American Journal of the Medical Sciences, Lipids, BioMedical Engineering Online, Antioxidants, Cell Death & Disease, Archives of Medical Research, Cellular Physiology & Biochemistry, Journal of Cardiology and Cardiovascular Sciences Professional Society Service 2013-2015 Member, Microcirculatory Society Awards Committee 2010-2014 Member, American Heart Association SouthWest Affiliate Research Advisory Committee


Grant Review Service 2019 Reviewer, NSF Graduate Research Fellowship Program 2018 Reviewer, American Heart Association AIREA Program 2018 Reviewer, NSF Graduate Research Fellowship Program 2017 Reviewer, NSF Graduate Research Fellowship Program 2016 (Spring) Reviewer, American Heart Association Cell Transport Peer Review Study Group 2016 Reviewer, NSF Graduate Research Fellowship Program 2015 Reviewer, NIH Special Emphasis Panel/Scientific Review Group 2015/05 ZRG1 EMNR-P

(02) M (Pregnancy and Neonatology) 2013 (Spring) Reviewer, American Heart Association Vascular Wall Biology Peer Review Study Group 2012 (Fall) Reviewer, American Heart Association Cell Transport Peer Review Study Group 2012 (Spring) Reviewer, American Heart Association Cell Transport Peer Review Study Group Committee & Other Service – University Level 2019-2022 Diversity Advisory Board 2018 Homecoming Judge for OSU Alumni Association 2018-2019 SCORE Research Culture Working Group 2017-2020 Faculty Council (Secretary)

Executive Committee (2017-)

Rules and Procedures Committee (chair) (2017-)

Faculty Committee (ex officio) (2017-) 2014-2017 Faculty Council (Representative, Center for Veterinary Health Sciences)

Executive Committee (2014-2016)

Budget Committee (chair) (2014-2016)

Faculty Committee (member, 2014-2016; chair, 2016-2017) 2010-2014 Graduate Council

Chair, Group VI of the OSU Graduate Faculty (2012-2014)

Academic Program Committee (2012-2014)

Vice Chair, Group VI of the OSU Graduate Faculty (2010-2012)

Membership Committee (2010-2012) 2016-2017 ITA Test Working Group 2014-2015 Core Facilities Committee 2013 Advisory Committee, BD FACS Aria III 2013 University Faculty Preparation Graduate Certificate review committee 2013-2016 Library Advisory Committee 2012-2013 Termination Hearing Board 2013 Regents Distinguished Teaching Award selection committee 2013 Regents Distinguished Research Award selection committee 2013 Niblack Research Scholars selection committee 2012 Academic Integrity Facilitator 2010 Honorary Degree Committee Committee Service – College Level 2018- Curriculum Review and Revision Committee (for the preclinical DVM curriculum) 2017 Veterinary Pathobiology Faculty Search Committee 2015-2017 Veterinary Faculty Council (ex officio)


2013- Graduate Education Advisory Committee (ex officio) 2012 Dean’s Task Force on Departmental Organization 2010-2013 Graduate Education Advisory Committee 2010 Program Selection Committee, Veterinary Research Scholars Program 2009-2012 Continuing Education Committee 2009-2010 Chair, Student Technology Fee Committee 2008-2009 Graduate Education Advisory Committee (ad hoc) 2007-2009 Student Technology Fee Committee Committee Service – Department & Facility Level 2018, 2019 Physiological Sciences Faculty Search Committee 2014 Department Head Search Committee 2011- Physiological Sciences Research Committee 2011, 2009 Faculty Search Committee 2010 Advisory Committee, OSU Microscopy Lab 2008-2010 Staff Incentive Ad Hoc Committee 2006-2011 Physiological Sciences Teaching Committee Teaching (OSU) Years Course

# Course Title (semester) Role Duties Contact

Hours/year

2008- VMED 7114

Veterinary Physiology I (fall, every year)

Lecturer Presented lectures in cardiovascular physiology to ~82-106 first year DVM students

12-15

2008- VBSC 5010

Professional Skills for Biomedical Scientists (fall, every year from 2018)

Instructor of Record

Developed & taught orientation course to 5-10 graduate students

28

2014- VBSC 6110

Seminar (fall, spring) Instructor of Record

Organize seminar schedule for required graduate course; recruit visiting speakers and seminar graders

32

2010, 2011, 2015, 2017

VBSC 5013

Cellular & Molecular Biology (fall) Lecturer Presented lectures to~20 graduate students

2-3

2012, 2014

VBSC 5110

Advanced Cardiovascular Physiology Lecturer Presented 2-3 lectures on vascular physiology to ~10 graduate students

8

2009- n/a Veterinary Scholars Summer Research Program (summer)

Lecturer Presented lecture “Abstracts and Posters” to 14-18 DVM students

1.5

Teaching (other institutions)

Years Course #

Course Title Role Duties Contact Hours/year

2005 X604 Concepts of Health & Disease (Indiana University)

Facilitator Guided a group of 8 first-year MD students in PBL

25

1995-1996

PHYS 201

Elements of Physiology (University of Missouri)

Graduate TA

Assisted allied health students in lab ~100


Trainees Supervised Graduate students Oluwayemisi Semola (MS student). Major advisor (2017-) Bo Zhai (PhD student). Major advisor (2013-2018).

Received PhD degree 12/2018

Next position: Postdoctoral fellow, Department of Immunology, University of Pittsburgh Farzana Rouf (PhD student, Mechanical & Aerospace Engineering). Co-advisor (2013-2016)


Awarded OSU Women’s Faculty Council Research Award (2016) Asitha Silva (PhD student). Major advisor (2011-2015)


Abstracts selected for oral presentation, Harold Hamm Diabetes Center Research Symposium, OU Health Sciences Center, Oklahoma City, OK (2013, 2014)

Next position: Postdoctoral fellow, Department of Surgery, UT Southwestern Medical Branch, Dallas, TX

Current position: Associate Professor, Lone Star College, Houston, TX Nabil Rashdan (PhD student). Major advisor (2010-2015)


Awarded Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award (2012)

Awarded Distinguished Graduate Fellowship (OSU, 2013-2015)

Next position: Postdoctoral fellow, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK

Current position: Postdoctoral fellow, Louisiana State University - Shreveport Postdoctoral fellows Rohan Varshney, PhD. Mentor (2011-2013)

Next position: Postdoctoral fellow, OU Health Sciences Center, Oklahoma City, OK. Jennifer Shaw, PhD. Mentor (2009-2012)

Next position: Assistant Professor (tenure-track), Department of Integrative Biology, Oklahoma State University. Awarded tenure 2018.

Current position: Associate Professor, Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine - South Georgia

Professional students/Undergraduates Kristin Coleman (DVM student). Mentor, Veterinary Research Scholars Program (2009) Desiree Poore (DVM student). Mentor, Veterinary Research Scholars Program (2008) Abby McKisson (Early-admit student). Research mentor, Veterinary Research Scholars Program (2013) Jaron Soulek (Wentz Fellowship student). Research mentor, 2010-2011 Samantha Bilko (Early-admit student). Research mentor, Veterinary Research Scholars Program (2010)

& Freshman Research Scholars Program (2010-2011). *Winner of a David S. Bruce Award for Excellence in Undergraduate Research at Experimental Biology 2011


Graduate Student Committee Member Ramasamy Selvarani (PhD, Veterinary Biomedical Sciences) (2015-2017). Received MS degree 12/2017. Xuxu Gou (PhD, Veterinary Biomedical Sciences) (2015-2016). Received MS degree 5/2016. Lakmini Senavirathna (PhD, Veterinary Biomedical Sciences) (2015-) Mallika Achanta (PhD, Veterinary Biomedical Sciences) (2014-2016). Left program. Mina Derakhshan (PhD, Chemical Engineering) (2014-2018). Committee reorganized. Niloufar Mehrafza (MS, Mechanical & Aerospace Engineering) (2013-2014). Received degree 5/2014. Damir Kolasinac (MS, Mechanical & Aerospace Engineering) (2013-2014). Received degree 5/2014. Mahmudul Hasan (MS, Mechanical & Aerospace Engineering) (2013). Received degree 5/2013. Sarmin Sultana (MS, Mechanical & Aerospace Engineering) (2012-2013). Received degree 12/2013. Tahanee Mujib (MS, Mechanical & Aerospace Engineering) (2011-2013). Received degree 12/2013. Zahra Maria (PhD, Mechanical & Aerospace Engineering) (2011-2016). Received degree 8/2016. Farzana Rouf (MS, Mechanical & Aerospace Engineering) (2010-2011). Received degree 5/2011. Blake Morton (MS, Mechanical & Aerospace Engineering) (2010-2011). Left program. Harry Gichinga (PhD, Anatomy & Cell Biology, OSU-Tulsa (2010-2013). Received MS degree 8/2013. Saravan Kumar (PhD, Mechanical & Aerospace Engineering) (2009-2013). Received degree 5/2013. Heidi Banse (PhD, Veterinary Biomedical Sciences) (2009-2013). Received degree 5/2013. Yang Wang (PhD, Veterinary Biomedical Sciences) (2007-2011). Received degree 12/2011. Nicole Singleton (MS, Veterinary Biomedical Sciences) (2007). Left program. Presentation Judging Phi Zeta Research Day (2019, 2018, 2011, 2010, 2008) Microbiology and Molecular Genetics GSA Graduate Research Symposium (2016, 2015) Veterinary Research Scholars Program (2015, 2007) Professional Development Activities/Training “Preparing Future Faculty.” April 4, 2019. Panel member for discussion presented by Women’s Faculty

Council. “Designing an Effective Course/Writing Learning Outcomes.” February 4, 2019. Teaching workshop

(presented by Dr. Brandon Raczkoski). “Academic Leadership Academy.” Fall 2016/Spring 2017. Professional development seminar series. “Articulating Learning Outcomes & Learning Opportunities.” February 10, 2017. Assessment workshop

(presented by Dr. Linda Suskie). “Women’s Leadership Academy.” Spring 2013. Mentor: Dr. Jean van Delinder, Associate Dean, OSU

Graduate College.

Invited Talks 1. “Effects of Western diet induced metabolic dysfunction on angiogenic signaling in mice.”

Department of Nutrition & Exercise Physiology, University of Missouri. Columbia, MO. Oct. 8, 2015. 2. “Hemodynamics, oxidative stress, and the arteriogenic growth factor PLGF.” Invited speaker,

symposium in honor of Dr. Ronald Terjung’s retirement. University of Missouri College of Veterinary Medicine. Columbia, MO. June 2, 2013.

3. “Regulation of PLGF expression in vascular cells by reactive oxygen species and shear stress.” University of Oklahoma Health Sciences Center. Oklahoma City, Oklahoma. March 1, 2012.

4. “PLGF expression in vascular cells: effects of reactive oxygen species, mechanical stimuli, and diabetes.” Oklahoma State University Center for Health Sciences. Tulsa, OK. Nov. 4, 2011.


5. “Hydrogen peroxide as a novel mediator of placenta growth factor expression in vascular smooth muscle.” Texas A&M Health Science Center Cardiovascular Research Institute seminar series. (Also presented to the Temple campus of the Texas A&M Health Science Center College of Medicine via teleconference). College Station, TX. July 2, 2009.

6. “Influence of metabolic state on regulation of the arteriogenic protein PLGF: a role for reactive oxygen species?” Department of Nutrition & Exercise Physiology, University of Missouri. Columbia, MO. Sept. 11, 2008.

7. “Hyperlipidemia induced dysregulation of placenta growth factor expression.” Vasculogenesis/ Angiogenesis/Arteriogenesis Platform Session of the American Association of Anatomists. Experimental Biology 2007. Washington, DC. May 1, 2007.

National Meeting Attendance/Poster Presentations (since joining OSU faculty) Experimental Biology 2015. March 28-April 2, 2015 (Boston, MA). Keystone Symposium: Engineering Cell Fate & Function. April 6-11, 2014 (Olympic Valley, CA). Keystone Symposium: Metabolism and Angiogenesis. March 16-21, 2014 (Whistler, BC Canada). Arteriosclerosis, Thrombosis, & Vascular Biology 2013. May 1-3, 2013 (Lake Buena Vista, FL). Keystone Symposium: Stem Cell Regulation in Homeostasis and Disease. February 24-March 1, 2013

(Banff, AB Canada). Experimental Biology 2012. April 21-25, 2012 (San Diego, CA). Experimental Biology 2011. April 9-13, 2011 (Washington, DC). Experimental Biology 2010. April 24-28, 2010 (Anaheim, CA). Frontiers in Microcirculation: Control Processes & Clinical Applications. Oct. 17-19, 2009 (Columbia

MO). International Society for Heart Research. May 26-29, 2009 (Baltimore, MD). Experimental Biology 2008. April 5-9, 2008 (San Diego, CA). Experimental Biology 2007. April 28-May 2, 2007 (Washington, DC).


Publications (under former name Pamela G. Lloyd prior to 2018)

https://orcid.org/0000-0001-7943-4722 1. Rashdan NA, Zhai B, Clarke SL, and Lovern PC. Fluid shear stress regulates PLGF expression via

heme oxygenase 1 and iron. In preparation, 2019. 2. Silva AT, Rouf F, Semola O, Payton ME, and Lovern PC. Placental growth factor levels in quadriceps

muscle are reduced by a Western diet in association with advanced glycation end products. Accepted for publication, American Journal of Physiology: Heart and Circulatory Physiology, 2019.

3. Shoop S, Maria Z, Rashdan N, Campolo AR, Martin D, Lovern P, Lacombe VA. Glial growth factor 2 regulates glucose transport in healthy and failing cardiac myocytes via an Akt-dependent pathway. Frontiers in Physiology 10: 189, 2019.

4. Sivasami P, Poudel N, Munteanu MC, Hudson J, Lovern P, Liu L, Griffin T, and Hinsdale ME. Adipose tissue loss and lipodystrophy in xylosyltransferase II deficient mice. International Journal of Obesity 2019 Feb 18 doi: 10.1038/s41366-019-0324-1 (Epub ahead of print).

5. Rashdan NA and Lloyd PG. Fluid shear stress upregulates placental growth factor in the vessel wall via NADPH oxidase 4. American Journal of Physiology: Heart and Circulatory Physiology 309(10):H1655-66, 2015.

6. Zhang L, Huang C, Guo Y, Gou X, Hinsdale M, Lloyd P and Liu L. MicroRNA-26b modulates the NF-B pathway by regulating PTEN in alveolar macrophages. Journal of Immunology 195(11):5404-14, 2015.

7. Xiao X, Huang C, Zhao C, Hinsdale M, Lloyd P and Liu L. Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition. Archives of Biochemistry and Biophysics 566: 49-57, 2015.

8. Xiang L, Varshney R, Rashdan NA, Shaw JH, and Lloyd PG. Placenta growth factor and vascular endothelial growth factor-A have differential, cell-type specific patterns of expression in vascular cells. Microcirculation 21(5): 368-379, 2014. doi: 10.1111/micc.12113

9. Liu L, Lloyd PG, and Hinsdale ME. “Lung development.” In: MicroRNA in Regenerative Medicine, edited by Chandan K. Sen. Elsevier, 2013.

10. Haas TL, Lloyd PG, Yang HT, and Terjung RL. Exercise and peripheral arterial insufficiency. Invited review. Comprehensive Physiology 2: 2933-3017, 2012.

11. Shaw JH and Lloyd PG. Placenta growth factor mRNA is regulated by hydrogen peroxide at the post-transcriptional level. Microvascular Research 84(2): 155-160, 2012.

12. Lloyd PG. Caveolin-1, anti-apoptosis signaling, and anchorage-independent cell growth. American Journal of Physiology: Cell Physiology 302(9): C1282-1283, 2012.

13. Shaw J, Xiang L, Shah A, Yin W, and Lloyd PG. Placenta growth factor expression is regulated by hydrogen peroxide in vascular smooth muscle cells. American Journal of Physiology: Cell Physiology 300 (2): C349-355, 2011.

14. Lloyd PG and Hardin C. Caveolae and cancer: two sides of the same coin? American Journal of Physiology: Cell Physiology 300 (2): C232-234, 2011.

15. Yang HT, Prior BM, Lloyd PG, Taylor JC, Laughlin MH, and Terjung RL. Training-induced vascular adaptations to ischemic muscle. Journal of Physiology and Pharmacology 59 (Suppl 7): 57-70, 2008.

16. Lloyd PG, Sheehy AS, Edwards JM, Mokelke EA, Vuchetich JP, and Sturek M. Leukemia inhibitory factor is upregulated in stented coronary arteries of Ossabaw swine. Coronary Artery Disease 19(4): 217-226, 2008.

https://orcid.org/0000-0001-7943-4722


17. Edwards JM, Long XL, Alloosh MA, Dick GM, Lloyd PG, Mokelke EA, and Sturek M. Adenosine A1 receptors in neointimal hyperplasia and in-stent stenosis in Ossabaw miniature swine model of the metabolic syndrome. Coronary Artery Disease 19(1): 27-31, 2008.

18. Sturek M, Alloosh M, Wenzel J, Byrd JP, Edwards JM, Lloyd PG, Tune JD, March KL, Miller MA, Mokelke EA, and Brisbin IL Jr. Ossabaw Island miniature swine: cardiometabolic syndrome assessment. In: Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition. M.M. Swindle (Ed.). Boca Raton: CRC Press, 2007.

19. Mattern HM, Lloyd PG, Sturek M, and Hardin CD. Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Molecular & Cellular Biochemistry 302: 43-49, 2007.

20. Raikar LS, Vallejo J, Lloyd PG, and Hardin CD. Overexpression of caveolin-1 results in increased plasma membrane targeting of phosphofructokinase: the structural basis for a membrane associated metabolic compartment. Journal of Cellular Biochemistry 98(4): 861-871, 2006.

21. Lloyd PG, Prior BM, Li H, Yang HT, and Terjung RL. VEGF receptor antagonism blocks arteriogenesis, but only partially inhibits angiogenesis, in skeletal muscle of exercise trained rats. American Journal of Physiology Heart and Circulatory Physiology 288: H759-H768, 2005.

22. Prior BM, Lloyd PG, Ren J, Li H, Yang H, Laughlin MH, and Terjung RL. Time-course of changes in collateral blood flow and isolated vessel size and gene expression following femoral artery occlusion in the rat. American Journal of Physiology Heart and Circulatory Physiology 287: H2434-H2447, 2004.

23. Prior BM, Lloyd PG , Li Z, Ren J, Yang H, Laughlin MH, and Terjung RL. Arteriogenesis: role of nitric oxide. Endothelium 10: 207-216, 2003.

24. Lloyd PG, Prior BM, Yang HT, and Terjung RL. Angiogenic growth factor expression in rat skeletal muscle in response to exercise training. American Journal of Physiology Heart and Circulatory Physiology 284: H1668-H1678, 2003.

25. Prior BM, Lloyd PG, Yang HT, and Terjung RL. Exercise-induced vascular remodeling. Exercise and Sports Sciences Reviews 31(1): 26-33, 2003.

26. Lloyd PG, Yang HT, and Terjung RL. Arteriogenesis and angiogenesis in rat ischemic hindlimb: role of nitric oxide. American Journal of Physiology Heart and Circulatory Physiology 281: H2528-H2538, 2001.

27. Lloyd PG and Hardin CD. Caveolae and the organization of carbohydrate metabolism in vascular smooth muscle. Journal of Cellular Biochemistry 82(3):399-408, 2001.

28. Lloyd PG and Hardin CD. Sorting of metabolic pathway flux by the plasma membrane in cerebrovascular smooth muscle cells. American Journal of Physiology Cell Physiology 278: C803-C811, 2000.

29. Lloyd PG, Hardin CD, and Sturek M. Examining glucose transport in single vascular smooth muscle cells with a fluorescent glucose analog. Physiological Research 48 (6): 401-410, 1999.

30. Lloyd PG and Hardin CD. The role of microtubules in the regulation of metabolism in isolated cerebral microvessels. American Journal of Physiology Cell Physiology 277: C1250-C1262, 1999.

Published Abstracts 1. Shoop SA, Rashdan N, Maria Z, Campolo AR, Martin D, Jackson EE, Lloyd P, Lacombe VA. Glial

growth factor 2 regulates glucose transport in cardiac myocytes via an Akt-dependent pathway. Submitted to American Heart Association Scientific Sessions 2016.

2. Rouf F and Lloyd PG. Placental growth factor expression is inhibited by hyperglycemia in cardiac cells. Presented at “Experimental Biology 2016.”


3. Rouf F and Lloyd PG. Effect of diabetes-associated metabolic factors on placental growth factor in skeletal muscle cells. Presented at “Experimental Biology 2016.”

4. Silva AT and Lloyd PG. Abnormal regulation of placental growth factor in skeletal muscle of Western-diet fed mice. Presented at “Experimental Biology 2015.”

5. Rashdan NA and Lloyd PG. Autocrine and paracrine effects of VEGF-A on PLGF in an in vitro model of the vessel wall. Presented at “Experimental Biology 2015.”

6. Rashdan NA and Lloyd PG. Nox4 and HO-1 mediate effects of fluid shear stress on PLGF in an in vitro model of the vessel wall. Presented at “Experimental Biology 2015.”

7. Rashdan NA and Lloyd PG. Regulation of PLGF by shear stress in an in vitro model of the vessel wall via redox signaling. Presented at Keystone Symposium on “Metabolism and Angiogenesis,” 2014.

8. Silva A and Lloyd PG. Placenta growth factor expression in mouse heart correlates with long term diet induced hyperlipidemia and oxidative stress. Presented at Keystone Symposium on “Metabolism and Angiogenesis,” 2014.

9. Zhai B, Zhang L, Huang C, Varshney R, Sivasami P, Hinsdale M, Liu L, Lloyd PG. Mesenchymal stem cell expressed VEGF-E protects pulmonary endothelial cells from cigarette smoke toxicity. Accepted to “Experimental Biology 2014.”

10. Rashdan NA and Lloyd PG. Shear stress upregulates placenta growth factor in an in vitro model of the vessel wall in a reactive oxygen species dependent manner. Presented at “Arteriosclerosis, Thombosis, and Vascular Biology 2013.”

11. Silva, AT and Lloyd PG. Effect of long-term diet-induced hyperglycemia and hyperlipidemia on placenta growth factor expression in mouse heart. Presented at “Arteriosclerosis, Thombosis, and Vascular Biology 2013.”

12. Shaw JH, Rashdan NA, and Lloyd PG. Shear stress induces the expression of connexin-43 in human coronary smooth muscle. Presented at “Arteriosclerosis, Thombosis, and Vascular Biology 2013.”

13. Varshney R, Sivasami P, Zhang L, Rubenstein D, Liu L, Hinsdale M, and Lloyd PG. Mesenchymal stem cell conditioned medium protects lung endothelial cells against cigarette smoke induced cell death. Presented at Keystone Symposium on “Stem cell regulation in homeostasis and disease,” 2013.

14. Zhang L, Huang C, Sivasami P, Varshney R, Lloyd PG, Hinsdale M, Liu L. MicroRNAs enhance the differentiation of mouse induced pluripotent stem cells into alveolar type II cells. Presented at Keystone Symposium on “Stem cell regulation in homeostasis and disease,” 2013.

15. Sivasami P, Varshney R, Zhang L, Lloyd PG, Liu L, and Hinsdale M. Molecular understanding of proteoglycans and adult stem cell niches. Accepted to Keystone Symposium “Stem cell regulation in homeostasis and disease,” 2013.

16. Rashdan NA and Lloyd PG. Shear stress upregulates PLGF protein expression in an endothelial cell/vascular smooth muscle cell coculture system. FASEB Journal 26: 683.8, 2012.

17. Shaw JH and Lloyd PG. Placenta growth factor is regulated by hydrogen peroxide at the post-transcriptional, but not the transcriptional, level in vascular smooth muscle. FASEB Journal 26: 863.5, 2012.

18. Varshney RR and Lloyd PG. Mesenchymal stem cells isolated from bone marrow and compact bone express both VEGF and PLGF. FASEB Journal 26: 856.4, 2012.

19. Xiang L and Lloyd PG. Evidence for a role of endothelial-cell derived PLGF in paracrine communication. FASEB Journal 26: 1129.23, 2012.

20. Rashdan NA, Soulek J, and Lloyd PG. PLGF expression in coronary artery smooth muscle cells is sensitive to changes in shear stress. FASEB Journal 25:lb462, 2011.

21. Shaw JH and Lloyd PG. Hydrogen peroxide increases PLGF mRNA half-life via a p38 and ERK1/2 kinase dependent mechanism. FASEB Journal 25: 821.36, 2011.


22. Rubenstein DA, Mujib T, Shaw JH, Lloyd PG, and Yin W. Altered gravity promotes platelet-endothelial cell interactions that precede cardiovascular diseases. FASEB Journal 25:668.5, 2011.

23. Bilko SJ, Xiang L, Liu L, and Lloyd PG. VEGF family growth factor ratio is abnormal in bronchopulmonary dysplasia. FASEB Journal 25:660.3, 2011.

24. Xiang L, Yin W, and Lloyd PG. Cell-type specific patterns of gene expression predict the existence of VEGF and PLGF homo- and heterodimer gradients in the vascular wall. FASEB Journal 24:1031.11, 2010.

25. Shaw JH and Lloyd PG. Hydrogen peroxide upregulates PLGF and VEGF-A expression in primary human coronary artery smooth muscle cells. FASEB Journal 24:1031.9, 2010.

26. Lloyd PG, Xiang L, Coleman K, and Yin W. VEGF and PLGF levels vary strikingly across vascular cell lines. Microcirculation 2009.

27. Shah A, Poore D, and Lloyd PG. Reactive oxygen species regulate placenta growth factor expression in vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology 46(5), supplement: S21, 2009.

28. Shah A, Poore D, and Lloyd PG. Cardiac expression of placenta growth factor is inhibited by hyperlipidemia in mice. Journal of Molecular and Cellular Cardiology 46(5), supplement: S46, 2009.

29. Shah A, Sitzmann JV, and Lloyd PG. Expression of placenta growth factor in cardiac and vascular tissue and in hemangioendothelioma cells. Journal of Molecular and Cellular Cardiology 46(5), supplement: S21, 2009.

30. Lloyd PG, Shah A, and Yin W. Placenta growth factor gene expression is increased in vascular smooth muscle cells in association with metabolic stress. FASEB Journal, 2008.

31. Lloyd PG, Alloosh M, and Sturek M. Hyperlipidemia induced dysregulation of placenta growth factor expression. FASEB Journal, 2007.

32. Lloyd PG, Dick GM, Alloosh M, Unthank JL, and Sturek M. Exercise training improves peripheral vascular function following chronic femoral artery occlusion in the Ossabaw swine model of cardiometabolic risk. Medicine & Science in Sports & Exercise 38, Suppl. 1:S1, 2006.

33. Long X, Edwards JM, Lloyd PG, Mokelke EA, and Sturek M. Activation of adenosine A1 receptors induces coronary smooth muscle cell proliferation in an in vitro model of atherosclerosis. Medicine & Science in Sports & Exercise 38, Suppl. 1:S34, 2006.

34. Lloyd PG and Sturek M. Coronary artery placenta growth factor expression is reduced by diabetes and hyperlipidemia. FASEB Journal 20(4): A716, 2006.

35. Lloyd PG, Fang M, Brisbin IL, Andersson L, and Sturek M. AMP kinase gene mutation is consistent with a thrifty phenotype (metabolic syndrome) in a population of feral swine. FASEB Journal 20(4): A299, 2006.

36. Lloyd PG, Mokelke EA, Kaser S, Alloosh M, Hou Y, Clauss M, and Sturek M. Placenta growth factor expression is regulated by stretch and correlates with microvascular dysfunction and plasma LDL. FASEB Journal 20(4): A716, 2006.

37. Long X, Lloyd PG, Sheehy AJ, Mokelke EA, and Sturek M. Bare metal stents increase mitogenic receptor gene expression in coronary artery of Ossabaw pig model of the metabolic syndrome. FASEB Journal 20(4): A699, 2006.

38. Hand A, Lloyd PG, Alloosh M, Cameron JA, and Sturek M. Adenosine A1 receptors in the metabolic syndrome and coronary artery disease. FASEB Journal, 2006.

39. Sheehy AJ, Mokelke EA, Lloyd PG, Sturek J, and Sturek M. Reduced expression of leukemia inhibitory factor correlates with coronary atherosclerosis in the metabolic syndrome. FASEB Journal 20(4): A698, 2006.


40. Hardin CD, Lloyd PG, Mattern HM, Stricklin C, Sturek M, and Roberts TM. Smooth muscle caveolin-1 mRNA levels are reduced in a genetic model of type 2 diabetes and modulated by high fat diets. FASEB Journal 19(4): A195, 2005.

41. Hardin CD, Raikar LS, Lloyd PG, and Roberts TM. Overexpression of caveolin-1 results in increased plasma membrane targeting of phosphofructokinase (PFK): The structural basis for a membrane associated metabolic compartment. FASEB Journal 19(4): A27, 2005.

42. Mattern HM, Lloyd PG, Sturek M, Hardin CD. Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. FASEB Journal 19(4): A260, 2005.

43. Prior BM, Lloyd PG, Ren J, Li H, Yang HT, and Terjung RL. Exercise-induced collateral vascular remodeling and function in rats with femoral artery occlusion. FASEB Journal 17(4): A501, 2003.

44. Yang HT, Lloyd PG, Prior BM, Li H, and Terjung RL. VEGF receptor antagonist blocks training-induced collateral vascular remodeling. FASEB Journal 17(4): A498, 2003.

45. Yang HT, Lloyd PG, Prior BM, Li H, and Terjung RL. VEGF receptor antagonist reduces training-induced angiogenesis in active muscle. Medicine & Science in Sports & Exercise 35(5) supplement, 2003.

46. Prior BM, Lloyd PG, Yang HT, and Terjung RL. Exercise training increases angiogenic growth factor mRNA expression in muscle of rats with hindlimb ischemia. FASEB Journal 16(4): A90-91, 2002.

47. Lloyd PG, Prior BM, Yang HT, Yan Z, and Terjung RL. Angiopoietin and Tie-2 mRNA expression in rat white gastrocnemius is altered by exercise and femoral ligation. FASEB Journal 15(4): A118, 2001.

48. Lloyd PG, Prior BM, Gale NW, Yancopoulos GD, and Terjung RL. Angiopoietin-2 expression in adult mouse skeletal muscle vasculature. FASEB Journal 15(4): A118, 2001.

49. Prior BM, Lloyd PG, Yang HT, Yan Z, and Terjung RL. Angiopoietin and Tie-2 mRNA expression in adult skeletal muscle of rat hindlimb varies with fiber type. FASEB Journal 15(4): A792, 2001.

50. Lloyd PG, Yang HT, Chen JP, and Terjung RL. Exercise-induced angiogenesis in rat white gastrocnemius is unaffected by nitric oxide synthesis blockade. The Physiologist 43(4): 350, 2000.

51. Lloyd PG and Hardin CD. Caveolae and metabolic organization. FASEB Journal 14(4): A149, 2000. 52. Lloyd PG and Hardin CD. Channeling and organization of glycolysis and gluconeogenesis in

permeabilized pig cerebral microvessels (PPCMV). FASEB Journal 13(4): A33, 1999. 53. Lloyd PG and Hardin CD. The role of microtubules in the regulation of glycolysis in freshly isolated

pig cerebral microvessels (PCMV). Biophysical Journal 76(1): A42, 1999. 54. Hardin CD, Lloyd PG, Jeffrey TM, Roberts TM, and Finder DR. Organization and integration of

metabolism in vascular smooth muscle (VSM) assessed by 13C-NMR. Biophysical Journal 74(2): A224, 1998.

55. Lloyd PG, Hardin CD, and Sturek M. Use of a small fluorescent glucose analog as an indicator of glucose transport in pig vascular smooth muscle cells (VSMC). Journal of Molecular and Cellular Cardiology 30: A63, 1998.

56. Lloyd PG, Thompson AD, and Hardin CD. Examining the structural basis of compartmented glycolysis in pig cerebral microvessels (PCMV). Journal of Molecular and Cellular Cardiology 30: A122, 1998.

pamela lovern, ph.d.vetmed.okstate.edu/site-files/docs/faculty-staff-cv/pamela-lovern-cv.… ·...

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