palliation with endoluminal stents todd h. baron, m.d., f.a.c.p. professor of medicine...
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Palliation With Endoluminal Palliation With Endoluminal StentsStents
Todd H. Baron, M.D., F.A.C.P.Todd H. Baron, M.D., F.A.C.P.
Professor of MedicineProfessor of Medicine
Gastroenterology & HepatologyGastroenterology & Hepatology
Mayo Clinic College of MedicineMayo Clinic College of Medicine
Enteral StentsEnteral Stents
Malignant Gastric Outlet Malignant Gastric Outlet ObstructionObstruction
Clinical SituationsClinical Situations• Unresectable CAUnresectable CA
pancreatic, GB, Cholangiopancreatic, GB, Cholangio• Metastatic diseaseMetastatic disease• Local invasion - colonLocal invasion - colon• Gastric CAGastric CA• primaryprimary•RecurrentRecurrent
SEMS: OverviewSEMS: Overview
• May be placed endoscopically or May be placed endoscopically or radiologicallyradiologically
• Non-TTS difficult but possibleNon-TTS difficult but possible
• TTS placement - can be placed TTS placement - can be placed beyond ligament of Treitz - beyond ligament of Treitz - uncovereduncovered
WallstentWallstent
• Delivery diameter: Delivery diameter: 10F10F
• Deployed diameter: Deployed diameter:
20mm20mm
22mm22mm
• TTSTTS
ENDO ENDO GASTRO-JGASTRO-J p p
Number of patients Number of patients 1212 15 15
Median survival (days) Median survival (days) 9494 9292 NS NS
Median charges incurred Median charges incurred $9921 $9921 $28,173 $28,173 < 0.005 < 0.005
Median hospitalizationMedian hospitalization stay required (days) stay required (days) 4 4 14 14 < 0.005< 0.005
Number requiring repeat procedures Number requiring repeat procedures and hospitalization and hospitalization 7 (58.3%) 7 (58.3%) 15 (100%) 15 (100%)
Yim, et al., GIE, 2001Yim, et al., GIE, 2001
Cost of Palliation: Pancreatic CACost of Palliation: Pancreatic CA
Malignant Colorectal Malignant Colorectal ObstructionObstruction
Metal Colonic StentsMetal Colonic Stents• Wilson-Cook Z stentWilson-Cook Z stent
• Microvasive WallstentMicrovasive Wallstent
• Precision Ultraflex ColonicPrecision Ultraflex Colonic
OTHEROTHER• Ultraflex Esophageal StentUltraflex Esophageal Stent
Colonic Z-StentColonic Z-Stent
• Delivery diameter:Delivery diameter:
10mm (30F)10mm (30F)
• Deployed diameter: Deployed diameter: 35/25mm35/25mm
Indications for Colorectal StentsIndications for Colorectal Stents
• Pre-operativePre-operative
• PalliativePalliative
• IndeterminateIndeterminate
Potential Benefits ofPotential Benefits ofPre-operative Colon StentsPre-operative Colon Stents
• One-stage operationOne-stage operation
• Reduced costsReduced costs
• Improved QOLImproved QOL
• Elective operationElective operation
• Pre-operative assessmentPre-operative assessment
tumor resectabilitytumor resectability
patient operabilitypatient operability
Complications of Enteral Stents Complications of Enteral Stents • Tumor ingrowth/overgrowthTumor ingrowth/overgrowth
• MigrationMigration
• PerforationPerforation
immediateimmediate
delayeddelayed
• Impaction Impaction
• BleedingBleeding
• Pain/TenesmusPain/Tenesmus
ConclusionsConclusions• SEMS are effective for closing TEF and SEMS are effective for closing TEF and
treating all forms of malignant treating all forms of malignant esophageal obstructionesophageal obstruction
• SEMS are cost-effective for palliation of SEMS are cost-effective for palliation of malignant GOO for pancreatic CAmalignant GOO for pancreatic CA
• SEMS can be used for both pre-SEMS can be used for both pre-operative and palliative treatment of operative and palliative treatment of malignant colonic obstruction malignant colonic obstruction