p504s (SP116) Rabbit Monoclonal Primary AntibodyDeliver diagnostic confidence

p504s (SP116) is a ready-to-use IHC antibody that enables you to evaluate the expression of p504s protein with clinical confidence

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p504s (SP116) Rabbit Monoclonal Primary Antibody (p504s (SP116) antibody) is directed against the p504s enzyme (also known as alpha-Methylacyl Coenzyme A racemase or AMACR). p504s is found to be overexpressed in human prostatic carcinoma, and exhibits a granular, cytoplasmic staining pattern in malignant glands and cells.1

Publications demonstrate the utility of p504s as an aid to the pathologist in recognizing small foci prostatic carcinoma when used to compliment an absence of basal cell staining.2 This can be achieved in a dual stain with the Basal Cell Cocktail (34βE12 + p63) to optimize the use of limited available tissue on small focal cancer biopsies.3

p504s (SP116) antibody has been optimized for use with the VENTANA ultraView Alkaline Phosphatase Red Detection kit as a single stain, and for use in a dual stain with the VENTANA Basal Cell Cocktail (34βE12 + p63), visualized with VENTANA ultraView Universal DAB Detection kit.

p504s (SP116) Rabbit Monoclonal Primary Antibody

Product name Catalogue number Ordering code Tests

p504s (SP116) Rabbit Monoclonal Primary Antibody 790-6011 08035130001 50

References

1. Jiang J et al. Using an AMACR (P504S/34βE12/p63 Cocktail for the Detection of Small Focal Prostate Carcinoma in Needle Biopsy Specimens. Am J Clin Pathol. 2005;123:231-236.

2. Epstein, J I. Diagnosis of limited adenocarcinoma of the prostate. Histopathology. 2012; 60:28-40.

3. Ng, V W et al. Is Triple Immunostaining With 34βE12, p63, and Racemase in Prostate Cancer Advantageous? A Tissue Microarray Study. Am J Clin Pathol. 2007; 127:248-253.

Prostate carcinoma stained with the p504s assay using ultraView Alkaline Phosphatase Red detection

Basal Cell Cocktail (34βE12/p63) and ultraView Universal DAB detection

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