p1 · magosney,jf rgosney, mlye 1106 hpvtype 16 in conjunctival andjunctional papilloma, dysplasia,...

Editorial

1075 Editors on Editors

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Leaders

1078 Subarachnoid haemorrhage and myths about saccular aneurysms R 0 Weller1082 Review of a consultant microbiologist's work practice-an audit S Mehtar

Papers

1087 Epidermal differentiation and dermal changes in healing followingtreatment of surgical wounds with sheets of cultured allogeneickeratinocytes S R Myers, HA Navsaria, A N Brain, P E Purkis, I M Leigh

1093 Role of transforming growth factor P1 on hepatic regeneration andapoptosis in liver.diseases S Takiya, T Tagaya, K Takahashi, H Kawashima,M Kamiya, Y Fukuzawa, et al

1098 Relation between stage, grade, proliferation, and expression of p53 andCD44 in adenomas and carcinomas of the colorectum PA Jackson,M A Green, A Pouli, R Hubbard, C G Marks, M G Cook

1102 Orthostatic hypotension and vasodilatory peptides in bronchial carcinomaM A Gosney, Jf R Gosney, M Lye

1106 HPV type 16 in conjunctival and junctional papilloma, dysplasia, andsquamous cell carcinoma M Saegusa, Y Takano, M Hashimura, I Okayasu,J Shiga

1111 Ten year follow up study of lymphocytic gastritis: further evidence onHelicobacter pylori as a cause of lymphocytic gastritis and corpus gastritisS Niemeld, T Karttunen, T Kerola, R Karttunen

1117 Spectrotypic analysis of antibodies to Helicobacter pylori in patients withantral gastritis and duodenal ulcer R Biselli, D Vaira, R Nisini, M Miglioli,L Menegatti, L Barbara, et al

1122 Quality assessment of Microbe Base antimicrobial susceptibility dataD I Limb, T G Winstanley, P F Wheat

1126 Audit of an emergency biochemistry service W S A Smellie, M Jf Murphy,P Jf Galloway, J Hinnie, J7 McIlroy, F 7 Dryburgh

1130 Immunoblotting in the diagnosis of culture negative endocarditis caused bystreptococci and enterococci J P Burnie, I Clark

Short reports

1137 Lymphocyte subset counts in skin puncture and venous blood comparedS E Cracknell, R F Hinchliffe, J S Lilleyman

1138 Detection of Ki67 antigen by a new sheep polyclonal antiserumGM Reynolds, D C Rowlands, G P Mead

1141 Non-neoplastic glandular structures in bone marrow: a technical artefactW G McCluggage, R Clarke, H Bharucha

1142 Clear cell adenocarcinoma of the colon C A Rubio1144 Introduction of computer assisted control of oral anticoagulation in general

practice MJ Galloway, J7J Foggin, S Dixon

Miscellanea

1147 List of assessors * Annual author index to volume 48 * Annual subjectindex to volume 48 * Annual contents index to volume 48

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Volume 48 * Contents

No 1 JANUARY 1995 Page Leaders1 Human papillomaviruses and cervical neoplasia. II. Interaction of HPV with other factors C S Herrington7 Apoptosis in the nervous system: New revelations S-C Chen, T Curran, J I Morgan

Papers13 Effect of thromboplastin and coagulometer interaction on the precision of the International Normalised Ratio D W Pi,

J M Raboud, C Filby, CJ Carter18 Expression of the bcl-2 protein in B cell lymphomas arising from mucosa associated lymphoid tissue E Navratil,

P Gaulard, P Kanavaros, J Audouin, Jf Bougaran, N Martin, et al22 Immunophenotypic analysis of childhood Burkitt's lymphoma in the West Midlands 1957-1986 T_JJones,

NA G Goad, KR Muir, S E Parkes, C D Evans, _J R Mann26 Cytokeratin intermediate filament expression in benign and malignant breast disease M Heatley, P Maxwell, C Whiteside,

P Toner33 HLA typing for DR3 and DR4 using artificial restriction fragment length polymorphism PCR from achival DNA

VA Horton, M Bunce, D R Davies, R C Tumrner, Y-M D Lo37 Inflammatory pseudotumour of lymph nodes N E New, P W Bishop, M Stewart, S S Banerjee, M Hamis41 Helicobacter pylon induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype

3 E Crabtree, A Covacci, S M Farmery, Z Xiang, D S Tompkins, S Perry, et al44 Expression of proliferating cell nuclear antigen in hyperplastic polyps, adenomas and inflammatory cloacogenic polyps

of the large intestine NJ Carr, 3'M Monihan, U C Nzeako, L A Murakara, L H Sobin53 Spectrum of carcinoembryonic antigen immunoreactivity from isolated ductal hyperplasias to atypical hyperplasias

associated with infiltrating ductal breast cancer F C Schmitt, L Andrade57 Diagnosis of genital infection caused by human papillomavirus using in situ hybridisation: The importance of the size of

the biopsy specimen F G6mez, M T Corcuera, E Mufioz, M Roldan, M 3 Alonso, M Abad, et al

59 Pathologist variation in reporting cervical borderline epithelial abnormalities and cervical intraepithelial neoplasiaT Creagh, J E Bridger, E Kupek, D E Fish, E Martin-Bates, M J Wilkins

61 Chemical gastritis induced by naproxen in the absence of Helicobacter pylon infection C 7 McCarthy, M McDermott,D Hourihane, C O'Morain

64 Specificity and usefulness of an IgE immunosorbent agglutination assay for toxoplasmosis D Ashburn, A W L Joss,T H Pennington, D 0 Ho-Yen

70 Limited discriminant value of lipoprotein AI, Lipoprotein Lp(a) and other lipoprotein particles in patients with andwithout early onset ischaemic heart disease D T VallUance, H A Staunton, A F Wnder

75 Comparative studies of types 1 and 2 herpes simplex virus infection of cultured normal keratinocytes S 3f Su, H H Wu,YH Lin, H Y Lin

80 Instructions to Authors

Short reports82 Angiomyxoid tumour in the renal peripelvic tissues with features of aggressive angiomyxoma T Gondo, M Takahashi,

Y Hoshii, T Iwata, T Kashiwagi, T Ishihara84 Gastrointestinal haemorrhage from jejunal gangliocytic paraganglioma W Aung, HJ Galagher, W PJoyce,

D Bouchier Hayes, M Leader86 Acute gonococcal arthritis: an unusual host and pathogen combination D A Lewis, L M Pollock, 7 Randell, P Wilson,

P G Kopelman89 Formalin fixation and patterns of antineutrophil cytoplasmic antibodies G P Spickett, V Broomhead

Miscellanea91 Correspondence * Book Reviews * Notices

No 2 FEBRUARY 1995 Page Leaders95 Cervical cytology extemal and internal quality assurance: a comparative appraisal D N Slater

98 Managing test demand by clinicians: computer assisted guidelines M Peters

Papers101 Duplex PCR system for simultaneous detection of Neisseria gonorrhoeae and Chlamydia tracho"matis in clinical specimens

K C Wong, B S W Ho, S I Egglestone, WH P Lewis105 Antigenaemia during acute graft versus host disease C Fegan, S Kj7ackson, J A Whittaker110 Changes in transferrin saturation after treatmnent with the oral iron chelator deferiprone in patients with iron overload

F N Al-Rafaie, C E De Silva, B Wonke, A V Hoffbrand120 Can histopathologists diagnose bronchopneumonia? C R Hunt, E W Benbowt, WF Knox, R F T McMahon,

L 3 McWUliam124 Biochemical assessment of acute myocardial ischaemia M D Perez-Ccirceles, E Osuna, D N Vieira, A MArtinez, A Luna

129 c-erbB-2 overexpression in the dysplasia/carcinoma sequence of Barrett's oesophagus R H Hardwick, N A Shepherd,M Moorghen, P V Newcomb, D Alderson

133 Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylon infectionX-G Fan, A Chua, X-J Fan, P WN Keeling

137 Neural invasion in gastric carcinoma M Mon, Y Adachi, T Kamakura, Y Ikeda, Y Maehara, K Sugimachi143 E-cadherin expression in intestinal epithelium A Dogan, Z D Wang, 7 Spencer147 Immunohistochemical study of topoisomerase II-s expression in primary ductal carcinoma of the breast P Hellemans,

PA van Dam, M Geyskens, A T van Oosterom, Ph Buytaert, E Van Marck

151 p53, Rb and bcl-2 expression during the cell cycle: a study in phytohaemagglutinin stimulated lymphocytes andmicrowave irradiated lymphoid tissue sections M S Mateo, M Sanchez-Beato, 3r C Martinez, A Orfao, 3 L Orradre,MA Pins

160 Transforming growth factor 11 messenger RNA in Reed-Sternberg cells in nodular sclerosing Hodgkin's diseaseS R Newcom, L Gu



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164 Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study S R Lakhani,M J O'Hare, P Monaghan, J Winehouse, J-C Gazet, J P Sloane

168 Internal quality assurance in a clinical virology laboratory. I. Internal quality assessment J _J Gray, T G Wreghitt,TA McKee, P McIntyre, C E Roth, D J Smith, et al

Short reports174 Latex agglutination for rapid detection of Pseudomonas pseudomallei antigen in urine of patients with melioidosis

M D Smith, V Wuthiekanun, A L Walsh, N Teerawattanasook, V Desakorn, Y Suputtamongkol, et al177 Heterotopic ossification induced by hypoxia in a retrosternal gastric tube following transhiatal oesophagectomy

H C 3.L Buscher, J _J B van Lanschot, A H Mulder, H W Tilanus179 Soluble forms of the adhesion molecule E-cadherin in urine R E Banks, WH Porter, P Whelan, P H Smith, P Selby181 Renal failure in a patient with chornoic lymphocytic leukaemia treated with fludarabine M P Macheta, L A Parapia,

D R Gouldesbrough183 "Pseudoclusters" and typing by random amplification of polymorphic DNA of Aspergillus fumigatus K W Loudon,

A P Coke, J P Burnie

Miscellanea185 Correspondence * Notices

No 3 MARCH 1995 Page Leaders189 The leukaemic phase of non-Hodgkin's lymphoma B J Bain, D Catovsky194 Contribution of immunophenotype in the diagnosis and classification of haemopoietic malignancies E Matutes

Papers198 Internal quality assurance in a clinical virology laboratory. II. Internal quality control _J 7 Gray, T G Wreghitt,

TA McKee, P McIntyre, C E Roth, D J Smith, et al203 Multiplex PCR for identifying mycobacterial isolates M Cormican,

M Glennon, U Ni Riain, _J Flynn206 Avidity of specific IgG antibodies elicited by immunisation against Haemophilus influenzae type b A E Agbarakwe,

H Griffiths, N Begg, HM Chapel210 Use of the Pastorex aspergillus antigen latex agglutination test for the diagnosis of invasive aspergillosis V Hopwood,

EM Johnson, JM Cornish, A B M Foot, E G V Evans, D W Warnock214 Detection of Chlamydia trachomatis antigen by enzyme immunoassay: importance of confirmatory testing K Fonseca,

D W Megran, CM Anand218 Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and

overexpression of the p53 protein product JM van Es, MM Polak, FM van den Berg, TB Ramsoekh,M E Craanen, R H Hruban, et al

223 Iron metabolism and fungal infections in patients with haematological malignancies C Iglesias-Osma,L Gonzalez-Villaron, J F San Miguel, M D Caballero, L Vazquez, S de Castro

226 Serosal reaction in chronic gastric ulcers: an immunohistochemical and ultrastructural study M A Pittt, N Y Haboubi229 Histomorphometric classification of postmenopausal osteoporosis: implications for the management of osteoporosis

M TA Rehman, JA Hoyland, J Denton, A J Freemont236 p53 expression in hepatocellular carcinoma in a population in Singapore with endemic hepatitis B virus infection

A Wee, M Teh, G C Raju239 Immunohistochemical detection of p53 and Bcl-2 proteins in Hashimoto's thyroiditis and primary thyroid lymphomas

R Chetty, JJ O'Leary, S C Biddolph, K C Gatter242 Apoptotic and mitotic indices in malignant melanoma and basal cell carcinoma E E Mooney, IM Ruis Pens, A O'Neill,

E C Sweeney245 Audit of tumour histopathology reviewed by a regional oncology centre R Jf Prescott, S Wells, D L Bisset, S S Banerlee,

M Harris250 Improvement of gastric inflammation and resolution of epithelial damage one year after eradication of Helicobacter pylon

EM Witteman, M Mravunac, M J CM Becx, WPM Hopman, JS C Verschoor, G NJ Tytgat, et al257 Functional hyposplenism following allogeneic bone marrow transplantation R J G Cuthbert, A Iqbal, A Gates,

P J Toghill, NH Russell260 Immunological factors and risk of infection in plateau phase myeloma R M Hargreaves, J R Lea, H Griffiths, Jt A Faux,

JM Holt, C Reid, et al

Short reports267 Dieulafoy's disease associated with early gastric cancer 0 Leone, M Zanelli, D Santini, F Minni, D Marrano270 Importance of hepatic artery node involvement in patients with colorectal liver metastases M 3r Dworkin, S Earlam,

C Fordy, T G Allen-Mersh272 An unusual case of colonic angiodysplasia NJ Trendell-Smith, B F Warren, E A Sheffield, P Durdey275 B cell signet-ring cell lymphoma of bone marrow W G McCluggage, H Bharucha, M El-Agnaf, P G Toner278 Degenerative changes in myometrium simulating diffuse leiomyomatosis after treatment with gonadotrophin releasing

hormone analogue M Jeffers, C Cowan, C B Lunan

Miscellanea280 Book Reviews * Notices.

No 4 APRIL 1995 Page Leaders283 Blood bank audit P H Pinkerton287 Clinicopathologic implications of Epstein-Barr virus related B cell lymphoma in immunocompromised patients

J A Thomas, D H Crawford, M Burke

Papers291 QBEND1 0 for the diagnosis of myelodysplastic syndromes in routinely processed bone marrow biopsy specimens

H-P Horny, M Wehrmann, H U H Schlicker, A Eichstaedt, M R Clemens, E Kaiserling



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295 Rapid and safe determination of human apolipoprotein E genotypes by miniaturised SDS-PAGE in non-insulindependent diabetes mellitus C Clavel, A Durlach, V Durlach, P Birembaut

300 Parathyroid horrnone related protein in oral squamous cell carcinomas invading the mandible F P Dunne, S J Bowden,J S Brown, WA Ratcliffe, R M Browne

304 Effects of treatment on the histopathology of leprosy I A Cree, G Coghill, A M C Subedi, N C Abbot, S R Butlin,P D Samson, et al

308 Immunohistochemical changes in sigmoid colon after allogeneic and autologous bone marrow transplantationG M Forbes, WN Erber, R P Herrmann, _rM Davies, B J Collins

314 The clinical value of urinary cytology: 12 years of experience with 615 patients U Maier, R Simak, N Neuhold318 Macroscopic assessment of pulmonary emphysema by image analysis P A Gevenois, Jf Zanen, V de Maertelaer,

P De Vuyst, P Dumortier, _J-C Yernault323 Distribution of cervical intraepithelial neoplasia: are hysterectomy specimens sampled appropriately? M Heatley325 The prevalence of lymphoid follicles in Helicobacter pylori associated gastritis in patients with ulcers and non-ulcer

dyspepsia A M Zaitoun330 Endothelin-1 in idiopathic pulmonary fibrosis M Uguccioni, L Pulsatelli, B Grigolo, A Facchini, L Fasano, C Cinti, et al335 Relation of granulomas to lymphatic vessels in Crohn's disease E E Mooney, J Walker, D O'B Hourihane339 Enhanced expression of type 1 procollagen and transforming growth factor-f in tuberculin induced delayed type

hypersensitivity A Wangoo, H T Cook, G M Taylor, R J Shaw346 Serological markers to differentiate between ulcerative colitis and Crohn's disease M Oudkerk Pool, G Bouma,

S G M Meuwissen, B M E von Blomberg, _J P van de Merwe, WL J M Devill, et al351 Histological diagnosis of cytomegalovirus hepatitis in liver allografts F Colina, N TJucJ, E Moreno, C Ballestin, J Fanria,

M Nevado, et al358 Serological testing in a microbiology laboratory of specimens from patients with suspected infectious disease

D J Waghorn364 Tissue and serum pepsinogen I and II in gastric cancer identified using immunohistochemistry and rapid ELISA

N Konishi, K Matsumoto, Y Hiasa, Y Kitahori, I Hayashi, H Matsuda368 Concentration of fetal plasma and amniotic fluid interleukin-1 in pregnancies complicated by preterm prelabour

amniorrhexis S G Carroll, A Abbas, Y Vile, N Meher-Homji, KH Nicolaides372 Laboratory turnround time: closing the loop W S A Smellie, P3t Galloway, J I J'ohnston376 Absence of pepsinogen A3 gene expression in the gastric mucosa of patients with gastric cancer EJ Kuipers, A S Pefia,

J B A Crusius, Jr Defize, P van der Stoop, S GM Meuwissen, et al380 Metastatic breast carcinoma with appearance resembling micropapillary ductal carcinoma in situ A H S Lee, T P Telfer,

R R Millis

Short reports383 Routine urinanalysis in renal transplant patients P Hashmi, C Ho, S Morgan, J R Stephenson385 Free radical activity in young adult cigarette smokers M B Leonard, K Lawton, I D Watson, I MacFarlane387 Acquired protein S deficiency in a patient with systemic lupus erythematosus causing central retinal vein thrombosis

HM Prince, P Jf Thurlow, R C Buchanan, KM A Ibrahim, PJ Neeson390 Epstein-Barr virus associated lymphoproliferative disorder. with fatal involvement of the gastrointestinal tract in an

infant L X Pan, P Ramani, T C Diss, L N Liang, P G Isaacson

Miscellanea393 Correspondence * Book Review * Notices

No 5 MAY 1995 Page Leaders395 The biology of low grade MALT lymphoma P G Isaacson, J Spencer398 Public perception of histopathology R D Start, C A Saul, D WK Cotton, NJ Mathers, J C E Undervood

Papers402 Have declining clinical necropsy rates reduced the contribution of necropsy to medical research? R D Start, JfA Firth,

F Macgillivray, S S Cross405 Multifactorial audit of invasive cervical cancer: key lessons for the National Screening Programme D N Slater408 Composition of cervical smears in patients with and without a cervical ectropion

F Buntinx, G G M Essed, H WHM Van der Putten, R F F Buchholz, J' W Arends, J A Knottnerus410 Antibodies to human papillomavirus type 16 E7 related to clinicopathological data in patients with cervical carcinoma

M F D Baay, J M Duk, M PM Burger, J' Walboomers, J ter Schegget, KH Groenier, et al415 Comparative analysis of human papillomavirus detection by PCR and non-isotopic in situ hybridisation C S Herrington,

SM Anderson, HM Bauer, G Troncone, M L de Angelis, H Noell, et al420 Observer reliability in assessing placental maturity by histology T Y Khong, A Staples, R W Bendon, HM Chambers,

S Jf Gould, S Knowles, et al424 Loss of heterozygosity on chromosome 1 lq in breast cancer I P M Tomlinson, J E Stickland, A S G Lee, L Bromley,

M F Evans, J Morton, et al429 Immunohistochemical quantitation of oestrogen receptors and proliferative activity in oestrogen receptor positive breast

cancer VJensen, M Ladekarl433 Immunocytological analysis of the Tn associated antigen 83D4 in serous effusions from patients with cancer:

comparison with Tn soluble glycoprotein M Beuzelin-Yvraut, A Bourguignat, E Phillips, A Roseto, E Osinaga438 Immunohistochemical demonstration of different latent membrane protein-I epitopes of Epstein-Barr virus in

lymphoproliferative diseases NM Jiwa, JJ Oudejans, D F Dukers, W Vos, A Horstmzan, P van der Valk, et al443 Cytodiagnosis and the necropsy S K Suvarna, R D Start447 Oncogene proteins and proliferation antigens in thymomas: increased expression of epidermal growth factor receptor

and Ki67 antigen N E Gilhus, M Jones, H Turley, K C Gatter, N Nagvekar, J Newsom-Davis, et al456 Light scatter characteristics of blast cells in acute myeloid leukaemia: association with morphology and

immunophenotype M B Vidriales, A Orfao, M C Lopez-Berges, M Gonzalez, A Lopez-Macedo, M A Garcia, et al463 Thyroid autoantibodies and the response to thyrotropin releasing hormone in patients with subclinical hypothyroidism

0 A Mojiminiyi, V Rege, J7 Bolodeoku, A H Wilcox, J L Barron466 Volatile organic compounds in the breath of patients with schizophrenia M Phillips, G A Erickson, M Sabas, J P Smith,

J Greenberg470 Membrane staining for hepatitis B surface antigen on hepatocytes: a sensitive and specific marker of active viral

replication in hepatitis B C-M Chu, Y-F Liaw



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474 Clinical evaluation and reproducibility of the Pastorex Aspergillus antigen latex agglutination test for diagnosing invasiveaspergillosis P E Verweij, A J MM Rijs, B E De Pauw, A M Horrevorts, J7 A A Hoogkamp-Korstanje, J F G M Meis

477 Plasma cell proliferation in monoclonal gammopathies: measurement using BU-1 antibody in flow cytometry andmicroscopy: comparison with serum thymidine kinase C M Schambeck, M Wick, R Bartl, R Lanmerz, A Fateh-Moghadam

482 Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells T Mainou-Fowler,7 A Copplestone, A G Prentice

Short reports488 Selective media for isolation of Burkholderia (Pseudomonas) cepacia from the respiratory secretions of patients with cystic

fibrosis N Cimolai, C Trombley, A G F Davidson, L T K Wong490 False negative results in enzyme linked immunosorbent assays using synthetic HIV antigens L McAlpine, V Parry,

D Shanson, P P Mortimer493 Anticomplementary activity in serum samples from patients with acute parvovirus B 19 infection S A Barton, _ Q Nash,

J J7ones, M Sillis, B J Cohen494 Expression of MHC class II antigens by placental villi: no relationship with villitis of unknown origin T Y Khong


No 6 JUNE 1995 Page Leaders497 Public perceptions of necropsy R D Start, C A Saul, D WK Cotton, N J' Mathers, Jf C E Undenrood501 Routine and specialised techniques in the diagnosis of haematological neoplasms B 7 Bain

Papers509 Antigliadin antibody measurement by chemiluminescence ELISA in the diagnosis of coeliac disease S R Merridew,

D V Wilson, E J Williams513 Differences in androgens of HIV positive patients with and without Kaposi sarcoma N Christeff, C Winter,

S Gharakhanian, N Thobie, E Wirbel, D Costagliola, et al519 Circulating endothelin- 1 concentrations in patients with chronic hypoxia C Ferri, C Bellini, C De Angelis, L De Siati,

A Perrone, G Properzi, et al525 Activated phenotype in neutrophils and monocytes from patients with primary proliferative polycythaemia

N B Westwood, E R Copson, L A Page, A R Mire-Sluis, KA Brown, T C Pearson531 p53 protein accumulation in oesophageal squamous cell carcinomas and precancerous lesions A Volant, J-B Nousbaurni,

M-A Giroux, I Roue-Quintin, 7-P Metges, C Ferec, et al535 Desmin expression in rhabdomyosarcoma: influence of the desmin clone and immunohistochemical method L Pollock,

D Ramnpling, S E Greenwald, M Malone539 Expression of HLA-ABC, HLA-DR and intercellular adhesion molecule-I in oesophageal carcinoma C Rockett,

S 3 Darnton, _ Crocker, H R Matthews, A G Monmis545 Evaluation of anticoagulant control in a pharmacist operated anticoagulant clinic A S Radley, Hall, M Farrow,

PJ Carey548 CD 19 and immunophenotype of bone marrow plasma cells in monoclonal gammopathy of undetermined significance

M Zandecki, T Facon, F Bernardi, V Izydorczyk, L Dupond, M Francois, et al553 Histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs M Caselli,

R LaCorte, L DeCarlo, A Aleotti, L Trevisani, M Ruina, et al556 Histological changes associated with an artificial anterior cruciate ligament M Barry, SM Thonizas, A Rees, B Shafighian,

M A S Mowbray560 Internal audit in a microbiology laboratory A J Mifsud, M S Shafi564 Commercially available versus home produced egg media for isolation of mycobacteria G Hamrs, A Rayner, B Watt568 Enteric media: pre-poured or in-house? C A Persaud, S J Eykyn571 Relationship of blood rheology to lipoprotein profile during normal pregnancies and those with intrauterine growth

retardation A Munoz, J3 Uberos, A Molina, A Valenzuela, D Cano, C Ruiz, et al575 Detection of cytomegalovirus using PCR in serum from renal transplant recipients R Cunningham, A Harris,

A Frankton, WIrving

Short reports578 Seasonal variation in the necropsy incidence of pulmonary thromboembolism in Hong Kong K Y Chau, S T Yuen,

M P Wong579 Idiopathic granulomatous vasculitis: response to immunosuppressive therapy G F Alguacil-Garcia, J Moreno-Requena,

M Martinez-Albadalejo, H Hallal-Hachem, B Gonzalez-Pina, M de Paco-Moya582 Histological features of the thyroid gland in a patient with lithium induced thyrotoxicosis Y Mizukanmi, T Michigishi,

A Nonomtura, S Nakamura, M Noguchi, E Takazakura584 Splenic lymphoma with circulating villous lymphocytes F Imbing Jrr, D Kumar, S Kumar, G Yuoh, F Gardner587 Lipoprotein composition and serum Lp(a) lipoprotein in hypobetalipoproteinaemia M Crook, R Swaminathan589 Gastric polyposis caused by multiple carcinoids and early carcinoma S Bhatnagar, A Borg-Grech592 Amyloid tumour of the colon G T Deans, R J Hale, R F T McMahon, WA Brough594 Frequency of coincident iron deficiency and P-thalassaemia trait in British Asian children R F Hinchliffe, J S Lilleyman


No 7 JULY 1995 Page Leaders597 Recent advances in muscular dystrophies and myopathies J7 R Anderson602 ACP Broadsheet 145: Investigation of patients with autoimmune haemolytic anaemia and provision of blood for

transfusion R J Sokol, D J Booker, R Stamps



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Papers611 Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p

S R Lakhani, N Collins, M R Stratton, J P Sloane616 Interobserver variation in cell selection for DNA image cytometry

FA Carey, E Gray, M Salto-Tellez, C Kelly, R Dye, E Duvall, et al620 Quantification of proliferative activity in colorectal adenomas by mitotic counts: relationship to degree of dysplasia and

histological type G A Meijer, J PA Baak626 OV 632 and MOC 31 in the diagnosis of mesothelioma and adenocarcinoma: an assessment of their use in formalin

fixed and paraffin wax embedded material C Edwards, J Oates631 Distribution of OV-TL 3 and MOv18 in normal and malignant ovarian tissue M R Buist, C FM Molthoff, P Kenemans,

C J L M Meijer637 A necropsy and histomorphometric study of abnormalities in the course of the vertebral artery associated with ossified

stylohyoid ligaments C P J7ohnson, M Scraggs, T How, 7 Burns641 Thiol methyltransferase activity in colonocytes and erythrocyte membranes WJ7 Babidge, S H Millard, WE W Roediger645 Effect of proctocolectomy on serum antineutrophil cytoplasmic antibodies in patients with chronic ulcerative colitis

P Aitola, A Miettinen, A Mattila, M Matikainen, E Soppi648 Variation in serum electrolytes and enzyme concentrations in patients with sickle cell disease N Nduka, Y Kazem,

B Saleh652 Enzyme immunoassays for IgG and IgM antibodies to Toxoplasma gondii based on enhanced chemiluminescence

C F Crouch658 Value of screening for oro-pharyngeal Chlamydia trachomatis infection S P R Jebakumar, C Storey, M Lusher, 7 Nelson,

B Goorney, K R Haye662 High prevalence of Helicobacter pylori in saliva demonstrated by a novel PCR assay C Li, P R Musich, T Ha,

D A Ferguson Jr, N R Patel, D S Chi, et al667 Documentation of blood culture results R A Howe, C J7 Bates, P Cowling, N Young, R C Spencer

Short reports670 Growth and detection of filamentous fungi in the BacT/Alert blood culture system A Breathnach, J Evans672 Longstanding proliferation of CD3 negative large granular lymphocytes preceding the development of high grade non-

Hodgkin's lymphoma S R Smith, P G Middleton, PJ_ Birch, L Morgan, P W G Saunders676 Nuclear pseudoinclusions in melanocytic naevi and melanomas D S C Rose678 Brenner tumour of the vagina A-M H Rashid, H Fox679 P-glycoprotein positive, drug resistant invasive lymphoepithelial thymoma: treatment response to chemotherapy with

cyclosporin and quinine J L Gala, H Noel, J Rodhain, D F F Ma, A Ferrant682 Microscopic thymoma and myasthenia gravis F Puglisi, N Finato, L Mariuzzi, C Marchini, G Floretti, C A Beltrami683 Evaluation of the API-Campy System in the biochemical identification of hippurate negative campylobacter strains

isolated from faeces J Reina, M J Ros, A Serra

Technical report686 A new, fast and convenient method for layering blood or bone marrow over density gradient medium A Islam

Miscellanea689 Correspondence - Book Reviews * Notices

No 8 AUGUST 1995 Page Leaders693 Macroscopic examination of prostatic specimens P Harnden, M C Parkinson701 Lesser known mycobacteria B Watt

Papers706 Detection of mycobacteria in bone marrow biopsy specimens taken to investigate pyrexia of unknown origin

U B G Riley, S Crawford, S P Barrett, S H Abdalla710 Evaluation of the Cult-Dip Plus dip slide method for urinary tract infection J M Blondeau, Y Yaschuk, D Galenzoski,

D Hrabok, M Isaacson, L Lee, et al714 Comparison of agar based media for primary isolation of Helicobacter pylori C Y Hachem, J E Clarridge, D G Evans,

D Y Graham717 Rate of growth of Pseudomonas fluorescens in donated blood A P Gibb, KM Martin, G A Davidson, B Walker,

W G Murphy719 Simple method for quantifying viable bacterial numbers in sputum A Pye, R A Stockley, S L Hill725 Detection and identification of gastrointestinal microsporidia using non-invasive techniques G D Corcoran, D G Tovey,

A H Moody, P L Chiodini728 Human papillomavirus in false negative archival cervical smears: implications for screening for cervical cancer

JMM Walboomers, A-M de Roda Husman, PJ F Snijders, H V Stel, E KJt Risse, TJ M Helmerhorst, et al733 Retrospective determination of HIV-1 status by a PCR method on paraffin wax embedded sections T Slavik,

M Wolfaardt, H van Zyl, I W Simson737 Apocrine adenosis: a precursor of aggressive breast cancer? C A Wells, I L McGregor, C N Makunura, P Yeomans,

7 D Davies743 Intraepithelial and lamina propria leucocyte subsets in inflammatory bowel disease: an immunohistochemical study of

colon and rectal biopsy specimens T Caballero, F Nogueras, M T Medina, M D Caracuel, C de Sola,F J Martinez-Salmer6n, et al

749 Histological discrimination of idiopathic inflammatory bowel disease from other types of colitis N Le Berre, D Heresbach,M Kerbaol, S Caulet, J F Bretagne, _T Chaperon, et al

754 Chromogranin positive cells in colorectal carcinoma and transitional mucosa M Mori, K Mimori, T Kamakura,Y Adachi, Y Ikeda, K Sugimachi

759 S100, a-smooth muscle actin and cytokeratin 19 immunohistochemistry in odontogenic and soft tissue myxomasT Lombardi, C Lock, _J Samson, E W Odell

763 Postmortem blood ferritin concentrations in sudden infant death syndrome M Worwood, R Raha-Chowdhury,D G Fagan, C A Moore

768 Organophosphates and monocyte esterase deficiency E McClean, H Mackey, GM Markey, T C M Morris



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771 Serum glutathione S-transferase B, activity as an index of liver function in cystic fibrosis J M Rattenbury, C J Taylor,P K Heath, A F Howie, G J7 Beckett

Short reports775 Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with

cirrhosis M Ip, _7 G C Teo, A F B Cheng777 Microbiological investigation of polyarthralgia J Wynne Jones, Jf V S Pether, R WP Frost779 Fatal adenovirus 32 infection in a bone marrow transplant recipient A K Charles, E 0 Caul, H 7 Porter, A Oakhill781 Sudden death from coronary artery dissection A C Bateman, PJf Gallagher, A C Iincenti

Miscellanea785 Correspondence * Book Reviews * Notices

No 9 SEPTEMBER 1995 Page Leaders789 Molecular genetics of familial breast-ovarian cancer E van Rensburg, B A J Ponder796 Computerised image handling in pathology S-K Cheong, K Micklem, D Y Mason

Papers803 Detection of C-polysaccharide in serum of patients with Streptococcus pneumoniae bacteraemia S H Gillespie, M D Smith,

A Dickens, _J G Raynes, K P WJ7 McAdam807 Evaluation of the AUXACOLOR system, a new method of clinical yeast identification K G Davey, PM Chant,

C S Downer, C K Campbell, D W Warnock810 Routine application of the polymerase chain reaction for detection of Mycobacterium tuberculosis in clinical samples

G T Noordhoek, _J A Kaan, S Mulder, H Wilke, A HJ Kolk815 Chlamydia trachomatis and ectopic pregnancy: retrospective analysis of salpingectomy specimens, endometrial biopsies,

and cervical smears J Lan, A _J C van den Brule, D 3 Hemrika, E K J Risse, 3'M M Walboomers, M E I Schipper, et al820 Quantitation of hepatitis C viral RNA in liver and serum samples using competitive polymerase chain reaction

M Sugano, Y Hayashi, S Yoon, M Kinoshita, T Ninomiya, K Ohta, et al826 Production and characterisation of an antimelanoma monoclonal antibody KBA.62 using a new melanoma cell line

reactive on paraffin wax embedded sections E Cohen-Knafo, T Al Saati, J Aziza, E Ralfliaer, J Selves,B Gorguet, et al

832 Identification of parietal cells in gastric body mucosa with HMFG-2 monoclonal antibody M M Walker, A Smolka,3 M Waller, Dj Evans

835 Circulating Ki67 positive lymphocytes in multiple myeloma and benign monoclonal gammopathy A Miguel-Garcia,E Matutes, F Tarin, J Garcia-Talavera, A Miguel-Sosa, F Carbonell, et al

840 Immunohistochemical staining of plastic embedded bone marrow trephine biopsy specimens after microwave heatingW G McCluggage, S Roddy, C Whiteside, _J Burton, H McBride, P Maxwell, et al

845 Down-regulation of Epstein-Barr virus nuclear antigen 1 in Reed-Sternberg cells of Hodgkin's disease G Khan,M A Naase

849 Influence of local peritoneal involvement on pelvic recurrence and prognosis in rectal cancer N A Shepherd, KJf Baxter,S B Love

856 Malignant mesothelioma of the pleura: interobserver variability A Andrion, C Magnani, P G Betta, A Donna, F Mollo,M Scelsi, et al

861 Comparison of haemoglobin H inclusion bodies with embryonic globin in screening for ot thalassaemia L C Chan,J C C So, D H K Chui

Short reports865 Management of blood donors whose donations are repeatedly falsely positive by the HIV antibody screening test

H I Atrah, _J V Parry, D Gough, Tosswill, F A Ala867 Osteolytic bone lesions in a patient with idiopathic myelofibrosis and bronchial carcinoma D J Clutterbuck,

A E Morrison, C A Ludlam869 Combined goblet cell -carcinoid and mucinous cystadenoma of the appendix R KAl-Talib, C H Mason, J M Theaker871 Hodgkin's disease in a patient with common variable immunodeficiency C Christopoulos, Th Papadaki, P Vlavianos,

G Kokkini873 Immunohistochemical analysis of T cell proliferation in normal tonsil and B cell lymphoma J7 Wang, P G Isaacson,

_ Spencer876 A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast

carcinomas S Detre, G Saccani _otti, M Dowsett878 Granulomatous bone marrow infiltration during treatment of chronic myeloid leukaemia with interferon-alpha-2b

A Siboni, T Mourits-Andersen, .T Moesner880 Hepatitis C virus replication in hepatocellular carcinoma J Niu, U Kumar, _J Monjardino, R Goldin, D Rosin,

H C Thomas

Miscellanea883 Correspondence * Book Review * Notices * Correction

No 10 OCTOBER 1995 Page Leaders885 Testing healthcare staff for infection with HIV and hepatitis: logistic and ethical considerations A Newell, S E Barton890 Steroid hormone receptors and their clinical significance in cancer R I Nicholson, R A McClelland, J M W Gee

Papers896 Parathyroid hormone related protein and interleukin-6 mRNA expression in larynx and renal cell carcinomas from

normocalcaemic and hypercalcaemic patients D H Schweitzer, I L A Boxman, C W G M Ldwik,_r H JrM van Kreiken, M G Weissglas, R J Baatenburg de _Jong, et al



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901 An easier alternative to orthogonal regression for calculation of International Sensitivity Indexes D A Taberner,JfM K Dufty

904 Use of dried blood spots for the detection and confirmation of HTLV-I specific antibodies for epidemiological purposesS P Parker, M B Taylor, A E Ades, WD Cubitt, C Peckham

908 Serological reactivity against cyst and tachyzoite antigens of Toxoplasma gondii determined by FAST-ELISA Y W Zhang,A Fraser, A H Balfour, T G Wreghitt, J J_ Gray, J E Smith

912 Detection of bacteraemia by the continuously monitoring BacT/Alert system G T Kennedy, Jf G Barr, C Goldsmith915 Perceptions of a medical microbiology service: a survey of laboratory users M S Morgan919 Comparison of three methods for culture confirmation of Neisseria gonorrhoeae strains currently circulating in the UK

A Turner, K R Gough, A E Jephcott924 IS6110 based amplityping assay and RFLP fingerprinting of clinical isolates of Mycobacterium tuberculosis K Y Yuen,

C M Chan, K S Chan, W C Yam, P L Ho, P Y Chau929 Lethal synergy between toxins of staphylococci and enterobacteria: implications for sudden infant death syndrome

NM Sayers, D B Drucker, Jf A Morris, D R Telford933 Sampling variability of percutaneous liver biopsy in primary sclerosing cholangitis R Olsson, I Hagerstrand, U Broome,

A Danielsson, G Jarnerot, L Loof, et al936 Prospective audit of mucosal biopsy specimens of the gastrointestinal tract PM Stephenson, PJ Gallagher939 Lymphocytic gastritis and associated small bowel disease: a diffuse lymphocytic gastroenteropathy? D A F Lynch,

G M Sobala, M F Dixon, A Gledhill, PJackson, J E Crabtree, et al946 Association of Epstein-Barr virus with sinonasal angiocentric T cell lymphoma G O'Leary, S M Kennedy950 Immunohistochemical identification of tumours of adipocytic differentiation using an antibody to aP2 protein

J H Bennett, S Shousha, B Puddle, N A Athanasou955 Diagnostic relevance of peripheral blood immunocytochemistry in hairy cell leukaemia I Cordone, L Annino, S Masi,

E Pescarmona, S Rahimi, A Ferrari, et al

Short reports961 Hypercalcaemia due to calcium binding IgM paraprotein in Waldenstr6m's macroglobulinaemia L Side,

M N Fahie-Wilson, M J Mills963 Langerhans' cell histiocytosis: possible association with malignant germ cell tumour WK Ng, K Y Lam, I 0 L Ng965 Papillary mucinous adenoma arising in adenomyomatous hyperplasia of the gall bladder G Y Lauwers, S J Wahl,

G V Scott, S J DeRoux967 Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori

J7 E Crabtree, Z Xiang, I J D Lindley, D S Tompkins, R Rappuoli, A Covacci969 A practical single sample dry latex agglutination test for Helicobacter pylori antibody detection P D Midolo, J R Lambert,

E G Russell, S K Lin971 Corynebacterium aquaticum septicaemia in neutropenic patient C Moore, R Norton973 Transient abnormal myelopoiesis accompanied by hepatic fibrosis in two infants with Down syndrome N Yagihashi,

K Watanabe, S Yagihashi975 Acute hepatic and renal failure caused by Pneumocystis carinii in patients with AIDS R Boldorini, S Guzzetti, L Meroni,

T Quirino, S Cristina, G Monga

Miscellanea979 Correspondence - Notices

No 11 NOVEMBER 1995 Page Leaders981 Prognostic factors in primary breast carcinoma S E Pinder, I 0 EUlis, C WElston984 The age related amyloids: a growing family of unique biochemical substances G G Cornwell III, KH _Johnson,

P Westermark

Papers990 Diagnosis of Helicobacter pylon infection by specific gastric mucosal IgA and IgG pylori antibodies R A Veenendaal,

_'M Gotz, V Schroijen, F Kurban, A T Bernards, M Veselic, et al994 Early ultrastructural changes of antral mucosa with aspirin in the absence of Helicobacter pylori C J McCarthy,

E Sweeney, C O'Morain998 Perinatal and infant postmortem examinations: how well are we doing? G M Vujanic, P H T Cartlidge, J H Stewart,

A J Dawson1002 Role of re-screening of cervical smears in internal quality control A Baker, D Melcher, R Smith1005 Flow cytometry in diagnosis and management of large fetomaternal haemorrhage P R E Johnson, R C Tait, E B Austin,

KH Shwe, D Lee1009 Tissue diagnosis of intestinal microsporidiosis using a fluorescent stain with Uvitex 2B C Franzen, A Muller,

B Salzberger, G Fdtkenheuer, S Eidt, G Mahrle, et al1011 Immunostaining for CD31 and CD34 in Kaposi sarcoma R Russell Jones, G Orchard, B Zelger, E Wlson Jones1017 In situ end-labelling, light microscopic assessment and ultrastructure of apoptosis in lung carcinoma E F Gaffney,

A J O'Neill, M J Staunton1022 Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus S Y Leung, L P Chung,

S T Yuen, CM Ho, M P Wong, S Y Chan1028 Specimen slice radiography of cancer in breast conserving excisions K L Oakley, J J Going1031 Vimentin and cytokeratin expression in nodular hyperplasia and carcinoma of the prostate M Heatley, P Maxwell,

C Whiteside, P Toner1035 Immunohistochemistry in apparently normal bone marrow trephine specimens from patients with nodal follicular

lymphoma R Chetty, G Echezarreta, M Comley, K Gatter1039 Tissue polypeptide specific antigen for the detection of lymphoproliferative diseases induced by cyclosporin M Vogl,

A Griesmacher, M Grimm, W Klepetko, MM Miller1045 The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas T C Diss, M Watts,

L X Pan, M Burke, D Linch, P G Isaacson1051 Changes in cytomorphology of childhood lymphoblastic leukaemia at the time of disease relapse J S Lilleyman,

R F Stevens, I M Hann, B E S Gibson, JtA Britton, PJ Darbyshire, et al1054 Screening criteria for fi thalassaemia trait in pregnant women M Rogers, L Phelan, B Bain



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Short reports1057 Ceroid granulomas in the female genital system K Ooi, C Riley, V Billson, A G Ostor1059 Pseudoangiosarcomatous carcinoma of the genitourinary tract M A Pitt, G Morphopoulos, S Wells, D L Bisset1061 Elevated serum o-fetoprotein in a patient with undifferentiated carcinoma of the gall bladder WK Ng, WF Ng1064 Lack of correlation of P-glycoprotein expression with response to MIC chemotherapy in oesophageal cancer

S _J Darnton, KJenner, R S Steyn, D R Ferry, H R Matthews1067 Do blood cultures need continuous monitoring so that clinical action can be taken outside normal working hours?

D A Murdoch, R _t Koerner, G E Speirs, A P MacGowan, D S Reeves1068 Neomycin blood agar as a selective medium for vancomycin resistant Enterococcus faeciunz P R Chadwick,

B A Oppenheini1070 Gold granuloma after accidental implantation F R Scott, A P Dhillon, Jr F Lewin, W Flavell, IM Laws1072 Failure to detect Helicobacter pylori in nasal mucus in H pylori positive dyspeptic patients L Cellini, N Allocati, B Dainelli

Miscellanea1074 Correspondence * Book Review * Notice * Correction

No 12 DECEMBER 1995 Page Editorial1075 Editors on Editors

Leaders1078 Subarachnoid haemorrhage and myths about saccular aneurysms R 0 Weller1082 Review of a consultant microbiologist's work practice-an audit S Mehtar

Papers1087 Epidermal differentiation and dermal changes in healing following treatment of surgical wounds with sheets of cultured

allogeneic keratinocytes S R Myers, H A Navsaria, A N Brain, P E Purkis, IM Leigh1093 Role of transforming growth factor 31 on hepatic regeneration and apoptosis in liver diseases S Takiya, T Tagava,

K Takahashi, H Kawashima, M Kaniuya, Y Fukuzawa, et al1098 Relation between stage, grade, proliferation, and expression of p53 and CD44 in adenomas and carcinomas of the

colorectum PA Jackson, M A Green, A Pouli, R Hubbard, C G Marks, M G Cook1102 Orthostatic hypotension and vasodilatory peptides in bronchial carcinoma M A Gosney, 7 R Gosney, M Lye1106 HPV type 16 in conjunctival and junctional papilloma, dysplasia, and squamous cell carcinoma M Saegusa, Y Takanlo,

M Hashimura, I Okayasu, J Shiga1111 Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic

gastritis and corpus gastritis S Niemeld, T Karttunen, T Kerola, R Karttunen1117 Spectrotypic analysis of antibodies to Helicobacter pylon' in patients with antral gastritis and duodenal ulcer R Biselli,

D Vaira, R Nisini, M Miglioli, L Menegatti, L Barbara, et al1122 Quality assessment of Microbe Base antimicrobial susceptibility data D I Limb, T G Winstanley, P F Wheat1126 Audit of an emergency biochemistry service W S A Smellie, M3 Murphy, PJ Galloway, _J Hinnie, J McIlroy,

F Dryburgh1130 Immunoblotting in the diagnosis of culture negative endocarditis caused by streptococci and enterococci Y P Burmnie,

I Clark

Short reports1137 Lymphocyte subset counts in skin puncture and venous blood compared S E Cracknell, R F Hinchliffe, J S Lilleynian1138 Detection of Ki67 antigen by a new sheep polyclonal antiserum G M Reynolds, D C Rowlands, G P Mead1141 Non-neoplastic glandular structures in bone marrow: a technical artefact W G McCluggage, R Clarke, H Bharucha1142 Clear cell adenocarcinoma of the colon C A Rubio1144 Introduction of computer assisted control of oral anticoagulation in general practice M Y Galloway, Y Y Fogginl, S Dlxon

Miscellanea1147 List of assessors * Annual author index to volume 48 * Annual subject index to volume 48 * Annual

contents index to volume 48



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p1 · magosney,jf rgosney, mlye 1106 hpvtype 16 in conjunctival andjunctional papilloma, dysplasia,...

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