Plenary Lectures Thursday 1 December Plenary lecture I Steven M. Cramer (Rensselaer Polytechnic Institute, Troy, NY, USA) Downstream bioprocessing: recent advances and future promise Plenary lecture II John McKinney (Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland) Individuality of microbial responses to antibiotics Plenary lecture III Luuk van der Wielen (Delft University of Technology, Delft, The Netherlands)

TBA Friday 2 December Plenary lecture IV Merja Penttilä (Technical Research Centre of Finland VTT, Helsinki, Finland)

TBA Plenary lecture V Heinz D. Osiewacz (J.W. Goethe University, Frankfurt/ Main, Germany) Unravelling a hierachical network of molecular pathways involved in fungal senescence and lifespan control Saturday 3 December Plenary lecture VI Hermínia de Lencastre (Instituto de Tecnologia Química e Biológica (ITQB), UNL, Oeiras, Portugal)

TBA

Thursday 1 December Symposium 1: Industrial and Food Microbiology and Biotechnology Keynote speaker Alexandra Mendes Ferreira (Institute for Biotechnology and Bioengineering (IBB), Portugal)

Saccharomyces cerevisiae responses and tolerance to stresses relevant in enology Keynote speaker Maria Teresa Barreto Crespo (IBET, Oeiras, Portugal)

Emerging pathogens and their impact in research and global market S1: 1 R Duarte, L Carreto, B Cambon, S Dequin, MAS Santos, M Casal, D Schuller (CBMA, Braga,Portugal)

Microevolutionary changes of commercial Saccharomyces cerevisiae strains recovered from vineyard environments identified by comparative genome hybridization on array S1: 2 Joana F. Guerreiro, Nuno P. Mira, Isabel Sá-Correia (IBB-IST, Lisbon, Portugal) Adaptive response to acetic acid in the highly resistant yeast species Zygosaccharomyces bailii, revealed by quantitative proteomics S1: 3 Ana R.F.C. Ferreira, Andreia B. Figueiredo, Dmitry V. Evtuguin, Jorge Manuel Alexandre Saraiva (Universidade de Aveiro, Portugal ) Enhancement of rate and extension of enzymatic hydrolysis of cellulose by high pressure pre-treatments S1: 4 Thomas Kennedy (Department of Agriculture, Food and the Marine, Dublin, Ireland) Evaluating food safety management performance in an Irish milk pasteurising facility using a microbiological assessment scheme

Thursday 1 December Symposium 2: Environmental Microbiology and Biotechnology Keynote speaker Célia Manaia (Escola Superior de Biotecnologia, Portugal)

Antibiotic resistance and the urban water cycle Keynote speaker Gilda Carvalho (REQUIMTE/CQFB, Portugal)

Identification and carbon source preference of the microbial communities in a polyhydroxyalkanoate-producing mixed culture from fermented molasses S2: 1 Marta Tacão, Isabel Henriques, António Correia (CESAM, Aveiro, Portugal) Antibiotic resistance in a portuguese lotic ecosystem: focus on clinically relevant extended-spectrum beta-lactamases S2: 2 Cátia Fidalgo, Ana Tenreiro, Rogério Tenreiro, Rui Malhó, Sandra Chaves (Universidade de Lisboa, Lisboa, Portugal) Unveiling cadmium resistance mechanisms in an extremophilic yeast S2: 3 Ashmita Arjoon, Ademola Olaniran, Balakrishna Pillay (University of KwaZulu-Natal, Durban, South Africa) Bioremediation of water co-contaminated with 1,2-dichloroethane and arsenic or lead S2: 4 Marta Martins Neto, David Ribas, Nelson Lima, Manuel Mota, Ana Nicolau (IBB-CEB, Universidade do Minho, Portugal ) Protozoa grazing evaluation: a novel way to assess wastewater treatment performance?

Thursday 1 December Symposium 3: Health Microbiology and Biotechnology Keynote speaker Fani Sousa (CICS-UBI, Covilhã, Portugal) Plasmid DNA for gene therapy applications: from the purification to the in vitro evaluation Keynote speaker Mario Ramirez (FMUL, Portugal) More than meets the eye in relationship between pneumococci and its bacteriophages S3: 1 Joana Rolo, Maria Miragaia, Agata Turlej, Joanna Empel, Ons Bouchami, Nuno Alexandre Faria, Ana Tavares, Waleria Hryniewicz, Ad C. Fuit, Hermínia de Lencastre, and the CONCORD working group (ITQB), Oeiras, Portugal) High genetic diversity of community-associated (CA) Staphylococcus aureus in Europe S3: 2 Andreia Couto, Lídia M.D. Gonçalves, Lara Figueiredo, Catarina Santos, António J. Almeida, João Gonçalves (URIA-CPM, Faculdade de Farmácia de Lisboa, Portugal)

An HIV-1 gp120 loop grafted in a single domain VL antibody inhibits HIV-1 infectivity and is a potential HIV-1 vaccine S3: 3 Nuno Bernardes, Ana Sofia Ribeiro, Bruna Mota, Rute G. Matos, Cecilia M Arraiano, Raquel Seruca, Joana Paredes, Arsénio M Fialho (IBB-IST, Lisboa, Portugal) Bacterial protein azurin as a new candidate drug to treat P-cadherin-overexpressing breast cancer S3: 4 Adelaide Almeida, Liliana Costa Costa, Eliana Alves Alves, Ângela Cunha, Newton Gomes, Carla Carvalho, João Tomé, Augusto Tomé, Amparo Faustino, Graça Neves, José Cavaleiro (University of Aveiro, Portugal) Photodynamic inactivation of pathogenic microorganisms by tetrapyrrolic photosensitizers

Friday 2 December Symposium 4: Next Generation Sequencing, Comparative Genomics

and Evolution Keynote speaker Gabriela Moura (Department of Biology & CESAM, University of Aveiro, Portugal) The role of transfer RNAs on gene evolution – insights from the fungal Saccharomycotina subphylum Keynote speaker Pedro M. Santos (CBMA, University of Minho, Portugal) Exploring the genome catalogs of Pseudomonas using next generation sequencing technologies S4: 1 Teresa Nogueira, Eduardo Rocha (Centro de Biologia Ambiental, Universidade de Lisboa, Lisboa, Portugal)

Bacterial sociality and virulence are mainly encoded on mobile non-core regions of the genome S4: 2 Marco A. Coelho, Paula Gonçalves, José Paulo Sampaio (CREM, Universidade Nova de Lisboa, Portugal)

Evidence of maintenance of sex determinants but not of sexual stages in red yeasts S4: 3 Catarina Lopes Santos, Margarida Correia-Neves, Marta Vaz Mendes (IBMC, Porto, Portugal)

An Actinobacterial census: the diversity and ecological context of quorum-sensing LuxR regulators S4: 4 Rita Gonçalves Sobral, Michael Mwangi, Ana Madalena Ludovice, Raquel Pereira Portela, Hermínia de Lencastre, Alexander Tomasz (CREM, , Universidade Nova de Lisboa, Portugal) Genome comparison of a Staphylococcus aureus mutant showing decreased antibiotic resistance and its revertant strain

Friday 2 December Symposium 5: Bioprocess Engineering Keynote speaker Gabriel Monteiro (IST, IBB, Portugal)

Rational engineering of E. coli strains and plasmids for improved manufacturing of plasmid biopharmaceuticals Keynote speaker Lígia Rodrigues (CEB-IBB, University of Minho, Portugal)

New strategies for the production of biosurfactants towards biomedical applications S5: 2 Ana Júlia Cavaleiro, Diana Sousa, Madalena Alves (IBB-Centre of Biological Engineering, Portugal) Innovative start-up strategies for optimal methane production from lipids in anaerobic bioreactors S5: 3 Belinda Pérez Bibbins, Noelia Rodríguez Pazo, Ana María Torrado Agrasar, Jose Manuel Domínguez González (Universidad de Vigo, Spain) High xylitol bioproduction by Debaryomyces hansenii immobilized in alginate beads in an airlift bioreactor operated in fed-batch mode S5: 4 Carla Amarelo Santos, Leonor Caldeira, Julio Maggiolly Novais, Alberto Reis (LNEG, Portugal) Microalgae fermentation to produce biodiesel and simultaneously improving autotrophic growth S5: 5 Luís Borlido, A.M. Azevedo, A.C.A. Roque, M.R. Aires-Barros (IBB-IST, Lisbon, Portugal) Potential of boronic acid magnetic particles in the direct purification of human monoclonal antibodies from CHO cell supernatants

EMbaRC Symposium Paul de Vos (EMbaRC Consortium) European Consortium of Microbial Resources Centres (EMbaRC): Secure the future of microbial resources at laboratory scale

Friday 2 December Symposium 6: Molecular Microbiology and Microbial Physiology Keynote speaker Luisa Figueiredo (IMM, Universidade de Lisboa, Portugal)

The role of chromatin in antigenic variation of African Trypanosomes Keynote speaker Vítor Costa (Instituto de Biologia Molecular e Celular, Porto, Portugal) Sphingolipid signaling, redox homeostasis and lifespan in yeast S6: 1 Luis G Gonçalves, Nuno Borges, François Serra, Pedro L Fernandes, Hernán Dopazo, Helena Santos (Instituto de Tecnologia Química e Biológica, Portugal) Evolution of the biosynthesis of di-myo-inositol phosphate, a marker of adaptation to hot marine environments S6: 2 Inês Vinga, Catarina Baptista, Isabelle Auzat, Lina Jakutytė, Rudi Lurz, Isabelle Petipas, Paulo Tavares, Mario Almeida Santos, Carlos São-José (Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Portugal) Identification of the navigation system of bacteriophage SPP1: a single tail protein that finds and binds two receptors of the host cell surface S6: 3 Gabriel Paiva, Diogo N. Proença, Susana S. Santos, Luis Fonseca, Isabel M.O Abrantes, Paula Veríssimo, Paula V. Morais (IMAR-CMA, Coimbra, Portugal) Production of nematocidal extracellular proteases by the nematode-associated bacterium Serratia sp. A88C13 S6: 4 Júlia Santos, Maria João Sousa, Cecília Leão (ICVS, University of Minho, Braga, Portugal) Ammonium is toxic for amino acid-starved yeast cells under extreme calorie restriction, inducing cell death through the regulation of PKA, TOR and Sch9 activities

Friday 2 December Symposium 7: Cell and Tissue Engineering and Biomaterials Keynote speaker Helena Sepúlveda Azevedo (3B's Research Group, University of Minho, Portugal) Biomimetic extracellular matrices as artificial environments for cell culture Keynote speaker Susana Rosa (Center for Neurosciences and Cell Biology, Portugal) Stem cells and biomaterials for the treatment of ischemic diseases S7: 1 Andreia Madeira, Francisco dos Santos, Cláudia Lobato da Silva, Emilio Camafeita, Joaquim MS Cabral, Isabel Sá-Correia (IBB-IST, Lisboa, Portugal) Molecular and cellular networking underlying the ex-vivo expansion of human mesenchymal stem cells revealed by 2-DE based quantitative proteomics S7: 2 Wojciech Szymczyk, Albino Pereira Martins, Vitor Manuel Correlo, Nuno Neves, Alexandra Pinto Marques, Rui Luís Reis (3B's Research Group, University of Minho, Portugal) Fabrication and evaluation of scaffolds for small diameter blood vessel engineering S7: 3 Catarina Madeira, M.S.C. Reis, Frederico I.G. Ferreira, Carlos A.V. Rodrigues, Margarida M. Diogo, Joaquim Cabral (IBB-IST, Lisboa, Portugal) Non-viral gene delivery strategies using minicircles into neural stem cells S7: 4 Tiago Fernandes, Carlos A.V. Rodrigues, Catarina C. Miranda, Margarida M. Diogo, Joaquim Cabral (IBB-IST, Lisboa, Portugal) Towards fully defined culture systems for human induced pluripotent stem cell expansion

Saturday 3 December Symposium 8: Functional Genomics and Systems and Synthetic Biology Keynote speaker Isabel Rocha (CEB-IBB, Portugal) New tools for the simulation and optimization of microbes in metabolic engineering problems Keynote speaker Miguel Cacho Teixeira (Institute for Biotechnology and Bioengineering (IBB), Portugal) Role and regulation of the drug:H+ antiporter family: from S. cerevisiae to C. glabrata S8: 1 Nuno P Mira, Silvia F Henriques, Greg Keller, Miguel C Teixeira, Rute G Matos, Cecília M Arraiano, Dennis R Winge, Isabel Sá-Correia (IBB-IST, Lisbon, Portugal) Haa1p-dependent regulatory network of the yeast response to acetic acid stress S8: 2 Rosa Grenha, Sylvie Nessler, Didier Lereclus (LEBS-CNRS, Gif-sur-Yvette, France) Structural study of PlcR, a quorum sensing effector of Bacillus cereus S8: 3 Rita Branco, Paula V. Morais (IMAR-CMA, Coimbra, Portugal) Whole-cell biosensors for the detection of chromate in environmental samples S8: 4 André da Costa, Raul Machado, Margarida Casal (CBMA, Universidade do Minho, Portugal) Solvent-cast films of an elastin-like polymer fused to an antimicrobial peptide, ABP-CM4, exhibits high antibacterial activity against Pseudomonas aeruginosa

Saturday 3 December Symposium 9: Cellular Microbiology and Pathogenesis Keynote speaker João Gonçalves (URIA/IMM, Lisboa, Portugal) The interplay of restriction and helper factors during HIV-1 infection in T-lymphocytes Keynote speaker Kimberly Jefferson (VCU, Richmond, VA, USA) Unraveling the etiologic mystery of bacterial vaginosis Keynote speaker Margarida Saraiva (ICVS-3Bs Laboratório Associado, Braga, Portugal) Recognition of Mycobacterium tuberculosis by macrophages and dendritic cells: implications for IL-10 gene regulation S9: 1 Palmira Barreira-Silva, Margarida Borges, Manuela Florido, Margarida Correia-Neves, Rui Appelberg (ICVS/3B’s, University of Minho, Braga, Portugal) Thymic atrophy upon infection with a highly virulent strain of Mycobacterium avium S9: 2 Christian G Ramos, Paulo JP da Costa, André M Grilo, Jörg D Becker, Leonilde M Moreira, Jorge H Leitão (IBB-IST, Lisbon, Portugal) Hfq-like RNA chaperones and sRNAs: A new layer of complexity in virulence regulation S9: 3 Ana Almeida, Philippe Sansonetti, Régis Tournebize (Pathogénie Microbienne Moléculaire, Institut Pasteur, France) A murine model of human rhinoscleroma identifies specific Mikulicz cells as atypical inflammatory monocytes

Saturday 3 December Symposium 10: Nanotechnology Keynote speaker Pedro Fernandes (Instituto Superior Tecnico, Portugal) Miniaturization in bioprocesses: a resilient approach or just another fad? Keynote speaker Sara Beirão da Costa (CEER – Biosystems Engineering, Technical University of Lisbon, Portugal) Micro- and nanotechnology in the food field S10: 1 Romeu M. Francisco, Pedro M. de Abreu, Bradley A. Plantz, Vicki L. Schlegel, Rui A. Carvalho, Paula V. Morais (IMAR-CMA, Coimbra, Portugal) Chromium remediation by extracellular phosphate nanoparticles induced by iron in Ochrobactrum tritici 5bvl1 S10: 2 Sofia de Medina Aires Martins, João Trabuco, Gabriel A Monteiro, João P Conde, Virginia Chu, Miguel DMF Prazeres (IST-IBB, Portugal) Microfluidic cell chips: monitoring GPCR activation S10: 3 Orfeu Flores (STAB VIDA, Portugal) Nanoparticles for theragnostics of Alzheimer disease S10: 4 Ana Isabel F. Martins, Pedro Brogueira, Marília Mateus (IBB, IST-UTL, Lisbon, Portugal) On the development of a plasmid DNA probe for interaction force measurements and characterization of membrane adsorbers by AFM