overview of our businesses - ir pocketpdf.irpocket.com/c7575/uxy1/bwj8/mc1o.pdf · cardiac rhythm...
TRANSCRIPT
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Overview of Our Businesses
June 26, 2019
Japan Lifeline Co., Ltd.
This briefing material is used to explain our businesses for general shareholders after the 39th General Shareholders’ Meeting held on June 26, 2019.
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1.Business OverviewSenior Executive Vice President and COO
Atsuhiro Suzuki2.Mid-term Outlook by Segment
(1) Cardiac Rhythm ManagementVice President Executive Manager of CRM Business Unit
Osamu Watanabe(2) EP/Ablation
Vice President Executive Manager of EP Business UnitKazuhiko Nogami
(3) Cardiovascular SurgeryVice President Executive Manager of CV Business Unit
Toru Takamiya(4) Transvascular Intervention
Vice President Executive Manager of CV Business UnitToru Takamiya
(5) Development and ProductionVice President Executive Manager of R&D and Manufacturing Department
Kenji Yamada
3.Mid-Term PlanSenior Executive Vice President and COO
Atsuhiro Suzuki4.Q&A
Today’s Agenda
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1. Business Overview
Senior Executive Vice President and COOAtsuhiro Suzuki
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Business Field
42013/5/15
リズムデイバイ
EP/Ablation
・EP Catheter・Ablation Catheter・Radiofrequency Transseptal Needle・Esophageal Temperature Monitoring catheter
リズムデイバイ
Cardiac Rhythm Management
・Cardiac Pacemaker
・ICD
・CRT-D
・AED
Arrhythmia Treatment
Transvascular Intervention
リズムデイバイ
Cardiovascular Surgery・Guidewire
・Balloon Catheter
・Coronary Stent
・ASD Closure Device
・Vascular Graft
・Open Stent Graft
・Stent Graft
・Tissue Valve, Annuloplasty Ring
Cardiovascular Surgery Treatment
(aortic aneurysm, heart valve disease)
Ischemic Cardiac Disease Treatment
(cardiac infarction, angina pectoris)
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Revenue Composition FY3/19
52013/5/15
12.9%
50.7%
25.8%
10.7%
Cardiac Rhythm Management
EP/ablation
Cardiovascular Surgery
Transvascular Intervention
FY3/19Consolidated
Sales
45,525(¥ million)
YoY
+7.6%
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In-house Ratio (Non-consolidated)
62013/5/15
FY3/19 In-house Ratio (revenue)
In-house54.9%
Third-party’s45.1%
・EP Catheter・Ablation Catheter・Internal Atrial Cardioversion
Catheter・Esophageal Temperature
Monitoring Catheter
Main in-house products
EP/AblationEP/Ablation
・Vascular Graft・Open Stent Graft
Cardiovascular SurgeryCardiovascular Surgery
・Guidewire・Balloon Catheter
Transvascular InterventionTransvascular Intervention
24,971(¥ million)
20,512(¥ million)
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Track Record of Revenue from In-house Products(non-consolidated)
72013/5/15
0.0%
25.0%
50.0%
75.0%
0
10,000
20,000
30,000
40,000
50,000Third-party's
In-house
In-house ratio
(¥million)
1.1%
54.9%
In-house ratio has leveled off due to increase in third-party products
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Sales Offices
82013/5/15
Provide service through all-Japan sales network
47Sales Offices
As of April 2019
Sales Offices
Logistics Bases
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FY3/20 Plan Cosolidated Sales
92013/5/15
30,540 37,181
42,298 45,525
54,059
0
10,000
20,000
30,000
40,000
50,000
60,000
FY3/16Actual
FY3/17Actual
FY3/18Actual
FY3/19Actual
FY3/20Plan
Intervention
Surgery
EP/ablation
CRM
Continuously expect high growth in FY3/20
+18.7%(¥ million)
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FY3/19 Actual vs. FY3/20 Plan
12.9%
50.7%
25.8%
10.7%Intervention CRM
EP/Ablation
Surgery 45,525(¥ million)
Contribution of CRM will expand
FY3/19Consolidated Sales
20.9%
50.0%
19.0%
10.1% CRMIntervention
Surgery
EP/Ablation
54,059(¥ million)
FY3/20Consolidated Sales
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Cardiac Rhythm Management• A major turning point: Change to BSC*1 products
EP/Ablation• With number of AF cases continuously growing, AF-related
products are expected to increaseCardiovascular Surgery
• Ended the valve business• Concentrate on aorta therapeutic area
Transvascular Intervention• Drug-eluting stent gained a certain market share• Enter into new therapeutic area
Development & Production• Investment with a mid-to-long term perspective• Initiatives as a Japanese manufacturer
Initiatives by Business Category
11
*1 BSC: Boston Scientific Corporation *2 AF: Atrial Fibrillation
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2. Medium-term Outlook by Business Category
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1. Cardiac Rhythm Management
Vice President Executive Manager of CRM Business Unit
Osamu Watanabe
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CRM Medium-term Outlook
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1. Scale CRM business with BSC products
2. Aim to expand market share swiftly with superior tachycardia treatment devices
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Exclusive Distribution Agreement regarding CRM-related products
15
Establish exclusive sales channel– Payment of fixed amount for BSJ due to Sales Support Agreement– All BSJ’s CRM sales reps to be temporarily transferred to JLL from
September 1, 2019
Establish a long-term partnership
Counterparty
Contract Date
Product
Nature of Contract
Contract Period
Upfront Payment
︓Boston Scientific Japan
︓November 2, 2018
︓BSC’s CRM-related products
︓Exclusive Distributorship in Japan
︓10 years from September 1, 2019
(automatic renewal every 2 years thereafter)
︓¥3.0 billion
CRM Exclusive Distribution Agreement
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CRM About Boston Scientific Corporation
– Started in 1979, USA. Headquarters located in Massachusetts
– About 29,000 employees in global
– 13 manufacturing bases
– Established firm positions in as many as 125 countries
– Broad business sphere with more than 13,000 kinds of products
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No. Name Sales($B)1 Medtronic 29.62 Johnson & Johnson 26.23 Fresenius 21.74 GE 18.85 Philips 17.1 6 Siemens 16.67 Cardinal Health 14.08 Abbot 12.39 Stryker 12.110 Becton, Dickinson 12.1
No. Name Sales($B)11 Baxter 10.412 Boston Scientific 8.813 Essilor 8.514 Zimmer Biomet 7.815 Novartis 5.916 3M 5.717 Olympus 5.218 Terumo 4.919 Smith & Nephew 4.720 Cannon 3.9
Source: Economy, Trade and Industry Ministry
Worldwide major medical device company
CRM About Boston Scientific Corporation
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18*1 as of April 1, 2019
CRM Partnership with BSJ
Best & strongest sales team ever
・Strong product portfolio
・Sales reps with high expertise& skills
・Competitive edge in R&D as a global player
・Experience in arrhythmia therapeutic field
・All-Japan sales network
・As many as 242 sales reps with high expertise*1
Product Sales
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Brady44.2 billion
56%
Tachy34.3 billion
44%
Brady(Pacemakers) Tachy(ICD-related)
CRM Domestic Market 2017
(R&D CY2017)
In the amount, Brady/Tachy leads are included.
5,674 6,4635,169
724584
496
6,617 7,247
5,862
0
2,500
5,000
7,500
10,000
FY3/17 FY3/18 FY3/19
JLL’s CRM sales
Brady(Pacemakers) Tachy(ICD-related) Others
(¥ million)
• JLL’s CRM business has been highly weighted on brady
• Tachy area occupies a high ratio in domestic CRM market
CRM Market
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Initiated sale of S-ICD in advance of the full-release– JLL’s exclusive EMBLEM MRI S-ICD– Accumulating sales know-how since April ’19 to prepare for the
full-launch from September of this year• Much less risk of complications related to leads
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Tap into tachy treatment market with strong products swiftly
EMBLEM MRI S-ICD SystemS-ICDConventional ICD
Implanted subcutaneously(No contact with cardiovascular system)
Implanted via venous(Lead left in heart)
CRM Main Product in Tachy Treatment Area
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Make a big leap in CRM market
CRM Our Message
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2 EP/Ablation
Vice PresidentExecutive Manager of EP Business Unit
Kazuhiko Nogami
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EP/ABL Medium-term Outlook
1. AF*1 ablation cases growing at double digits
2. Increase penetration of Endoscopic laser ablation catheter
3. Address continuous development, improvement and expansion of in-house products
23*AF: Atrial Fibrillation
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EP/ABL Forecast of AF ablation cases
• AF cases continuously growing at double digits to reach more than 130,000 cases in FY3/24
• Products for treatment to contribute more as well as currently well-received products for diagnosis
5,122 6,181 9,019
11,448 14,371
17,528 20,364
23,060
27,047
0
5,000
10,000
15,000
20,000
25,000
30,000
35,000
0
25,000
50,000
75,000
100,000
125,000
150,000
FY3/12 FY3/13 FY3/14 FY3/15 FY3/16 FY3/17 FY3/18 FY3/19 FY3/20 FY3/21 FY3/22 FY3/23 FY3/24
EP/ABL Sales AF Cases
(cases) (¥ million)
*Number of AF cases are JLL’s estimates
24
Estimate
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*Products for diagnosis/operative use include internal atrial cardioversion catheter, esophageal temperature monitoring catheter, radiofrequency transseptal needle and etc
Products for treatment only account for 5.9% of the whole EP/ABL (FY3/19 actual)
5,122 6,191
9,019
11,448
14,371
17,528
20,364
23,060
0
5,000
10,000
15,000
20,000
25,000
'12/3 '13/3 '14/3 '15/3 '16/3 '17/3 '18/3 '19/3
EP/ABL売上⾼For diagnosis/operative use (EP catheter etc)
94.1%
5.9%
JLL’s EP/ABLSales (FY3/19)
For diagnosis/operative use (EPcatheter etc)For treatment use (ABL catheter)
(¥ million)
Ramp up products for treatment use
EP/ABL Sales Composition by Use of Product
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EP/ABL HeartLight
Concentrate on products for treatment for further growth
– Endoscopic laser ablation catheter– HeartLight by CardioFocus– Launched in July 2018
• Ablation with a direct vision of PV (pulmonary vein) through endoscope
• Applicable to various anatomies of PV
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Endoscopic Laser Ablation SystemHeartLight
Left: catheter Right: consoleWorking for an early launch of the next generation
– X3 shortens procedure time greatly– Anticipate to launch in FY3/22
Aim for further penetration of endoscopic laser ablation with highly competitive products of next generation
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EP/ABL In-house New Product Variations
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BeeATVia IVC*Approach
Steerable SheathFor Left-handed
Full launch in Feb. 2019 To be launched in July 2019
Via IVC approach
*IVC: inferior vena cava
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Via IVC approach
Strengthen JLL-exclusive product while no competitors can beat to it
The conventional product was not suitable to be inserted from vessels at groin (IVC
approach)
Change made to the tip of the curve enabled it to be inserted from groin
Tap into the unmet needs of doctors who adopt IVC approach
EP/ABL In-house New Products IVC BeeAT
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Developing efforts realized super user-friendly products that no other competitors have
The conventional product required operations by both hands and thus
procedure took many steps
Improvements on the handle have enabled doctors to use in one-hand
Address various unmet needs
EP/ABL In-house New Product Guidee Leftee
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EP/ABL Our Message
1. Tap into AF treatment market with HeartLight
2. Endless developing efforts to strengthen the firm position of in-house products even more
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3. Cardiovascular Surgery
Vice PresidentExecutive Manager of CV Business Unit
Toru Takamiya
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Surgery Medium-term Outlook
1. Valve business ended at the end of May 2019
2. Concentrate on aorta therapeutic area
3. Early launch of thoracic stent graft
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780 1,448
773
9,133
0
2,500
5,000
7,500
10,000
FY3/10 FY3/11 FY3/12 FY3/13 FY3/14 FY3/15 FY3/16 FY3/17 FY3/18 FY3/19
JLL’s sales of tissue valve & vascular graft
Tissue valve-related Vascular graft-related
(¥ million)
Surgery End of Valve Business
Ended valve business with the expiration of the distribution agreement with LivaNova
Open Stent Graft
Thoracic Stent Graft
Abdominal Stent Graft
Concentrate on growing vascular graft-related area
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Surgery Aorta Therapeutic Area
Only JLL has all these variations of products
JLL’s exclusiveOpen Stent Graft Frozenix
In-houseVascular Graft
Thoracic
ENDOLOGIXStent Graft AFX2
Abdominal
In-houseVascular Graft
Aorta
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Unique company that has full-lineup in aorta therapeutic area
Surgery Aorta Therapeutic Area
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Surgery Introduction Plan of Stent Graft
Re-entry to thoracic stent graft market
– Branched thoracic stent graft NEXUS
– Manufactured by Endospan (Israel)
– Simplification of procedure and
reduction of the complication risk
– Aim to launch in FY3/24
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Branched Thoracic Stent GraftNEXUS
Based on broad experience, planning to introduce attractive products
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Surgery Our Message
Stay in the top share in aorta therapeutic area with rich product variations
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4. Transvascular Intervention
Vice PresidentExecutive Manager of CV Business Unit
Toru Takamiya
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Intervention Midium-term Outlook
1. Expand sales of drug-eluting coronary stent
2. Enter into diagnostic devices for ischemic cardiac diseases
3. Enrich the product lineup for structural heart disease area
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Intervention Drug-eluting Coronary Stent
Drug-eluting coronary stent Orsiro– World’s thinnest strut (60μm*)
– Gained 7% of market share after 1 year of the launch
Initiated CASTLE Study* in May 2019– Establishing clinical evidence based on Japanese patients’ cases (more
than 50 institutions joining all over Japan)
– Verify the non-inferiority in terms of long-term clinical capabilities
*Randomized Comparison “All-Comers” Study of Ultra Thin-Strut and Thin Strut Drug-Eluting Stents40
Drug-eluting Coronary Stent Orsiro
*60μm: less than 3.00 mm in the diameter of the stent
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Intervention Diagnostic Devices
Aim to enter into intravascular imaging devices– IVUS*/OCT*hybrid catheter Novasight Hybrid
– Aim to launch in the 1st half of FY3/21
– Both imaging modalities of IVUS & OCT can be utilized in a single catheter
simultaneously
41
Introduce diagnostic devices for PCI treatment– Optowire; a guidewire installed with a special optical
fiber sensor for measuring intravascular pressure
– Launched in Oct. 2018
– Examination has become mandatory* since Apr. 2018
for more appropriate PCI treatment
* In cases of stable angina, evaluation of functional ischemia was added to insurance calculation requirements for PCI treatment
*IVUS: Intravascular Ultrasound *OCT : Optical Coherence Temograghy
FFR Pressure GuidewireAbove: OptoMonitor
Below: OptoWire
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42
Intervention Structural Heart Disease Therapeutic
Increase presence in ASD* treatment area– ASD closure device Figulla FlexⅡ
– Launched in Feb. 2016. Top share in the market.
Aim to launch new devices– PLD (Paravalvular Leak Device)
– PFO (Patent Foramen Ovale)
– VSD (Ventricular Septal Defect)
Strengthen product lineup in structural heart disease therapeutic area
Image of treatment
*ASD: Atrial Septal Defect
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43
Intervention Our Massage
1. Accelerate sales of drug-eluting stent2. Early introduction of new products in
structural heart disease therapeutic area
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5. Development and Production
Vice PresidentExecutive Manager of R&D and Manufacturing Department
Kenji Yamada
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Development and Production Mid-term Outlook
45
1. Development and production in mid-to-long term
2. Reflect needs in clinical practice into product development
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Development and Production Facilities
46
リサーチセンター(⼾⽥市)
Ichihara Factory(Ichihara City, Chiba)
Vascular Graft & OSG(development & production)
Malaysia Factory(Penang Province, Malaysia)
Overseas Factory 2
To start operation from Jan. 2020
Shenzhen Factory(Shenzhen, China)
Overseas Factory 1
Core Factory
Toda Factory(Toda City, Saitama)
R&D
Research Center(Toda City, Saitama)
Oyama Factory(Oyama City, Tochigi)
Mass Production
SynexMed JLL Malaysia
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Name ︓Medical Technology Park (MTP)
Facilities ︓North Square (Research Center)
South Square (Toda Factory)
47
Development and Production Medical Technology Park
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482013/5/15
North Square (Research Center)(Since April 2018)
Base facility for R&D
Land space ︓Total floor space ︓Location ︓
3,655㎡4,590㎡ (five-story bld.)Toda City, Saitama
Development and Production R&D Facility
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492013/5/15
South Square (Toda Factory)(Since Dec. 2011)
Mother factory for domestic production
Land SpaceTotal floor spaceLocationProducts manufactured
︓2,917㎡︓5,802㎡ (four-story bld.)︓Toda City, Saitama︓EP catheter, ABL catheter
Development and Production Production Base
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502013/5/15
Oyama Factory(Since Oct. 2014)
Manufacture mainly EP/Ablation products
Land spaceTotal floor spaceLocationProducts manufactured
︓ 22,504㎡︓ 4,414㎡ (two-story bld.)︓ Oyama City, Tochigi︓ EP catheter, ABL catheter
Development and Production Production Base
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512013/5/15
Oyama Factory’s 2nd Facility(To start operation from Apr. 2020)
Land spaceTotal floor spaceLocation
︓ 22,504㎡︓ 5,903㎡ (two-story bld.)︓ Oyama City, Tochigi
1st Facility 2nd Facility
Rendering CG
Development and Production Production Base
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522013/5/15
Ichihara Factory(Since Dec. 2010)
Manufacture mainly surgery-related products
Land spaceTotal floor spaceLocationProducts manufactured
︓7,467㎡︓5,469㎡ (two-story bld.)︓Ichihara City, Chiba︓Vascular Graft, Open Stent Graft,
Blood Purification Equipment
Development and Production Production Base
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532013/5/15
Shenzhen FactorySynexMed
(Since Oct. 2010)
Manufacture mainly intervention products
Total floor spaceLocationProducts manufactured
︓ 3,256㎡ (two floors)︓ Shenzhen, China︓ Balloon Catheter,
Guidewire etc.
Development and Production Production Base (overseas)
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542013/5/15
Positioned as a mother factory overseas
Rendering CGProgress
Land spaceTotal floor spaceLocationProducts manufactured
︓ 16,000㎡︓ 9,124㎡ (three-story bld.)︓ Penang Province, Malaysia︓ EP Catheter etc (TBD)
Development and Production Production Base (overseas)
Malaysia FactoryJLL Malaysia Sdn. Bhd.(To start operation from Jan. 2020)
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55
Development and Production Reflect Needs in Clinical Practice
Clinical settings
Toda Factory(manufacture)
Research Center(R&D)
Sales offices & HQ marketers
New needs
Mass produce products
Find unmet needs
Put into product design
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Collect information for development of new products
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Set up many opportunities for exchanging opinions such as speaking engagements and experiments
Lecture by KOL* Evaluation of a product with a prototype
*KOL: Key Opinion Leader
Development and Production Reflect Needs in Clinical Practice
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1. Maintain high quality and stable supply (delivery) of in-house products
2. Develop medical devices with high novelty
3. Overseas manufacturing and marketing
Development and Production Our Massage
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3. Mid-term Plan
Senior Executive Vice President and COOAtsuhiro Suzuki
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Our Basis for Growth
592013/5/15
医療現場のニーズを反映した⾃社製品の開発
海外の最先端の医療機器の探索・商権獲得
Strong sales network covering all over Japan
Early introduction of medical devices backed by regulatory strategy
Expand scale and increase profitability to achieve high growth
+Manufacturer Trading Company
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Our mid-term plan adopts the annual rolling method
• Plan excludes products for which the time of launch
has not been specified as of the date of planning
• Plan factors in status of distribution contracts, latest
development and results of clinical studies
• Plan factors in NHI price revisions Expect revisions in Oct. 2019 concurrently with the
consumption tax hike
Expect revisions in April of each year of 2020, 2021*, 2022 &
2023. (*From 2021, revisions would take place annually in our assumption)
Premises
60
Adjust to ever-changing business circumstances
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Mid-Term Plan – Financial Goals
61
FY3/2023
Consolidated Sales
¥77.7BOP Margin
25%
Previous PlanAnnounced on May 29, 2018
FY3/2024
Consolidated Sales
¥89.4BOP Margin
23%
New PlanAnnounced on May 22, 2019
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Mid-Term Plan – Sales Highlight
6.6 7.2 5.8 11.217.5 20.3 23
2710.2 11.4 11.7
10.22.7
3.2 4.85.4
37.1 42.2 45.554
63.571.7
84.4 89.4
0
25
50
75
100
125
FY3/17Actual
FY3/18Actual
FY3/19Actual
FY3/20Plan
FY3/21Plan
FY3/22Plan
FY3/23Plan
FY3/24Plan
Cardiac Rhythm Management EP/ABL Cardiovascular Surgery Transavascular Intervention
(¥ billion)
Arrhythmia therapeutic field will be the solid base for growth
62
Revenue from arrhythmia
therapeutic field is likely to account for
70%
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Mid-Term Plan – Outlook & Challenges
1. Expansion of arrhythmia therapeutic filed
2. Tap into new market other than cardiovascular
3. Tackle overseas expansion with respect to in-house products
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#1 Outlook & Challenges Expansion of Arrhythmia Therapeutic Field
Increase our presence in CRM market even more with top-class sales force specialized in arrhythmia
Competitive
BSC products
CRMSuperior products
including JLL’s exclusive
EP/ABL
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• Solely Japan-made colonic stentLeverage the stent-weaving technology for in-house Open Stent Graft
65
Enter into gastrointestinal therapeutic area
Leverage unique and exclusive technology in a cross-sectoral manner to tap into other
new market
• Radio-frequency ablation system for liver cancer
Leverage the ablation technology of which we have accumulated know-how
Colonic Stent JENTLY
Radio-frequency ablation system arfa
#2 Outlook & Challenges Tap Into New Market
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#3 Outlook & Challenges Overseas Expansion of In-house Products
66
Tackle overseas marketing ever more
Aiming to accelerate overseas strategy
• Asian PacificIn April 2019, a new sales office in South Korea.
Regulatory approval for BeeAT has been completed.
• EuropeWork for CE mark for Open Stent Graft
• North AmericaPreparing for exportation of half-finished EP catheters (limited
models) for North America
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Mid-Term Plan – Financial Highlight
67
Anticipate to scale business and improve OP margin
5463.5
71.7
84.489.4
19.4%20.6%
21.4%
22.9% 23.0%
15.0%
20.0%
25.0%
30.0%
0
25
50
75
100
FY3/20 FY3/21 FY3/22 FY3/23 FY3/24
Sales OP Margin
15.0%
20.0%
25.0%
30.0%
0
25
50
75
100(¥ billion)
Sales In-house OP Margin
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Robust base for arrhythmia therapeutic field
FY3/24
Consolidated Sales ¥89.4B
Operating Margin 23%
Scale business with new third-party’s products
Solid growth for in-house products
Mid-Term Plan Our Massage
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…for patient comfort.
Thank you for your attention
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Among the descriptions in this document, the matters that are not historic fact are the forecast concerning the future of our company and the future prospects based on forecasts. Particularly, the matters concerning clinical trials, regulatory approval and launch timing, which are involved in introduction of products, are our company’s prediction obtained from past experiences and available information. Since the actual result may be different from the forecast described in this document, due to the influences of various risks and uncertain factors, please do not depend on these forecasts excessively.
Precautions
Contact:
Japan Lifeline Co., Ltd.Corporate Planning Section
TEL:03-6711-5214E-Mail:[email protected]
URL:http://www.jll.co.jp