overview of medications to treat addiction in primary care
DESCRIPTION
These materials provide information on prescribing details for FDA-approved medications used to treat addiction in primary care. Visit CASAColumbia.org for more detailsTRANSCRIPT
OVERVIEW OF MEDICATIONS TO
TREAT ADDICTION IN PRIMARY CARE
Prepared byCASAColumbia®
February 2014
© CASAColumbia 2014
Outline
• Introduction
• Addiction Involving:
− Tobacco/Nicotine
− Alcohol
− Opioids
− Other Drugs
• Further Considerations
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INTRODUCTION
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Addiction
For background information on addiction Addiction Medicine: Closing the Gap between Science and Practice1
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Addiction
For information on screening, diagnosis, treatment planning & management
Overview of Addiction Medicine for Primary Care2 (62 Slides)
Overview of Addiction Medicine for Primary Care: Supplement3 (30 Pages)
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Stabilization
• Withdrawal in some cases can be life-threatening
• Medical management for stabilization/detoxification may be required
• Details for these topics can be found on Pages 88-92 of the CASAColumbia® report Addiction Medicine: Closing the Gap between Science and Practice1
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Addiction Treatment
• Treat addiction as a primary disease
• Address tobacco/nicotine, alcohol & other drugs
• Manage co-occurring disorders
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dopamine transporters
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Combined Treatment
• Medications & psychosocial therapies
• Can increase retention in treatment
• Can decrease relapse rates
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Combined Treatment
• To achieve the best results medications should be combined with psychosocial therapies
• Research studies illustrate the effectiveness of various combinations of treatment4-6
• Details for psychosocial therapies can be found on Pages 102-106 of the CASAColumbia® report Addiction Medicine: Closing the Gap between Science and Practice1
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Specialist Referral
• Addiction medicine physicians find a doctor near you
• Addiction psychiatrists find a doctor near you
Addiction medicine physician: http://www.abam.net/find-a-doctorAddiction psychiatrist: https://application.abpn.com/verifycert/verifyCert.asp?a=4
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Consider for Complex Cases
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ADDICTION INVOLVING TOBACCO/NICOTINE
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FDA-Approved Meds
• varenicline (Chantix)
• bupropion (Zyban, Wellbutrin)
• nicotine replacement therapy (e.g., patch, gum, lozenge, inhaler, nasal spray)
• combinations
• combine with psychosocial therapies
Tobacco/Nicotine
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varenicline(Chantix)
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• 3X higher odds of smoking cessation7
• Nicotinic acetylcholine receptor partial agonist8
• Superior to bupropion & single-form nicotine replacement therapy9
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varenicline(Chantix)
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• Begin 1wk prior to target quit date
• Starting dose 0.5mg QD x 3dy
• Up to 1mg BID x 12wk extension of 12wk
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varenicline(Chantix)
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• Black Box Warning: neuropsychiatric events
• Common Side Effects: headache, insomnia, nausea, abnormal dreams
• FDA Warning: increased risk of CV events in patients with known CVD
• Meta-analyses show no increased risk of neuropsychiatric events9 or cardiac events9-10
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bupropion(Zyban, Wellbutrin)
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• 2X higher odds of smoking cessation11
• Inhibits norepinephrine & dopamine uptake12
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bupropion(Zyban, Wellbutrin)
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• Begin 1wk prior to target quit date
• Starting dose 150mg QD x 3dy
• Up to 150mg BID x 7-12wk extension of 12wk
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bupropion(Zyban, Wellbutrin)
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• Black Box Warning: neuropsychiatric events
• Contraindications: seizure disorder / predisposition; abrupt cessation of alcohol / sedatives; risky use / addiction involving alcohol
• Common Side Effects: insomnia, tachycardia, weight loss, headache, lower seizure threshold
• Meta-analysis shows no increased risk of neuropsychiatric events9
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nicotine replacement(Nicoderm, Nicorette, Commit, Nicotrol)
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• 1.5X to 2X higher odds of smoking cessation13
• Nicotine without exposure to other toxins
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nicotine replacement(Nicoderm, Nicorette, Commit, Nicotrol)
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• Contraindications: severe angina, post-myocardial infarction, pregnancy, hypersensitivity
• Side Effects: minimal except nasal spray (local irritation, cough, headache, dyspepsia)
• Combination long-acting (e.g., patch) & short-acting (e.g., gum) better than single form13
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nicotine replacement(Nicoderm, Nicorette, Commit, Nicotrol)
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Dosing for 1 cigarette 1mg of nicotine
• Patch (OTC): 7/14/21mg, q12-24hr, 8wk taper
• Gum (OTC): 2/4mg, q1-2hr, 3mo taper
• Lozenge (OTC): 2/4mg, q1-2hr, 3mo taper
• Inhaler (Rx): 6-16 cartridges, q24hr, 3-6mo taper
• Nasal Spray (Rx): 1-2 sprays, q1hr, 3-6mo taper
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nicotine replacement(Nicoderm, Nicorette, Commit, Nicotrol)
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Delivery method characteristics
• Patch (OTC): only long-acting method
• Gum (OTC): “chew & park” technique crucial; should not be used with acidic food or liquids
• Inhaler (Rx): beneficial for behavioral rituals
• Nasal Spray (Rx): fastest absorption, most side effects
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ADDICTION INVOLVING ALCOHOL
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FDA-Approved Meds
• acamprosate (Campral)
• disulfiram (Antabuse)
• naltrexone (ReVia, Depade, Vivitrol)
• combine with psychosocial therapies
Alcohol
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acamprosate(Campral)
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• Improves abstinence & treatment retention14
• May modulate glutamate & GABA15
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acamprosate(Campral)
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• Begin once abstinent for >24hr if possible
• Dose at 666mg TID x 6mo
• Safe even with severe hepatic disease
• Contraindication: severe renal disease
• Common Side Effects: diarrhea, fatigue
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disulfiram(Antabuse)
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• Best efficacy with routine use in monitored systems given high rates of noncompliance16
• Aldehyde dehydrogenase inhibitor
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disulfiram(Antabuse)
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• Causes diaphoresis, headache, dyspnea, hypotension, palpitations, nausea, vomiting (when using alcohol)
• Monitoring by spouse, supervisor, etc. is highly recommended
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disulfiram(Antabuse)
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• Starting dose: 250-500mg QD x 1-2wk
• Maintenance dose: 125-500mg QD x 6mo
• Clinicians often start & maintain at 250mg QD
• Remains active 14 days after discontinuation
• Contraindications: severe myocardial occlusive disease, psychosis, hypersensitivity
• Side Effects: hepatitis, psychosis
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naltrexone(ReVia, Depade, Vivitrol)
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• Decreases drinking by 83% over placebo17
• FDA-approved for alcohol or opioids
• Mu opioid receptor inhibitor
• Genetic factors affect efficacy
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naltrexone(ReVia, Depade, Vivitrol)
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• Only begin after abstinence from opioids >7dy
• Starting oral dose
25mg QD (Day 1), 50mg QD (Day 2)
• Maintenance oral dose 50mg QD x 6mo
• Depot dose 380mg IM q4wk: better compliance
• Trial of at least 3mo recommended
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naltrexone(ReVia, Depade, Vivitrol)
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• Black Box Warning: hepatotoxicity
• Contraindications: acute hepatitis, liver failure, prescribed opioids
• Side Effects: headache, GI distress, syncope, LFT elevation
• Literature review suggests no increased risk for causing or worsening hepatic disease18-19
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ADDICTION INVOLVING OPIOIDS
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FDA-Approved MedsOpioids
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• buprenorphine/naloxone (Subutex, Suboxone, Zubsolv)
• methadone (Methadose)
• naltrexone (ReVia, Depade, Vivitrol)*
• combine with psychosocial therapies
* details for naltrexone included on previous slides for addiction involving alcohol
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buprenorphine/naloxone(Subutex, Suboxone, Zubsolv)
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• Reduced use & better treatment retention20
• Partial opioid agonist + opioid antagonist
• Exercise caution in quantities prescribed per visit due to potential for misuse
• Special training required in order to prescribe
• See details under section “For Physicians” at buprenorphine.samhsa.gov
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buprenorphine/naloxone(Subutex, Suboxone, Zubsolv)
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• Starting dose
8mg QD (Day 1)16mg QD (Day 2-3)
• Maintenance dose 12-16mg QD
• Contraindication: hypersensitivity
• Side Effects: respiratory depression, headache, pain, insomnia, GI symptoms
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methadone(Methadose)
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• Reduced use & better treatment retention21
• Long-acting opioid agonist
• Distributed only by licensed facilities
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methadone(Methadose)
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• Starting dose 20-40mg QD
• Maintenance dose 80-120mg QD
• Dose may be less depending on baseline opioid use
• Must follow licensed facility protocol, e.g., EKGs
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methadone(Methadose)
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• Contraindications: respiratory depression, severe asthma, ileus, hypersensitivity
• Side Effects: QT prolongation, respiratory depression
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ADDICTION INVOLVING OTHER DRUGS
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FDA-Approved MedsOther Drugs
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• Currently no FDA-approved medications for addiction involving other drugs
• Research & development ongoing for marijuana, cocaine, others
• Combine with psychosocial therapies
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FURTHER CONSIDERATIONS
© CASAColumbia 2014
For Prescription Drugs
Always consider risks of addiction if prescribing
• Opioids
• Benzodiazepines
• Stimulants
• Other addictive prescription drugs
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For Adolescent Patients
• Only buprenorphine/naloxone is FDA-approved for 16 years & older
• All other medications are FDA-approved for 18 years & older
• Adolescent treatment should focus more on psychosocial therapies
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For Elderly Patients
• Monitor for drug-drug interactions
• For renal insufficiency adjust dosing of varenicline, bupropion, acamprosate, methadone
• For hepatic insufficiency adjust dosing of bupropion, buprenorphine/naloxone, methadone, naltrexone (contraindication if severe)
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References1. CASAColumbia. Addiction medicine: closing the gap between science and practice. 2012 Jun. http://
www.casacolumbia.org/addiction-research/reports/addiction-medicine
2. CASAColumbia. Addiction medicine: primary care clinical guide. 2013 Aug. http://www.casacolumbia.org/health-care-providers/guide
3. CASAColumbia. Addiction medicine: primary care clinical guide supplement. 2013 Aug. http://www.casacolumbia.org/health-care-providers/guide-supplement
4. Amato L, et al. Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification. Cochrane Database Syst Rev. 2011 Sep 7;(9):CD005031.
5. Anton RF, et al. Naltrexone combined with either cognitive behavioral or motivational enhancement therapy for alcohol dependence. J Clin Psychopharmacol. 2005 Aug;25(4):349-57.
6. Feeney GF, et al. Cognitive behavioural therapy combined with the relapse-prevention medication acamprosate: are short-term treatment outcomes for alcohol dependence improved? Aust N Z J Psychiatry. 2002 Oct;36(5):622-8.
7. Fiore MC, et al. Clinical practice guideline. Treating tobacco use and dependence: 2008 update. U.S. Department of Health and Human Services, 2008 May.
8. U.S. Food and Drug Administration. Highlights of prescribing information for Chantix (varenicline). 2013 Feb. http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021928s030lbl.pdf
9. Cahill K, et al. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev. 2013 May 31;5:CD009329.
10. Prochaska JJ, et al. Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis. BMJ 2012; 344:e2856.
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References11. Hughes JR, et al. Antidepressants for smoking cessation. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD000031.
12. U.S. Food and Drug Administration. Prescribing information: Zyban (bupropion hydrochloride). 2012 Jan. http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020711s036lbl.pdf
13. Stead LF, et al. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2012 Nov 14;11:CD000146.
14. Rösner S, et al. Acamprosate for alcohol dependence. Cochrane Database Syst Rev. 2010 Sep 8;(9):CD004332.
15. U.S. Food and Drug Administration. Highlights of prescribing information for Campral (acamprosate calcium). 2012 Jan. http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021431s015lbl.pdf
16. Laaksonen E, et al. A randomized, multicentre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependence. Alcohol Alcohol. 2008 Jan-Feb;43(1):53-61.
17. Rösner S, et al. Opioid antagonists for alcohol dependence. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD001867.
18. Brewer C, et al. Naltrexone: report of lack of hepatotoxicity in acute viral hepatitis, with a review of the literature. Addict Biol. 2004 Mar;9(1):81-7.
19. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. Naltrexone: LiverTox Clinical and Research Information on Drug-Induced Liver Injury. http://livertox.nih.gov/Naltrexone.htm
20. Mattick RP, et al. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD002207.
21. Mattick RP, et al. Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD002209.
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Acknowledgements
• Margot Cohen contributed much of the research and writing for these materials.
• The following subject-matter experts served as external reviewers for these materials: Kevin Kunz, M.D., M.P.H., Frances Levin, M.D., Charles O’Brien, M.D., Ph.D.
• Funding was provided by The Joseph A. Califano, Jr. Institute for Applied Policy.
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