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UMIB Summit 2015® | ICBAS-FFUP Multidisciplinary Meeting

UMIB SUMMIT 2015® - TRANSLATIONAL RESEARCH, INNOVATION AND PROGRESS IN THE FIELD OF BIOMEDICINE

I

ORAL

COMMUNICATIONS



II

24 Sep 2015 | 18h00-19h30

BIOLOGY OF REPRODUCTION ORAL COMMUNICATIONS – SESSION I

ROOM: To be confirmed MODERATORS:

Maria Isabel Malheiro (ICBAS, HSA-CHP) Maria de Lourdes Pereira (UA)

CO0002 18h00-18h08

p.2

PROFILING SIGNALING PROTEINS IN HUMAN SPERMATOZOA: BIOMARKER IDENTIFICATION FOR SPERM QUALITY EVALUATION Joana Vieira Silva, Maria João Freitas, Bárbara Regadas Correia, Luís Korrodi-Gregório, António Patrício, Steven Pelech, Margarida Fardilha.

CO0003 18h10-18h18

p.3

NEW INSIGHTS INTO THE REGULATION OF HUMAN SERTOLI CELLS METABOLISM: DIFFERENTIAL EFFECTS OF DEHYDROEPIANDROSTERONE AND 7-OXO-DEHYDROEPIANDROSTERONE Tânia R. Dias, Marco G. Alves, Susana P. Almeida, Joaquina Silva, Alberto Barros, Mário Sousa, Branca M. Silva, Samuel M. Silvestre, Pedro F. Oliveira.

CO0007 18h20-18h28

p.4

THE ANTIDIABETIC DRUG PIOGLITAZONE ALTERS HUMAN SERTOLI CELLS METABOLISM BY INCREASING ITS GLYCOLYTIC EFFICIENCY Maria J. Meneses, Raquel L. Bernardino, Rosália Sá, Joaquina Silva, Alberto Barros, Mário Sousa, Branca M. Silva, Pedro F. Oliveira, Marco G. Alves.

CO0008 18h30-18h38

p.5

MAMMALIAN TARGET OF RAPAMYCIN IS A NOVEL MODULATOR OF SERTOLI CELLS GLYCOLYTIC AND OXIDATIVE PROFILES Tito T. Jesus, Pedro F. Oliveira, Joaquina Silva, Alberto Barros, Mário Sousa, C. Yan Cheng, Branca M. Silva, Marco G. Alves.

CO0009 18h40-18h48

p.6

PROTECTIVE EFFECTS OF N-ACETYLCYSTEINE ON HUMAN SPERM DNA DURING SHORT-TERM ETOPOSIDE EXPOSURE A. Rabaça, A. Gonçalves, C. Ferreira, R.L. Bernardino, A. Barros, M.G. Alves, M. Sousa, P.F. Oliveira, R. Sá.

CO0010 18h50-18h58

p.7

METFORMIN PRESERVES HUMAN SPERM DNA INTEGRITY DURING SHORT-TERM INCUBATION C Ferreira, A Gonçalves, A Rabaça, R.L. Bernardino, A. Barros, PF Oliveira, M. Sousa, MG Alves, R. Sá.

CO0022 19h00-19h08

p.8

MATERNAL AGE AND PLACENTA REDOX CHANGES Soares AI, Silveira S, Matos L, Guedes-Martins L, Saraiva J, Almeida H, Silva E.

CO0047 19h10-19h18

p.9

CANNABINOID SIGNALING IN HUMAN PLACENTA: EFFECTS OF CANNABINOIDS IN CYTOTROPHOBLAST CELLS Lia Costa, Bruno Fonseca, Cristina Amaral, Alexandrina Mendes, Jorge Braga, Natércia Teixeira, Georgina Correia-da-Silva.

CO0049 19h20-19h28

p.10

SCHISTOSOMA MANSONI INFECTION IMPAIRS REPRODUCTION IN MICE Reding C, Reding A, Lopes G, Sousa M, Gartner F, Alves H, Richter J, Oliveira PA, Botelho MC.



III

24 Sep 2015 | 18h00-19h30

ENDOCRINOLOGY AND DIABETES ORAL COMMUNICATIONS – SESSION II


Marcos Couselo Carreira (USC) To be confirmed

CO0006 18h00-18h08

p.11

WHITE TEA CONSUMPTION IMPROVES THE GLYCOLYTIC AND OXIDATIVE PROFILES OF CEREBRAL CORTEX OF PREDIABETIC WISTAR RATS: A POSSIBLE ROLE FOR NEUROPROTECTION? Ana R. Nunes, Marco G. Alves, Tânia R. Dias, Ana C. Cristóvão, Paula I. Moreira, Pedro F. Oliveira, Branca M. Silva.

CO0014 18h10-18h18

p.12

ANTI-INFLAMMATORY EFFECTS OF INCRETIN DRUGS IN THE SPINAL CORD OF DIABETIC RATS Lucas Lopes, José Tiago Pereira, Sandra Marisa Oliveira, Isaura Tavares, Carla Morgado

CO0019 18h20-18h28

p.13

Akt/Smad3 SIGNALING INCREASES WITH ADIPOSITY AND CORRELATES TO TRANSFORMING GROWTH FACTOR β (TGF-β) LEVELS IN HUMAN ADIPOSE TISSUE Adriana R. Rodrigues, Maria J. Salazar, Ângela Moreira, Marta Guimarães, Mário Nora, Henrique Almeida, Mariana P. Monteiro3, Alexandra M. Gouveia.

CO0025 18h30-18h38

p.14

THE EFFECT OF OBEX® ON HFD FED MICE AND IN 3T3 CELLS S. Andrade, MC. Carreira, B. Cabia, M. Amil, AB Crujeiras, M. P. Monteiro, FF.Casanueva1,3

CO0032 18h40-18h48

p.15

ADRENOCORTICAL TUMORS DISPLAY DECREASED N-CADHERIN AND PRESERVED TELOMERASE EXPRESSION Sofia S. Pereira, Valdemar Máximo, Ricardo Coelho1,2; Rui Baptista1,2; Paula Soares; Manuel Sobrinho Simões, Mariana P. Monteiro, Duarte Pignatelli.

CO0033 18h50-18h58

p.16

VITAMIN D DEFICIENCY AND SECONDARY HYPERPARATHYROIDISM ARE HIGHLY PREVALENT IN THE OBESITY AND ARE AGGRAVATED BY BARIATRIC SURGERY Ana Catarina Carvalho, Tiago Guedes, Tiago Morais, Marta Guimarães, Mário Nora, Mariana P Monteiro.

CO0034 19h00-19h08

p.17

LONG BILIOPANCREATIC LIMB GASTRIC BYPASS RESULTS IN IMPROVED GLYCAEMIC CONTROL DESPITE SIMILAR WEIGHT LOSS COMPARED TO THE CLASSICAL TECHNIQUE Marta Guimarães, Ana Carvalho, Tiago Guedes, Tiago Morais, Mário Nora, Mariana P. Monteiro.

CO0035 19h10-19h18

p.18

PLASMA LEPTIN RESPONSE AFTER CHRONIC GLP-1 EXPOSURE IS MODULATED BY THE INTEGRITY OF THE VAGUS NERVE Tiago Morais, Sofia S. Pereira, Sara Andrade, Ângela Moreira, Duarte Monteiro, Madalena Costa, Bárbara Patrício, Marcos Carreira, Felipe F. Casanueva, Mariana P. Monteiro.

CO0067 19h10-19h18

p.19

ADIPOCYTE SECRETED FACTORS OF OBESE INDIVIDUALS INCREASE THE METABOLIC ACTIVITY OF THE ADRENOCORTICAL TUMOR CELLS Sofia S Pereira, Joana R Pereira, Ângela Moreira, Marta Guimarães, Mário Nora, Duarte Pignatelli, Mariana P Monteiro.



IV

24 Sep 2015 | 18h00-19h30

GENETICS ORAL COMMUNICATIONS – SESSION III


Maria João Sá (CGMJM-CHP) José Luís Costa (IPATIMUP)

CO0094 18h00-18h08

p.20

LONG-TERM FOLLOW-UP OF 132 PATIENTS WITH PHENYLKETONURIA: POTENTIAL EFFECTS OF PHE LEVELS ON NEUROPSYCHOLOGICAL DEVELOPMENT Carmona Carla Maria, Almeida Manuela, Fortuna Ana Maria.

CO0095 18h10-18h18

p.21

ORIGIN OF NORMAL-SIZE FMR1 ALLELES WITHOUT [AGG] INTERSPERSIONS Maia N.*, Loureiro J.*, Oliveira B., Marques I., Santos R., Martins S.5 e Jorge P. *Equal contributors

CO0096 18h20-18h28

p.22

MORPHOLOGICAL AND PROTEOMIC STUDIES ON SMITH-LEMLI-OPITZ SYNDROME: FURTHER EVIDENCE THAT CHOLESTEROL DEFICIENCY CAUSES AUTOPHAGY Maria Luis Cardoso, Rui Vitorino, Rosário Pinto Leite, Regina Arantes-Rodrigues, Rui Fernandes, Cristina Amaral, Carina Bernardo, Henrique Reguengo, Rita Ferreira, Francisco Amado, Franklim Marques.

CO0097 18h30-18h38

p.23

MANDIBULOFACIAL DYSOSTOSIS (TREACHER COLLINS SYNDROME) – NOVEL DE NOVO MUTATION IN TCOF1 M. Martins, P. Botelho, M. Souto, R. Arantes, O. Moutinho, R. Pinto Leite.

CO0098 18h40-18h48

p.24

MEDICAL STUDENTS’ OPINIONS CONCERNING GENETIC TESTS, GENETIC DIAGNOSIS AND RELATED BIOETHICAL PROBLEMS: A SURVEY DURING THE ACADEMIC YEAR 2014-2015 Oliva-Teles, Natália*; Carmona, Carla*; Nunes, Rui; Fortuna, Ana. *Shared authorship

CO0099 18h50-18h58

p.25

THE GENETICS OF HEREDITARY MYOPATHIES REVISITED BY MASSIVE PARALLEL SEQUENCING Jorge Oliveira, Conceição Egas, José Carlos Machado, Mário Sousa*, Rosário Santos* *These authors contributed equally to this work.

CO0100 19h00-19h08

p.26

DIFFICULT GENETIC COUNSELING IN A SUBTELOMERIC SYNDROME Pinto Leite R.,Souto M., Botelho P., Severo R., Moutinho O., Martins M.

CO0101 19h10-19h18

p.27

BEWARE OF FABRY DISEASE DIAGNOSIS – INSIGHTS FROM AN ATYPICAL PORTUGUESE FAMILY Ribeiro I, Silva E, Pinto E, Pinto F, Rocha S, Ferreira C, Ribeiro H, Maia C, Quelhas D, Laranjeira F, Caseiro C, Lacerda L.

CO0102 p.28

LACK OF ASSOCIATION OF ASAP1 GENE AND TUBERCULOSIS IN CHINESE Nelson Tang, Amy Wang, CC Leung, KC Chang, M Hui, CY Chan.



V

24 Sep 2015 | 18h00-19h30

IMMUNITY AND INFLAMMATION ORAL COMMUNICATIONS – SESSION IV


Margarida Saraiva (IBMC-UP) Cidália Vaz (HSJ, FMUP)

CO0018 18h00-18h08

p.29

A SAFE AND STABLE NEONATAL VACCINE TARGETING GAPDH CONFERS PROTECTION AGAINST GBS INFECTIONS IN ADULT SUSCEPTIBLE MICE Joana Alves*, Pedro Madureira*, Maria Teresa Baltazar, Leandro Barros, Liliana Oliveira, Ricardo Jorge Dinis-Oliveira, Elva Bonifácio Andrade, Adília Ribeiro, Luís Mira Vieira, Patrick Trieu-Cuot, José Alberto Duarte, Félix Carvalho, Paula Ferreira*. *These authors contributed equally to this work

CO0040 18h10-18h18

p.30

THE MYCOBACTERIUM TUBERCULOSIS NON-RIBOSOMAL PEPTIDE SYNTHASE NRP MODULATES THE HOST IMMUNE RESPONSE AND IS REQUIRED FOR OPTIMAL COLONIZATION Henrique Machado, Filipa Cardoso, Jeremy Sousa, Fernando Rodrigues, António Gil Castro, Apoorva Bhatt, Egídio Torrado, Margarida Saraiva.

CO0031 18h20-18h28

p.31

POLY-N-ACETYL GLUCOSAMINE EXPRESSION IN STAPHYLOCOCCUS EPIDERMIDIS BIOFILM CELLS AFFECTS THE IMMUNE RESPONSE AND PROMOTES TISSUE PATHOLOGY IN INFECTED HOSTS Pedro Ferrerinha*, Begoña Pérez-Cabezas*, Alexandra Correia, Bruna Miyazawa, Augusto Faustino, Anabela Cordeiro-da-Silva, Luzia Teixeira, Nuno Cerca, Manuel Vilanova. * Both authors contributed equally to this study

CO0030 18h30-18h38

p.32

CANDIDA ALBICANS SECRETED ASPARTIC PROTEASE EXPRESSION FACILITATES MURINE PERITONEAL INFECTION IN A Treg / IL-10-DEPENDENT MANNER Alexandra Correia, Bruno Cerqueira-Rodrigues, Luzia Teixeira, Henrique Fernandes, Íris Caramalho, Paula Sampaio, Célia Pais, Margarida Correia-Neves, Rui Appelberg, Manuel Vilanova.

CO0051 18h40-18h48

p.33

CANDIDA GLABRATA AND CANDIDA BRACARENSIS: TWO SISTER SPECIES INDUCING DISPARATE INNATE IMMUNE RESPONSES Tânia Lima, Catarina Carneiro, Elisabete Coelho, Paula Sampaio, Manuel A. Coimbra, Manuel Vilanova, Célia Pais, Alexandra Correia.

CO0027 18h50-18h58

p.34

DODAB: MONOOLEIN LIPOSOMES CONTAINING CANDIDA ALBICANS CELL WALL SURFACE PROTEINS: A NOVEL ADJUVANT AND DELIVERY SYSTEM Catarina Carneiro, Alexandra Correia, Tânia Lima, Manuel Vilanova, Célia Pais, Andreia C, Gomes, M. Elisabete C.D. Real Oliveira, Paula Sampaio.

CO0005 19h00-19h08

p.35

USING RESOLVIN D1 TO MODULATE THE INFLAMMATORY RESPONSE TO 3D CHITOSAN SCAFFOLDS. Daniela P. Vasconcelos, Madalena C. Costa, Isabel F. Amaral, Mário A. Barbosa, Artur P. Águas, Judite N. Barbosa.



VI

IMMUNITY AND INFLAMMATION ORAL COMMUNICATIONS – SESSION IV

CO0001 19h10-19h18

p.36

IMMUNE RESPONSE AND INNERVATION IN OSTEOARTHRITIS AND HIP IMPLANTS ASEPTIC LOOSENING Daniel M. Vasconcelos, Manuel R. Silva, António Mateus, Juliana Alves, Gil Machado, Joana Santos, Diogo Paramos, Inês Alencastre, Rui Henrique, Gilberto Costa, Mário A. Barbosa1, Meriem L. Lamghari.

CO0013 19h20-19h28

p.37

NEW INSIGHTS INTO THE IMPAIRED T-CELL FUNCTION IN DIABETIC FOOT ULCERATIONS João Moura, João Rodrigues, Marta Gonçalves, Cláudia Amaral, Margarida Lima, Eugénia Carvalho.



VII

24 Sep 2015 | 18h00-19h30

NEPHROLOGY ORAL COMMUNICATIONS – SESSION V


Isabel Fonseca (UMIB, HSA-CHP) Patrícia Martins (Nephrology Service - CHSJ)

CO0004 18h00-18h08

p.38

PROSPECTIVE EVALUATION OF PLASMATIC ADVANCED GLYCATION ENDPRODUCTS (AGE) AFTER PANCREAS-KIDNEY TRANSPLANTATION: – CARBOXYMETHYLLISINE SIGNIFICANTLY DECREASED DURING THE FIRST YEAR La Salete Martins, José Carlos Oliveira, Isabel Fonseca, António C Henriques, Anabela Rodrigues.

CO0016 18h10-18h18

p.39

TRANSTHYRETIN AMYLOIDOSIS AFTER SEQUENTIAL LIVER TRANSPLANTATION: THE KIDNEY IS ALSO A TARGET IN ACQUIRED AMYLOIDOSIS Ana Rocha, Josefina Santos, Ramón Vizcaíno, Helena Pessegueiro, Cristina Alves, Luísa Lobato.

CO0020 18h20-18h28

p.40

ADMISSIONS TO A NEPHROLOGY WARD IN PATIENTS UNDERGOING CHRONIC DIALYSIS: IMPACT OF DIABETES MELLITUS Vanda Guardado, Lígia Bessa, Carla Leal Moreira, Jorge Malheiro, Josefina Santos, António Cabrita.

CO0026 18h30-18h38

p.41

THE IMPACT OF DIABETES MELLITUS IN HOSPITALIZED PATIENTS WITH NON-END STAGE RENAL DISEASE OR ACUTE KIDNEY INJURY Carla Moreira, Lígia Bessa, Vanda Guardado, Jorge Malheiro, Josefina Santos, António Cabrita.

CO0044 18h40-18h48

p.42

PREGNANCY IN RENAL TRANSPLANT RECIPIENTS: OBSTETRIC OUTCOMES AND RISK OF ALLOSENSITIZATION Sofia Santos, Jorge Malheiro, Andreia Campos, Sofia Pedroso, Manuela Almeida, La Salete Martins, Leonídio Dias, Castro Henriques, António Cabrita.

CO0046 18h50-18h58

p.43

RISK FACTORS FOR MORTALITY IN END-STAGE KIDNEY DISEASE PATIENTS UNDER ONLINE-HEMODIAFILTRATION: THREE-YEAR FOLLOW-UP STUDY Pedro de Sousa-Martins, Alexandra Moura, José Madureira, Pablo Alija, José Gerardo Oliveira, Martin Lopez, Madalena Filgueiras, Leonilde Amado, Maria Sameiro-Faria, Vasco Miranda, Edgar Mesquita, Laetitia Teixeira, Alice Santos-Silva, Luísa Lobato, Elísio Costa.

CO0050 19h00-19h08

p.44

IMPACT OF DE NOVO DONOR-SPECIFIC ANTI-HLA ANTIBODIES IN KIDNEY GRAFT FAILURE: A CASE-CONTROL ANALYSIS Jorge Malheiro, Sandra Tafulo, Leonidio Dias, La Salete Martins, Idalina Beirão, António Castro-Henriques.



VIII

24 Sep 2015 | 18h00-19h30

NEUROSCIENCES AND AUTOIMMUNITY ORAL COMMUNICATIONS – SESSION VI


Carmen Jerônimo (ICBAS, IPO) Graça Porto (IBMC-UP, ICBAS)

CO0012 18h00-18h08

p.45

MICROANGIOPATHY IN SYSTEMIC SCLEROSIS: ROLE OF ENDOTHELIAL DYSFUNCTION AND MICROVASCULAR DAMAGE Ivone Silva, Andreia Teixeira, José Oliveira, Rui Almeida, Carlos Vasconcelos.

CO0023 18h10-18h18

p.46

TRANSTHYRETIN PROMOTES Aβ CLEARANCE THROUGH LRP1 IN THE LIVER Mobina Alemi, Cristiana Gaiteiro, Carlos Ribeiro, Isabel Cardoso.

CO0028 18h20-18h28

p.47

CALCULATING PRE-DELIRIC MODEL WITH SAPS II FOR EARLY DETECTION OF DELIRIUM IN ICU PATIENTS. Marco Sampaio, Teresa Cardoso, Irene Aragão.

CO0029 18h30-18h38

p.48

ANIMAL MODEL OF CUPRIZONE-INDUCED DEMYELINATION: THE BEGINNING OF A STORY WITH POSSIBLE CLINICAL APPLICATIONS Filipe Palavra, Sara Nunes, Lorena Petrella, João Dinis, Frederico C. Pereira, Luís Almeida, António Francisco Ambrósio, Miguel Castelo-Branco, Flávio Reis.

CO0036 18h40-18h48

p.49

“MIND THE METHOD!” – A LONGITUDINAL ASSESSMENT OF METHODOLOGICAL SOUNDNESS AND QUALITY OF REPORTING OF ALS RESEARCH ON THE SOD1G93A MOUSE N.H. Franco, J. G. Fernandes, A.J. Grierson, A.J. Furley, I.A.S. Olsson.

CO0039 18h50-18h58

p.50

EFFECTS OF WINE POLYPHENOLS IN THE NEUROPROTECTIVE ROLE OF TRANSTHYRETIN IN ALZHEIMER’S DISEASE LM Santos, D Rodrigues, M Alemi, CA Ribeiro, I Cardoso.

CO0041 19h00-19h08

p.51

EXPRESSION OF INFLAMMATION-ASSOCIATED microRNAs IN EPILEPSY – A PRELIMINARY STUDY Bárbara Leal, Cláudia Carvalho, Ricardo Ferreira, João Chaves, Andreia Bettencourt, Joel Freitas, João Lopes, João Ramalheira, António Martins da Silva, Paulo Pinho e Costa, Berta Martins da Silva.

CO0042 19h10-19h18

p.52

THE ROLE OF TWO Nrf2 POLYMORPHISMS ON MULTIPLE SCLEROSIS IN A PORTUGUESE POPULATION Andreia Bettencourt, Andreia Cunha, Nuno Sepúlveda, Ernestina Santos, Paulo Pinho e Costa, Miguel Soares, Berta Martins da Silva, Ana Martins da Silva.

CO0043 19h20-19h28

p.53

MicroRNA-146a AND MULTIPLE SCLEROSIS Andreia Bettencourt, Rita Brás, Cláudia Carvalho, Bárbara Leal, Raquel Samões, Ernestina Santos, Paulo Pinho e Costa, Ana Martins da Silva, Berta Martins da Silva



IX

24 Sep 2015 | 18h00-19h30

ONCOLOGY ORAL COMMUNICATIONS – SESSION VII


Rui Medeiros (IPO) Manuel Magalhães (IPO)

CO0011 18h00-18h08

p.54

GASTRIC CANCER IN THE ELDERLY: THE IMPACT OF OLD AGE ON GASTRECTOMY Isabel Mesquita, Carlos Nogueira, Jorge Santos, Mario Marcos, Eduarda Matos.

CO0015 18h10-18h18

p.55

EXPRESSION OF IRON-RELATED PROTEINS IN LYMPHOCYTES AND MACROPHAGES OF BREAST DUCTAL CARCINOMAS Marques, Oriana; Porto, Graça; Rêma, Alexandra; Faria, Fátima; Cruz Paula, Arnaud; Gomez-Lazaro, Maria; Silva, Paula; Martins da Silva, Berta; Lopes, Carlos.

CO0017 18h20-18h28

p.56

CARCINOGENIC COMPOUNDS IN COOKED MEAT: INTAKE, BIOAVAILABILITY AND MITIGATION STRATEGIES Isabel M.P.L.V.O. Ferreira, Olga Viegas, Armindo Melo, Miguel Faria, Olívia Pinho.

CO0021 18h30-18h38

p.57

EFFICACY OF PROPIONIBACTERIUM FREUDENREICHII FERMENTED BROTHS ON COLORECTAL CANCER Marta Casanova, Lígia Rodrigues, Ana Preto.

CO0024 18h40-18h48

p.58

FASTING GLUCOSE BUT NOT METABOLIC SYNDROME OR OTHER COMPONENTS IS FREQUENTLY ELEVATED IN DIGESTIVE NEUROENDOCRINE TUMORS Santos Ana P, Santos Ana C, Castro C, Raposo L, Torres I, Henrique R, Monteiro MP; Cardoso MH.

CO0037 18h50-18h58

p.59

THE EFFECTS OF ENDOCANNABINOIDS ANANDAMIDE (AEA) AND 2-ARACHIDONOYLGLYCEROL (2-AG) IN THE ENDOMETRIAL CANCER CELL LINES Fonseca, B.M., Correia-da-Silva, G., Teixeira N.A.

CO0038 19h00-19h08

p.60

PROTEIN PROFILE IN PROSTATE CANCER: IDENTIFICATION OF NOVEL BIOMARKERS Maria João Freitas, Joana Vieira Silva, Juliana Felgueiras, António Patrício, Nuno Maia, Steven Pelech, Margarida Fardilha.

CO0045 19h10-19h18

p.61

ESTROGEN-DEPENDENT BREAST CANCER: AUTOPHAGY AS A POTENTIAL MECHANISM OF EXEMESTANE-ACQUIRED RESISTANCE Cristina Amaral, Georgina Correia-da-Siva, Fernanda M. Roleira, Elisiário Tavares da Silva, Natércia Teixeira

CO0048 19h20-19h28

p.62

EXCESS ADIPOSITY CORRELATES WITH THE EXPRESSION LEVELS OF MYC AND PTEN ON THE MAMMARY GLAND OF A DIET-INDUCED OBESITY RAT MODEL Cabia B., Amil M., Andrade S., Couselo M. C., Casanueva F. F., Crujeiras A. B.



X

POSTERS



XI

24 Sep 2015 | 19h30-20h00

BIOLOGY OF REPRODUCTION POSTERS – SESSION I


Maria Isabel Malheiro (UMIB, ICBAS-UP) Marco Alves (CICS-UBI)

P0052 p.64

EMBRYOLOGICAL AND CLINICAL OUTCOMES OF PATIENTS WITH Y-CHROMOSOME MICRODELETIONS Carolina Gonçalves, Mariana Cunha, Eduardo Rocha, Susana Fernandes, Joaquina Silva, Paulo Viana, Luís Ferraz, José Teixeira da Silva, Cristiano Oliveira, Alberto Barros, Mário Sousa.

P0053 p.65

EFFECT OF LONG-TERM TREATMENT WITH ROYAL JELLY ON FOLLICULAR DEVELOPMENT OF RATS WITH STEROID-INDUCED POLYCYSTIC OVARIES Virgínia Pereira, Simone Maria Oliveira Viana, Ricardo Fakhoury.

P0054 p.66

ESTROGEN RECEPTORS alpha (ER-α), beta (ER-β) AND G PROTEIN-COUPLED RECEPTOR 30 (GPR30) IN THE TESTICULAR TISSUE OF INDIVIDUALS WITH KLINEFELTER SYNDROME Raquel L. Bernardino, Marco G. Alves, Joaquina Silva, Alberto Barros, Luis Ferraz, Mário Sousa, Rosália Sá, Pedro F. Oliveira.

P0057 p.67

TESTICULAR METABOLIC REPROGRAMMING IN NEONATAL STREPTOZOTOCIN-INDUCED TYPE 2 DIABETIC RATS IMPAIRS GLUCOSE METABOLISM AND PROMOTES GLYCOGEN ACCUMULATION L. Rato, M. G. Alves, T. R. Dias, J. E. Cavaco, Pedro F. Oliveira.

P0058 p.68

HOW DOES SERTOLI CELL METABOLISM RESPONDS TO THE REDUCED TESTOSTERONE LEVELS INDUCED BY PROGRESSIVE STAGES OF DIABETES MELLITUS? J.E. Cavaco*, L. Rato*, M.G. Alves, A.I. Duarte, M.S. Santos, P.I. Moreira, P. F. Oliveira. * both authors contributed equally

P0059 p.69

SPERM QUALITY OF PRE-DIABETIC WISTAR RATS IS RESTORED AFTER A DIET WITH WHITE TEA Branca M. Silva, Gonçalo D. Tomás, Tânia R. Dias, Ana D. Martins, Luís Rato, Marco G. Alves, Pedro F. Oliveira.

P0060 p.70

TESTICULAR METABOLIC BIOMARKERS IN MEN WITH KLINEFELTER SYNDROME Susana P. Almeida, Ana D. Martins, Ivana Jarak, Alberto Barros, Joaquina Silva, Mário Sousa, Pedro F. Oliveira, Marco G. Alves.

P0063 p.71

MUTATION ANALYSIS IN PATIENTS WITH TOTAL SPERM IMMOTILITY AND DYSPLASIA OF THE FIBROUS SHEATH Rute Pereira, Jorge Oliveira, Luis Ferraz, Alberto Barros6, Rosário Santos, Mário Sousa.

P0065 p.72

LEPTIN MODULATES HUMAN SERTOLI CELLS GLUCOSE METABOLISM: RELEVANCE FOR OBESITY-INDUCED MALE INFERTILITY Ana D. Martins, Ana C. Moreira, Rosália Sá, Mariana P. Monteiro, Mário Sousa, Rui A. Carvalho, Branca M. Silva, Pedro F. Oliveira, Marco G. Alves.



XII

BIOLOGY OF REPRODUCTION POSTERS – SESSION I

P0068 p.73

DOWNREGULATION OF THE AXIS FORMED BY ANGIOTENSIN-CONVERTING ENZYME TYPE 2, ANGIOTENSIN(1-7) AND MAS RECEPTOR IN A RAT MODEL OF POLYCYSTIC OVARIES Virgínia Mara Pereira, Almir Souza Martins, Adelina Martha dos Reis.

P0079 p.74

TOWARDS HUMAN ENDOMETRIUM DECIDUALIZATION: A DIALOGUE BETWEEN ENDOCANNABINOIDS AND PROSTAGLANDINS Marta Almada, Georgina Correia-da-Silva, Fabiana Piscitelli F, Vincenzo Di Marzo, Natércia A. Teixeira, and Bruno M. Fonseca.

P0083 p.75

ULTRASTRUCTURAL ANALYSIS OF A PATIENT WITH TOTAL SPERM IMMOTILITY DUE TO ABSENCE OF DYNEIN ARMS AND NEXIN BRIDGES Elsa Oliveira, Ângela Alves, Helena Figueiredo, Luis Ferraz, Mário Sousa.



XIII

24 Sep 2015 | 19h30-20h00

ENDOCRINOLOGY AND DIABETES POSTERS – SESSION II


Alexandra Gouveia (FMUP) To be confirmed

P0062 p.76

BROWNING OF WHITE ADIPOCYTES: MELANOCORTINS AS ESSENTIAL PLAYERS M. J. Salazar, A. R. Rodrigues , S. Rocha-Rodrigues, I.O. Gonçalves, H. Almeida, J. Magalhães, A. M. Gouveia.

P0064 p.77

ANALYSIS OF HEART RATE VARIABILITY AFTER MAJOR ABDOMINAL SURGERY Pedro Moreira, Filipa Guimarães, Filipe Valadas, Bruno Santos, Sílvia Pereira, Carla Quintão,

Jorge Santos, Gil Faria.

P0073 p.78

HIGHER ENDOGENOUS LEPTIN IS ASSOCIATED WITH DECREASED EPITHELIAL CELL NUCLEAR DENSITY IN THE NORMAL PROSTATE GLAND Pedro R Pereira, Sofia S Pereira, Ângela Moreira, Madalena M Costa, Ricardo Marcos, Mariana P Monteiro.

P0075 p.79

PROSTATE CANCER CELLS ARE ABLE TO INTERACT WITH SURROUNDING ADIPOCYTES INDUCING PHENOTYPIC ALTERATIONS THAT CAN PROMOTE TUMOR EXPANSION Ângela Moreira, Sofia S. Pereira, Sara Andrade, Adriana Rodrigues, Madalena Santos, Tiago Morais, Alexandra Gouveia, Mariana P. Monteiro.

P0076 p.80

LYMPHATIC VESSEL DENSITY IS HIGHER IN THE SURROUNDING THYROID TISSUE OF MEDULLARY COMPARED TO PAPILLARY CARCINOMAS Filipe Pereira, Sofia S. Pereira, Tiago Morais, Madalena Costa, Pedro Quelhas, Carlos Lopes, Mariana P. Monteiro, Valeriano Leite.

P0077 p.81

EFFECT OF CHRONIC GLP-1 EXPOSURE ON THE MORPHOLOGY OF PANCREATIC ISLETS OF INTACT AND TRUNCAL VAGOTOMIZED RATS Tiago Morais, Bárbara Patrício, Sofia S. Pereira, Madalena Costa, Ângela Moreira, Sara Andrade, Duarte Monteiro, Marcos Carreira, Felipe F. Casanueva, Mariana P. Monteiro.

P0084 p.82

NUTRITIONAL STATUS DEFICIENCY IN CHILDREN INFECTED WITH SCHISTOSOMA HAEMATOBIUM Reding A, Reding C, Machado A, Carvalho A, Vilaça M, Conceição O, Alves H, Richter J, Bordalo A.A, Botelho MC.



XIV

24 Sep 2015 | 19h30-20h00

GENETICS POSTERS – SESSION III


Dulce Quelhas (CGMJM-CHP) Sílvia Álvares (HSA-CHP)

P0087 p.83

BETA CHOLINE KINASE DEFICIENCY: A RARE CAUSE OF MUSCULAR DYSTROPHY, CARDIOMYOPATHY AND INTELLECTUAL DISABILITY Jorge Oliveira, Luís Negrão, Isabel Fineza, Ricardo Taipa, Manuel Melo-Pires, Ana Rita Gonçalves, Emília Vieira, Márcia E. Oliveira, Ana Maria Fortuna, Mário Sousa*, Rosário Santos* * These authors contributed equally to this work

P0088 p.84

SCREENING FOR MED12 VARIANTS IN OPITZ-KAVEGGIA AND LUJAN-FRYNS SYNDROMES Cathy Paulino*, Isabel Marques*, Raquel Chaves, Paula Jorge, Rosário Santos. *Equal contributors

P0089 p.85

CASE REPORT: A DOUBLE TRANSLOCATION FOUND IN PRENATAL DIAGNOSIS Botelho P.,Souto M., Rodrigues A., Carnide C., Martins M., Moutinho O., Pinto Leite R.

P0090 p.86

IMPORTANCE OF CYTOGENETIC STUDY IN MULTIPLE MYELOMA M. Souto, P. Botelho, M. Cunha, M. Guerra, O. Moutinho, M. Martins, R. Pinto Leite.

P0091 p.87

FMR1 GENE-ZYGOSITY DISCRIMINATION: THE USE OF hrMCA IN FEMALE SAMPLES Salgado S., Maia N., Cruz E., Marques I., Santos R., Jorge P.

P0092 p.88

FAMILIAL SUBTELOMERIC REARRANGEMENT INVOLVING CHROMOSOMES 2 AND 16 DETECTED BY ARRAY-CGH AND MOLECULAR CYTOGENETICS. A R Soares, G Soares, C Candeias, M M Freitas, N O Teles, A M Fortuna, M L Silva.

P0093 p.89

GENETICALLY ENGINEERED CONSTRUCTION AND CREATION OF A RECOMBINANT ADENOVIRUS AS AN APPROACH FOR GENE THERAPY OF DYSFERLINOPATHIES. Starostina I.G., Solovyova V.V., Rizvanov A.A., Deev R.V.



XV

24 Sep 2015 | 19h30-20h00

IMMUNITY AND INFLAMMATION POSTERS – SESSION IV


Fátima Macedo (IBMC-UP | UA) Margarida Lima (UMIB, HSA-CHP)

P0070 p.90

FLOW CYTOMETRY FOR THE DIAGNOSIS OF HEREDITARY DEFICIENCY OF PLATELET DENSE GRANULES Catarina Lau, José Carlos Ferreira, Marta Gonçalves, Marco Sampaio, Sara Morais, Manuel Campos, Margarida Lima.

P0066 p.91

MECHANICAL ISOLATION AND FLOW CYTOMETRY CHARACTERIZATION OF ENDOTHELIAL CELLS Cláudia Torres, Rui Machado, Margarida Lima.

P0080 p.92

A DECREASE IN INFLAMMATION ASSOCIATES WITH AN IMPROVEMENT IN IRON STATUS IN OBESE CHILDREN AND ADOLESCENTS Susana Coimbra, Cristina Catarino, Henrique Nascimento, Ana Inês Alves, Ana Filipa Medeiros, Elsa Bronze-da-Rocha, Elísio Costa, Petronila Rocha-Pereira, Luísa Aires, André Seabra, Jorge Mota, Helena Ferreira Mansilha, Carla Rêgo, Alice Santos-Silva, Luís Belo.

P0081 p.93

ROLE OF MACROPHAGES IN THE PATHOGENESIS OF THE RABBIT HAEMORRHAGIC DISEASE (RHD) R.M. Marques, Joana C. Ribeiro, L. Teixeira, A.P. Águas, A. Costa-e-Silva, P.G. Ferreira.

P0082 p.94

DETERMINATION OF MACROPHAGE ACTIVATION PROFILE DURING TOXOPLASMA GONDII INFECTION AND IMPLICATIONS ON PREGNANCY OUTCOME USING THE MICE MODEL C. Brito, A. Gonçalves, T. M. Silva, N. Teixeira, M. Borges.

P0069 p.95

MUCOSAL IMMUNIZATION WITH MEMBRANE ANTIGENS CONFERS LONG-TERM PROTECTION AGAINST THE INTRACELLULAR PARASITE NEOSPORA CANINUM Pedro Ferreirinha, Alexandra Correia, Luzia Teixeira, António Rocha, Manuel Vilanova.

P0074 p.96

INTERFERON-γ PRODUCTION RATHER THAN CYTOTOXICITY MEDIATES PROTECTION CONFERRED BY CD8+ T CELLS IN ACUTE NEOSPOROSIS Alexandra Correia, Pedro Ferreirinha, Sofia Botelho, Ana Belinha, Catarina Leitão, Íris Caramalho, Luzia Teixeira, África González-Fernandéz, Rui Appelberg, Manuel Vilanova.

P0086 p.97

INCREASED LEPTIN AND TNF-α EXPRESSION IN ADIPOSE TISSUE EXPLANTS INFECTED IN VITRO WITH NEOSPORA CANINUM Alexandra Correia, Filipa Bezerra, Pedro Ferreirinha, Raquel M Marques, Pedro Meireles, Paula G Ferreira, Manuel Vilanova, Luzia Teixeira.

P0085 p.98

CELL SOURCES OF IFN-γ PRODUCTION IN THE ADIPOSE TISSUE OF MICE INFECTED WITH NEOSPORA CANINUM Luzia Teixeira, Raquel M Marques, Pedro Ferreirinha, Filipa Bezerra, Joana Melo, João Moreira, Ana Pinto, Alexandra Correia, Paula G Ferreira, Manuel Vilanova.



XVI

24 Sep 2015 | 19h30-20h00

NEUROSCIENCES AND AUTOIMMUNITY POSTERS – SESSION VI


Ana Martins Silva (ICBAS, HSA-CHP) Pedro Madureira (IBMC-UP)

P0055 p.99

IMPACT OF MTHFR GENE POLYMORPHISMS ON AUTISM Mahsa Delshadpour

P0056 p.100

THE IMPORTANCE OF CNTNAP2 GENE POLYMORPHISM IN AUTISM Sahar zare ghorbaninezhad

P0078 p.101

APOLIPOPROTEIN E POLYMORPHISMS AND SUSCEPTIBILITY TO GENETIC GENERALIZED EPILEPSIES Ricardo Ferreira1, Bárbara Leal1,2, João Chaves3, Cláudia Carvalho1,2, Andreia Bettencourt1,2, Joel Freitas3, João Lopes3, João Ramalheira3, Paulo Pinho e Costa1,2,4, António Martins da Silva, Berta Martins da Silva 1,2



XVII

24 Sep 2015 | 19h30-20h00

ONCOLOGY POSTERS – SESSION VII


Raquel Catarino (HSA-CHP) Ana Luísa Coelho (HSA-CHP)

P0061 p.102

THE PROTECTIVE EFFECT OF WHITE TEA EXTRACT AGAINST BLADDER CANCER PROGRESSION IS ACCOMPANIED BY CHANGES IN THE METABOLIC PHENOTYPE OF CELLS Luís R. Silva, Marco Alves, Elsa Ramalhosa, José A. Pereira, Pedro Oliveira, Branca Silva.

P0071 p.103

FERRITIN EXPRESSION IN BREAST CANCER INFILTRATING LYMPHOCYTES Leite, Luciana; Marques, Oriana; Rosa, Ana; Rêma, Alexandra; Faria, Fátima; Porto, Graça; Cruz Paula, Arnaud; Lopes, Carlos; Martins da Silva, Berta.

P0072 p.104

PHOSPHOPROTEIN PHOSPHATASE 1 INTERACTOME IN HUMAN PROSTATE CANCER: A MYRIAD OF POTENTIAL THERAPEUTIC OPPORTUNITIES Juliana Felgueiras, Joana Vieira Silva, Margarida Fardilha.

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