oncomicsoncomics ex vivo primary cancer growing model. a lot of different cell types. due to cancer...
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Oncomics.deanticancer drug development
and theranostic service
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Main anticancer drug developmental problem is: pharma R&D have NO model for specific pharmacological activity – we can try medication efficiency on patients only
• In vitro cell cultures (even 3D, primary, long-term, ets.) - not representative
• Murine cancer models (both mice and rats)– not representative
In vitro 3D cultures Ex vivo In vivo mousecancer model
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Oncomics ex vivo primary cancer growing model. A lot of different cell types.
Due to cancerplasticity:differentcell types with functional heterogeneity among cancer cells in some tumors
Why?
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At the present time reliable results of the anticancer drugs effects can be only if we grow human cancer in mice
Human cancer in miceHuman
cancer
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Project mission is: the providing of powerful high-tech tools set service for anticancer drug discovery:
•Targeted Cancer Therapies•Radiotracers for Oncology •Clinical Oncology and Science
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1. Cancer tissue isolation- Cancer tissues:
- surgery- open biopsy- laparoscopic
biopsy- surface biopsy
- Body liquids- Blood
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2. Liquid biopsy growing- Fast biopsy blast
growing method*:- 3 day- 1 week
- Low speed biopsy growing method*:
- up to 1 year
*know how
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3. Engraftment tumor in PDX- Mice tumor
engraftment :- P0-P12 PDX- Orthotopic and
heterotopic surgery transplantation
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4. Cancer growing visualization
Mice magnetic resonance imaging (MRI)
Mice computed tomography imaging (CT)
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5. Treatment examination
2.Chemotherapy or/and radiotherapy
1.Mice cancer engrafting
4.Analysis(DNA damage imaging)
1.1.And liquid biopsycultivation
3.Surgery isolation
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6. Blast clones growingCancer tissue clones «fast growing»
- ex vivo clones
PD-1 PDL-1 CTLA4
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7. Surgery facility
Cancer tissue surgery and isolation
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8. Metastatic PDX model
Metastatic cancer PDX models
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General technics:- Cancer tissue isolation: all types of cancer
can be used* and any surgery technics can be performed;
- Fast or slow primary cancer liquid biopsy growing;
- Engraftment the cancer in mice (PDX);
- Treatment, surgery and treated cancer tissue examination
* All types of cancer which can be grown – cancer must be able to grow in models.
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Key features:- Whole research cycle – «only medication
from the pharma company-client»;
- Treatment mice with human protocols and with the same instruments;
- Lead scientific and oncologists administration;
- Human experimental treatment (in accordance with the official protocols);
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Key techniques:- Primary cancer tissues are used
(maximally representative of the patient tumor clone structures)
- Cancer therapy combination can be performed (e.g. combination of chemotherapy, radiotherapy and target therapy)
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Animal protection note:- Our research protocols
exclude the premeditated killing of animals
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Thank you for attention!