on the application potential of gold nanoparticles in nanoelectronics and biomedicine by melanie...

On the application potential of gold nanoparticles in nanoelectronics and biomedicine

by Melanie Homberger, and Ulrich Simon

Philosophical Transactions AVolume 368(1915):1405-1453

March 28, 2010

©2010 by The Royal Society

(a) Microcrystals of Au55(PPh3)12Cl6 and (b) high-resolution image of a thin crystal part indicating the highly ordered cluster layers.

Melanie Homberger, and Ulrich Simon Phil. Trans. R. Soc. A 2010;368:1405-1453


Organization of full-shell clusters.



Optimized geometry of the stable isomers of (a) Au55, (b) Au55(PH3)12, (c) Au55(PH3)12Cl6 and (d) Au55(PH3)12Cl6 54H2O.



Structure of the [Au9(P(C6H5)3]8]3+ cluster cation determined by single crystal X-ray measurements.



(a) Two views of the Au102(p-MBA)44 cluster.



The tunnelling of a single electron between two metal electrodes through an intermediate island (quantum dot) can be blocked by the electrostatic energy of a single excess electron trapped on

the central island.



Experimental set-up to image and investigate ligand-protected nanoparticles by STM and STS, respectively.



SET on a single ligand-stabilized Au55 cluster at 90 K.



(a) STM image of a single Au55[P(C6H5)3]12Cl6 cluster on an Au(111) surface at 7 K, obtained at a bias of 2 V and a current of 100 pA using a Pt–Ir tip.



Tunnelling spectra acquired at the two distinct locations marked in figure 9a.



Schematic of the set-up for single particle measurements.



(a) Pt electrodes (white) separated by an approximately 14 nm gap.



Current–voltage curves measured at 4.2 K (open squares) and at 295 K (solid squares).



Sketch of intended construction of a cross-bar system with single quantum dots between each cross-point.



SET transistor based on SA of AuNPs on electrodes fabricated by electron beam lithography.



(a) SEM image of a three-electrode configuration with source, drain and gate electrodes.



Scheme for the AFM-supported generation of thiol-functionalized monolayer that is capable of binding Au55 clusters upon thiolate/gold bond formation.



AFM image of strictly one-dimensionally ordered Au55(PPh3)12−xCl6 clusters.



(a) Scheme of the incorporation of artificial DNA bases into the DNA strand by PCR, followed by attachment of azide-terminated nanoparticles to the strand via a Cu(I)-catalysed click reaction.



Preparation of monoaldehyde- and dialdehyde-functionalized DNA. Reproduced with permission from Wirges et al.



HR-STEM micrographs.



(a–f) Corresponding SEM pictures of the electrical transport measurements along decreasing tip-to-tip distance.



(a) I–V characteristics of as-prepared AuNP chains with different numbers of particles and a reference measurement on the PMMA surface.



(a) Electron microscope image of the investigated device, (b) I(V) characteristics of the device at different stages in the exchange experiments, (c) scheme of the exchange reaction in the

monolayer of the nanoparticles, (d) electron microscopy pictures of ...



(a) Scheme of the switching molecule, a dithiolated diarylethene; top, closed form (‘on’ state); bottom, open form (‘off’ state).



Schematic of the immobilization of AuNPs by DNA hybridization on silicon dioxide surfaces.



AFM image of a densely packed monolayer of 15 nm spherical AuNPs applying the DNA hybridization scheme as described earlier.



Arrhenius plots of samples prepared by specific (triangles) and non-specific (dots) immobilization.



Parameters influencing the interaction of AuNPs in biological surroundings are the size, the nature of the ligand particle surface bonding and the nature of the ‘outer’ ligand shell (ligand

charge).



Cytotoxicities of Au compounds during the logarithmic growth phase of four cell lines.



Determination of live, apoptotic and necrotic HeLa cells untreated or treated with the indicated compounds for 6, 12, 18 and 24 h.



NAC, GSH and TPPMS but not ascorbic acid can partially inhibit the cytotoxicity of 100 μM Au1.4MS.



AFM image of a y-formed piece of B-DNA, partially covered with clusters.



Modelling of the interaction of bare Au55 clusters with the major grooves of B-DNA.



(a) Experimental set-up for the laser-induced melting of AuNP–DNA networks by Reismann et al.



Principle of the photothermal experiment.



on the application potential of gold nanoparticles in nanoelectronics and biomedicine by melanie...

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