P-270 Devarm

"*f~-,iti:{":i

Prostat Kanseri Tam - Lokalize Hastallk1:~)'I!if4.t'f

~.?,,'I.!'1

,,>

)'t:'t

,/'!'l-i 21ULUSAL\'"~O'i .UROLO]i KONGRESi

30-Ekim03 Kaslm2010,Istanbul liitii K!rd,uKofl9re: Meritezi _

P-269 DevarmTHE RELATIONSHIP BETWEEN PSA VALUE AND TESTOSTERONELEVEL IN TWO DIFFERENT REGIONS OF TURKEV

Mahmoud Mustafa', Ozan Horsenti", Metin gelik', Rahim Horuz',Akif Kucukcan''Osmaniye State Hospital, Urology Department, Osmaniye2/zmir Ataturk Teaching Hospital, Urology Department, Izmir

Purpose: To investigate the relationship between testosterone hormoneand PSA levels in two different geographic regions of Turkey,Material-Methods: The first group included 119 patients with meanage 52,73+7.53 who visited Osmaniye State Hospital for routine check-up. The second group consisted of 196 patients with mean age 50.32+7.84 who applied to outpatients clinics in Izmir Ataturk TeachingHospital. Ages of patients were _60 and PSA values_ 4ng/ml. Serumtestosterone and PSA values were determined and the associationbetween them was evaluated and compared on the basis of the differentregions.Results: The mean values of PSA for group I and group 11 were1.11 +0.78 ng/ml and 1.75+ 10.6 ng/ml respectively(p=0.5). The meanvalues of testosterone levels in group I (386.4+ 154.6 ng/dl) and groupII (383.9+ 1706 ng/dl) showed no Significant difference(p=0.89). Therewas positive correlation between age of the patients and testosteronelevel (rO.22,p=0.015) in group I, however in group 11 there was a significantnegative correlation between ages and serum testosterone levels (r=-0.16, p=0.022). Serum testosterone showed no significant correlationwith PSA values in both groups(group I r=0.032,p=0.73), group 11 r=-0.03,p=0.65).Conclusion: No signifiq.nt diflerence between testosterone and PSAvalues irr both regions. There was no relation between testosteroneand TPSA values. In group 11 testosterone level decreases with age,however in group I, testosterone showed significant increment. Furtherstudies are needed to confirm these preliminary results and investigatethe impact of this variation on the oncologic features of prostate cancerand other urologic diseases.Keywords: PSA,Prostate,Testosterone

P-270PROSTAT APEWKSiNEDE PERiPROSTATiK LiDOKAiNENJEKSiVONU UVGULANMASININ STANDART PROSTAT- SEiNALVEziKUL iNFiL TRASVON ANESTEZisiNE USTUNLUGU VAR MI?

ibrahim Orkunt Ayaz', lbrebim Cevik', Ozdal Dillioglugif, Atd Akda$'.URO- TIP Tetu Merkezi, Istanbul2Kocaeli Universitesi Tip Fakultesi Uroloji ABD,Kocaeli

Arnac: Transrektal ultrason e~liginde yapilan prostat igne biyopsilerindelakal anestezinin uygulama veri ve seklinin agfl ve rahatsizhk hissiuzerine olan etkilerinin arastmlmasiMateryal-Metod: Total prostat spesifik antijen (PSA) yuksekligi ve/veyaanarmal parmakla rektal muayene bulgusu nedenleri ile transrektalprostat biyopsisi yapilan 100 hasta bu cahsrnaya dahil edildi. Hastalariki gruba aynldr. Grup I'deki hastalara biopsiden 20 dakika once prostat-seminal vezikul bileskesine her iki tarafa toplam 6cc %2 lidokain, GrupIl'deki hastalara ise prostat- seminal veziku: bileskesi ve prostateapeksine ayru miktarda %2 lidokain verildi. istem esnasinda hissedilenagfl modifiye edilen VAS (Vi sue I Analog Scale) ile degerlendirildi.Bulqular: Ortama agfl skoru apikal enjeksiyon yapilan grupta daha azolarak saptanrnasma ragmen istatistiksel tarkhhk saptanrnadr. Gruplararasinda yas, total PSA, prostate hacrru, ortalama biopsi surest vekamplikasyonlar acilarindan istatistiksel tarklrhk saptanrnadi.Sonuc: Bazal bolqsnin yarunda apikal periprostatik bolgeyede lokalanestezi uygulanmaSI ile daha dli~lik agrl skoru saptanrnasma rag mensadece bazal bolqeys lokal anestezi uygulanan hastalara gore istatistikselIarkhhk saptanmaoi. Apikal bolqeye ek enjeksiyon yapilmasi komplikasyonorarum artturnarnaktadrr.Anahtar Kelimeler: lidokain enjeksiyonu, prostat biyopsisi

DOES PERIPROSTATIC L1DOCAIN INJECTION AT PROSTTAICAPEX MAKE DIFFERENCE OVER STANDART PROSTATO-VESICULAR INFILTRATION ANESTHESIA?

ibrahim Orkunt Avaz', lbrebim Cevik', Ozdel Dillioglugif, Aid Akda~''URO- TIP Diagnosis Genter, Istanbul2Kocaeli University School of Medicine Department of Urology, Kocaeii

Objective: To evaluate the efficacy of local anesthetic infiltration sitein decreasing discomfort and pain experienced by patients undergoingtransrectal ultrasound guided biopsy of prostate.Materials-Method: 100 consecutive eligible patients who had elevatedtotal prostate specific antigen (PSA) and/or abnormal digital rectalexamination were included into this study. Patients were randomisedinto two groups Group I received 6 cc of 2% lidocaine injected into theprostato-vesicular junction on each side 20 minutes before transrectalultrasound guided biopsy and Group 11 received same amount of lidocaineinto the same area plus apex. Pain was assessed using a 10 pointmodified visual analog scale (VAS).Results: Mean pain scores were found to be lower in basal plus apicalinjection group but no statistically significant difference was found. Nosignificant difference was observed for mean age, prostatic volume,mean biopsy time, PSA level and complications between thesetwagroups.Conclusion: Although apical periprostatic nerve block resulted lowerpain scores compared to basal only group, no statistically significantdiflerence was found also increased number of injections due to apicallidocain infiltration had no effect on complication rates.Keywords: lidocain injection,prostatic biopsy

P-271PROSTAT ADENOKARSiNOMU TANISINDA CAVEOLiN-1 PSA'VAAL TERNATiF OLASiLiR Mi?

ft~\

~'"

M. B. Gan Betci, Ozkan Onuk, Aydm ismet Hazar, Memduh Aydm,Tuncay Tes, Bens NuhogluTaksim Egitim ve Ara~tlrma Hastanesi, 2. Uroloji Klinigi, istanbul

t(•~

Arnac: Prostat kanserlerini saptamada hi<;:kuskusuz PSA degerleribizim iqin cok onernh olmakla beraber tPSA degeri 2,5'un attrnda olsada hastalarda prostat kanseri olaslllgl drslanamarnaktadir. Bu cahsrnadaCaveolin-1 degerlendirerek prostat adenokarsinomlu hastalarda tamdaPSA' ya alternatif bir tetkik olup olrnayacaqrru ar astrr d.k.Gerec ve Yonternler: Calisma Eylul 2009 ve Nisan 2010 tarihleriarasrnda Taksim Egitim ve Arastirrna Hastanesi 2.Uroloji Klinigi'ndeya§ ortaiarnasi 66.57 (45-96) olan 35 adenokarsinomlu ve yas ortalarnasi56.68 (48-77) 16 kisilik kontrol grubu uzerinde yaprlrrusnr. Alman, kontrolve hasta serum <;:ozeltileri ikiser kez okuyup ortalarnastru ahn ve buortalama, degerden smr standardm ortalama optik dansitesini cikartarak,dort parametreli lojistik egri (4 PL) olusturrna kapasitesine sahip bilgisayaryazihrru kullarup veriler olusturuldu.Bulgular: Hastalanrruzdan ahnan numunelerden kontrol grubunun PSAortalarnasi 1.1 (+0.64), adenokarsinomlu hastalarda 12.3( +8,7) olaraktespit edildi. Caveolin 1 seviyesi kontrol grubunda ortalama 336 (+ 44,1),adenokarsinomlu hastalarda 476 (+66,9) olarak tespit eoiloisonuctar: Prostat adenokarsinomun da hig kuskusuz ki PSA degerlerive RT taruda cok onernli 2 parametredir. Caveolin-1 degerinin prostatadenokarsinomlu hastalarda yuksek bulunmasr, Caveolin-1 'i alternatifbir tetkik gibi sunsa da; tan I koyma, maliyet ve cahsrna kolayhqr acrsmdanPSA' ya ustun degildir.Anahtar Kelimeler: Biyomarkrr, caveolin-1, prostan kanseri, PSA

·,'~

I

e

•~{,t

.t

,•t