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  • OFFER OF TRAINING FORM SUMMER 2019

    Proposer details:

    Title: Generating, storing and releasing oxygen for biomedical applications

    Name: Prof. Dr. Mathias O. Senge

    Email: sengem@tcd.ie

    Website: http://chemistry.tcd.ie/staff/people/mos/Home.html

    If your grade does not allow you to supervise students, please supply the name of support PI:

    Student required:

    Specify any previous training / experience the student should have:

    Fundamentals in chemistry, physics, biology

    Study level (3rd year, 4th year) 3rd year and 4th year

    Any other requirements: none

    Traineeship offered:

    Brief job description: (please include (1) type of work, (2) what student should hope to achieve at end of the process, (3) who will supervise student on daily basis (post-doc etc.))

    (1) Synthetic bioorganic chemistry, (2) work in an internationally leading, multicultural and multidisciplinary research group, development of research level laboratory skills, planning and executing target oriented syntheses, preparation of results for publication, publication (3) supervision by PI and Susan Callaghan (postgraduate student)

    Link to research group or supervisor webpage:

    http://chemistry.tcd.ie/staff/people/mos/Home.html

    Location of lab: SFI Tetrapyrrole Laboratory, Trinity Biomedical Sciences Institute, 7th floor

    Working hours: Number of Weeks offered: 12 Hours per week: 40 Earliest Start Date possible: Any time Latest End Date possible: Any time

    mailto:sengem@tcd.ie http://chemistry.tcd.ie/staff/people/mos/Home.html http://chemistry.tcd.ie/staff/people/mos/Home.html

  • OFFER OF TRAINING FORM SUMMER 2019

    Proposer details:

    Title: An electroactive, non-viral gene delivery biomaterial platform for external enhancement and control of gene therapy and regeneration

    Name: Michael Monaghan

    Email: monaghmi@tcd.ie

    Website: www.monaghanlab.com

    If your grade does not allow you to supervise students, please supply the name of support PI:

    n/a

    Student required:

    Specify any previous training / experience the student should have:

    Wet lab skills, materials fabrication, biomaterials, some knowledge of biology

    Study level (3rd year, 4th year) Preferably 4th

    Any other requirements:

    Traineeship offered:

    Brief job description: (please include (1) type of work, (2) what student should hope to achieve at end of the process, (3) who will supervise student on daily basis (post-doc etc.)) Background: Myocardium infarction is the leading cause of death in the western world, causing 1 of every 7 deaths. Current clinical solutions consist of bridge therapies for the whole organ transplantation. In the context of tissue engineering and regenerative medicine, researchers in the lab of Dr. Michael Monaghan are developing cell-based strategies to obtain adult cardiac tissues differentiated from stem cell sources to repair damaged myocardium or engineer cardiac organoids in vitro. The recapitulation of the cardiac electro-mechanical environment can be a pivotal trigger for the mature cardiac phenotype maturation. Conductive polymers such as poly(3,4- ethylenedioxythiophene) :poly(styrenesulfonate) (PEDOT:PSS) are electrically conductive, easily processable, biocompatible and are being harnessed into both 2D and 3D structures for in vitro cardiac tissue engineering (www.monaghanlab.com). Recently, the Dr. Monaghan’s Team have had performed successful feasibility studies in employing these electroconductive materials as controllable platforms of non-viral delivery. Non-viral delivery can be used as a therapeutic to reprogram cells to make proteins that can be therapeutic and enhance wound healing and stem cell differentiation. This breakthrough is a novel approach in employing electrical stimulation to enhance and control gene-delivery

    mailto:monaghmi@tcd.ie http://www.monaghanlab.com/ http://www.monaghanlab.com/

  • which allows the merging of smart biomaterials with genetic engineering The overall goal of this project is to apply defined electric field patterns (using an established custom-bioreactor system) to 3D electroconductive scaffolds loaded with non- viral gene vectors and study their effect on prolonged and transient protein expression. Objectives: 1) To load, conjugate and characterise a non-viral gene vector encapsulated in 3D scaffolds 2) To investigate the correlation between electrical field stimulation of 3D PEDOT:PSS porous scaffolds already developed in the Monaghan Lab with expression of reporter proteins 3) To design a prototype able to apply electric field stimulation to a porous scaffold PEDOT:PSS scaffold. Methods Employed: non-viral gene therapy, nucleic acids research, polymer chemistry, biomaterial fabrication, in vitro cell culture, cell isolation, electro- conductivity testing, mechanical testing (dynamic compression), statistical analysis, 3D modelling, 3D printing. Deliverable: This project will lay a strong framework towards impacting the field of flexible electroconductive 3D biomaterials as drug delivery and/or gene activating matrices. Mentorship: Student will work on a team with one PhD student as a main contact point and will be supported by the PI and the rest of the team.

    Link to research group or supervisor webpage:

    www.monaghanlab.com

    Location of lab: Trinity Biomedical Sciences Institute

    Working hours:

    Number of Weeks offered: Minimum of 12

    Hours per week: 40

    Earliest Start Date possible: 1st May 2019

    Latest End Date possible: 14th September 2019

    C

    B

    Figure 1 (A) 3D porous PEDOT:PSS scaffold employed in this research. . (B &C) Fibroblasts that have been subjected to delivery of green fluorescent protein (GFP) gene delivery using non-viral gene therapy with (B) merging of brightfield and GFP channels and (C) GFP channel alone. Both micrographs are co-incident on identical imaging regions. Scale bar equals 500 um.

    http://www.monaghanlab.com/

  • OFFER OF TRAINING FORM SUMMER 2019

    Proposer details:

    Title: Postdoctoral Researcher

    Name: Dr. Mathieu Riffault

    Email: riffaulm@tcd.ie

    Website: https://www.tcd.ie/bioengineering/biomaterials/hoeylab/

    If your grade does not allow you to supervise students, please supply the name of support PI:

    Prof. David Hoey

    Student required:

    Specify any previous training / experience the student should have:

    Ideally theoretical knowledge of mammalian cell culture and immunohistochemistry techniques.

    Study level (3rd year, 4th year) 3rd or 4th year undergraduate preferable

    Any other requirements:

    Traineeship offered:

    Brief job description: (please include (1) type of work, (2) what student should hope to achieve at end of the process, (3) who will supervise student on daily basis (post-doc etc.))

    This project aims to characterise the role of bone marrow stem cells in bone formation and during osteoporosis in mice and evaluate the effect of a novel therapy.

    1. This internship will consist of performing immunohistochemistry labelling and histological staining and then acquisition and analysis of images of mouse tissue, the intern will also be involved in micro-CT analysis of bone formation.

    2. The student should hope to leave the process with a proficient knowledge of histology, basic fluorescent microscopy, and analysis of bone formation as well as some experience in basic statistical analysis.

    The project will run alongside the work of a PhD student and the intern will be trained and supervised on a day to day basis by a post-doc. Prof. Hoey will provide additional supervision and guidance at structured lab meetings.

    Link to research group or supervisor webpage:

    https://www.tcd.ie/bioengineering/biomaterials/hoeylab/

    Location of lab: Trinity Biomedical Sciences Institute, 152-160 Pearse St.

    mailto:riffaulm@tcd.ie https://www.tcd.ie/bioengineering/biomaterials/hoeylab/ https://www.tcd.ie/bioengineering/biomaterials/hoeylab/

  • Working hours:

    Number of Weeks offered: 8 to 12 weeks

    Hours per week: 35 hours per week

    Earliest Start Date possible: 1st April 2019

    Latest End Date possible: 30th August 2019

  • OFFER OF TRAINING FORM SUMMER 2019

    Proposer details:

    Title: Prof

    Name: Jane Stout

    Email: stoutj@tcd.ie

    Website: https://www.tcd.ie/research/profiles/?profile=stoutj

    If your grade does not allow you to supervise students, please supply the name of support PI:

    Student required:

    Specify any previous training / experience the student should have:

    Knowledge and interest in environmental issues, entomology, pollination biology, agroecology.

    Study level (3rd year, 4th year) Either

    Any other requirements: Willingness to work in both field and lab, and to work with insects, including bees

    Traineeship offered:

    Brief job description: (please include (1) type of work, (2) what student should hope to achieve at end of the process, (3) who will supervise student on daily basis (post-doc etc.))

    (1) Type of Work: The student will work alongside PhD students collecting field data (from farmland sites outside Dublin, as well as possibly sites within Dublin), and processi