OEB 192 – 11.11.28

Evolution of pathogens

(Grenfell et al., 2004. Science)http://www.occc.edu/biologylabs/Documents/Homeostasis/Lynx%20and%20Hare%20Populations.htm

In what way are these two patterns similar or different?

http://en.wikipedia.org/wiki/Rabbits_in_Australia

http://www.marcgunther.com/2011/06/09/dengue-fever-coming-to-a-neighborhood-near-you/

(Hoffmann et al., 2011. Nature)

(Walker et al., 2011. Nature)

(Kerr et al., 2006. Nature)

(Grenfell et al., 2004. Science)

(Smith et al., 2004. Science)

Spring 2012: OEB 100 (‘Evolution in Action’)

Instructor: Christopher Marx (cmarx@oeb.harvard.edu, Biolabs 3083)Teaching fellow: Sean Carroll (scarroll@oeb.harvard.edu, Biolabs 3079)

Weekly meeting: Northwest Building room B127Time: M 4:00 – 5:30 pm

Laboratory: Northwest Building room 152

Time: 24/7/365 open access

Website (last year’s): http://isites.harvard.edu/k77185

Goals: This course’s primary aim is to teach students how to design, perform, interpret, and discuss independent research in a collaborative atmosphere. A second goal is to utilize the unique advantages of studying experimental

populations of microbes in the laboratory as a means to explore evolution in ‘real time’. Finally, this course will provide an opportunity to integrate within a single, hands-on class, concepts from genetics, biochemistry, systems

biology, microbiology, evolution and ecology.

This year’s concentrates upon adaptation of metabolic systems following horizontal gene transfer, epistasis, and testing our ability to predict the strength of selection upon gene products.

(Note that this course can freely substitute for the Research experience requirement for an MCB concentration, the LS100r requirement for a Secondary Field in Microbial Sciences, or can count toward either an OEB Concentration

or Secondary Field.)

Wednesday (11/30):

Final exam… (on material since 10/12)

2nd Avida draft – now 12/2

And please provide course evaluations…