ocaline - valerijono vaistinė · use of care products ... • a clinical evaluation of the skin...
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OCALINE Preventive care for sensitive skin and immediate soother
• In vivo proven efficacy • Available in Ecocert approved reference
• Other cosmetic references: Ocaline XP Ecocert approved / Ocaline PF
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• Every skin type can be affected by problems of sensitivity or reactivity: greasy skins / dry skins / normal skins
• Every area of the skin can be affected
• But the face expresses skin sensitivity the most
Skin
se
nsi
tiv
ity
Environment
cold / sun / pollution
Internal factors
External factors
Way of life
stress / tobacco / alcohol
/ unbalanced eating
Frequent and unadapted use of care products detergent soaps
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Ind
uc
tio
n o
f th
e «
ne
uro
ge
nic
»
infla
mm
atio
n
These neurotransmitters lead to the release of numerous mediators responsible for the inflammation characterized by:
- redness and heat due to a vasodilatation of the blood vessels
- oedema and pain due to the extravasation (fluid plasma and protein leak)
The Substance P is the most
important neurogenic inflam-
mation neurotransmitter.
When stimulated, the nerve
fibers release the Substance P
which induces the release of
histamin by the mastocytes,
an important inflammation
mediator.
Nociceptive stimuli
Release of
Neurotransmitters
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• A collaboration work between SOLIANCE and other laboratories led to the development of a new Neurocosmetic® active: Ocaline
• Ocaline inhibits degranulation of mastocytes normally induced by the Substance P
Ocaline is an optimized and patented blend of two natural ingredients with synergic activities: • Spring Sea Water®, a unique water stemming from Brittany, France, naturally rich in minerals and trace elements • Cucurbitine, an alkaline amino-acid extracted from Cucurbita pepo seeds
Oc
alin
e P
F
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Bio
log
ica
l a
ctio
n
Ocaline inhibits masto-cyte degranulation and histamine release induced by the substance P
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Ocaline inhibits the mast cells degranulation induced by Substance P
Ex v
ivo
te
sts
on
ma
sto
cyte
s c
ultu
re
Protocol A solution of 10% Ocaline was applied on skin explants using patches for 24h (D0 and D1). On D1’s evening, the culture medium was renewed as well as the product. The Substance P (10 μM) was also added to the culture medium during additional 24h. The percentage of degranulated mastocytes and biochemical dosage of released histamine were determined for the following skin fragments: 1 - the control skin (not stimulated, not treated) 2 - the skin stimulated by the Substance P only 3 - the skin pre-treated by Ôcaline, then washed, stimulated buy the Substance P and treated with Ôcaline again. On D2, skin fragments were fixed in Bouin’s liquid and included in paraffin. Mast cells presence was revealed in purple blue with Toluidine’s blue coloration.
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Ocaline inhibits histamine release. Inflammation symptoms induced by Substance P during neurogenous inflammation sharply decrease
Ex v
ivo
te
sts
on
hu
ma
n s
kin
Mastocytes are strongly colored: they contain numerous histamine granules
Mastocytes are less colored: they are degranulated
Control skin
Skin +
Substance P
Skin + Substance P
+ Ocaline
Mastocytes are strongly colored: they contain numerous histamine granules
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Protocol - Stinging test • The preventive effect of Ocaline has been evaluated on a sensitive skin panel (20 women).
• Panelists applied a cream containing 5% Ocaline to their faces once a day for 14 consecutive days.
• A stinging test was conducted by a dermatologist to evaluate the skin sensitivity threshold.
Ocaline at 5% soothes the sensitive skin within 7 days of daily use
Pre
ve
ntiv
e e
ffe
ct
on
se
nsi
tiv
e s
kin
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Protocol • A panel (10 women, over 18 years old) applied Ocaline at 10% 3 times a day on the forearm area pre-treated with an irritating agent (strong acid).
• A clinical evaluation of the skin roughness and erythema was performed by a dermatologist (scoring from 0 to 4).
Erythema reduction
Ocaline smoothes irritated skins within 1 hour
So
oth
ing
eff
ec
t -
In v
ivo
te
sts
Reduction of skin roughness
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Protocol The volunteers answered to a questionnaire to which they expressed their own skin tolerability. Then, they were asked about their estimation of the product cosmetic advantages
80% of the panel appreciate the product containing Ocaline
90% of the panel thinks that the product is effective
80% of the panel would buy the product containing Ocaline
Co
nsu
me
r te
st
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• Nomenclature INCI (US): Sea water (and) Water (and) Cucurbita pepo (pumpkin) seed extract (and) Citric acid
• Preservative: Ocaline: Chlorphenesin and phenonip Ocaline XP: Benzyl alcool and potassium sorbate Ocaline PF: Potassium sorbate and Phenoxyethanol
• Regulation: Ocaline XP is Ecocert approved • Organoleptic characteristics: Aspect: pale yellow liquid Odour: characteristic
• Dosage: 3-5% for sensitive skin care 5-10% for immediate soothing effect
Tec
hn
ica
l in
form
atio
n
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• Ocaline is recommended from 3 % to 5% in products lines specially designed for sensitive skins, as preventive care:
Soothing serum
Day cream
Soothing lotion
• Ocaline is recommended from 5% to 10% in products dedicated to all skin types, as an immediate soother:
After sun care / lotion
Soothing cream
Soothing fresh gel or lotion for irritated skin
Babycare (erythema or other irritated zones)
Acne products Co
sme
tic
use
s
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• Ocaline is an active ingredient for the prevention of sensitive skin
• Ocaline represents an excellent immediate soothing care for all skin
types
• Synergic combination of two 100% natural products
Co
nc
lusi
on