obstructive sleep-related breathing disorders in adults dr. mohsen pazooki
TRANSCRIPT
OBSTRUCTIVE SLEEP-RELATED
BREATHING DISORDERS IN ADULTS
DR. MOHSEN PAZOOKI
Obstructive sleep-related breathing disorders
Snoring Upper Airway Resistant Syndrome
Obstructive Sleep Apnea Syndrome
Snoring Incidence 40% M20% F
Often (but not always) accompanies sleep disordered breathing
Not ass. With excessive daytime sleepiness or insomnia
Snoring AHI < 5 without daytime symptoms
PSG is not required for DxNo ass. With :- Arousals- Desaturations- Airflow limitation- Arrhythmias
Upper airway resistant syndromeDo not meet OSA criteria but experience excessive daytime somnolence and other debilitating somatic complaints
Upper airway resistant syndromecharacterized by respiratory effort related arousals (RERAs)
RERA is detected using esophageal pressure manometry, which reveals a pattern of progressively increasing negative esophageal pressure followed by an arousal.
Upper airway resistant syndromePSG : - Frequent arousals associated with snoring, abnormally negative intrathoracic pressure, or increased diaphragmatic electromyogram activity.
OSASIncident : 2% of F & 4% of M > 50y
OSASfive or more respiratory events (apneas, hypopneas, or RERAs)
Ass. with - excessive daytime somnolence, - Waking with gasping, choking, or brearh-holding, or
- witnessed reports of apneas, loud snoring, or both
OSASapnea or hypopnea commonly accompanied by:
- Reductions in blood oxygen saturation of at least 3% to 4%
- Usually terminated by brief, unconscious arousals
OSASSnoring: - frequent complaint of bed partners
- often the symptom that prompts these patients to seek medical attention
Excessive daytime somnolence : common presenting complaint
OSASOther complaints : - Automobile accidents - increased cardiovascular morbidity and mortality
- morning headache, sore throat- fatigue or a feeling of being unrefreshed regardless of the duration of sleep
OSASExacerbation : - ingestion of alcohol- Sedative use- weight gain
Sleep disordered breathing sympRestless sleepLoud snoringObserved apnea,choking or gasping episodes
Excessive daytime sleepiness(E DS)Morning fatigue or irritabilityMemory lossDecreased cognitive function
Sleep disordered breathing sympDepressionPersonality or mood changesDecreased libido and impotenceMorning and nocturnal headaches
Nocturnal sweatingNocturnal enuresis
Pathophysiology collapse of the pharyngeal airway during sleep due to relaxation of the pharyngeal dilator muscles
Obesity soft tissue hypertrophycraniofacial characteristics such as retrognathia
Major areas of obstructionNosePalate Hypopharynx
laryngeal obstruction from bilateral laryngeal paralysis, laryngomalacia, and obstructing laryngeal lesions has also been reported.
Obesity major risk factor for OSAdeleterious effects on metabolism, ventilation, and lung volume, resulting in V/Q mismatch
Significantly reduce lung volume, which results in a reduction of functional residual capacity
Adenotonsillar hypertrophy : major cause in children
In adults : multiple craniofacial variations
Consequences of untreated OSASincreased mortality increase in cardiovascular disease:- hypertension, coronary heart disease, congestive heart failure, arrhythmias, sudden death, pulmonary hypertension, and stroke
neurocognitive difficultiesincreased risk of motor vehicle accidents by 2.5-fold
Consequences of untreated OSASindependent risk factor for insulin resistance
contribute to the development of diabetes and metabolic syndrome,the term used to describe the commonly occurring conditions of obesity, insulin resistance, hypertension, and dyslipidemia.
Consequences of untreated OSASGERD : (Treatment with CPAP decreases the occurrence of GERD)
problems with attention, working memory, and executive function (all of which are improved with CPAP treatment)
Diagnosis most common symptoms :- loud snoring- restless sleep- daytime hypersomnolence
Diagnosis Obesity :70% of adult patientsScreening, including a detailed sleep history and physical examination, is recommended for all obese patients
Epworth Sleepiness Scale
Epworth Sleepiness ScaleOSA may be suspected in patients with an ESS greater than 10
Dxpatients with HTN, CAD, CHF, CVA, and DM, must be carefully screened for the signs and symptoms of OSA
Women : insomnia, heart palpitation, ankle edema
P.E.P.E. strengthens the DxBMI , BP , Neck circumference
DxFiberoptic Flexible Nasopharyngoscopy (with Muller’s Maneuver)
Drug induced sleep videoendoscopy
Nocturnal PSG : gold standard
Sleep related breathing disorders
Sleep related breathing disorders
Medical Tx.a stepwise manner begins with
conservative medical measures.'Weight loss” for all overweight
patients Consultation with a bariatric surgeon
in morbidly obese patientssurgically induced weight loss
significantly improves obesity-related OSA and parameters of sleep quality as early as 1 month after surgery.
Medical Tx.CPAP : gold standard for moderate to
severe OSASReduction in AHI, sleepiness, CVA,
motor vehicle accidents & improvement in QOL
Decreased inflammation as measured by a decrease in the inflammatory markers CRP and IL-6, improved endothelial function, and reduced diurnal sympathetic activity.
Medical Tx.BiPAPAPAP
Oral appliances for mild, moderate OSA (greater satisfaction)
Pharmacologic therapy: alternative in CPAP intolerance: Modafinil, Fluticazone, Montelukast, nasal dilator strips, topical decongestants
Indications of Surgical Tx.
Sx. options
Sx. options
Sx. options