obesity - the challenge; the potential for cross-disciplinary studies in food science and medicine...

Obesity - the challenge;Obesity - the challenge;the potential for cross-disciplinary the potential for cross-disciplinary

studies in Food Science and Medicinestudies in Food Science and Medicine

Anthony R LeedsAnthony R LeedsFaculty of Life Sciences, University of Copenhagen,Faculty of Life Sciences, University of Copenhagen,

Diabetes Centre, Central Middlesex Hospital, London;Diabetes Centre, Central Middlesex Hospital, London;Medical Director,Medical Director,

Cambridge Weight PlanCambridge Weight PlanFood for thoughtWorkshop IUniversity of Copenhagen29th August 2011 [email protected]

http://www.cambridgeweightplan.com/healthcare-professionals.asp

BBC Website BBC Website

Global governments must get tough on Global governments must get tough on ObesityObesity

At: At: http://www.bbc.co.uk/news/health-14669203

On 26On 26thth August 2011 August 2011

Obesity – a global and national Obesity – a global and national crisiscrisis

We know some of the causesWe know some of the causesWe know how to influence some of themWe know how to influence some of themBut we don’t have proven long term But we don’t have proven long term

methods for treatment (except perhaps methods for treatment (except perhaps surgery)surgery)

Drug and Surgical treatments are/will be Drug and Surgical treatments are/will be costlycostly

Do we have any food-based solutions?Do we have any food-based solutions?

Is there a food-based solution?Is there a food-based solution?

Qualitative and Quantitative aspectsQualitative and Quantitative aspects– Food properties and diet composition can be Food properties and diet composition can be

manipulatedmanipulatede.g proportion of energy from protein, glycaemic e.g proportion of energy from protein, glycaemic indexindex

– Pay attention to the quantitative aspectsPay attention to the quantitative aspects– Weight loss is related to the energy deficitWeight loss is related to the energy deficit– Current medical research shows that amounts Current medical research shows that amounts

of weight loss needed are more than can be of weight loss needed are more than can be achieved by usual diets (500 to 600kcal/d achieved by usual diets (500 to 600kcal/d deficits)deficits)

Food development through Food development through interdisciplinary studiesinterdisciplinary studies

A solution for the need for greater energy A solution for the need for greater energy deficitsdeficitsTake the dietary intake down to a lower level Take the dietary intake down to a lower level

– either a VLCD (very low-calorie diet – either a VLCD (very low-calorie diet <800kcal/d) or a LCD (low-calorie diet 800-<800kcal/d) or a LCD (low-calorie diet 800-1000kcal/d)1000kcal/d)

To supply all needed micronutrients and To supply all needed micronutrients and sufficient protein - led over 26 years ago to sufficient protein - led over 26 years ago to the development of formula dietsthe development of formula diets

In the last few years there has been a In the last few years there has been a renewed interest in this old idearenewed interest in this old idea

To demonstrate efficacyTo demonstrate efficacy ‘‘how do I know that the Cambridge Diet does what how do I know that the Cambridge Diet does what

you say it does’you say it does’ To measure the amount of effectTo measure the amount of effect

‘‘how much weight will I lose and will it be safe?’how much weight will I lose and will it be safe?’ To measure health benefitsTo measure health benefits

‘‘how does losing weight benefit me?’how does losing weight benefit me?’ To determine frequency of adverse or side-To determine frequency of adverse or side-

effects [and take action to reduce these]effects [and take action to reduce these] ‘‘will I lose my hair?, get constipated? feel cold?’will I lose my hair?, get constipated? feel cold?’

To demonstrate weight maintenanceTo demonstrate weight maintenance ‘‘how will I avoid re-gaining weight afterwards’how will I avoid re-gaining weight afterwards’

Medical Research ProgrammeMedical Research Programme Objectives Objectives and questionsand questions

Our requirementsOur requirements

The programme must be evidence basedThe programme must be evidence basedThere must be research evidence for There must be research evidence for

translation into primary care or other translation into primary care or other contextscontexts

Fully defined adverse events profiles must Fully defined adverse events profiles must be publishedbe published

Independent analyses of health economics Independent analyses of health economics implications of the treatment must be implications of the treatment must be publishedpublished


Industrial partner

Adverse eventsprofiles

Evidence ofeffect

Parker Institute, andLIFE, Copenhagen

UniversityEffect of weight loss in

Obese people with kneeosteoarthritis

Reformulationto reduce

adverse events


Industrial partner

Skin flakiness –? Modify dietary

fat profile

Gentofte Hospital, and

LIFE, KUEffect of weight loss in

Obese people with psoriasis

Development and Reformulation

to modify responses


Industrial partner Gentofte Hospital, and




to modify responses

Bispebjerg Hospital, and


Obese people after heart attack


Industrial partner Gentofte Hospital, and




to modify responses

Bispebjerg Hospital, and


Obese people after heart attack

Sønderborg Hospital, and

Parker InstituteEffect of weight loss in

Obese people before knee replacement

Problems inProblems inPrivate-Public partnershipsPrivate-Public partnerships

Vested interestsof all team members

Who owns the data?

Transparencywith respect to roles

Academic,Healthcare provider

partner

Industrial partner

Problems and Solutions inProblems and Solutions inPrivate-Public partnershipsPrivate-Public partnerships

Vested interestsof all team members

Full declarations

Who owns the data?

The research teamAnd there must be

full publicationof data

Transparencywith respect to roles

Full public description

Incl travel grants

Academic,Healthcare provider

partner

Industrial partner

Obesity - the challenge;Obesity - the challenge;the potential for cross-disciplinary the potential for cross-disciplinary

studies in Food Science and Medicinestudies in Food Science and Medicine

Food is produced by private companiesFood is produced by private companiesPrivate-public partnerships in research Private-public partnerships in research

mustmustDefine the relationship clearly at outsetDefine the relationship clearly at outsetState data ownership at the startState data ownership at the startFullly publish the data (compare the record of Fullly publish the data (compare the record of

the pharmaceutical industry) including the pharmaceutical industry) including adverse eventsadverse events

Be fully transparent – declaration of interestsBe fully transparent – declaration of interests

obesity - the challenge; the potential for cross-disciplinary studies in food science and medicine...

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