obat obgyn

7/28/2019 Obat Obgyn

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Jawahir bin Madeaming (11-2011-150)

EPIDOSIN

Contents Valethamate Br

Indications GI spasm (cardiospasm, spastic constipation, ulcerative complaints), spasm of biliary &urinary tract, spasmodic dysmenorrhea, delayed dilatation of the cervix in parturition.

Childn: Pylorospasm, spastic bronchitis, acetonemic vomiting.

Dosage Drag 1-2 tab 3 times daily. Inj1-2 amp IV, IM or SC.

Contraindications Closed-angle glaucoma; urinary or GI obstruction, prostatic hypertrophy, megacolon,

pyloric stenosis.

Adverse Drug

Reactions

Cycloplegia, mydriasis, dry mouth, flushing, tachycardia, palpitations, constipation,

rash, vomiting, photophobia.

Drug Interactions Anticholinergic activity may be increased by other parasympatholytics. Guanethidine,

histamine & reserpine can antagonise the inhibitory effect of anticholinergics on

gastric acid secretion. Antacids may impair absorption.

MIMS Class Antispasmodics

Epidosin drageeEpidosin 10 mg x 100's (Rp55580)

Epidosin injection Epidosin (amp) 8 mg/1 mL x 1 mL x 10's (Rp55020)

PROLIC

Contents Clindamycin

Indications Treatment of serious infections caused by susceptible anaerobic bacteria, Strep,

Pneumococci & Staph.

Dosage AdultSerious infections: 150-300 mg. More severe infections: 300-450 mg. To be taken

6 hrly. Childn Serious infections: 8-16 mg/kg body wt/day. More severe infections: 16-

20 mg/kg body wt/day.

Administration May be taken with or without food (Swallow whole w/ a full glass of water & in anupright position.).

Contraindications Hypersensitivity.

Special Precautions Elderly, pregnancy; history of GI disease, particularly colitis; during prolonged therapy,

periodic liver & kidney function tests & blood count should be performed. Very severe

renal disease &/or hepatic disease.

Adverse Drug

Reactions

GI disturbances, hypersensitivity reactions, jaundice, hematopoietic changes.

View ADR Monitoring Form

Drug Interactions Potentiates effects of neuromuscular blockers.

Prolic capsuleProlic 150 mg x 10 x 10's (Rp277000)

Prolic 300 mg x 10 x 10's (Rp574000)
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PRONALGES

Contents Ketoprofen

Indications RA, osteoarthritis, ankylosing & cervical spondylitis, acute joint & adjacent structures

symptoms, low back & musculoskeletal pain. Relieve joint pain & inflammation &

facilitating mobility; reduce dependency function.

Dosage

CR Cap 1 cap once daily. Tab 75 mg 3 times daily or 50 mg 4 times daily. Max: 300 mgdaily.AmpRA & osteoarthritis 50 mg 3-4 times daily. Pain 25-50 mg 6-8 hrly. Supp 1

supp twice daily.

Administration Should be taken with food (Take immediately after meals. CR cap: Swallow whole, do

not chew/crush.).

Contraindications Hypersensitivity to aspirin or other NSAIDs; gastric/peptic ulcer or acute GIT

inflammation; severe kidney & liver function impairment.

Special Precautions Patients receiving anticoagulant, heart failure, HTN & other conditions related to fluid

retention; childn 2-16 yr w/ juvenile rheumatoid arthritis.

ADR GI disorders, headache, drowsiness, dizziness, vertigo & edema.

Drug Interactions Protein-binding drugs, thrombolytics (eg streptokinase) or anticoagulants (eg

warfarin), diuretics, probenecid, methotrexate.

BACTECYN

Contents Sultamicillin: Ampicillin, sulbactam

Indications Upper & lower resp tract infections; bacterial pneumonia; UTI & pyelonephritis; intra-abdominal infections; bacterial septicaemia; skin, soft tissue, bone & joint infections,

gonococcal infections. Prophylaxis of post-op infection in patients undergoing

abdominal or pelvic surgery. Prophylaxis of post-op sepsis in termination of pregnancy

or caesarean section.

Dosage TabAdult & childn >30 kg 375-750 mg twice daily. Childn


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MEFINAL

Contents Mefenamic acid

Indications Pain in rheumatic conditions, soft tissue injuries, other painful musculoskeletal

conditions, dysmenorrhoea, headache, toothache, post-op pain.

Dosage Adult & childn >14 yr500 mg then 250 mg 6 hrly, 6 mth 3-6.5 mg/kg body wt 6 hrly.

Max: 7 days.Administration Should be taken with food (Take immediately after meals.).

Contraindications Peptic or intestinal ulceration.

Special Precautions Pregnancy & lactation.

Adverse Drug

Reactions

GI disturbances & bleeding, peptic ulceration.

Drug Interactions Oral anticoagulants.

Mefinal capsule Mefinal 250 mg x 10 x 10's (Rp46000)

Mefinal film-

coated capletMefinal 500 mg x 10 x 10's (Rp102500)

HYSTOLAN

Contents Isoxsuprine HCl

Indications Uterine relaxation. Peripheral vascular disorders, arteriosclerosis obliterans,

thromboangiitis obliterans, Raynaud's disease.

Dosage 20 mg 3-4 times daily.

Administration May be taken with or without food (May be taken w/ meals, milk or antacids to

minimise GI discomfort.).

Contraindications Arterial haemorrhage, post partum bleeding.

Special Precautions Severe cerebrovascular disease or MI, severe ischemic heart disease, glaucoma.

Lactation.

Adverse Drug

Reactions

Flushing, hypotension, tachycardia, skin rashes, GI disorders, dizziness (orthostatic

hypotension).

MIMS Class Drugs Acting on the Uterus

ATC Classification C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative

agents. Used as peripheral vasodilators.

Hystolan tablet Hystolan 20 mg x 50's (Rp147500)

LAKTAFIT

Manufacturer Dexa Medica

Contents Placenta extr 15 mg, vit B12 20 mcg, Ca phosphate tribasic 12 mg

Indications Hypogalactia.

Dosage 1 tab 3 times daily during lactation.

Administration May be taken with or without food

MIMS Class Supplements & Adjuvant Therapy

ATC Classification G02CX - Other gynecologicals ;

LaktaFit tablet LaktaFit 60's (Rp135000)
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KALMETHASONE

Contents Dexamethasone

Indications Inflammatory, allergic & other glucocorticoid-responsive diseases.

Dosage Tab 0.75-9 mg daily. Inj4-20 mg IM/IV.

Administration Should be taken with food

Contraindications Ocular herpes simplex; pyogenic or fungal infection.

Special Precautions Hypothyroidism, hepatic cirrhosis; long-term therapy.

Adverse Drug

Reactions

Muscle weakness; osteoporosis; peptic ulceration; impaired wound healing; increased

sweating; headache; menstrual irregularities, growth suppression in childn; decreased

carbohydrate tolerance.

MIMS Class Corticosteroid Hormones

ATC Classification H02AB02 - dexamethasone ; Belongs to the class of glucocorticoids. Used in systemic

corticosteroid preparations.

HEMOBION

Contents Fe fumarate 360 mg, folic acid 1.5 mg, vit B12 15 mcg, vit C 75 mg, Ca carbonate 200mg, cholecalciferol 400 IU

Indications Hematinic preparation for treatment of anemia, which also contains calcium,

cholecalciferol and ascorbic acid as supplement.

As vitamin in anemia during pregnancy and lactation and anemia due to other origin.Dosage 1 cap daily.Administration Should be taken with food (Take after meals.). Special Precautions Hemobion may cause blackening of stool.Storage Store below 25C.

Description Each capsule contains ferrous fumarate 360 mg, folic acid 1.5 mg, vitamin B12 15

mcg, ascorbic acid 75 mg, calcium carbonate 200 mg, cholecalciferol 400 iu.MIMS Class Vitamins & Minerals (Pre & Post Natal) / Antianemics

ATC Classification B03AD - Iron in combination with folic acid ; Used in the treatment of anemiaPresentation/Packing Cap 10 x 10's.

Kalmethasone tablet Kalmethasone 0.5 mg x 20 x 10's (Rp16500)

Kalmethasone injection (amp) Kalmethasone 4 mg/1 mL x 5's (Rp25000)

Kalmethasone 5 mg/1 mL x 5's (Rp26500)

Kalmethasone injection (vial) Kalmethasone 5 mL x 1's (Rp21000)
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VASDALAT

Contents Nifedipine

Indications Prophylaxis & treatment of variant angina (Prinzmetal's angina, chronic stable angina,

unstable angina; as adjunctive treatment of HTN.

Dosage Angina pectoris Initially 10 mg 3 times daily or 20 mg twice daily, may be increased to

20 mg 3 times daily or 40 mg twice daily. Variant angina 20-30 mg 3-4 times daily.HTN 10 mg 3 times daily or 20 mg twice daily, may be increased to 20 mg 3 times daily

or 40 mg twice daily.

Administration May be taken with or without food (Avoid grapefruit juice.).

Contraindications Pregnancy.

Special Precautions Poor cardiac reserve; diabetes, impaired liver function. Abrupt w/drawal. Childn.

Adverse Drug

Reactions

Headache, flushing, peripheral edema, orthostatic hypotension, dizziness, fatigue,

worsening of anginal symptoms, cerebral ischemia, nausea, vomiting, epigastric pain,

tinnitus, leg cramps, rash, glucose intolerance, hepatitis.

Drug Interactions -blockers, cimetidine, digoxin, insulin.

MIMS Class Calcium Antagonists

Vasdalat tablet Vasdalat 5 mg x 50's (Rp16500)

Vasdalat 10 mg x 50's (Rp26500)

Vasdalat Retard

retard tabletVasdalat Retard 20 mg x 50's

BIOXON

Contents Ceftriaxone disodiumIndications Sepsis, meningitis, infection of the lower resp tract, UTI, skin & soft tissue

infection, bone infection, intra-abdominal infections, septicaemia, gonorrhoea,

peri-op surgical prophylaxis.Dosage Adult & childn >12 yr1-2 g once daily. Dosage may be increased to 4 g daily in

severe infections. Infants & childn


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POSPARGIN

Contents Methylergometrine maleate

Indications Prevention & treatment of postpartum & postabortal haemorrhage. Active

management of 3rd stage of labour. Uterine haemorrhage following separation of the

placenta, uterine atony, subinvolution of the puerperal uterus, lochiometra.

Dosage Caesarian section 0.2 mg IM or 0.1-0.2 mg IV or via intramural inj, after the baby isdelivered by extraction.Active management of 3rd stage of labour 0.1-0.2 mg IM

following delivery of the head or anterior shoulder or immediately after delivery of the

child. 3rd stage of labour w/ general anaesth 0.2 mg IV. Uterine atony 0.2 mg IM or

0.1-0.2 mg IV. Promotion of uterine involution 0.125 mg orally 3 times daily for 3-4

days. Puerperium bleeding, subinvolution, lochiometra 0.125-0.25 mg orally 3

times daily or 0.1-0.2 mg IM daily.

Contraindications Induction of labour, severe HTN, preeclampsia or eclampsia, imminent abortion,

primary & secondary uterine inertia, pregnancy.

Special Precautions Severe or persistent sepsis, peripheral vascular disease, ischaemic heart disease,

impaired renal or hepatic function.

Adverse Drug

Reactions

Nausea, vomiting, abdominal pain, HTN (after rapid IV administration).

ATC Classification G02AB01 - methylergometrine ; Belongs to the class of ergot alkaloids. Used to induceabortion or augment labour and to minimize blood loss from the placental site.

REMOPAIN

Contents Ketorolac tromethamine

Indications Short-term management of moderate to severe pain.

Dosage Initially 10 mg IM/IV, then 10-30 mg every 4-6 hr when required. Max: 90 mg daily. Max

duration of treatment (IM or IV administration) should not exceed 5 days.

Contraindications Active peptic ulceration or recent GI haemorrhage or perforation, history of peptic ulcer

disease or GI bleeding, severe renal dysfunction or those at high risk of renal failure,

cerebrovascular disease, haemorrhagic diathesis, operations w/ high risk of

haemorrhage or incomplete haemostasis, confirmed or suspected cerebrovascular

bleeding; moderate or severe renal impairment; hypovolaemia or dehydration.

Special Precautions Patients on anticoagulant therapy or w/ haemophilia, CV disease, acute renal failure,

HTN or other conditions related to fluid retention, hepatic dysfunction or a history of

hepatic disease, childn


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CLANEKSI

Contents Per capletCo-amoxiclav: Amoxicillin trihydrate 500 mg, K clavulanate 125 mg. Per 5

mL syr Co-amoxiclav: Amoxicillin trihydrate 125 mg, K clavulanate 31.25 mg. Per 5

mL Forte syr Co-amoxiclav: Amoxicillin trihydrate 250 mg, K clavulanate 62.5 mg. Per

1 g vial Co-amoxiclav: Amoxicillin 1,000 mg, K clavulanate 200 mg

Indications Upper & lower resp tract, GUT, skin & soft tissue, bone & joint infections.Dosage CapletAdult & childn >12 yrSevere infections: 1 caplet. Dry syrChildn 25 mg/kg body

wt 8 hrly, 1-6 yr5 mL, 6 yr5 mL. Doses to be taken 3

times daily. InjAdult & childn >12 yr1 g 6-8 hrly, 3 mth-12 yr25 mg/kg body wt 6-8

hrly, 0-3 mth 25 mg/kg body wt 8-12 hrly. Renal dysfunction w/ CrCl 10-30 mL/min

1 g inj followed by 0.5 g IV 12 hrly. CrCl


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