315Eighth Gttingen Meeting of the German Neuroscience SocietyProgramMarch 25 29, 2009316NeuroscienceNeurosciencewww.biotrend.comNeurochemistryDrug DiscoveryCustom Labeling Signal TransductionPharmacologyPhysiologyCustom SynthesesBIOTREND Chemikalien GmbHIm Technologiezentrum KlnEupener Str. 157D-50933 KlnTel.+49 221 949 83 20Fax. +49 221 949 83 25jaeger@biotrend.com18th GTTINGEN MEETING OF THE GERMANNEUROSCIENCE SOCIETY32th GTTINGEN NEUROBIOLOGYCONFERENCEMarch25-29,2009 March25-29,2009 March25-29,2009 March25-29,2009 March25-29,2009Program2EXTRAORDINARY CRAFTSMANSHIP.Fine Science Tools is committed to serving the worlds scientic and biomedical research communities with a full range of precision surgical and micro-surgical instruments. Unparalleled quality and customer service has made us the leading global distributor of ne European surgical tools.nescience.de+49(0) 6221 905050FI NESURGI CALI NSTRUMENTSFORRESE ARCHTM3Authors IndexAuthors IndexAuthors IndexAuthors IndexAuthors IndexKeyword IndexKeyword IndexKeyword IndexKeyword IndexKeyword IndexT TT TTableofContents ableofContents ableofContents ableofContents ableofContentsWelcome AddressAcknowledgementExhibitorsExhibition Floor PlanList of AdvertisersAwardsYoung Investigator StipendsCommittees and OrganizationGeneral InformationMap of GttingenScientific ProgramNeurowissenschaftliche Gesellschaft e.V.Plenary LecturesSatellite SymposiaSymposiaExplanation of Abstract NumbersPoster TopicsPoster ContributionsAuthors IndexKeyword IndexParticipants AddressesProgram at a glanceTABLE OF CONTENTSAddressesAddressesAddressesAddressesAddressesPP PP PostersostersostersostersostersGeneral InfoGeneral InfoGeneral InfoGeneral InfoGeneral InfoScientific Programcientific Programcientific Programcientific Programcientific ProgramSymposiaSymposiaSymposiaSymposiaSymposia4681820222426282937485052561041051091972312453124WELCOME ADDRESSW WW WWelcomeAddress elcomeAddress elcomeAddress elcomeAddress elcomeAddressIt is a great pleasure for us to welcome you to the 8th Gttin-gen Meeting of the German Neuroscience Society.SincetheinitialNeurobiologyConferenceinGttingen,initiated and organized by the late Otto Creutzfeldt (1927 1992) together with Ernst Florey (1927 1997) in 1973 asa small expert meeting, the conference has steadily growninsizeandsignificantlybroadeneditsspectrum.ItnowcoversallresearchfieldsinNeurosciencesuptotranslational aspects in Clinical Neurology.Withmanyhigh-rankingproposalsforsymposiaandexcellent suggestions for keynote speakers, it was again adifficultjobfortheorganizingcommitteetoselectthecontributions that you will now find in the final program. Weare very happy and pleased that we could allure such highprofile scientists for our meeting and we look very muchforward to their presentations. In this context, we would liketo especially highlight the featured lectures like the Roger-EckertLecture,theErnst-FloreyLectureandtheOtto-CreutzfeldtLecturewhichhavealreadyalongstandingtradition at the conference, and the 2nd Zlch-Lecture thatwas introduced last year to cover the field of translationalclinically oriented Neuroscience.However, the meeting would not be successful without theplethoraofcontributionsbyyoungresearchers,whichpresent and discuss their findings in front of their posters.We have received well over 950 poster submissions, manyof which are first-authored by young scientists. We thank allof them for their interest in the meeting and their invaluablecontributions. Since we have again such a large amount ofposter presentations we will have two poster sessions onThursday, Friday and Saturday each. In addition to that, wewillhavealsotwolecturesbeinggivenbytwoyoungneuroscientists who have been awarded one of the scientificpricesoftheGermanNeuroscienceSociety,theAgilentTechnologies price for excellent achievements in developingnoveltechniquesinneuroscience,andtheSchilling-Forschungspreis of the German Neuroscience Society, whichis donated by the Schilling Foundation.We would like to take this opportunity to deeply thank thesetwo institutions and all the other sponsors, especially thecompanies, which present their products in the hall for theirgeneroussupportofthemeeting.Withoutthemmanyamenities like the free buffets and the party night would nothave been possible! We also thank the University of Gttin-gen for providing the conference center for the meeting andin particular the Deutsche Forschungsgemeinschaft (DFG)which approved our grant application to support the meetingandallowedustoinvitemanyinternationallyrenownedscientists to this conference. Last but not least, we wouldlike to thank all the other volunteers who helped to organize5WELCOME ADDRESSthis conference in many ways and who make this conferenceenjoyable for all of us.Unfortunately,KerstinKrieglstein,whosuccessfullyorganized the last meetings of the German NeuroscienceSocietytogetherwithherteam,leftGttingenin2007.Therefore, it was necessary to establish a new organizationteam in Gttingen for this years conference.Inga Zerr andhercoworkersfromthePrionResearchGroupintheDepartment of Neurology in Gttingen took over this task.Their engagement and the help of the Berlin office, namelyAnnikaBuchheisterandMeinoGibson,allowedustocontinue the local tradition of this meeting.The contents of the meeting will again be provided on CD.In addition to that this program booklet is available. TheCD, which contains the abstracts is a supplement to Neuro-forum and thus citable. Furthermore, an itinerary planner isavailableonthemeetingwebsite(http://www.nwg-goettingen.de/2009/) which allows a creation of individualtimetables.Finally,wewouldliketoannouncethattherewillbenomeeting in Gttingen in 2010.All participants are asked tocontribute in this year to the FENS meeting will be held inAmsterdam from July 3 through 7, 2010, organized by theDutch Neurofederation. We hope that you will support thisconference as much as the last FENS Forum in Geneva,which was a great success also due to the many excellentcontributions from Germany.Hope to see you there and at the next German NeuroscienceSociety Meeting 2011 in Gttingen. Unfortunately, the datesfor this conference are not available yet since the Universityof Gttingen will change its teaching schedule from semestersto trimesters and the final schedule is not fixed so far. WewillprovidethisinformationassoonaspossibleontheNWG website.Now we wish you a great conference and a pleasant stay inGttingenProf. Dr. Mathias Bhr Prof. Dr. Inga Zerr6Acknowledgement Acknowledgement Acknowledgement Acknowledgement AcknowledgementACKNOWLEDGEMENTTheGermanNeuroscienceSociety(NWG)andtheorganizersofthismeetinggratefullyacknowledgethecollaborationandthefinancialsupportofthefollowingpartners:Deutsche Forschungsgemeinschaft (DFG)Bereich HumanmedizinGeorg-August-Universitt GttingenHerrmann und Lilly Schilling-Stiftung frmedizinische Forschung im Stifterverband fr dieDeutsche Wissenschaft, EssenAgilent Technologies GmbH, GrfenfingGertrud Reemtsma StiftungRoger Eckert Fund, Gttingenand Guido Nikkhah, Freiburg,for providing the cover figure.7 InteIIigent Imaging Innovations GmbHKnigsaIIee 9-21, 37081 Gttingen, Germany3ieurope@inteIIigent-imaging.comSolutions for Advanced Fluorescence MicroscopySystems- MarianasTM Fluorescence maging Workstation for multi-dimensional live cell imaging, tailored to specific applications- MarianasTM SDC Spinning Disk Confocal Workstations for fast and long term live cell imaging- VivoTM turn-key system designed specifically for the most demanding intravital imaging applications- VivoTM 2p - high-speed multiphoton imaging of live animals and tissue. Using a resonant scanner, it can collect images at speeds up to 60 frames per second.System Options and add-ons:- scanning FRAP and instantaneous FRAP (photoablation, photoactivation, photoconversion)- FLIM upgrade any system with our integrated frequency domain lifetime imaging setup to dowidefield FLM, TRF-FLM, SDC-FLM- TIRF - fast, affordable, multi-color TRF- Motorized Spherical Aberration CorrectionOptics considerably improve the quality of 3D widefield and 3D confocal imagesSystems.Hardware.Software.Solutions.8Exhi bi tors Exhi bi tors Exhi bi tors Exhi bi tors Exhi bi torsTheconferenceisgenerouslysupportedby: Theconferenceisgenerouslysupportedby: Theconferenceisgenerouslysupportedby: Theconferenceisgenerouslysupportedby: Theconferenceisgenerouslysupportedby:EXHIBITORSADInstrumentsGmbHADInstrumentsGmbHADInstrumentsGmbHADInstrumentsGmbHADInstrumentsGmbH(BoothNo.32)Reichartshuser Berg 3, 74937 Spechbachwww.adinstruments.comAgilentT AgilentT AgilentT AgilentT AgilentTechnologies echnologies echnologies echnologies echnologies(BoothNo.53)Lochhamer Schlag 19, 82166 Grfelfingwww.agilent.comAgnthosAgnthosAgnthosAgnthosAgnthos(BoothNo.50)Pyrolavgen 3, 18160 Liding, Swedenwww.agnthos.seAGOWAGmbH AGOWAGmbH AGOWAGmbH AGOWAGmbH AGOWAGmbH(BoothNo.22)Ostendstr. 25, TGS Haus 8, 12459 Berlinwww.lgc.co.uk/genomicsAlphaOmegaGmbHAlphaOmegaGmbHAlphaOmegaGmbHAlphaOmegaGmbHAlphaOmegaGmbH(BoothNo.6)Ubstadter Str. 28, 76698 Ubstadt-Weiherwww.alphaomega-eng.comAperioT AperioT AperioT AperioT AperioTechnologiesechnologiesechnologiesechnologiesechnologies(Booth108)1360 Park Center Dr., Vista, Ca 92081, USAwww.aperio.comAppliChemGmbHAppliChemGmbHAppliChemGmbHAppliChemGmbHAppliChemGmbH(BoothNo.51)Ottoweg 4, 64291 Darmstadtwww.applichem.comAscentScientific AscentScientific AscentScientific AscentScientific AscentScientific(BoothNo.38)Unit 68, Gazelle Road, Weston-Super-Mare,BS24 9ES, UKwww. ascentscientific.comBayerVitalGmbH BayerVitalGmbH BayerVitalGmbH BayerVitalGmbH BayerVitalGmbH(BoothNo.4)Rosdorfer Weg 9, 37073 Gttingenwww.bayervital.deBernstei nNetworkComputati onal Neurosci ence Bernstei nNetworkComputati onal Neurosci ence Bernstei nNetworkComputati onal Neurosci ence Bernstei nNetworkComputati onal Neurosci ence Bernstei nNetworkComputati onal Neurosci enceHansa Str. 9a, 79104 Freiburgwww.nncn.deBilaneyConsultantsGmbHBilaneyConsultantsGmbHBilaneyConsultantsGmbHBilaneyConsultantsGmbHBilaneyConsultantsGmbH(BoothNo.33)Schirmerstr. 23, 40211 Dsseldorfwww.Bilaney.deBioT BioT BioT BioT BioTrendChemikalienGmbH rendChemikalienGmbH rendChemikalienGmbH rendChemikalienGmbH rendChemikalienGmbH(BoothNo.14)Eupener Str. 157, 50933 Klnwww.biotrend.comBIOMOLGmbHBIOMOLGmbHBIOMOLGmbHBIOMOLGmbHBIOMOLGmbH(BoothNo.15)Waidmannstr. 85, 22769 Hamburgwww.biomol.de9npi electronic GmbHHauptstrasse 96, D-71732 Tamm, GermanyPhone +49 (0)7141-9730230; Fax: +49 (0)7141-9730240support@npielectronic.com; http://www.npielectronic.comnpiElectronicInstrumentsfor the Life SciencesVersatile All-in-One AmplifiersELC SeriesELC-03XSELC-03MJuxtacellular filling of dyes and DNA,extra- and intracellular recordings,whole-cell patch clamp in CC or VCmode, single cell stimulation andelectroporation, and iontophoresisELC-01XISO STIM01D Stimulus Isolator without batteries,100V, 10 mA, bipolar stimulus generationEXT-02F Two-channel extracellular amplifier withfilters, audio monitor and optional headstages10EXHIBITORSBiozolDiagnosticaV BiozolDiagnosticaV BiozolDiagnosticaV BiozolDiagnosticaV BiozolDiagnosticaVertriebGmbH ertriebGmbH ertriebGmbH ertriebGmbH ertriebGmbH(BoothNo.20)Obere Hauptstr. 10b, 85386 Echingwww.biozol.deBitplaneAG BitplaneAG BitplaneAG BitplaneAG BitplaneAG(BoothNo.7)Badener Str. 682, 8048 Zrich, Switzerlandwww.bitplane.comCarlZeissMicroImagingGmbH CarlZeissMicroImagingGmbH CarlZeissMicroImagingGmbH CarlZeissMicroImagingGmbH CarlZeissMicroImagingGmbH(BoothNo.47)Standort Gttingen, Knigsallee 9 21, 37081 Gttingenwww.zeiss.de/mikro-workshopsCharlesRiverCharlesRiverCharlesRiverCharlesRiverCharlesRiver(BoothNo.19)Sandhofer Weg 7, 97633 Sulzfeldwww.criver.comDeutscheForschungsgemeinschaft(DFG)DeutscheForschungsgemeinschaft(DFG)DeutscheForschungsgemeinschaft(DFG)DeutscheForschungsgemeinschaft(DFG)DeutscheForschungsgemeinschaft(DFG)(BoothNo.1)Kennedyallee 40, 53175 Bonnwww.dfg.dedianovaGmbHdianovaGmbHdianovaGmbHdianovaGmbHdianovaGmbH(BoothNo.28)Warburgstr. 45, 20354 Hamburgwww.dianova.deDigitimerL DigitimerL DigitimerL DigitimerL DigitimerLTd.Td.Td.Td.Td.(BoothNo.27)37 Hydeway, Welwyn Garden City AL7 3BE, UKwww.digitimer.comExperimetriaLtd.ExperimetriaLtd.ExperimetriaLtd.ExperimetriaLtd.ExperimetriaLtd.(BoothNo.107)87 Podmaniczky St., Budapest, 1062 , Hungarywww.experimetria.com/F FF FFineScienceT ineScienceT ineScienceT ineScienceT ineScienceToolsGmbH oolsGmbH oolsGmbH oolsGmbH oolsGmbH(BoothNo.41)Im Weiher 12, 69121 Heidelbergwww.finescience.deflyionGmbHflyionGmbHflyionGmbHflyionGmbHflyionGmbH(BoothNo.111)Waldhaeuserstrasse 64 , 72076 Tuebingenwww.flyion.comGatanGmbH GatanGmbH GatanGmbH GatanGmbH GatanGmbH(BoothNo.21)Ingolstdter Str. 12, 80807 Mnchenwww.gatan.comHamamatsuPhotonicsDeutschlandGmbH HamamatsuPhotonicsDeutschlandGmbH HamamatsuPhotonicsDeutschlandGmbH HamamatsuPhotonicsDeutschlandGmbH HamamatsuPhotonicsDeutschlandGmbH(BoothNo.2)Arzbergerstr. 10, 82211 Herrschingwww.hamamatsu.deHEKAElektronikDr HEKAElektronikDr HEKAElektronikDr HEKAElektronikDr HEKAElektronikDr.SchulzeGmbH .SchulzeGmbH .SchulzeGmbH .SchulzeGmbH .SchulzeGmbH(BoothNo.26)Wiesenstr. 71, 67466 Lambrechtwww.heka.comHISSDiagnosticsGmbH HISSDiagnosticsGmbH HISSDiagnosticsGmbH HISSDiagnosticsGmbH HISSDiagnosticsGmbH(BoothNo.12)Colombistr. 27, 79098 Freiburgwww.hiss-dx.de11npiElectronicInstrumentsfor the Life SciencesOther npi electronicinstrumentsTwo Electrode voltage clamp amplifiersTemperature control systemsBridge-/Intracellular amplifiersExtracellular amplifiersModular systemLow pass Bessel filtersFast iontophoretic drug application systemsFast pneumatic drug application systemsAutomatic chloriderALA Scientific perfusion systems and accessoriesEXFO Burleigh micropositionersScientifica PatchStar and LBM-7micromanipulatorsScientifica posts and platformsnpi electronic GmbHHauptstrasse 96, D-71732 Tamm, GermanyPhone +49 (0)7141-9730230; Fax: +49 (0)7141-9730240support@npielectronic.com; http://www.npielectronic.comOptional features of npis SEC amplifiersVCcCC option:Voltage Clamp controlled Current ClampRef.: Sutor et al. (2003), Pflgers Arch. 446:133-141 DHC option:Dynamic Hybrid ClampRef.: Dietrich et al. (2002), J.Neurosci.Meth. 116:55-63MODULAR option (SEC-03M):Versatility of Single Electrode Clamping inmodular design for maximum flexibilityLINEARoption:VCx1:reduced noise for small currentsCC/VCx10: electroporation of dyes and DNASingle Electrode High SpeedVoltage/Patch Clamp Amplifiers12EXHIBITORSIBAGmbHIBAGmbHIBAGmbHIBAGmbHIBAGmbH(BoothNo.29)Rudolf-Wissell-Str. 28, 37079 Gttingenwww.iba-go.cominomedMedizintechnikGmbH inomedMedizintechnikGmbH inomedMedizintechnikGmbH inomedMedizintechnikGmbH inomedMedizintechnikGmbH(BoothNo.105)Tullastr. 5a, 79331 Teningenwww.inomed.comIntelligentImagingInnovationsGmbH IntelligentImagingInnovationsGmbH IntelligentImagingInnovationsGmbH IntelligentImagingInnovationsGmbH IntelligentImagingInnovationsGmbH(BoothNo.52)Knigsallee 9 21, 37081 Gttingenwww.intelligent-imaging.comL LL LLaVisionBioT aVisionBioT aVisionBioT aVisionBioT aVisionBioTecGmbHecGmbHecGmbHecGmbHecGmbH(BoothNo.5)Meisenstr. 65, 33607 Bielefeldwww.lavisionbiotech.comLehmannsFachbuchhandlungLehmannsFachbuchhandlungLehmannsFachbuchhandlungLehmannsFachbuchhandlungLehmannsFachbuchhandlung(BoothNo.101-103)Weender Str. 87, 37073 Gttingenwww.LOB.deL LL LLeicaMikrosystemeV eicaMikrosystemeV eicaMikrosystemeV eicaMikrosystemeV eicaMikrosystemeVertriebGmbH ertriebGmbH ertriebGmbH ertriebGmbH ertriebGmbH(BoothNo.35/36)Ernst-Leitz-Str. 17 37, 35578 Wetzlarwww.leica-microsystems.comLI-CORBioscienceGmbH LI-CORBioscienceGmbH LI-CORBioscienceGmbH LI-CORBioscienceGmbH LI-CORBioscienceGmbH(BoothNo.54)Siemensstr. 25, 61352 Bad Homburgwww.licor.comLohmanResearchEquipment LohmanResearchEquipment LohmanResearchEquipment LohmanResearchEquipment LohmanResearchEquipment(BoothNo.43)Am Frdertum 9, 4475 Castrop-Rauxelwww.lohres.deLuigs&NeumannFeinmechanik+Elektrotechnik Luigs&NeumannFeinmechanik+Elektrotechnik Luigs&NeumannFeinmechanik+Elektrotechnik Luigs&NeumannFeinmechanik+Elektrotechnik Luigs&NeumannFeinmechanik+ElektrotechnikGmbHGmbHGmbHGmbHGmbH(Booth No. 39)Boschstrae 19, 40880 Ratingenwww.luigs-neumann.comMetrisB MetrisB MetrisB MetrisB MetrisB.V .V .V .V .V.....(BoothNo.37)Kruisweg 25, 2132 NG Hoofddorp, The Netherlandswww.metris.nlMicrobrightfieldEuropee.K. MicrobrightfieldEuropee.K. MicrobrightfieldEuropee.K. MicrobrightfieldEuropee.K. MicrobrightfieldEuropee.K.(BoothNo.16)Matthissonstr. 6, 39108 Madgeburgwww.mbfbioscience.comMilliporeGmbH MilliporeGmbH MilliporeGmbH MilliporeGmbH MilliporeGmbH(BoothNo.109)Am Kronberger Hang 5, 65824 Schwalbachwww.millipore.comMiltenyiBiotecGmbH MiltenyiBiotecGmbH MiltenyiBiotecGmbH MiltenyiBiotecGmbH MiltenyiBiotecGmbH(BoothNo.11)Friedrich-Ebert-Str. 68, 51429 Bergisch Gladbachwww.miltenyibiotec.comMultichannelSystems MultichannelSystems MultichannelSystems MultichannelSystems MultichannelSystems(BoothNo.48)Aspenhaustr. 21, 72770 Reutlingenwww.multichannelsystems.com13EXHIBITORSThe PatchStar is a highprecision, stable andmotorized manipulator,controlled by a cube ora PatchPad Lite. It offersaresolution of 20 nm,less than 1 m drift in 2hours, 4 axes of motion(three real, one virtual)and is electrically silent.PatchStarPrecise MicromanipulationVariable MountingRigid Post and Platforms, Manual or MotorizedXY-Stages, or Motorized Movable Top Plateswith 50 Memory PositionsOther Scientifica InstrumentsLBM-7 Manual Manipulator [Robust Slice Platforms for Upright andInverted Microscopes[PatchPro Integrated Patch Clamping Solution [SliceMaster, FibreMaster Complete Systems [Distributed bynpiElectronicInstrumentsfor the Life Sciencesnpi electronic GmbH, Hauptstrasse 96D-71732 Tamm, Germanywww.npielectronic.com, sales@npielectronic.com14EXHIBITORSNarishigeInternationalLtd. NarishigeInternationalLtd. NarishigeInternationalLtd. NarishigeInternationalLtd. NarishigeInternationalLtd.(BoothNo.8)Unit 7, Willow Business Park, Willow Way, London DE264QP, UKwww.narishige.co.jp/nilNDIEuropeGmbH NDIEuropeGmbH NDIEuropeGmbH NDIEuropeGmbH NDIEuropeGmbH(Booth18)Fritz-Reichle-Ring 2, 78315 Radolfzellwww.ndieurope.comNeurostarGmbHNeurostarGmbHNeurostarGmbHNeurostarGmbHNeurostarGmbH(BoothNo.40)Dachsklingeweg 17, 71067 Sindelfingenwww.neurostar.deNikonGmbH NikonGmbH NikonGmbH NikonGmbH NikonGmbH(BoothNo.3)Tiefenbroicher Weg 25, 40472 Dsseldorfwww.nikon-intruments.comNoldusInformationT NoldusInformationT NoldusInformationT NoldusInformationT NoldusInformationTechnologyechnologyechnologyechnologyechnology(BoothNo.49)Nieuwe Kanaal 5, 5700 AG Wageningen, Netherlandswww.noldus.comnpielectronicGmbHnpielectronicGmbHnpielectronicGmbHnpielectronicGmbHnpielectronicGmbH(BoothNo.46)Hauptstr. 96, 71732 Tammwww.npielectronic.comOl ympusDeutschl andGmbH Ol ympusDeutschl andGmbH Ol ympusDeutschl andGmbH Ol ympusDeutschl andGmbH Ol ympusDeutschl andGmbH(BoothNo.10)Wendenstrae 14-18, 20097 Hamburgwww.olympus.deP PP PPerimedABerimedABerimedABerimedABerimedAB(BoothNo.55)Datavgen 9A, SE-175 26 Jrflla-Stockholm, Swedenwww.perimed.seR&DSystemsGmbHR&DSystemsGmbHR&DSystemsGmbHR&DSystemsGmbHR&DSystemsGmbH(BoothNo.13)Borsigstr. 7, 65205 Wiesbadenwww.rndsystems.comRappOptoElectronicGmbHRappOptoElectronicGmbHRappOptoElectronicGmbHRappOptoElectronicGmbHRappOptoElectronicGmbH(BoothNo.24)Gehlenkamp 9a, 22559 Hamburgwww.rapp-opto.comScienceProductsGmbH ScienceProductsGmbH ScienceProductsGmbH ScienceProductsGmbH ScienceProductsGmbH(BoothNo.42)Hofheimer Str. 63, 65719 Hofheimwww.science-products.comSensoMotoricInstrumentsGmbH SensoMotoricInstrumentsGmbH SensoMotoricInstrumentsGmbH SensoMotoricInstrumentsGmbH SensoMotoricInstrumentsGmbH(BoothNo.112)Warthestr. 21, 14513 Teltowwww.smivision.comSigma-AldrichChemieGmbH Sigma-AldrichChemieGmbH Sigma-AldrichChemieGmbH Sigma-AldrichChemieGmbH Sigma-AldrichChemieGmbH(BoothNo.25)Eschenstr. 5, 82024 Taufkirchenwww.sigmaaldrich.comStoeltingEuropeStoeltingEuropeStoeltingEuropeStoeltingEuropeStoeltingEurope(BoothNo.23)1a Dartmouth Terrace, Ranelagh, Dublin 6, Irelandwww.stoeltingeurope.com15EXHIBITORSEthoVision - Video tracking system for automation of behavioral experiments such as mazes, forced swim test, novel object recognition task, and many more.CatWalk- Gait analysis system for assessment of locomotor deficits and pain syndromes in rats and mice.PhenoTyper - Video-based observation system for continuous and automated assessment of rodent behavior.The Observer XT - Behavior recording for live or video-based observation. Integrated physiological measurements. Also available on handheld computers. Innovative solutions for behavioral researchAnalyze this!New:EthoVision XTNoldus Information Technology bvWageningen, The NetherlandsE-mail:info@noldus.nlNoldus Information Technology Inc.Leesburg, VA,U.S.A.E-mail: info@noldus.comwww.noldus.com16EXHIBITORSSutterInstrumentCo. SutterInstrumentCo. SutterInstrumentCo. SutterInstrumentCo. SutterInstrumentCo.(BoothNo.104)1 Digital Drive Novato, Ca 94949, USAwww.sutter.comSynapticSystemsGmbH SynapticSystemsGmbH SynapticSystemsGmbH SynapticSystemsGmbH SynapticSystemsGmbH(BoothNo.44)Rudolf-Wissell-Str. 26, 37079 Gttingenwww.sysy.comThermoScientificThermoScientificThermoScientificThermoScientificThermoScientific(Booth110)Industriezone III, Industrielaan 27 , 9320 Erembodegem,Belgiumwww.thermo.comThomasRecordingGmbHThomasRecordingGmbHThomasRecordingGmbHThomasRecordingGmbHThomasRecordingGmbH(BoothNo.17)Winchester Str. 8, 35394 Gieenwww.thomasrecording.comTSESystemsGmbHTSESystemsGmbHTSESystemsGmbHTSESystemsGmbHTSESystemsGmbH(BoothNo.45)Siemensstr. 21, 61352 Bad Homburgwww.TSE-Systems.comT TT TTucker ucker ucker ucker ucker-DavisT -DavisT -DavisT -DavisT -DavisTechnologiesechnologiesechnologiesechnologiesechnologies(BoothNo.31)11930 Research Circle Alachua, FL 32615, USAwww.tdt.comVisitronSystemsGmbHVisitronSystemsGmbHVisitronSystemsGmbHVisitronSystemsGmbHVisitronSystemsGmbH(BoothNo.30)Gutenbergstr. 9, 82178 Puchheimwww.visitron.devonGegerfeltPhotonics vonGegerfeltPhotonics vonGegerfeltPhotonics vonGegerfeltPhotonics vonGegerfeltPhotonics(BoothNo.9)Frbelstr. 54, 64625 Bensheimwww.vongegerfeltphotonics.comW WW WWorldP orldP orldP orldP orldPrecisionInstruments recisionInstruments recisionInstruments recisionInstruments recisionInstruments(BoothNo.34)Liegnitzer Str. 15, 10999 Berlinwww.wpi-europe.com17NOTES18EXHIBITION FLOOR PLANExhibitionFloorPlan ExhibitionFloorPlan ExhibitionFloorPlan ExhibitionFloorPlan ExhibitionFloorPlanGroundFloor GroundFloor GroundFloor GroundFloor GroundFloorTheboothnumbersbehindthecompany Theboothnumbersbehindthecompany Theboothnumbersbehindthecompany Theboothnumbersbehindthecompany Theboothnumbersbehindthecompanys s s s snamerefertotheboothnumbersonthe namerefertotheboothnumbersonthe namerefertotheboothnumbersonthe namerefertotheboothnumbersonthe namerefertotheboothnumbersonthefloorplan. floorplan. floorplan. floorplan. floorplan.19EXHIBITION FLOOR PLANExhibitionFloorPlan ExhibitionFloorPlan ExhibitionFloorPlan ExhibitionFloorPlan ExhibitionFloorPlanF FF FFirstFloor irstFloor irstFloor irstFloor irstFloor20ListofAdvertisers ListofAdvertisers ListofAdvertisers ListofAdvertisers ListofAdvertisersLIST OF ADVERTISERSAbcam(insert)Bayer Schering Pharma (p. 39, 40)BiomolGmbH(insert)BiotrendChemikalien(cover)Fine Science Tools GmbH (p. 2)Gatan GmbH (p. 34, 35)IntelligentImagingInnovationsGmbH(p.7)LeicaMicrosystemeVertriebGmbH(insert)MicroBrightField Europe e.K. (p. 27)NarishigeInternationalLimeted(p.31)Noldus Information Technology (p. 15)npi electronic GmbH (p. 9, 11, 13)PromoCell GmbH (insert)S. Karger AG (insert)Science Products GmbH (p. 23, 25)Spektrum der Wissenschaft (insert)Synaptic Systems GmbH (insert)Thomas Recording GmbH(p. 21)TSE (cover)21Thomas RECORDINGGmbHTheMicrodriveCompany- Drives multiple Tetrodes/Heptodes- Patented Rubber Tube Drive- Record while Electrode moves- Modular: 1 - 16 individual drive units- Low cost System- Cortical and deep brain recordings- Precise Positioning- Place multiple heptodes individually- No noise pickup from environment- No additional shielding required- Fast electrode exchange- Adaptable to all recording applicationsAnd many features more...visit us at:Booth # 17Thomas RECORDING is BERNSTEIN Partner:with outstanding features:22AWARDSAgi l entT Agi l entT Agi l entT Agi l entT Agi l entTechnol ogi esT echnol ogi esT echnol ogi esT echnol ogi esT echnol ogi esTechnol ogyAwardofthe echnol ogyAwardofthe echnol ogyAwardofthe echnol ogyAwardofthe echnol ogyAwardoftheGermanNeuroscienceSociety2009 GermanNeuroscienceSociety2009 GermanNeuroscienceSociety2009 GermanNeuroscienceSociety2009 GermanNeuroscienceSociety2009This prize is awarded by the German Neuroscience Societyforoutstandingcontributionstothedevelopmentofnewtechnologies in the field of brain research. The prize moneyis donated by the company Agilent Technologies in Grfel-fing.This award supports young researchers of an age under 35.The sum awarded is 2.500 Euro. Qualified research is re-flected in outstanding publications. Elegible are scientistseither working in a German laboratory or she/he is a Ger-man native working abroad. Applications from all fields ofneuroscienceresearchareinvited.Thecandidateeitherapplies directly for the award or is nominated by anotherperson. Being a member of the German Neuroscience So-ciety is not mandatory.The prize was given for the first time in 2003, at that timeunder the name of Till Photonics Technology Award. It isawarded during the Congress of the German NeuroscienceSociety in Gttingen.Agi l entT Agi l entT Agi l entT Agi l entT Agi l entTechnol ogi es echnol ogi es echnol ogi es echnol ogi es echnol ogi esLochhamer Schlag 1982166 Grfelfingwww.agilent.comSchilling-ResearchAwardoftheGermanNeuro- Schilling-ResearchAwardoftheGermanNeuro- Schilling-ResearchAwardoftheGermanNeuro- Schilling-ResearchAwardoftheGermanNeuro- Schilling-ResearchAwardoftheGermanNeuro-sci enceSoci ety2009 sci enceSoci ety2009 sci enceSoci ety2009 sci enceSoci ety2009 sci enceSoci ety2009This prize is awarded by the German Neuroscience Societyfor outstanding contributions in the field of brain research.The award supports young researchers up to the age of 35.Theprizemoneyamountsto20.000Euro.Qualifiedresearchisreflectedinoutstandingpublications.Theapplicant can either work in a German laboratory or she/heis of German origin working abroad. The applicaton can besubmitted by the applicant her-/himself or the candidate canbe nominated. Applications from all fields of neuroscienceresearchareinvited.BeingamemberoftheGermanNeuroscience Society is not mandatory.The prize was given for the first time in 2005 during the 6thconfernceof the German Neuroscience Society in Gttin-gen.StifterverbandfrdieDeutscheWissenschaft StifterverbandfrdieDeutscheWissenschaft StifterverbandfrdieDeutscheWissenschaft StifterverbandfrdieDeutscheWissenschaft StifterverbandfrdieDeutscheWissenschaftPostfach 16446045224 Essenwww.stifterverband.deBoth prize winners will present their work in a lecture onFriday, March 27, between 15:00 and 16:00 h.Awards Awards Awards Awards Awards23AmplifiersData Acquisition and Data Analysis SystemsElectrodes, Wires &GlassesElectrode Holders Micropipette Pullers Microforges and Bevelers MicromanipulatorsMicroinjection Systems PerfusionSystems Stereotaxic InstrumentsStimulators and Stimulus IsolatorsTables and Faraday Cages Temperature Controllers and more!SCIENCE PRODUCTS GmbHxHofheimer Str. 63xD 65719 HofheimxTel.:+49 (0) 6192 901396Fax:+49 (0) 6192 901398xinfo@science-products.comxwww.science-products.com24Y YY YYoungInvestigatorStipends oungInvestigatorStipends oungInvestigatorStipends oungInvestigatorStipends oungInvestigatorStipendsT TT TTravelgrantsfromtheGerman ravelgrantsfromtheGerman ravelgrantsfromtheGerman ravelgrantsfromtheGerman ravelgrantsfromtheGermanNeuroscienceSociety NeuroscienceSociety NeuroscienceSociety NeuroscienceSociety NeuroscienceSocietyThefollowingapplicantsweregrantedatravelstipendamountingto300Euro from the German NeuroscienceSociety:YOUNG INVESTIGATOR STIPENDSSusanne Bastian (Dresden, Germany)Stefan Bittner (Wrzburg, Germany)Akos Boros (Pecs, Hungary)Monika J. B. Eberhard (Vienna, Austria)Nadja Freund (Bochum, Germany)Pia Glckner (Leipzig, Germany)Franziska Greifzu (Jena, Germany)Joanna Gruszczynska-Biegala (Warsaw, Poland)Anna-Maria Hartmann (Oldenburg, Germany)Laura Hausmann (Aachen, Germany)Sandra Hofer (Bern, Switzerland)Therse Kallur (Kln, Germany)Juntang Lin (Jena, Germany)Agnieszka Nikiforuk (Krakw, Poland)Hanna Regus-Leidig (Erlangen, Germany)Andrea Schfers (Bielefeld, Germany)Julia Schuckel (Halifax, Canada)Ole Jan Simon (Wrzburg, Germany)Miriam Annika Vogt (Mannheim, Germany)Ulrike Winkler (Leipzig, Germany)25offers the newest CEDhard - and software Micro MK II and Power MK II Power1401 expansion boxes Mikro1401 expansion boxesThe Power1401mkIIisahigh performancedataacquisitioninterface.ItusesStrongARMtechnologygivingyouthemostpowerful lifesciencelaboratoryinterfaceintheworld.Maximumsamplingrate:1MHz multi-channel,upto2MHz singlechannel.TheMicro1401mkIIisa lowcost, versatile data acquisition unit.The on-boardprocessorwithhigh speed memory is optimised for real timeprocessing,freefrom theconstraintsofthehost computeroperatingsystem.Itfeatureshigh-speed waveform capture at rates upto 500kHz with 32-bit resolution.Both interfaces now with USB2.Spike2Ver.6.Spike2deliverspowerfulldatacapture and analysis,stimulussequencingandexperimentalcontrolusingoneoftheCED 1401family of data acquisiton periphals.Signal Ver. 4. Signal delivers powerfull sweep- based data captureandanalysis,stimulus generationandcontrolusingoneofthe CED1401dataacquisitonperiphals.Nowwith PatchClampmodule.SCIENCE PRODUCTS GmbHxHofheimer Str. 63xD 65719 HofheimxTel.:+49 (0) 6192 901396Fax:+49 (0) 6192 901398xinfo@science-products.comxwww.science-products.com26CommitteesandOrganization CommitteesandOrganization CommitteesandOrganization CommitteesandOrganization CommitteesandOrganizationProgramCommi ttee ProgramCommi ttee ProgramCommi ttee ProgramCommi ttee ProgramCommi tteeMathias Bhr(President)Ad AertsenNiels BirbaumerUlrich DirnaglAndreas DraguhnUlf EyselMichael FrotscherEckart GundelfingerHanns HattHans-Peter HartungKlaus-Peter HoffmannUwe HombergSigrun KorschingErwin NeherRainer SchwartingHomepage Homepage Homepage Homepage Homepagewww.nwg-goettingen.de/2009Local Organi zati on Local Organi zati on Local Organi zati on Local Organi zati on Local Organi zati onMathias BhrInga ZerrUta HeinemannUniversittsklinik GttingenDirektor der Abteilung NeurologieRobert-Koch-Str. 4037075 GttingenTel.: +49 551 39 6603; Fax: +49 551 39 8405E-Mail: nwg2009@med.uni-goettingen.deCOMMITTEES AND ORGANIZATIONNWGOffi ce NWGOffi ce NWGOffi ce NWGOffi ce NWGOffi ceGeschftsstelle der Neurowissenschaftlichen Gesellschaft e.V.Annika Buchheister/Meino Alexandra GibsonMax Delbrck Center for Molecular Medicine (MDC)Robert-Rssle-Str.1013092BerlinTel.: +49 30 9406 3336, Fax: +49 30 9406 3819E-Mail: a.buchheister@mdc-berlin.de / gibson@mdc-berlin.de2728GeneralInformation GeneralInformation GeneralInformation GeneralInformation GeneralInformationV VV VVenue enue enue enue enueCentral Lecture Hall Building (Zentrales Hrsaalgebude),GeorgAugustUniversityGttingen,PlatzderGttingerSiebenConferenceOffice ConferenceOffice ConferenceOffice ConferenceOffice ConferenceOfficeDuringthemeetingtheconferenceofficeisopenonWednesday, March 25, from 12 to 7 p.m. and from Thursday,March 26 to Saturday, March 28, from 8 a.m. to 9 p.m. andon Sunday, March 29, from 8 a.m. to 1 p.m.Phone: +49 551/39 9595Fax: +49 551/39 9596E-Mail: nwg2009@med.uni-goettingen.deExhi bi ti on Exhi bi ti on Exhi bi ti on Exhi bi ti on Exhi bi ti onThe exhibition is open from Thursday, March 26to Saturday,March 28, 2007 from 9 a.m. to 7 p.m.P PP PPublicT ublicT ublicT ublicT ublicTransportationandT ransportationandT ransportationandT ransportationandT ransportationandTravel ravel ravel ravel ravelThe meeting site is only about ten minutes walk from thecenter of the city and from the train station. Bus lines No. 2,3, 5, 9, 10, 12 and 14 stop near the venue. The bus stopsare called Auditorium, Kreuzbergring, Blauer Turm, Cam-pus.Registration Registration Registration Registration RegistrationOn site registration will be available. Please pay in cash orby Visa or Eurocard.EUR 130 (members of the German or the AustrianNeuroscience Society)EUR 180 (non-members)EUR 80 (student members of the German or theAustrian Neuroscience Society)EUR 120 (student non-members)Students must show a copy of their student identity card.The registration fee includes:- free access to the scientific program- congress bag- abstract CD- program bookletGENERAL INFORMATIONGeneral InfoGeneral InfoGeneral InfoGeneral InfoGeneral Info29MapofGttingen MapofGttingen MapofGttingen MapofGttingen MapofGttingenMAP OF GTTINGENGeneral InfoGeneral InfoGeneral InfoGeneral InfoGeneral InfoBahn- Bahn- Bahn- Bahn- Bahn-hof hof hof hof hof30General InfoGeneral InfoGeneral InfoGeneral InfoGeneral Info- evening reception with food and drinks at the meeting siteon Thursday, Friday and Saturday- coffee breaksLunch Lunch Lunch Lunch LunchLunch is available from Wednesday to Saturday in the Men-sa in the same building.InternetAccess InternetAccess InternetAccess InternetAccess InternetAccessAs a special service we offer an Internet Caf to providefree Internet access for all participants of the meeting.WLan is available in the building as well.P PP PPosterpresentations osterpresentations osterpresentations osterpresentations osterpresentationsEachposterwillhangforoneday.Posterswithposternumbers containing A will hang on Thursday, posters withposter numbers containing B will hang on Friday, and posterswith poster numbers containing C will hang on Saturday(see also explanation on page 104).Thepresentingauthorofeachposterisrequestedtobepresentather/hisposterduringthepostersession.Thepostersessionsaredividedintooddandevenserialnumbers. Each poster is presented in two sessions of onehour.P PP PPosterswithnumberscontainingA osterswithnumberscontainingA osterswithnumberscontainingA osterswithnumberscontainingA osterswithnumberscontainingAThursday, March 26, 2009(hanging of posters: before 12:45)12:45 - 13:45odd serial numbers (e.g. T20-1 11 11A)13:45 - 14:45even serial numbers (e.g. T20-2 22 22A)16:00 - 17:00odd serial numbers (e.g. T20-1 11 11A)17:00 - 18:00even serial numbers (e.g. T20-2 22 22A)(all posters must be removed immediately after 18:00)P PP PPosterswithnumberscontainingB osterswithnumberscontainingB osterswithnumberscontainingB osterswithnumberscontainingB osterswithnumberscontainingBFriday, March 27, 2009(hanging of posters: before 13:00)13:00 - 14:00odd serial numbers (e.g. T20-1 11 11B)14:00 - 15:00even serial numbers (e.g. T20-2 22 22B)16:00 - 17:00odd serial numbers (e.g. T20-1 11 11B)17:00 - 18:00even serial numbers (e.g. T20-2 22 22B)(all posters must be removed immediately after 18:00)GENERAL INFORMATION31General InfoGeneral InfoGeneral InfoGeneral InfoGeneral Info32P PP PPosterswithnumberscontainingC osterswithnumberscontainingC osterswithnumberscontainingC osterswithnumberscontainingC osterswithnumberscontainingCSaturday, March 28, 2009(hanging of posters: before 13:00)13:00 - 14:00 odd serial numbers (e.g.T20-1 11 11C)14:00 - 15:00 even serial numbers (e.g. T20-2 22 22C)16:00 - 17:00 odd numbers (e.g.T20-1 11 11C)17:00 - 18:00 even numbers (e.g. T20-2 22 22C)(all posters must be removed immediately after 18:00)Please be aware that the registration number you receivedis NOT corresponding to your poster number. You can easilyfind your poster using the online itinerary planer (www.nwg-goettingen.de/2009) or with the auhors index in this pro-gram booklet.The size of the poster is 1 x 1 m. Pins to hang your posterwill be available.Projection Projection Projection Projection ProjectionThestandardequipmentinalllectureroomsisonePowerPoint projector as well as one overhead, but there arenot two. We therefore have to ask you to present your talkwithout double projection. Furthermore, we must point outthat only one tape recorder for all lecture rooms is available.Inanycase,ifyouhavespecialrequirementsregardingprojection,pleaseletusknowbyMarch1,2009atthelatest (contact: uta.heinemann@med.uni-goettingen.de). Allsuch requests will be collected up to that date, after whichyouwillbeinformedaboutwhatarepossibleoptions.Language Language Language Language LanguageThe official language of this meeting is English.Hotels Hotels Hotels Hotels HotelsThe travel agency responsible for hotel reservation is theDeutsche Reisebro Berlin (Annemarie van der Hoff, DERDeutsches Reisebro GmbH & Co. OHG, Theodor-Heuss-Platz 2, 14052 Berlin, Tel.: +49 30 302 5002, Fax: +4930 301 9768, E-Mail: annemarie.vanderhoff@der.de).Insurance Insurance Insurance Insurance InsuranceTheorganizersdonottakeresponsibilityforindividualmedical,travelorpersonalinsurance.Participantsareadvised to carry out their own insurance policies.GENERAL INFORMATIONGeneral InfoGeneral InfoGeneral InfoGeneral InfoGeneral Info33GENERAL INFORMATIONElectricitySupply ElectricitySupply ElectricitySupply ElectricitySupply ElectricitySupply220 V - 50 Hz AC.General InfoGeneral InfoGeneral InfoGeneral InfoGeneral Info34Gatan Digital Imagingfor ElectronMicroscopy?Can your 3D microscopy systemautomatically produce perfectly aligned images showing 10,000 synapses?To learn how to accomplish this, visit us at the 8th Gttingen meeting of the German Neuroscience Society, booth 21, or go to www.gatan.com/answers353D image set generated by 3Viewof a neuron (blue) with its synapses (red) in the barrel cortex of a mouse. Reconstruction from 800 perfectly aligned image slices.3ViewDigitalMicrograph3D Visualizationtool5 mImage showing a neuropil areathrough a mouse barrel cortex (neuron shown in blue and synapses shown in red) processed for EM and generated using Gatans 3ViewSBFSEMmicroscopysystem.Eighthundredperfectlyalignedimage slicesof50nmwereacquired.GatansDigitalMicrograph3DVisualization toolwasusedtoshowtheZprojectionofthe800slices.Manualsegmentation usingReconstruct(GNUGeneralPublicLicenseversion2)softwaregenerated a 3D reconstruction of the neuronal cell including the dendrites and axon. The KPUGVKOCIGUJQYUCPKFGPVKGFU[PCRUGDGVYGGPCFGPFTKVGQHVJGTGEQPUVTWEVGFneuron and the axon labeled for parvalbumine (pre-embedding immunochemistrywithbiotinilatedantibody).Sample courtesy of Dr. Graham Knott, DBCM, University of Lausanne. 3ViewisaproductbasedonworkperformedbyWDenk and H Horstmann, Max-Planck Institute for Medical Research, Heidelberg, Germany. Plos Biology, 2004.2(11):p. 1900-1909.36NOTES37SCIENTIFIC PROGRAM (WEDNESDAY & THURSDAY)ScientificP ScientificP ScientificP ScientificP ScientificProgram rogram rogram rogram rogramW WW WWednesday ednesday ednesday ednesday ednesday,March25,2009 ,March25,2009 ,March25,2009 ,March25,2009 ,March25,200914:00-19:00 Satellite Workshop I, Hall 9Ani mal model sofneuropsychi a- Ani mal model sofneuropsychi a- Ani mal model sofneuropsychi a- Ani mal model sofneuropsychi a- Ani mal model sofneuropsychi a-tri cdi sorders-Thetransl ati onal tri cdi sorders-Thetransl ati onal tri cdi sorders-Thetransl ati onal tri cdi sorders-Thetransl ati onal tri cdi sorders-Thetransl ati onalval ueofbehavi oral tests val ueofbehavi oral tests val ueofbehavi oral tests val ueofbehavi oral tests val ueofbehavi oral testsChair: Michael Koch and EberhardFuchs, Bremen and Gttingen14:00-18:30 Satellite Symposium II , Hall 11SchramFoundati onSymposi um SchramFoundati onSymposi um SchramFoundati onSymposi um SchramFoundati onSymposi um SchramFoundati onSymposi umF F F F Fromneurontocircuit romneurontocircuit romneurontocircuit romneurontocircuit romneurontocircuit Chair: Hermann Rohrer, Frankfurt/M.Thursday Thursday Thursday Thursday Thursday,March26,2009 ,March26,2009 ,March26,2009 ,March26,2009 ,March26,20099:00 - 12:00 SymposiaI(S1-S6) SymposiaI(S1-S6) SymposiaI(S1-S6) SymposiaI(S1-S6) SymposiaI(S1-S6)9:00 - 12:00 Symposium 1, Hall 10Theclinicalimportanceof Theclinicalimportanceof Theclinicalimportanceof Theclinicalimportanceof Theclinicalimportanceofspreadi ngdepressi oni nmi grai ne spreadi ngdepressi oni nmi grai ne spreadi ngdepressi oni nmi grai ne spreadi ngdepressi oni nmi grai ne spreadi ngdepressi oni nmi grai neandacuteneuronalinjury andacuteneuronalinjury andacuteneuronalinjury andacuteneuronalinjury andacuteneuronalinjuryChair: Jens Dreier and Rudolf Graf,Berlin and Kln9:00 - 12:00 Symposium 2, Hall 105Neural computati onbyreti nal Neural computati onbyreti nal Neural computati onbyreti nal Neural computati onbyreti nal Neural computati onbyreti nalci r cui t s ci r cui t s ci r cui t s ci r cui t s ci r cui t sChair: Tim Gollisch and Gnter Zeck,Martinsried9:00 - 12:00 Symposium 3, Hall 104Microglia:thebigplayerin Microglia:thebigplayerin Microglia:thebigplayerin Microglia:thebigplayerin Microglia:thebigplayerinpat hol ogy pat hol ogy pat hol ogy pat hol ogy pat hol ogyChair: Helmut Kettenmann and KnutBiber, Berlin and Groningen(Netherlands)9:00 - 12:00 Symposium 4, Hall 9Unravelingthemechanismsof Unravelingthemechanismsof Unravelingthemechanismsof Unravelingthemechanismsof Unravelingthemechanismsofdopami nedysfuncti onsi nneuro- dopami nedysfuncti onsi nneuro- dopami nedysfuncti onsi nneuro- dopami nedysfuncti onsi nneuro- dopami nedysfuncti onsi nneuro-psychi at ri cdi sorders:f romworm psychi at ri cdi sorders:f romworm psychi at ri cdi sorders:f romworm psychi at ri cdi sorders:f romworm psychi at ri cdi sorders:f romwormt o(wo)men t o(wo)men t o(wo)men t o(wo)men t o(wo)menChair: Anna Katharina Braun andRichard Nass, Madgeburg and Indiana-polis(USA)Scientific Programcientific Programcientific Programcientific Programcientific Program38SCIENTIFIC PROGRAM (THURSDAY)Scientific Programcientific Programcientific Programcientific Programcientific Program9:00 - 12:00 Symposium 5, Hall 8Drosophi l asenses:genet i cdi s- Drosophi l asenses:genet i cdi s- Drosophi l asenses:genet i cdi s- Drosophi l asenses:genet i cdi s- Drosophi l asenses:genet i cdi s-sectionofneuralcircuitryand sectionofneuralcircuitryand sectionofneuralcircuitryand sectionofneuralcircuitryand sectionofneuralcircuitryandpr ocessi ng pr ocessi ng pr ocessi ng pr ocessi ng pr ocessi ngChair: Andr Fiala and MartinGpfert, Wrzburg and Kln9:00 - 12:00 Symposium 6, Hall 103Generat i onof cel l ul ardi versi t y Generat i onof cel l ul ardi versi t y Generat i onof cel l ul ardi versi t y Generat i onof cel l ul ardi versi t y Generat i onof cel l ul ardi versi t yintheforebrain intheforebrain intheforebrain intheforebrain intheforebrainChair: Victor Tarabykin andAlexandervon Holst, Gttingen and Bochum12:00-13:00 LunchBreak LunchBreak LunchBreak LunchBreak LunchBreak12:45-14:45 P PP PPost erSessi onI :P ost erSessi onI :P ost erSessi onI :P ost erSessi onI :P ost erSessi onI :Post ersA ost ersA ost ersA ost ersA ost ersA 12:45 - 13:45 Odd serial numbers 13:45 - 14:45 Even serial numbers14:45-15:00 OpeningCeremony OpeningCeremony OpeningCeremony OpeningCeremony OpeningCeremony,Hal l 11 ,Hal l 11 ,Hal l 11 ,Hal l 11 ,Hal l 1115:00-16:00 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11(Openi ngLect ure) (Openi ngLect ure) (Openi ngLect ure) (Openi ngLect ure) (Openi ngLect ure)Chair: Mathias Bhr, GttingenPeter Jonas, FreiburgMechanismsoffastsignalingin Mechanismsoffastsignalingin Mechanismsoffastsignalingin Mechanismsoffastsignalingin MechanismsoffastsignalinginGABAergi ci nt erneurons GABAergi ci nt erneurons GABAergi ci nt erneurons GABAergi ci nt erneurons GABAergi ci nt erneurons16:00-18:00 P PP PPost erSessi onI I :P ost erSessi onI I :P ost erSessi onI I :P ost erSessi onI I :P ost erSessi onI I :Post ersA ost ersA ost ersA ost ersA ost ersA 16:00 - 17:00 Odd serial numbers 17:00 - 18:00 Even serial numbers18:00-19:00 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11(K (K (K (K (K.J .J .J .J .J.ZlchL .ZlchL .ZlchL .ZlchL .ZlchLecture) ecture) ecture) ecture) ecture)Chair: Herbert Jckle, GttingenChristian Elger, BonnEpilepsyanditsmodels: Epilepsyanditsmodels: Epilepsyanditsmodels: Epilepsyanditsmodels: Epilepsyanditsmodels:progressorwrongtrack? progressorwrongtrack? progressorwrongtrack? progressorwrongtrack? progressorwrongtrack?19:00-20:00 ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer20:00-21:00 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11Chair: Niels Birbaumer, TbingenNikos Logothetis, TbingenEl ect ri cal mi crost i mul at i onand El ect ri cal mi crost i mul at i onand El ect ri cal mi crost i mul at i onand El ect ri cal mi crost i mul at i onand El ect ri cal mi crost i mul at i onandf MRI f MRI f MRI f MRI f MRI395 Minutes a Week.Convenience and flexibility you can count on.On the spot reconstitution of Betaferoneveryother day will take less than 5 minutes of yourpatients time per week. Starting treatment with Betaferonafter aClinically Isolated Syndrome (CIS) will give them an additional period of up to 363 days without progression to clinical definite MS (CDMS) asshown in the BENEFIT Study*.* Kappos et al. Neurology 2006; 67:12421249.Only CIS patients at high risk of developingCDMS meet the indication of Betaferon.www.ms-gateway.comEU.ST.BETAFE.06.2008.000640BetaferonComposition:Recombinantinterferonb-1b250g(8.0MIU)permlwhenreconstituted.Betaferoncontains300g(9.6millionIU)ofrecombinantIFNB-1bpervial.Indications:Betaferonisindicatedforthetreatmentofpatientswithasingledemyelinating event with an active inflammatory process, if it is severe enough to warranttreatment with intravenous corticosteroids, if alternative diagnoses have been excluded,and if they are determined to be at high risk of developing clinically definite MS. Patientswithrelapsing-remittingMSandtwoormorerelapseswithinthelasttwoyears,patientswithsecondaryprogressiveMSwithactivedisease,evidencedbyrelapses.Contraindications: Initiation of treatment in pregnancy. Patients with a history of hyper-sensitivity to natural or recombinant interferon b, human albumin or to any excipients.Patientswithcurrentseveredepressionand/orsuicidalideation.Patientswithdecom-pensatedliverdisease.Precautions:Theadministrationofcytokinestopatientswithapre-existingmonoclonalgammopathyhasbeenassociatedwiththedevelopmentofsystemiccapillaryleaksyndromewithshock-likesymptomsandfataloutcome.Inrarecases,pancreatitiswasobservedwithBetaferonuse,oftenassociatedwithhyper-triglyceridaemia. Betaferonshould be administered with caution to patients with previousorcurrentdepressivedisorders,inparticulartothosewithantecedentsofsuicidalideation. Depression and suicidal ideation are known to occur in increased frequency intheMSpopulationandinassociationwithinterferonuse.PatientstreatedwithBetaferonshould be advised to immediately report any symptoms of depression and/orsuicidal ideation to their prescribing physician. Patients exhibiting depression should bemonitored closely during therapy with Betaferonand treated appropriately. CessationoftherapywithBetaferonshouldbeconsidered.Betaferonshouldbeadministeredwithcautiontopatientswithahistoryofseizures,tothosereceivingtreatmentwithanti-epileptics, particularly if their epilepsy is not adequately controlled with anti-epileptics.Thyroid function tests are recommended regularly in patients with a history of thyroiddysfunctionorasclinicallyindicated.Inadditiontothoselaboratorytestsnormallyrequired for monitoring patients with MS. Complete blood and differential white bloodcell counts, platelet counts, and blood chemistries, including liver function tests (e.g. AST(SGOT), ALT (SGPT) and g-GT), are recommended prior to initiation and at regular intervalsfollowingintroductionofBetaferontherapy,andthenperiodicallythereafterintheabsence of clinical symptoms. As for other beta interferons, severe hepatic injury, includ-ing cases of hepatic failure, has been reported rarely in patients taking Betaferon. Themostseriouseventsoftenoccurredinpatientsexposedtootherdrugsorsubstancesknown to be associated with hepatotoxicity or in the presence of co-morbid medical con-ditions (e.g. metastasising malignant disease, severe infection and sepsis, alcohol abuse).Patientsshouldbemonitoredforsignsofhepaticinjury.WithdrawalofBetaferonshould be considered if the levels of serum transaminases significantly increase or if theyare associated with clinical symptoms such as jaundice. In the absence of clinical evidenceforliverdamageandafternormalisationofliverenzymesareintroductionoftherapycould be considered with appropriate follow-up of hepatic functions. Caution should beused and close monitoring considered when administering interferon b to patients withsevere renal failure. It should also be used with caution in patients who suffer from pre-existingcardiacdisorders.Patientswithpre-existingsignificantcardiacdisease,suchascongestive heart failure, coronary artery disease or arrhythmia, should be monitored forworseningoftheircardiaccondition,particularlyduringinitiationoftreatmentwithBetaferon. Rare cases of cardiomyopathy have been reported: If this occurs and a relation-ship to Betaferonis suspected, treatment should be discontinued. Serious hypersensitivityreactionsmayoccur.Ifreactionsaresevere,Betaferonshouldbediscontinuedandappropriate medical intervention instituted. Injection site necrosis has been reported inpatientsusingBetaferon.Itcanbeextensiveandmayresultinscarformation.Ifthepatientexperiencesanybreakintheskin,whichmaybeassociatedwithswellingordrainage of fluid from the injection site, the patient should be advised to consult withhis/her physician before continuing injections with Betaferon. If the patient has multiplelesions Betaferonshould be discontinued until healing has occurred. Patients with singlelesions may continue on Betaferonprovided the necrosis is not too extensive, as somepatientshaveexperiencedhealingofinjectionsitenecrosiswhilstonBetaferon.Neutralising activity was observed in patients in the different clinical trials. Between 23%and 41% of the patients developed serum interferon b-1b neutralising activity; between43%and55%ofthesepatientsconvertedtoastableantibodynegativestatusduringthesubsequentobservationalperiodoftherespectivestudy.Thedevelopmentofneutralising activity is associated with a reduction in clinical efficacy only with regard torelapse activity. The decision to continue or discontinue treatment should be based onclinicaldiseaseactivityratherthanonneutralisingactivitystatus.Sideeffects:Atthebeginning of treatment adverse reactions are common but in general they subside withfurthertreatment.Themostfrequentlyobservedadversereactionsareaflu-likesymptom complex and injection site reactions, which are mainly due to the pharmaco-logical effects of the medicinal product. Injection site reactions occurred frequently afteradministration of Betaferon. The following side effect listing is based on reports frompostmarketingsurveillance:Verycommon:Flu-likesymptoms,chills,fever,injectionsitereaction,injectionsiteinflammation,injectionsitepain;common:Injectionsitenecrosis, uncommon: anemia, thrombozytopenia, leukopenia, depression, hypertension,vomiting,nausea,alaninaminotransferaseincreased,aspartateaminotransferaseincreased, urticaria, rash, pruritus, alopecia, myalgia, hypertonia; rare: skin discolouration,menstrualdisorder,chestpain,malaise,sweating,weightdecrease.MarketingAuthorisationHolderandNumbers:BayerScheringPharmaAG(formerlyknownasScheringAG),D-13342Berlin,Germany,EU/1/95/003/003,-004,-005,-006PreparationDate: 06/06, Please refer to the Summary of Product Characteristics for further information.41F FF FFriday riday riday riday riday,March27,2009 ,March27,2009 ,March27,2009 ,March27,2009 ,March27,2009 9:00 - 12:00 SymposiaII(S7-S12) SymposiaII(S7-S12) SymposiaII(S7-S12) SymposiaII(S7-S12) SymposiaII(S7-S12)9:00 - 12:00 Symposium 7, Hall 105Spi nal cordi nj uryresearch: Spi nal cordi nj uryresearch: Spi nal cordi nj uryresearch: Spi nal cordi nj uryresearch: Spi nal cordi nj uryresearch:F FF FFrombenchtobedside rombenchtobedside rombenchtobedside rombenchtobedside rombenchtobedsideChair: Karim Fouad, Alberta (Canada)9:00 - 12:00 Symposium 8, Hall 9Thefine-scalestructureofthe Thefine-scalestructureofthe Thefine-scalestructureofthe Thefine-scalestructureofthe Thefine-scalestructureofthecort i cal net work:I mpl i cat i ons cort i cal net work:I mpl i cat i ons cort i cal net work:I mpl i cat i ons cort i cal net work:I mpl i cat i ons cort i cal net work:I mpl i cat i onsforitsdynamicsandfunction foritsdynamicsandfunction foritsdynamicsandfunction foritsdynamicsandfunction foritsdynamicsandfunctionChair: Tom Tetzlaff and Birgit Kriener,As (Norway) and Freiburg9:00 - 12:00 Symposium 9, Hall 10Neuropl ast i ci t yandneuropro- Neuropl ast i ci t yandneuropro- Neuropl ast i ci t yandneuropro- Neuropl ast i ci t yandneuropro- Neuropl ast i ci t yandneuropro-t ect i oni nneurodegenerat i ve t ect i oni nneurodegenerat i ve t ect i oni nneurodegenerat i ve t ect i oni nneurodegenerat i ve t ect i oni nneurodegenerat i vedi sease:model sand di sease:model sand di sease:model sand di sease:model sand di sease:model sandmechani sms mechani sms mechani sms mechani sms mechani smsChair: Markus Morawsk and MussaYoudim, Leipzig and Haifa (Israel)9:00 - 12:00 Symposium 10, Hall 8Stressandcogni ti on:F Stressandcogni ti on:F Stressandcogni ti on:F Stressandcogni ti on:F Stressandcogni ti on:From rom rom rom romst ruct uret ofunct i on st ruct uret ofunct i on st ruct uret ofunct i on st ruct uret ofunct i on st ruct uret ofunct i onChair: Mathias Schmidt and MichaelGru, Mnchen and Mgdeburg9:00 - 12:00 Symposium 11, Hall 104Thearthropodcentral compl ex: Thearthropodcentral compl ex: Thearthropodcentral compl ex: Thearthropodcentral compl ex: Thearthropodcentral compl ex:evol ut i onary evol ut i onary evol ut i onary evol ut i onary evol ut i onary,devel opment al , ,devel opment al , ,devel opment al , ,devel opment al , ,devel opment al ,geneticandfunctionalaspects geneticandfunctionalaspects geneticandfunctionalaspects geneticandfunctionalaspects geneticandfunctionalaspectsChair: George Boyan, Martinsried9:00 - 12:00 Symposium 12, Hall 103Caughtinthenet?-Extracellu- Caughtinthenet?-Extracellu- Caughtinthenet?-Extracellu- Caughtinthenet?-Extracellu- Caughtinthenet?-Extracellu-larmatrixmoleculesinsynapse larmatrixmoleculesinsynapse larmatrixmoleculesinsynapse larmatrixmoleculesinsynapse larmatrixmoleculesinsynapseformati onandpl asti ci ty formati onandpl asti ci ty formati onandpl asti ci ty formati onandpl asti ci ty formati onandpl asti ci tyChair: Constanze Seidenbecher andAndreas Faissner, Magdeburg andBochum12:00-13:00 LunchBreak LunchBreak LunchBreak LunchBreak LunchBreak12:00-13:00 DFG DFG DFG DFG DFG- -- --Seminar Seminar Seminar Seminar Seminar,,,,,Hall102Jan Kunze, DFGStartingyourresearchcareer- Startingyourresearchcareer- Startingyourresearchcareer- Startingyourresearchcareer- Startingyourresearchcareer-DFGfundingprogrammesand DFGfundingprogrammesand DFGfundingprogrammesand DFGfundingprogrammesand DFGfundingprogrammesandappl i cati onprocedures appl i cati onprocedures appl i cati onprocedures appl i cati onprocedures appl i cati onproceduresScientific Programcientific Programcientific Programcientific Programcientific ProgramSCIENTIFIC PROGRAM (FRIDAY)42SCIENTIFIC PROGRAM (FRIDAY AND SATURDAY)Scientific Programcientific Programcientific Programcientific Programcientific Program13:00-15:00 P PP PPosterSessi onIII:P osterSessi onIII:P osterSessi onIII:P osterSessi onIII:P osterSessi onIII:PostersB ostersB ostersB ostersB ostersB13:00 - 14:00 Odd serial numbers14:00 - 15:00 Even serial numbers15:00-16:00 AwardingandLectures,Hall11 AwardingandLectures,Hall11 AwardingandLectures,Hall11 AwardingandLectures,Hall11 AwardingandLectures,Hall11(Schilling Research Award Lecture)Chair: Andr Fischer, GttingenLawrence Rajendran, DresdenCel l ul armechani smsunderl yi ng Cel l ul armechani smsunderl yi ng Cel l ul armechani smsunderl yi ng Cel l ul armechani smsunderl yi ng Cel l ul armechani smsunderl yi ng-amyl oi dgenerati onandi ts -amyl oi dgenerati onandi ts -amyl oi dgenerati onandi ts -amyl oi dgenerati onandi ts -amyl oi dgenerati onandi tsi mpl i cat i onsf orAl zhei mer i mpl i cat i onsf orAl zhei mer i mpl i cat i onsf orAl zhei mer i mpl i cat i onsf orAl zhei mer i mpl i cat i onsf orAl zhei mer s s s s sdi sease di sease di sease di sease di sease(Agilent Technologies Prize Lecture)Chair: Michael Frotscher, FreiburgStefan Klppel, FreibugMRI-baseddi agnosi sofneuro- MRI-baseddi agnosi sofneuro- MRI-baseddi agnosi sofneuro- MRI-baseddi agnosi sofneuro- MRI-baseddi agnosi sofneuro-degenerati onusi ngsupport degenerati onusi ngsupport degenerati onusi ngsupport degenerati onusi ngsupport degenerati onusi ngsupportvect ormachi nes vect ormachi nes vect ormachi nes vect ormachi nes vect ormachi nes16:00-18:00 P PP PPosterSessi onIV osterSessi onIV osterSessi onIV osterSessi onIV osterSessi onIV:P :P :P :P :PostersB ostersB ostersB ostersB ostersB16:00 - 17:00 Odd serial numbers17:00 - 18:00 Even serial numbers18:00-19:00 ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer19:00-20:00 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11(RogerEckertLecture) (RogerEckertLecture) (RogerEckertLecture) (RogerEckertLecture) (RogerEckertLecture)Chair: Erwin Neher, GttingenPeter Fromherz, MunichSemi conductorchi psforneuro- Semi conductorchi psforneuro- Semi conductorchi psforneuro- Semi conductorchi psforneuro- Semi conductorchi psforneuro-physi ol ogy physi ol ogy physi ol ogy physi ol ogy physi ol ogySaturday Saturday Saturday Saturday Saturday,March28,2009 ,March28,2009 ,March28,2009 ,March28,2009 ,March28,20099:00 - 12:00 SymposiaIII(S13-S18) SymposiaIII(S13-S18) SymposiaIII(S13-S18) SymposiaIII(S13-S18) SymposiaIII(S13-S18) 9:00 - 12:00 Symposium13,Hall105Ani mal model sofpsychi atri c Ani mal model sofpsychi atri c Ani mal model sofpsychi atri c Ani mal model sofpsychi atri c Ani mal model sofpsychi atri ci l l nesses:fromri skgenestothe i l l nesses:fromri skgenestothe i l l nesses:fromri skgenestothe i l l nesses:fromri skgenestothe i l l nesses:fromri skgenestothepat hophysi ol ogi cal mechani sms pat hophysi ol ogi cal mechani sms pat hophysi ol ogi cal mechani sms pat hophysi ol ogi cal mechani sms pat hophysi ol ogi cal mechani smsChair: Peter Falkai, Gttingen 9:00 - 12:00 Symposium 14, Hall 8Cel l ul armechani smsofcorti cal Cel l ul armechani smsofcorti cal Cel l ul armechani smsofcorti cal Cel l ul armechani smsofcorti cal Cel l ul armechani smsofcorti calnet workosci l l at i ons net workosci l l at i ons net workosci l l at i ons net workosci l l at i ons net workosci l l at i onsChair: Tengis Gloveli, Berlin43Scientific Programcientific Programcientific Programcientific Programcientific Program44SCIENTIFIC PROGRAM (SATURDAY)) 9:00 - 12:00 Symposium 15, Hall 10Mechanicsinthenervous Mechanicsinthenervous Mechanicsinthenervous Mechanicsinthenervous Mechanicsinthenervoussyst em syst em syst em syst em syst emChair: Jochen Guck, Andreas Reichen-bach, and Dennis Bray, Cambridge (UK)and Leipzig 9:00 - 12:00 Symposium 16, Hall 9Mul t i cel l ul arrepresent at i onsof Mul t i cel l ul arrepresent at i onsof Mul t i cel l ul arrepresent at i onsof Mul t i cel l ul arrepresent at i onsof Mul t i cel l ul arrepresent at i onsofspati o-temporal percepti onand spati o-temporal percepti onand spati o-temporal percepti onand spati o-temporal percepti onand spati o-temporal percepti onandbehavi or behavi or behavi or behavi or behavi orChair: Christian Leibold andMartinPaul Nawrot, Martinsried and Berlin 9:00 - 12:00 Symposium 17, Hall 104Evol uti onofpepti desi gnal l i ng Evol uti onofpepti desi gnal l i ng Evol uti onofpepti desi gnal l i ng Evol uti onofpepti desi gnal l i ng Evol uti onofpepti desi gnal l i ngi nthenervoussystem i nthenervoussystem i nthenervoussystem i nthenervoussystem i nthenervoussystemChair: Christian Wegener andJoachimSchachtner, Marburg 9:00 - 12:00 Symposium 18, Hall 103Autophagiccelldeath:identi- Autophagiccelldeath:identi- Autophagiccelldeath:identi- Autophagiccelldeath:identi- Autophagiccelldeath:identi-fication,pathways,androlesin fication,pathways,androlesin fication,pathways,androlesin fication,pathways,androlesin fication,pathways,androlesinneuraldevelopmentanddisease neuraldevelopmentanddisease neuraldevelopmentanddisease neuraldevelopmentanddisease neuraldevelopmentanddiseaseChair: Paul Saftig, Andreas Schoberand Klaus Unsicker, Kiel andHeidelberg12:00-13:00 Annual General Assembl yofthe Annual General Assembl yofthe Annual General Assembl yofthe Annual General Assembl yofthe Annual General Assembl yoftheNeurowi ssenschaft l i cheGesel l - Neurowi ssenschaft l i cheGesel l - Neurowi ssenschaft l i cheGesel l - Neurowi ssenschaft l i cheGesel l - Neurowi ssenschaft l i cheGesel l -schaft(NWG),schaft(NWG),schaft(NWG),schaft(NWG),schaft(NWG),Hall11Guest: Jan Kunze (DFG)Fundingopportunities-DFG Fundingopportunities-DFG Fundingopportunities-DFG Fundingopportunities-DFG Fundingopportunities-DFGfactsandfigures factsandfigures factsandfigures factsandfigures factsandfigures13:00-15:00 P PP PPost erSessi onV ost erSessi onV ost erSessi onV ost erSessi onV ost erSessi onV:P :P :P :P :Post ersC ost ersC ost ersC ost ersC ost ersC 13:00 - 14:00 Odd serial numbers 14:00 - 15:00 Even serial numbers15:00-16:00 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11(Ernst Fl oreyLect ure) (Ernst Fl oreyLect ure) (Ernst Fl oreyLect ure) (Ernst Fl oreyLect ure) (Ernst Fl oreyLect ure)Chair: Eckart Gundelfinger, MagdeburgMartin Heisenberg, WrzburgThefly Thefly Thefly Thefly Thefly sselfandit sselfandit sselfandit sselfandit sselfandit sbrain sbrain sbrain sbrain sbrain16:00-18:00 P PP PPost erSessi onVI :P ost erSessi onVI :P ost erSessi onVI :P ost erSessi onVI :P ost erSessi onVI :Post ersC ost ersC ost ersC ost ersC ost ersC 16:00 - 17:00 Odd serial numbers 17:00 - 18:00 Even serial numbers18:0019:00 ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyer ColdBuffetintheFoyerScientific Programcientific Programcientific Programcientific Programcientific Program45Scientific Programcientific Programcientific Programcientific Programcientific Program19:00-20:00 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11(Ot t oCreut zf el dt Lect ure) (Ot t oCreut zf el dt Lect ure) (Ot t oCreut zf el dt Lect ure) (Ot t oCreut zf el dt Lect ure) (Ot t oCreut zf el dt Lect ure)Chair: Klaus-Peter Hoffmann, BochumAtsushi Iriki, Saitama (Japan)Neurosci enceofpri mat e Neurosci enceofpri mat e Neurosci enceofpri mat e Neurosci enceofpri mat e Neurosci enceofpri mat ei nt el l ect ual evol ut i on i nt el l ect ual evol ut i on i nt el l ect ual evol ut i on i nt el l ect ual evol ut i on i nt el l ect ual evol ut i onSunday Sunday Sunday Sunday Sunday,March29,2009 ,March29,2009 ,March29,2009 ,March29,2009 ,March29,20099:00 - 12:00 SymposiaIV(S19-S24) SymposiaIV(S19-S24) SymposiaIV(S19-S24) SymposiaIV(S19-S24) SymposiaIV(S19-S24)9:00 - 12:00 Symposium 19, Hall 8Newi nsi ght si nt oAl zhei mer Newi nsi ght si nt oAl zhei mer Newi nsi ght si nt oAl zhei mer Newi nsi ght si nt oAl zhei mer Newi nsi ght si nt oAl zhei mer s s s s sdi sease:model i ngneurodege- di sease:model i ngneurodege- di sease:model i ngneurodege- di sease:model i ngneurodege- di sease:model i ngneurodege-nerationcausesandconse- nerationcausesandconse- nerationcausesandconse- nerationcausesandconse- nerationcausesandconse-quences quences quences quences quencesChair: Thomas Bayer and OliverWirths,Gttingen9:00 - 12:00 Symposium 20, Hall 105NetworksonChips-Spatial NetworksonChips-Spatial NetworksonChips-Spatial NetworksonChips-Spatial NetworksonChips-Spatialandtemporalactivitydynamics andtemporalactivitydynamics andtemporalactivitydynamics andtemporalactivitydynamics andtemporalactivitydynamicsoffunct i onal net works offunct i onal net works offunct i onal net works offunct i onal net works offunct i onal net worksChair: Ulrich Egert and HerrmannWagner, Freiburg and Aachen9:00 - 12:00 Symposium 21, Hall 104Plasticityandfunctionofamyg- Plasticityandfunctionofamyg- Plasticityandfunctionofamyg- Plasticityandfunctionofamyg- Plasticityandfunctionofamyg-dalaandfear-circuitry:molecu- dalaandfear-circuitry:molecu- dalaandfear-circuitry:molecu- dalaandfear-circuitry:molecu- dalaandfear-circuitry:molecu-lar lar lar lar lar,cellularandbehavioral ,cellularandbehavioral ,cellularandbehavioral ,cellularandbehavioral ,cellularandbehavioralmechani sms mechani sms mechani sms mechani sms mechani smsChair: Ingrid Ehrlich and ThomasSeidenbecher, Basel (Switzerland) andMnster9:00 - 12:00 Symposium 22, Hall 10Goal -di rectedbehavi orThe Goal -di rectedbehavi orThe Goal -di rectedbehavi orThe Goal -di rectedbehavi orThe Goal -di rectedbehavi orTheneuralbasisofplanningand neuralbasisofplanningand neuralbasisofplanningand neuralbasisofplanningand neuralbasisofplanningandchoi ce choi ce choi ce choi ce choi ceChair: Alexander Gail and HansScherberger, Gttingen and Zrich(Switzerland) 9:00 - 12:00 Symposium 23, Hall 103Rest ori ngret i nal vi si on Rest ori ngret i nal vi si on Rest ori ngret i nal vi si on Rest ori ngret i nal vi si on Rest ori ngret i nal vi si onChair: Reto Weiler and Botond Roska,Oldenburg and Basel (Switzerland) 9:00 - 12:00 Symposium 24, Hall 9Mol ecul aranal ysi sofaxonal Mol ecul aranal ysi sofaxonal Mol ecul aranal ysi sofaxonal Mol ecul aranal ysi sofaxonal Mol ecul aranal ysi sofaxonaland and and and and dendri ti cbranchi ng dendri ti cbranchi ng dendri ti cbranchi ng dendri ti cbranchi ng dendri ti cbranchi ngChair: Fritz Rathjen and HannesSchmid, BerlinSCIENTIFIC PROGRAM (SATURDAY AND SUNDAY)46SCIENTIFIC PROGRAM (SUNDAY)Scientific Programcientific Programcientific Programcientific Programcientific Program12:00-13:00 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11 PlenaryLecture,Hall11Chair: S. Korsching, BonnPeter Mombaerts, Frankfurt/M.Ol facti ontargeted Ol facti ontargeted Ol facti ontargeted Ol facti ontargeted Ol facti ontargeted13:00 Depart ure Depart ure Depart ure Depart ure Depart ure47Scientific Programcientific Programcientific Programcientific Programcientific ProgramNOTES48Neurowissenschaftliche Neurowissenschaftliche Neurowissenschaftliche Neurowissenschaftliche NeurowissenschaftlicheGesellschafte.V Gesellschafte.V Gesellschafte.V Gesellschafte.V Gesellschafte.V. .. ..Zi el e Zi el e Zi el e Zi el e Zi el eDie Neurowissenschaftliche Gesellschaft e.V. hat sich zum Ziel gesetzt, die Neuro-wissenschaften in Forschung und Lehre zu frdern und in allen ihren Teilbereichenim In- und Ausland zu reprsentieren. Sie versucht, forschungspolitische Schwer-punktemit neurowissenschaftlicher Thematik zu setzen und neue Konzepte anzure-gen. Sie steht in Kontakt mit innerdeutschen Frdereinrichtungen und privatenStiftungenunduntersttztdieneurowissenschaftlicheAusrichtungderFrderprogramme der Europischen Union. Sie frdert die Kontakte zur Industrie.Sie tritt fr die Etablierung eines interdisziplinren neurowissenschaftlichen Aus-bildungskonzepts ein. Bei all dem verfolgt sie ausschlielich gemeinntzige Zwecke.Neur of or um Neur of or um Neur of or um Neur of or um Neur of or umDie Zeitschrift Neuroforum erscheint vierteljhrlich. Die Mitglieder erhalten siekostenlos. Neuroforum informiert ber Themen, Trends, Fortschritte, neue Metho-den, Forschungsschwerpunkte, Frdermglichkeiten, Stellenangebote und Aus-schreibungen.Met hodenkurse Met hodenkurse Met hodenkurse Met hodenkurse Met hodenkurseMehrmals jhrlich werden insbesondere fr Studenten, Doktoranden und jungeWissenschaftler Methodenkurse angeboten.Rund-Mai l sundSt el l enmarkt Rund-Mai l sundSt el l enmarkt Rund-Mai l sundSt el l enmarkt Rund-Mai l sundSt el l enmarkt Rund-Mai l sundSt el l enmarktEinmal monatlich werden an alle Mitglieder mit E-Mail-Zugang Rund-E-Mails mitInformationen zu Drittmitteln, Stipendien, Stellenanzeigen u.a. verschickt.Homepage Homepage Homepage Homepage HomepageDie Homepage informiert ber Kongresse, bietet Links zu Institutionen, Frderein-richtungen, neurowissenschaftlichen Zeitschriften, informiert ber Bezugsquellenund Produkte und die Aktivitten der Gesellschaft (http://nwg.glia.mdc-berlin.de).Kongresse Kongresse Kongresse Kongresse KongresseMit der Veranstaltung und Frderung der Gttinger Jahrestagung sowie mit derBeteiligung am FENS Forum verfolgt die Gesellschaft ihr interdisziplinres Konzeptweiter. Neurowissenschaftler aller Fachrichtungen aus Forschung und Industriesind zu einem lebendigen und fruchtbaren Meinungsaustausch aufgefordert.St i pendi en St i pendi en St i pendi en St i pendi en St i pendi enDie Gesellschaft stellt Stipendien fr Studenten, Doktoranden und junge Wissen-schaftler fr die Teilnahme an der eigenen Tagung wie auch fr das FENS Forumzur Verfgung.Frderprei se Frderprei se Frderprei se Frderprei se Frderprei seDieGesellschaftvergibtzweijhrlichdenmit2.500EurodotiertenAgilentTechnologies-Preis sowie den mit 20.000 Euro dotierten Schilling-Forschungspreis.Frei erZugangzuEJNonl i ne Frei erZugangzuEJNonl i ne Frei erZugangzuEJNonl i ne Frei erZugangzuEJNonl i ne Frei erZugangzuEJNonl i neDie Mitglieder der Gesellschaft haben kostenlosen Zugang zur Online-Version desEuropean Journal of Neuroscience.Lehr er f or t bi l dung Lehr er f or t bi l dung Lehr er f or t bi l dung Lehr er f or t bi l dung Lehr er f or t bi l dungBundesweit werden mit finanzieller Untersttzung der Hertie-Stiftung Fortbildungs-veranstaltungen fr Lehrer der gymnasialen Oberstufe zu neurowissenschaftlichenThemen angeboten.Sl ot sfrdasSFN-Meet i ng Sl ot sfrdasSFN-Meet i ng Sl ot sfrdasSFN-Meet i ng Sl ot sfrdasSFN-Meet i ng Sl ot sfrdasSFN-Meet i ngber die Mitgliedschaft in FENS erhalten die Mitglieder der NWG jedes Jahr frdas Meeting der amerikanischen Society fr Neuroscience sog. society sponsoredabstract slots. NWG-Mitglieder mit einem solchen Slot zahlen dieselbe reduzierteTeilnahmegebhr beim SfN-Meeting wie SfN-Mitglieder.DieNeurowissenschaftlicheGesellschafte.V DieNeurowissenschaftlicheGesellschafte.V DieNeurowissenschaftlicheGesellschafte.V DieNeurowissenschaftlicheGesellschafte.V DieNeurowissenschaftlicheGesellschafte.V. .. ..vertrittdeutscheNeuro-wissenschaftler in der IBRO, ist Grndungsmitglied der Federation of EuropeanNeuroscience Societies (FENS) und vertritt die nationalen Interessen in der FENS.Sie ist kooperatives Mitglied des Verbandes Deutscher Biologen (vdbiol). Die Deut-sche Gesellschaft fr Neurologie ist frderndes Mitglied der NeurowissenschaftlichenGesellschaft.Mi t gl i edschaf t Mi t gl i edschaf t Mi t gl i edschaf t Mi t gl i edschaf t Mi t gl i edschaf tMitglied der Gesellschaft kann werden, wer auf einem Gebiet der Neurowissenschaftenoder in verwandten Fchern ttig ist. Das Aufnahmegesuch ist mit der Befrwor-tung von zwei Mitgliedern der Gesellschaft an die Geschftsstelle zu richten, berdie Aufnahme entscheidet der Vorstand. Der Mitgliedsbeitrag fr Studenten betrgt25 Euro, fr Vollmitglieder 50 Euro pro Jahr.NEUROWISSENSCHAFTLICHE GESELLSCHAFT E.V.49http://nwg.glia.mdc-berlin.deVorstandderAmtsperiode2007-2009Prsident:Vizeprsident:Schatzmeister:Generalsekretr:MathiasB hrSigrunKorschingAndreasDraguhnUlrichDirnaglSektionssprecherComputationalNeuroscience:Entwicklung/Neurogenetik:KlinischeNeurowissen-Schaften:MolekulareNeurobiologie:Neuropharmakologie/-toxikologie:Systemneurobiologie:ZellulreNeurobiologie:KognitiveNeurowissen-schaften:Verhaltensneurowissen-schaften:AdAertsenMichaelFrotscherHans-PeterHartungEckartGundelfingerRainerSchwartingUlfEyselHannsHattNielsBirbaumerUweHombergGeschftsstelleNeurowissenschaftlicheGesellschafte.V.Max-Delbrck-CentrumfrMolekulareMedizin(MDC)BerlinBuchRobert-Rssle-Str.1013092BerlinTel.:03094063336Fax:03094063819Gibson@mdc-berlin.deAbbildung:Dr.WernerZuschratter,Magdeburg50PlenaryLectures PlenaryLectures PlenaryLectures PlenaryLectures PlenaryLecturesPLENARY LECTURESP PP PPeterJonas,eterJonas,eterJonas,eterJonas,eterJonas,Freiburg(OpeningLecture)MechanismsoffastsignalinginGABAergic MechanismsoffastsignalinginGABAergic MechanismsoffastsignalinginGABAergic MechanismsoffastsignalinginGABAergic MechanismsoffastsignalinginGABAergicinterneuronsinterneuronsinterneuronsinterneuronsinterneurons(P1)Thursday, March 26, 2009, 15:00 16:00 hChristianElger ChristianElger ChristianElger ChristianElger ChristianElger,,,,,Bonn(ZlchLecture)Epilepsyanditsmodels:progressorwrong Epilepsyanditsmodels:progressorwrong Epilepsyanditsmodels:progressorwrong Epilepsyanditsmodels:progressorwrong Epilepsyanditsmodels:progressorwrongtrack?track?track?track?track?(P2)Thursday, March 26, 2009, 18:00 19:00 hNi kosLogot het i s,Tbi ngen Ni kosLogot het i s,Tbi ngen Ni kosLogot het i s,Tbi ngen Ni kosLogot het i s,Tbi ngen Ni kosLogot het i s,Tbi ngenElectricalmicrostimulationandfMRIElectricalmicrostimulationandfMRIElectricalmicrostimulationandfMRIElectricalmicrostimulationandfMRIElectricalmicrostimulationandfMRI(P3)Thursday, March 26, 2009, 20:00 21:00LawrenceRajendran, LawrenceRajendran, LawrenceRajendran, LawrenceRajendran, LawrenceRajendran,Dresden(SchillingPrizeLecture)Cel l ul armechani smsunderl yi ngamyl oi d Cel l ul armechani smsunderl yi ngamyl oi d Cel l ul armechani smsunderl yi ngamyl oi d Cel l ul armechani smsunderl yi ngamyl oi d Cel l ul armechani smsunderl yi ngamyl oi dgenerati onandi tsi mpl i cati onsforAl zhei mer generati onandi tsi mpl i cati onsforAl zhei mer generati onandi tsi mpl i cati onsforAl zhei mer generati onandi tsi mpl i cati onsforAl zhei mer generati onandi tsi mpl i cati onsforAl zhei mer s s s s sdiseasediseasediseasediseasedisease(P4)Friday, March 27, 2009, 15:00 16:00 hStefanKlppel,StefanKlppel,StefanKlppel,StefanKlppel,StefanKlppel,Freiburg(AgilentTechnologiesTechnologie Preis 2009)MRI -baseddi agnosi sofneurodegenerat i on MRI -baseddi agnosi sofneurodegenerat i on MRI -baseddi agnosi sofneurodegenerat i on MRI -baseddi agnosi sofneurodegenerat i on MRI -baseddi agnosi sofneurodegenerat i onusi ngsupport usi ngsupport usi ngsupport usi ngsupport usi ngsupport vectormachines vectormachines vectormachines vectormachines vectormachines(P5)Friday, March 27, 2009, 15:00 16:00 hP PP PPeterF eterF eterF eterF eterFromherz,romherz,romherz,romherz,romherz,Munich(RogerEckertLecture)SemiconductorchipsforneurophysiologySemiconductorchipsforneurophysiologySemiconductorchipsforneurophysiologySemiconductorchipsforneurophysiologySemiconductorchipsforneurophysiology(P6)Friday, March 27, 2009, 19:00 20:00 hMartinHeisenberg MartinHeisenberg MartinHeisenberg MartinHeisenberg MartinHeisenberg,Wrzburg(Ernst-FloreyLecture)Thefly Thefly Thefly Thefly Thefly sselfandit sselfandit sselfandit sselfandit sselfandit sbrainsbrainsbrainsbrainsbrain(P7)Saturday, March 28, 2009, 15:00 16:00 hAtsushiIriki,AtsushiIriki,AtsushiIriki,AtsushiIriki,AtsushiIriki,Saitama(Japan)(Otto-CreutzfeldtLecture)Neurosci enceofpri mat ei nt el l ect ual evol ut i on Neurosci enceofpri mat ei nt el l ect ual evol ut i on Neurosci enceofpri mat ei nt el l ect ual evol ut i on Neurosci enceofpri mat ei nt el l ect ual evol ut i on Neurosci enceofpri mat ei nt el l ect ual evol ut i on(P8)Saturday, March 28, 2009, 19:00 20:00 hP PP PPeterMombaerts,eterMombaerts,eterMombaerts,eterMombaerts,eterMombaerts,Frankfurt/M.OlfactiontargetedOlfactiontargetedOlfactiontargetedOlfactiontargetedOlfactiontargeted(P9)Sunday, March 29, 2009, 12:00 13:00 hAll plenary lectures will take place in hall 11.51NOTES52SymposiaSymposiaSymposiaSymposiaSymposiaI ntroductoryR I ntroductoryR I ntroductoryR I ntroductoryR I ntroductoryRemarkstoSatel l i teW emarkstoSatel l i teW emarkstoSatel l i teW emarkstoSatel l i teW emarkstoSatel l i teWorkshop1 orkshop1 orkshop1 orkshop1 orkshop1Animalmodelsofneuropsychiatric Animalmodelsofneuropsychiatric Animalmodelsofneuropsychiatric Animalmodelsofneuropsychiatric Animalmodelsofneuropsychiatricdisorders-Thetranslationalvalue disorders-Thetranslationalvalue disorders-Thetranslationalvalue disorders-Thetranslationalvalue disorders-Thetranslationalvalueofbehavioraltests ofbehavioraltests ofbehavioraltests ofbehavioraltests ofbehavioraltestsMichael Koch and Eberhard Fuchs, Bremen and GttingenWell-validatedandrobustanimalmodelsareofprimeinterest for behavioural pharmacological investigations ofneurological and psychiatric disorders. Which are the bestmethodsfortestinghypothesesrelatedtotheetio-pathogenesis and treatment of diseases? Which is the opti-malexperimentaldesigntoreachreplicableandtranslationalresultsandtoavoidoverinterpretationandartefacts?Whatarethespecialconcernsthatmustbeaddressed when conducting animal behavioural studies?This workshop will provide an overview of test paradigms inseveral disease domains including learning and memorydeficits,motordysfunctions,drugabuse,behaviouralaberrationsrelatedtoschizophrenia,stress-induceddisorders and depression. To what extent can genetic andepigeneticinfluencesontheetiologyofdiseasesbediscerned? How do sex differences and developmental stagesaffect the course of the diseases? Are animal models reallysupportingrationalpharmacotherapy?Multidisciplinarycombinationsofbehavioural,electrophysiological,telemetric and neuropharmacological phenotyping will bepresentedtoillustratecomprehensiveanalysesofmammalianmodelsofneuropsychiatricdisorders.Thisworkshop consists of a series of short presentations by thefaculty followed by an informal round-table discussion. Thisformat particularly addresses the needs ofresearchers earlyin their carrier.SATELLITE I, WEDNESDAY, MARCH 25, 14:00 - 19:0053SATELLITE I, WEDNESDAY, MARCH 25, 14:00 - 19:00SymposiaSymposiaSymposiaSymposiaSymposiaSatelliteW SatelliteW SatelliteW SatelliteW SatelliteWorkshop1 orkshop1 orkshop1 orkshop1 orkshop1Wednesday, March 26, 200914:00 19:00, Hall 9Chair: Michael Koch and Eberhard Fuchs14:00Introductoryremark Introductoryremark Introductoryremark Introductoryremark IntroductoryremarkEberhard Fuchs and Michael Koch14:15Briefstatementsanddiscussion Briefstatementsanddiscussion Briefstatementsanddiscussion Briefstatementsanddiscussion Briefstatementsanddiscussion18:45Conclusion Conclusion Conclusion Conclusion Conclusion19:00Endoftheworkshop Endoftheworkshop Endoftheworkshop Endoftheworkshop EndoftheworkshopSponsoredby54SATELLITE II, WEDNESDAY, MARCH 25, 14:00 - 18:30SymposiaSymposiaSymposiaSymposiaSymposiaI ntroductoryRemarkstoSatel l i teSymposi um2 I ntroductoryRemarkstoSatel l i teSymposi um2 I ntroductoryRemarkstoSatel l i teSymposi um2 I ntroductoryRemarkstoSatel l i teSymposi um2 I ntroductoryRemarkstoSatel l i teSymposi um2SchramF SchramF SchramF SchramF SchramFoundationSymposium oundationSymposium oundationSymposium oundationSymposium oundationSymposiumF F F F Fromneurontocircuit romneurontocircuit romneurontocircuit romneurontocircuit romneurontocircuit Hermann Rohrer (Frankfurt/M)The Schram Foundation supports research in medicine andneuroscience, focussing on brain research, and was foundedby Dr. Armin Schram in 2000. The Schram Foundation isthe only private foundation supporting basic neuroscienceresearch in Germany. The aim of the present symposium isto provide a platform to present and discuss projects thathave been supported by the Schram Foundation. These coverimportantaspectsofneurondifferentiation,synapseformation and circuit function, summarized in the symposiumtitle From neuron to circuit. Following opening remarks byErwin Neher (Gttingen), Michael Wegner (Erlangen) willreport on the essential role of transcription factors of theSoxgenefamilyinthedevelopingnervoussystemanddelineate their function in neuronal and glial differentiation.ThepresentationbyHermannRohrer(Frankfurt/M)willprovide evidence that transcription factors that are essenti-alforneurotransmitterphenotypedifferentiationduringdevelopment are also required for the maintenance of thesefunctionsinmatureneurons.MichaelKiebler(Wien)addressesthemoleculareventsthatcauseanactivatedsynapse to be structurally and functionally rearranged. The-se alterations are considered to be molecular correlates oflearning and memory. Britta Qualmann (Jena) will providean insight into the molecular mechanisms underlying theformation, maturation and reorganisation of postsynapticnerve endings, as well as to shed light on the modulation oftheir function processes relevant for the formation andplasticity of neuronal networks. A novel signaling pathwayintheactivity-dependentmorphogenesisandstabilityofdendritesandspinesinvolvestheproteinJacob,whichinducessynapseremovalanddendriteretractionunderpathological conditions, will be described by Michael Kreutz(Magdeburg). In the presentation by Bernd Knll (Tbingen),theconsequencesofforebrain-specificconditionalinactivation of the transcription factor Srf will be covered.Srf controls gene expression of a wide range of target genes,includinggenesassociatedwithneuronalcytoskeletaldynamics. Petra Wahle (Bochum) will report on the in vitroeffects of early activity patterns on neuronal morphologyandgeneexpressionandHeikoLuhmann(Mainz)willaddress the question, which synchronized neuronal activitypatterns can be observed in the immature cerebral cortexand the role of these patterns in the construction of earlycortical networks and in the control of programmed celldeath. The symposium will be closed by concluding remarksof Dr. Armin Schram.55SATELLITE II, WEDNESDAY,MARCH 25, 14:00 - 18:30SymposiaSymposiaSymposiaSymposiaSymposiaSatelliteSymposium2 SatelliteSymposium2 SatelliteSymposium2 SatelliteSymposium2 SatelliteSymposium2Wednesday, March 25, 200914:00 18:30, Hall 11Chair: Heinrich Betz14:00 Openi ngRemarks Openi ngRemarks Openi ngRemarks Openi ngRemarks Openi ngRemarksErwin Neher, Gttingen14:10 Michael Wegner, ErlangenMOLECULAR ANALYSIS OF NEURAL SOXPROTEIN FUNCTIONS (Sat2-1)14: 35 Hermann Rohrer, Frankfurt/M.TRANSCRIPTIONALCONTROLOFAUTONO-MIC NEURON SPECIFICATION AND DIFFE-RENTIATION (Sat2-2)15:00 Michael Kiebler, WienMOLECULAR MECHANISMS OF LEARNINGAND MEMORY AT THE SYNAPSE (Sat2-3)15:25 Britta Qualmann, A. Haeckel, R. Ahuja, M. M.Kessels, JenaMOLECULARCOORDINATIONOF POST-SYNAPTIC PLASTICITY MECHANISMS (Sat2-4)15:50CoffeeBreak CoffeeBreak CoffeeBreak CoffeeBreak CoffeeBreakChair: Hermann Rohrer16:20 Michael R. Kreutz, A. Karpova, M. Mikhaylova, D.C. Dieterich, C. Spilker, MagdeburgSIGNALING FROM SYNAPSE TO NUCLEUS VIAJACOB (Sat2-5)16:45 Bernd Knll, TbingenTHE ROLE OF SRF-MEDIATED GENEEXPRESSION IN NEURONAL CIRCUIT ASSEMBLY(Sat2-6)17:10 Petra Wahle, C. Colovic, S. Patz, BochumCARBACHOL PROMOTES CORTICAL DIFFEREN-TIATION IN RAT (Sat2-7)17:35 Heiko Luhmann, MainzSHAPING EARLY CORTICAL CIRCUITS BYELECTRICAL ACTIVITY (Sat2-8)18:00 Concl udi ngRemarks Concl udi ngRemarks Concl udi ngRemarks Concl udi ngRemarks Concl udi ngRemarksDr. Armin Schram56SYMPOSIUM 1, THURSDAY, MARCH 26, 9:00 - 12:00SymposiaSymposiaSymposiaSymposiaSymposiaI ntroductoryRemarkstoSymposi um1 I ntroductoryRemarkstoSymposi um1 I ntroductoryRemarkstoSymposi um1 I ntroductoryRemarkstoSymposi um1 I ntroductoryRemarkstoSymposi um1Theclinicalimportanceofspreading Theclinicalimportanceofspreading Theclinicalimportanceofspreading Theclinicalimportanceofspreading Theclinicalimportanceofspreadingdepolarizationinmigraineand depolarizationinmigraineand depolarizationinmigraineand depolarizationinmigraineand depolarizationinmigraineandacuteneuronalinjury acuteneuronalinjury acuteneuronalinjury acuteneuronalinjury acuteneuronalinjuryJens Dreier and Rudolf Graf, Berlin and KlnProgressive ischaemic damage in animals is associated withspreading mass depolarisations of neurones and astrocytes,detectedasspreadingnegativeslowvoltagevariations.Speculation on whether spreading depolarisations occur inacute neuronal injury in humans has continued for the past60 years since Leos first description of spreading negati-ve slow voltage variations in response to either electricalstimulation or bilateral carotid artery occlusion. In patientsundergoing acute cerebral injury, subdural electrode stripsfor electrocorticography have made it possible to measurespreading depolarisations in the injured human brain. Aniniternational consortium, the Co-Operative Study on BrainInjury Depolarisations (COSBID) has now started to unravelthe role of spreading depolarisations in relation to clinicaloutcome, structural damage and neurobiological factorsincludingregionalcerebralbloodflowandneuronalmetabolism.Inviewoftheabundanceofthesedepolarisations in conditions such as traumatic brain injury,spontaneousintracerebralhaematoma,aneurysmalsubarachnoid haemorrhage (aSAH), delayed ischaemic strokeafter aSAH and malignant ischaemic stroke and the observedcharacteristicchangesinelectrocorticographicpatternassociatedwithstructuraldamage,itisnowincreasinglyrecognised that spreading depolarisations represent a coremechanism of damage in the human brain similar to theirrole in the brain of animals. The symposium will present thisrecent clinical evidence and discuss the wide implications ofthis succesful field of translational research from bench tobedside.57SYMPOSIUM 1, THURSDAY, MARCH 26, 9:00 - 12:00SymposiaSymposiaSymposiaSymposiaSymposiaSymposium1 Symposium1 Symposium1 Symposium1 Symposium1Thursday, March 26, 20099:00 12:00, Lecture Hall 10Chair: Jens Dreier and Rudolf Graf, Berlin and Kln9:00 Rudolf Graf, KlnPATHOPHYSIOLOGICAL BASIS OF SPREA-DING DEPOLARISATIONS, A CONTINUOUSSPECTRUM FROM ANOXIC DEPOLARISATIONTO SPREADING DEPRESSION (S1-1)9:25 Anthony J. Strong, M. Fabricius, J. Hartings,London (United Kingdom)THE CO-OPERATIVE STUDY OF BRAIN INJURYDEPOLARISATIONS (COSBID): THE IMPACTOF THE TSUNAMIS (S1-2)9:50 Jens P. Dreier, BerlinSPREADING DEPRESSION OF HIGH-FRE-QUENCY NEURONAL ACTIVITY AND LOW-FREQUENCYVASCULARFLUCTUATIONSCORRELATE IN THE HUMAN BRAIN DURINGNORMAL AND INVERSE NEUROVASCULARCOUPLING (S1-3)10:15 Cof f eeBreak Cof f eeBreak Cof f eeBreak Cof f eeBreak Cof f eeBreak10:45 Martin Fabricius, M. O. Group, Glostrup(Denmark)THE RELATION BETWEEN SPREADINGDEPOLARISATIONS AND OUTCOME AFTERACUTE NEURONAL INJURY IN THE HUMANBRAIN (S1-4)11:10 Christian Dohmen, O. W. Sakowitz, M. Fabricius,B. Bosche, J. P. Dreier, J. Woitzik, A. J. Strong, R.Graf, CologneSPREADING DEPOLARISATIONS OCCUR INHUMAN ISCHEMIC STROKE WITH HIGHINCIDENCE (S 1-5)11:35 Martin Lauritzen, Glos trup (Denmark)SPREADING DEPRESSION IN MIGRAINE (S1-6)58SYMPOSIUM 2, THURSDAY, MARCH 26, 9:00 - 12:00SymposiaSymposiaSymposiaSymposiaSymposiaI ntroductoryRemarkstoSymposi um2 I ntroductoryRemarkstoSymposi um2 I ntroductoryRemarkstoSymposi um2 I ntroductoryRemarkstoSymposi um2 I ntroductoryRemarkstoSymposi um2Neuralcomputation Neuralcomputation Neuralcomputation Neuralcomputation Neuralcomputationbyretinalcircuits byretinalcircuits byretinalcircuits byretinalcircuits byretinalcircuitsTim Gollisch and Gnther Zeck, MartinsriedHowdoneuronalcircuitsextractandrepresentspecificfeatures of the sensory environment? This is a question ofcentral interest in the study of brain function. To address it,theneuralnetworkofthevertebrateretinaprovidesanextraordinarymodelsystem.Itswell-establishedbasiccircuitry and good experimental accessibility together withprecisecontroloveritsinputsofferusauniquebasistostudy neural computation and population coding. Early on,this paved the road for paradigmatic discoveries in neuralprocessing,suchasthestructureofreceptivefieldsandmotion sensitivity, investigated by Hartline, Kuffler, Barlowand other pioneers in retina research. Today, the advent ofnew optical and electrical multi-neuron recording techniquesallow us to extend these approaches from single cells to thepopulation level and to study how different cell types in theretina contribute to particular computations. We are thusbeginning to understand which aspects of the populationactivity encode different stimulus features and how individu-alcircuitelementscontributetothisneuralcode.Thissymposium will discuss recent examples of using the newexperimentaltechniquestoinvestigatehowtheretinacomputes different components of the visual scene. To start,Thomas Euler will provide insights into the computationalpower of dendritic processing in the retina. Subsequently,Thomas Mnch and Michiel van Wyk will evaluate how retinalganglion cells integrate dendritic signals to represent rele-vant visual information. The single cell investigations aretaken to the population level in the talks of Michael BerryandJuttaKretzbergwhowillfocusontheencodingproperties of visual stimuli by populations of retinal ganglioncells. Finally, Matthias Bethges talk will shine light on theteleological aspect of neural computation in the retina.59SYMPOSIUM 2, THURSDAY, MARCH 26, 9:00 - 12:00SymposiaSymposiaSymposiaSymposiaSymposiaSymposium2 Symposium2 Symposium2 Symposium2 Symposium2Thrusday, Mach 26, 20099:00 12:00, Lecture Hall 105Chair: Tim Gollisch and Gnther Zeck, Martinsried9:00 I nt roduct i on I nt roduct i on I nt roduct i on I nt roduct i on I nt roduct i on9:05 Thomas Euler, HeidelbergTHE ROLE OF DENDRITIC PROCESSING INTHE RETINA (S2-1)9:30 Thomas A. Mnch, R. A. da Silveira, S. Siegert, B.Roska, TbingenAPPROACH SENSITIVITY IN THE MAMMALIANRETINA (S2-2)9:55 Michiel van Wyk, H. Wssle, Frankfurt/M.TEMPORAL FILTERING BY A-TYPE GANGLIONCELLS IN THE MOUSE RETINA (S2-3)10:20 Cof f eeBreak Cof f eeBreak Cof f eeBreak Cof f eeBreak Cof f eeBreak10:40 Michael J. Berry II, Princeton, New Yo