novo nordisk r&d china we are looking for talented people please send your cv to...
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Company Introduction
Novo Nordisk China R&D center is one of the biggest R&D centers set up by multinational pharmaceuticals companies in China. It is an integrated part of Novo Nordisk’s R&D organization, focusing on the innovative research to develop novel drugs for the treatment of diabetes, hemophilia, autoimmune and inflammatory diseases. Currently, the R&D center has 140 employees including >40 PhDs, and will expand to 200 people in next 2-3 years.
Company IntroductionMini-Pilot
The department of Mini-Pilot is responsible for the delivery of medium to large scale research grade proteins and peptides as well as the development of robust USP and DSP processes to CMC. Currently, the department consist of 4 scientists, 1 associate scientist, 5 research associates and a department director. We are a highly motivated and productive team with high standards for our deliveries into the projects. We work with state-of-the-art facilities and equipments and value a high team spirit, innovation and dynamic collaboration between both scientists and research assistants. Established in the beginning of 2011, the department is expected to grow significantly over the next years.
Senior Scientist/Principal Scientist in department of Mini-pilot (job code:MP5243)Responsibilities:To provide expertise in homogenization, centrifugation and filtration in a dynamic and diverse team. Your tasks will include, but not be limited to•Design, develop and optimize experiments for protein and peptide recovery from E. coli •Analyze data from experiments, write summaries, and prepare presentations•Manage projects in a diverse team environment•Supervise Junior staffs•Furthermore, you will be expected to lead the implementation of new technologies within protein and peptide recovery as needed.
Qualifications•PhD in chemical engineering, biochemical engineering, mechanical engineering and related field•2+ years of relevant industrial experience•In depth understanding of the biochemical, biophysical and mechanical properties of cells, inclusion bodies, proteins and peptides during initial recovery •Hands-on working knowledge of Gaulin homogenizer, UF-DF, continuous centrifugation, depth filtration from small to large scale•Process development and optimization experience in industry is a must•cGMP experience is a plus•Strong organization and communication skill, and a desire to work cooperatively in a team environment•You are proactive and able to take responsibility beyond own tasks. •You are communicating and collaborating in a positive and motivating way, a good team-player, highly flexible and have a “can-do” attitude.
Company IntroductionBiopharm Research China
Biopharm Research China (BRC) is one of the research units in Novo Nordisk China R&D and a fully integrated part of the Biopharmaceuticals Research Unit (BRU) in Denmark. BRC consists of three research departments: Cell Biology, Molecular Biology and Protein Chemistry.
We are committed to developing innovative biologics to improve the lives of people with haemophilia, growth disorders and autoimmune inflammatory diseases. By leveraging our core competences in protein and antibody engineering & production, we support Novo Nordisk pipeline projects in turning proteins into valuable pharmaceuticals and identifying new molecular targets for the treatment of diseases. . Our ability to excel depends on the integrity, knowledge, dedication, and teamwork from each employee. Joining us, you will have the opportunity to collaborate with talented colleagues in an international environment as well as to develop and expand your career. Welcome to BRC!
Open rank Scientist, High throughput Protein Expression(Job Code:BRC6167)
Responsibilities:•Play a primary role in establishing the automation platform and support various project needs via high throughput molecular cloning, mammalian cell transfection and protein expression •Supervise molecular design and expression aspects of research programs •Participate as protein expression expert in multiple projects •Propose and implement novel protein expression strategies that facilitate downstream high throughput protein purification and characterization •Apply innovative protein expression technologies and novel high-throughput solutions to conventional problems •Coordinate the work of other scientists and oversee the work of Research Associates. Contribute to scientific publications, conference presentations and patent applications
Qualifications•Ph.D. in Molecular Biology or relevant discipline•Experience in biotech/pharmaceutical environment is a plus •Proven hands-on experience in automation and high throughput liquid handling of biological samples is integral to candidate's success•Familiarity with molecular cloning and mammalian cell culture techniques is required•Substantial experience in programing and operation of Beckman Coulter Biomek FX and NX workstations is a strong plus•Experience with display technologies such as phage, yeast or E.coli display is a plus. •The ability to balance multiple priorities and timelines is expected•Must be a team player with pro-active behavior, strong oral and written communication skills
Senior /Principal Scientist:Bioinformatics and scientific computing (Job Code:BRC6169)
Responsibilities:•Play a primary role in bioinformatics and scientific computing tasks including protein design, protein and antibody sequence analysis, database set up, management and maintenance•Participate in projects and actively contribute to molecular modelling, protein structure prediction and optimization •Apply contemporary statistical and computational methods to protein centred studies•Coordinate cross functional projects and communicate with stakeholders to come up with innovative solutions •Build external visibility and maintain good publication record
Qualifications•Ph.D. in bioinformatics, structural biology, physics or related disciplines with >2yrs of post-doc training or equivalent •Knowledge in a broad range of contemporary statistical methods for classification and prediction•Good understanding of antibody sequence and structure•Demonstrated computational skills, e.g. programming, and data mining•Hands-on experience with protein structure modelling software such as MODELLER, DOCK •Familiarity with Discovery Studio software suite is preferred •Ability and desire to work both independently and collaboratively in a dynamic, innovative, and interdependent research environment•Industrial experience is a plus •Excellent oral and written communication skills are essential
High throughput Protein Purification, Protein Chemistry (BRC0726)
Responsibilities:•Develop and maintain a high throughput (HTP) protein purification platform•Work with cross functional teams to carry out protein purification tasks •Implement advanced protein characterization technologies in both conventional and HTP protein purification•Facilitate, promote and harmonize best practices in related technological areas•Build external visibility and maintain good publication record
Qualifications•Ph.D. in protein chemistry, biology, biochemistry or related discipline with at least five years focused experience in protein purification and/or characterization•Expertise in high throughput protein purification or hand-on experience on automation or robotic equipment is preferred•Thorough understanding and solid hands-on experience on protein engineering, refolding, purification and characterization•Experience in protein purification using general chromatographic methods (e.g. IEX, HIC, SEC, Affinity, and RP), instrumentation and software (AKTA and HPLC) are required•Industrial experience and experience in project coordination and management would be a plus•Excellent collaboration, communication and multitasking skills
Senior/Principle Scientist, Protein/Protein Interaction (Job Code:BRC6168)
Responsibilities:•Implement SPR and other real time label free biophysical technologies to provide affinity, specificity and kinetic data for protein/protein interactions•Build a high throughput protein/protein interaction screening platform•Establish and develop protein/protein interaction analysis to support protein characterization as well as drug target and lead selection•Work closely with cross functional team members to provide scientific expertise and insights
Qualifications•Ph.D. in biophysics, biochemistry, protein chemistry or related fields with >2yrs of postdoc training or industrial working experience•Excellent working knowledge and solid expertise in using Biacore/SPR or related platforms across a broad range of assays to characterize protein/protein interaction•Deep understanding of protein/protein interactions as well as proteins and their biochemical and biophysical properties •Experience with microarray and other protein-protein interaction technologies is a plus•Proactive and collaborative to work in a dynamic, innovative, and interdependent research environment•Excellent oral and written communication skills are essential
Company IntroductionDiabetes Research China
The department of Diabetes Pharmacology and Animal facility is part of Novo Nordisk China R&D centre as an integrated part of Novo Nordisk’s R&D organization and located in Beijing. The department is responsible for support of diabetes and obesity research projects in the discovery phase.
We are a highly motivated and productive team with high standards for our deliveries into the projects. We work with state-of-the-art facilities and equipment and value a high team spirit, good communication and dynamic collaboration between both scientists, technicians and external colleagues. The department is expected to grow significantly over the next years, which leads to excellent opportunities for individual development
In vivo pharmacologist , Diabetes Pharmacology (DRC001)
Responsibilities:•Be involved in both designing and executing large animal in vivo experiments, primarily focusing on dogs, both as part of screening plans and as more explorative studies. •Be involved in expanding our facilities and the types of techniques and models used. Especially, you will be involved in setting up our large animal in vivo pharmacology. •keeping up-to-date on diabetes and obesity research is going to be an important task, both in relation to evaluating new project opportunities as well as knowing what is going on in the scientific community.
Qualifications•PhD degree within experimental animal science, in vivo pharmacology, veterinary medicine, medicine or other relevant area.•Excellent scientific background with proved expertise of large animal in vivo pharmacological research within diabetes and/or obesity biology. Preferably you have solid experience working with dogs. •High standards for animal ethics and quality of your results based on in vivo studies•You are fluent in English and Experience from the pharmaceutical industry will be considered an advantage. •Flexible, open to new ideas, ambitious, innovative, result oriented and have a good sense of humour. •You have authority and thrive in a milieu where you have a lot of individual responsibility with a high degree of personal impact in the projects but at the same time you are good at collaborating in teams and mentoring colleagues. •You are good at communicating and are able to meet deadlines and keep overview.
Open Rank Scientist, Molecular biology (Job code: DRC5213)
Responsibilities:•Be involved in cross-functional project teams with colleagues from many different scientific backgrounds both in China and at head quarters in Denmark. •Contribute to several early stage projects with responsibility for designing expression systems and generating recombinant proteins preferentially from E. coli, but some experience within mammalian expression is also considered valuable. •Be responsible for process development and handing over of the E.coli process to CMC settings including documentation in relation to the transfer. •Be part of a team in a highly dynamic and challenging environment within the Diabetes Research Unit.
Qualifications•Ph.D. in molecular biology, biochemistry, genetics or related discipline with additional postdoctoral training or similar experience. •Excellent track record of original research as well as hands-on experience with state-of-the art molecular biological techniques. •Experience with expression of a range of proteins and peptides in E. coli , optimization of expression conditions and process development will be preferable. •Familiar with molecular cloning including E coli Knock-out and Knock-in•E.coli genetics and solid practical experience with engineering E.coli hosts for improved heterologous protein expression, setting up screens or selections and skilled in the art of protein secretion. •Experience with E coli metabolic engineering is a plus
Responsibilities:•Purify and characterize various proteins to support therapeutic protein drug R&D•Analyze data from experiments, write summaries, and prepare presentations•Manage projects in a diverse team environment•Supervise Junior staffs
Scientist/Senior scientist in Protein (Job code: DRC5216)
Qualifications•You hold a Ph.D. in protein chemistry, biophysics, biochemistry or related discipline with additional postdoctoral training within above mentioned disciplines. •In-depth understanding of the biochemical and biophysical properties of proteins and peptides.•A thorough understanding and solid hands-on experience on protein engineering, refolding purification, characterization and assay development.•You have an excellent track record of original research.•Experience from a biotech/pharmaceutical R&D setting with focus on therapeutic petides and some patent experience is considered an advantage.•You are flexible, open to new ideas, ambitious, innovative; result oriented and have a good sense of humour.•You have authority and thrive in an environment with individual responsibility and a high degree of personal impact in the projects but at the same time you are good at collaborating in teams.•You are good at communicating, able to meet deadlines and keep an overview.