novel multi-institutional technology transfer models as engines for economic growth anthony p....
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Novel Multi-Institutional Novel Multi-Institutional Technology Transfer Models as Technology Transfer Models as Engines for Economic GrowthEngines for Economic Growth
Anthony P. Green, Ph.D.VP, Technology Commercialization GroupBen Franklin Technology Partners/SEPBen Franklin Director, The Nanotechnology Institute
Navigating Technology TransferFed Lab Consortium Mid Atlantic Region Annual Meeting 24 October 2007
“I don’t care if it’s nano, micro, yocto, groucho or zeppo; if it gets me to the FDA 10 minutes faster, I’m interested”
Statement of the ProblemStatement of the Problem
How do you get a product out the door?
Statement of the ProblemStatement of the Problem
ChallengeChallenge
ChallengeChallenge
Institutions
Greedy Over-Protective Obstructionist
ChallengeChallenge
Institutions
Greedy Over-Protective Obstructionist
Industry
Stingy Over-Protective Obstructionist
Current ProcessCurrent Process
One-to-One negotiation Little Marketing—word-of-mouth Little direct commercialization experience
Solution?Solution?
Solution?Solution?
Breaking SetBreaking Set
Ben Franklin Technology Partners/SEPBen Franklin Technology Partners/SEP
WHO: Statewide network of 4 independent organizations 25th Anniversary 2008Commonwealth of PA core funding
WHY: Transition PA’s economy to tech based
HOW: Seed & grow new technology companies Assist established firms develop & commercialize new products Partner to advance new technologies & strengthen entrepreneurial
infrastructure: Across the state: BFTP Network Within 4 regions Tri-State Greater Philadelphia Region
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvaniaof Southeastern Pennsylvania
Grows Technology Companies in PennsylvaniaGrows Technology Companies in Pennsylvania
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvaniaof Southeastern Pennsylvania
Our Approach: Capital, Knowledge, NetworksOur Approach: Capital, Knowledge, Networks
Focus on technology entrepreneur
Integrate our “products” into systems that increase and/or strengthen:
Risk capitalBusiness & Commercialization servicesInnovation infrastructure
Innovate new products & models
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvania
Ben Franklin Technology Partners of Southeastern PA: 2001-2006
5,755 high value jobs created & retained 425 new technology companies funded 790 products & processed implemented & commercialized
• Since 1982, $130 million+ provided to more than 1,600 regional companies– $34 Million committed in the southeastern Pennsylvania region 2001-2007 – $24 Million+ currently invested in more than 120 companies – $620 Million+ in follow-on capital raised by BFTP/SEP companies 2001-2006
• Ben Franklin Seal of Approval
• Will invest at least $25M over the next 5 years– “First-in” money: $50,000 - $750,000
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvania
Stimulating Entrepreneurial PotentialStimulating Entrepreneurial Potential
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvaniaof Southeastern Pennsylvania
Knowledge: Technology Commercialization GroupKnowledge: Technology Commercialization Group Get Ideas to Market… Faster
Current BFTP Programs for early stage
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvaniaof Southeastern Pennsylvania
Knowledge: Technology Commercialization GroupKnowledge: Technology Commercialization Group Get Ideas to Market… Faster
Current BFTP Programs for early stage
• Pre-seed capital• Funds for small technology engagments• Tech-transfer consortia for small institutions without
tech transfer capabilities• IP donation program• NTI™
• MANA®
Partnership for Broadband Wireless Innovations• Collaboration to leverage R&D reputation of Villanova’s Center for Advanced Communication
– 20 year BFTP/SEP partnership• Funded by National Science Foundation: $600,000 from 2005-2007• $5.4M leveraged R&D• 4 BFTP/SEP company engagements
PA Green Growth Partnership • Consortium for Sustainable Design & Research:
– Philadelphia University Engineering & Design Studio in 2000: $500K from PA in 2001– Jt proposal with BFTP/SEP; develop & promote “sustainable development technologies”– Joined by Temple U, Villanova; PA $1.75M funding 2003-2006– $6.5M leveraged R&D– 10 BFTP/SEP engagements through partnership, 28 young companies assisted total– Partnership w/ Pittsburgh Green Bldg Alliance to form PA Green Growth Partnership; $1M in 2006
• Focus on constructing buildings that are Leadership in Energy & Environmental Design (LEED) certified
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvaniaof Southeastern Pennsylvania
Knowledge: Technology Commercialization Group Get Ideas to Market… Faster
PA Biotech Center of Bucks County• Ben Franklin Innovation Center created in the ’90s as a BFTP/SEP
experiment in technology commercialization & enterprise creation & support – BFTP/SEP continues to partner in successful federal funding to
continue evolution of model• Joint venture among Drexel University, the Hepatitis B Foundation & the
Delaware Valley College• Led to creation of the Regional Biotech Council, Central Bucks (RBCCB)• Spawned several new biotech enterprises:
– Nucleonics, NextGen, Immunotope, Oragen, BID Automation, Lampire Biologicals, others
• PA Biotech Center opened in 2006– Newly renovated 64,000 sq.ft. research center, educational campus & incubator
for biotech startups– Second facility acquired; planning underway
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvania
NetworksNetworks Mobilize Region Around the Next Big Idea
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvania
NetworksNetworks Mobilize Region Around the Next Big Idea
Ben Franklin Intellectual Property Donation Program • Commercialization Initiative which encourages corporate
donation of unprogressed intellectual property for maximize IP potential– State-funded– Partner with Phoenix IP Ventures for life science-related patents– Accepted assets can be used to:
• Start a new company• Donate to an existing company
– Protect current IP– Expand indications– Prevent others from acquiring
• Donate back to University for “tweaking”• “Outsource R&D”
Novel Model for Tech Transfer and Reducing Barriers to Commercialization
Novel Model for Tech Transfer and Reducing Barriers to Commercialization
Criteria:
• Focus on single technology platform– New– Novel– Broad Applications– Commercial Potential
A Comprehensive Model for Nano-Based Development:From Discovery to Commercialization
™
NTI Background• Conceived in 2000 by BFTP/SEP, Drexel University & The University of
Pennsylvania
• Seeded with $19.8M from the Commonwealth of Pennsylvania & $1.8M from BFTP/SEP
• First organized regional partnership to accelerate nanotechnology discoveries and development
• An alliance of business, academia & government facilitating the research, development & commercialization of bio-nano advances
NTI’s Objectives• Leverage diverse multi-institutional
resource base• Reduce barriers to accelerate
commercialization• Create strategic partnerships• Leverage regional federal dollars• Stimulate corporate involvement &
private investment• Support SME formation & growth• Prepare qualified workforce• Demonstrate leadership & innovation… Comprehensive Research Commercialization Model
The NTI wrap-around approach supports the creation of a new platform for economic growth.
MarketsPharmaceuticalBiotechnology
Medical DevicesDiagnostics
Focal AreasTissue EngineeringBiosensorsDrug DeliveryCellular Probes
Product Categories Tools
DevicesMaterials
Components
Current Primary Nano Efforts
The NTI Core Community
NTINTI
BFTP/SEPBFTP/SEP
DrexelDrexelUPennUPenn
State & FedState & FedAgenciesAgencies
CompaniesCompanies
BFTP/SEP– PA’s lead economic development partner for tech based development;– Nationally & int’ly recognized leader – Seeded more than 1,400 regional enterprises representing more than $110 million dollars– Invested in nano companies:
BioNanoMatrix NanoSelect PChem Reacta Nanoblox Phenotech
NanoMaterials
University of Pennsylvania– World leader in nano research– The Penn Regional Nanotechnology Facility– Nano/Bio Interface Center– Materials Research Science and Engineering Center– GRASP Laboratory of Robotics Research– Center for Molecular Discovery– Microfabrication, MicroArray and Regional Laser Facilities
Drexel University– A.J. Drexel Nanotechnology Institute– Centralized Materials Characterization Facility and Industry Consortium– Nano Certificate Program
The NTI Regional Community
NTINTI
BFTP/SEPBFTP/SEP
DrexelDrexelUPennUPenn
State & FedState & FedAgenciesAgencies
CompaniesCompanies
MANAMANA®®
OtherOtherEDO’sEDO’s
Bus OrgsBus OrgsVCsVCs
AngelsAngelsComm EntitiesComm Entities
Civic OrgsCivic Orgs
OtherOtherMemberMember
InstitutionsInstitutions
CommunityCommunityCollegesCollegesEd. Inst.Ed. Inst.
OtherOtherNanoNano
InitiativesInitiatives
The NTI Institutional Community
Affiliated Institutions– Fox Chase Cancer Center
– Thomas Jefferson University– Villanova– Temple– Children's Hospital of Philadelphia– University of the Sciences– Lankenau Institute for Medical Research– Widener– Haverford – Millersville State
NTI Management Structure
Oversight
Operations
NCG Advisory Groups
The NTI’s Unique Institutional Legal Structure
Novel Legal Agreements Common CDA MOU on Intellectual Property Inter-Institutional Agreement Common Sponsored Research Agreement
Novel Commercialization Programs NanoCommercialization Group
The NTI’s Unique Funding Elements
Translational Research to support commercially viable technology
• Single and multi-institutional• Vetted with outside Corporate Advisory Group
Proof-of-Concept funds-2 sources• Institutional• Corporate
Matched sponsored research agreements
The Role of the NanoCommercialization Group (NCG)
Resident in Penn/Drexel Tech Transfer Office Identify, file and manage all nano-related IP among NTI
Institutions Increase potential of IP
• Identify IP packages resulting in increased potential Includes limited due-diligence• Provide Proof-of-Concept funding
Help investigators engage with industry partners “One-stop shopping” for negotiating license agreements
Role of Corporate Partners
• Participation in Corporate Advisory Group– Help formulate research direction and strategies
− Serve on review committees
− Provide insight into commercialization activities
• Sponsored Research Opportunities− Technology Scouting among all NTI-affiliated institutions to match
corporate needs with available resources
− Matching funds for Sponsored Research Agreements
• Access to NCG, IP pools
IP Pkgs.IP Pkgs.
LicensesLicenses
New co’s
BFTPBio Advance
AngelsKIZs
SRAs
NAF
- NTI Assets/Programs- Intellectual Property- Corporate / EDO Engagements- Federally Funded Programs
PSTRPSTR
IPIP
NTINTIUniversity / University /
BFTPBFTP12 Institution 12 Institution Talent PoolTalent Pool
NCGNCG
Federally Funded Research
NTI Tech Development
Seed/Core Research
Companies
Institution
Corporate
IP Donation Program
NTI Commercialization PathwayNTI Commercialization Pathway
Technology Development-2007• Seed Grants
– High risk/high gain– 8 awarded @ $30,000 each to four different institutions– Topics Include:
• Nanoporous Carbons Tuned for Selective Adsorption of Proteins • Novel Alimentary Protein Based Nanofibrous Scaffolds for Tissue
Engineering and Regenerative Medicine • Engineered Dimeric Gold-Antibody Ensemble (EDGE) • Percolation-Threshold Nano-cluster Plasmonics for Bio-imaging • Magnetic Studies of Filled Carbon Nanotubes • Organogel/Carbon Nanotube Composites • Towards Realizing Cancer Immunotherapy Vaccines from Single
Dendritic Cells • Low Density Metals and Metallic Foams Using Sacrificial Scaffolding
Manufactured from Collagen Nanofibrils
• Core Translational Research Grants− Multi-institution/multi-investigator− $700,000 each− Two Projects Funded
− BioSensors (Drexel, Fox Chase Cancer Center, Penn)− Nano-based methods to detect immune responses to
therapeutic monoclonal antibodies
− BioProbes (Penn, Drexel, Temple)− Nanoscale Cellular Probes
Technology Development-2007
Key Accomplishments-FY2007
35 Disclosures/Patent Applications/Patents 6 Technology Licenses 4 NanoApplications Fund awards 12 PSTR Proof-of-concept awards approved 2 company spin-outs 2 Corporate Engagements
Key Accomplishments• Federal Research
– >$150M in Follow-on Federal Funding; $33.4M in new centers + many new individual and small group research grants
– Instrumentation match/leverage: $1,654,000
• Catalyzed & coalesced regional/state action− NanoForums− Regional university research initiatives:
− Nano now a priority across leading research universities in SE PA− A.J. Drexel Nanotechnology Institute− U Penn Nano/Bio Interface Center− MERSEC Renewal
− Tri-state Mid-Atlantic Nanotechnology Alliance (MANA®)
• Acknowledged national model by NNI− Comprehensive & multi-institutional: Discovery Commercialization
• Raised visibility of SE PA nano capabilities nationally & internationally; improved ranking of PA
www.sep.benfranklin.org
Ben Franklin Technology PartnersBen Franklin Technology Partnersof Southeastern Pennsylvania