Vol. 267, No. 36 The Journal of December 25,1992

Biological Chemistry Copyright 0 1992 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St.. Baltimore. MD 21202 U.S.A.

25621

25625

25628

25632

25636

25640

25644

25648

25652

25656

25660

25664

25668

CONTENTS*

MINIREVIEW Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins. Lawrence Chan

COMMUNICATIONS Protein control of iron-sulfur cluster redox po- tentials. Ralf Langen, Gerard M. Jensen, Uwe Jacob, Philip J. Stephens, and Arieh Warshel

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. Rony Seger, Dalia Seger, Fred J . Lozeman, Natalie G. Ahn, Lee M. Graves, Jean S. Campbell, Lowell Ericsson, Maria Harrylock, Amy M. Jensen, and Edwin G. Krebs

Immunochemical localization of a region of chap- eronin-60 important for productive interaction with chaperonin-10. Drusilla L. Burns, Martin Kes- sel, Juan L. Arciniega, Arthur Karpas, and Jeanine Gould-Kostka

A single nucleotide deletion in the skeletal mus- cle-specific calcium channel transcript of mus- cular dysgenesis (mdg) mice. Nirupa Chaudhari

Calcium-triggered fusion of exocytotic granules requires proteins in only one membrane. Steven S. Vogel, Leonid V. Chernomordik, and Joshua Zimmerberg

Visible light-inducible photolyase gene from the goldfish Carassius auratus. Shinji Yasuhira and Akira Yasui

An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis. Edit Tarcsa, Noemi Kedei, Vilmos Thom- azy, and Laszlo Fesus

Cloning and expression of the essential gene for guanylate kinase from yeast. Manfred Konrad

Conversion of the proximal histidine ligand to glutamine restores activity to an inactive mutant of cytochrome c peroxidase. Kalidip Choudhury, Munirathinnm Sundaramoorthy, J. Matthew Mauro, and Thomas L. Poulos

Function of the alB2y2S y-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. Stephan Kel- lenberger, Pari Malherbe, and Erwin Sigel

Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor. Tung Ming Fong, Ruey-Ruey C. Huang, and Catherine D. Strader

Molecular basis for the species selectivity of the neurokinin- 1 receptor antagonists CP-96,345 and RP67580. Tung Ming Fong, Hong Yu, and Cath- erine D. Strader

25672

25676

25685

25690

25697

25703

25709

25714

25722

25730

25734

25739

A newly synthesized protein interacts with GroES on the surface of chaperonin GroEL. Elena S. Bochknreva and Alexander S. Girshovich

ARTICLES Purification and characterization of DNA topo- isomerase IV in Escherichia coli. Jun-ichi Kato, Hideho Suzuki, and Hideo Ikeda

2”Deoxy-GTP in the microtubule cytoskeleton of neuronal cells cultured with nerve growth factor. James M. Angelastro and Daniel L. Purich

Heterologous expression, purification, and bio- chemistry of the oligomycin sensitivity confer- ring protein (OSCP) from yeast. Arindam Mukho- padhyay, Xue-qiong Zhou, Misook Uh, and David M. Mueller

Characterization of receptors for thyrotropin- releasing hormone-receptors potentiating pep- tide on rat anterior pituitary membranes. Ali Ladram, Marc Bulant, and Pierre Nicolas

Two isoforms of the thyrotropin-releasing hor- mone receptor generated by alternative splicing have indistinguishable functional properties. Pi- lar de la Peiiu, Luis M. Delgado, Donato del Camino, and Francisco Barros

Post-translational processing of rac p21s is im- portant both for their interaction with the GDP/ GTP exchange proteins and for their activation of NADPH oxidase. Satoshi Ando, Kozo Kaibuchi, Takuya Sasaki, Kunihiko Hiraoka, Takayuki Nishi- yama, Takakazu Mizuno, Makoto Asada, Hiroyuki Nu- noi, Zchiro Matsuda, Yoshiharu Matsuura, Paul Po- lakis, Frank McCormick, and Yoshimi Takni

Characterization of chlorophyll a/b proteins of photosystem I from Chlamydomonas reinhard- tii. Roberto Bassi, Su Yin Soen, Gerhard Frank, Her- bert Zuber, and Jean-David Rochaix

Tetrahydrobiopterin synthesis. An absolute re- quirement for cytokine-induced nitric oxide gen- eration by vascular smooth muscle. Steven S. Gross and Roberto Levi

Aspartic acid 85 in bacteriorhodopsin functions both as proton acceptor and negative counterion to the Schiff base. Sriram Subramaniam, Duncan A. Greenhalgh, and H. Gobind Khorana

Effect of introducing different carboxylate-con- taining side chains at position 85 on chromo- phore formation and proton transport in bacte- riorhodopsin. Duncan A. Greenhalgh, Sriram Subra- maniam, Ulrike Alexiev, Harald Otto, Maarten P. Heyn, and H. Gobind Khorana

CrATP-induced Ca2+ occlusion in mutants of the Ca2+-ATPase of sarcoplasmic reticulum. Bente Vilsen and Jens Peter Andersen

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1992) J. Biol. Chem. 267,13781-13789, and reprints may be obtained from the editorial office.

111 ...

iv

25744

25748

25754

25759

25764

25168

25776

25786

25192

25798

25803

25810

25816

25822

25830

__

Fibronectin receptor modulates cyclin-depend- ent kinase activity. B. Erhan Symington

Dopamine D2 receptor stimulation of Na+/H+ ex- change assessed by quantification of extracellu- lar acidification. Kim A. Neve, Michael R. Kozlowski, and Mary P. Rosser

Site-directed mutagenesis of tyrosine hydroxyl- ase. Role of serine 40 in catalysis. Jing Wu, David Filer, Arnold J . Friedhoff, and Menek Goldstein

Rabbit skeletal muscle glycogenin. Molecular cloning and production of fully functional pro- tein in Escherichia coli. Emil Viskupic, Youjia Cao, Weiming Zhang, Christine Cheng, Anna A. De- Paoli-Roach, and Peter J . Roach

The low density lipoprotein receptor-related protein/cu2-macroglobulin receptor binds and me- diates catabolism of bovine milk lipoprotein lip- ase. David A. Chappell, Glenna L. Fry, Michelle A. Waknitz, Per-Henrik Iverius, Suzanne E. Williams, and Dudley K. Strickland

Construction of a chimeric ArsA-ArsB protein for overexpression of the oxyanion-translocating ATPase. Dexian Dou, Joshua B. Owolabi, Saibal Dey, and Barry P. Rosen

Identification of a M$+- and guanyl nucleotide- dependent glucagon receptor cycle by use of per- meabilized canine hepatocytes. Steven R. Post, Hi- roomi Miyazaki, and Howard s. Tager

Thyroid hormone-induced gene expression changes in the developing frog limb. Leonard Buckbinder and Donald D. Brown

Structural and functional characterization of band 3 from Southeast Asian ovalocytes. Ryuichi Moriyama, Hiroshi Ideguchi, Christian R. Lombardo, Heidi M. Van Dort, and Philip S. Low

Activation of phospholipase C by a,-adrenergic receptors is mediated by the (Y subunits of Gq family. Dianqing Wu, Arieh Katz, Chang-Ho Lee, and Melvin I. Simon

Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix. David Moscatelli

Investigation of the lectin-like binding domains in pertussis toxin using synthetic peptide se- quences. Identification of a sialic acid binding site in the S2 subunit of the toxin. Louis D. Heerze, Pele C. S. Chong, and Glen D. Armstrong

Structural organization of proteins on the oxi- dizing side of photosystem 11. Two molecules of the 33-kDa manganese-stabilizing proteins per reaction center. Qiang Xu and Terry M. Bricker

Catalytic properties of streptococcal NADH oxi- dase containing artificial flavins. S. Ashrafuddin Ahmed and A1 Claiborne

The conformation of apolipoprotein A-I in dis- coidal and spherical recombinant high density lipoprotein particles. 13C NMR studies of lysine ionization behavior. Daniel L. Sparks, Michael C. Phillips, and Sissel Lund-Katz

25839

25848

25856

25864

25873

25881

25889

25898

25908

25916

25922

25927

25934

25939

The charge and structural stability of apolipo- protein A-I in discoidal and spherical recombi- nant high density lipoprotein particles. Daniel L. Sparks, Sissel Lund-Katz, and Michael C. Phillips

p-Hydroxyphenylacetate-3-hydroxylase. A two- protein component enzyme. Usha Arunachalam, Vincent Massey, and C. S. Vaidyanathan

Structural requirements for transformation of substrates by the S-adenosyl-L-methionine: A24(2s)-ster~1 methyltransferase. Inhibition by analogs of the transition state coordinate. Giselle G. Janssen and W. David Nes

Calcium fluxes in T lymphocytes. Emmanuel Don- nadieu, Georges Bismuth, and Alain Trautmann

Kallistatin: a novel human tissue kallikrein in- hibitor. Purification, characterization, and re- active center sequence. Gary X. Zhou, Lee Chao, and Julie Chao

Human T-cell leukemia virus type I tax transfor- mation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo. Isao Kitajima, Toshiya Shinohara, Tani Minor, Lisa Bibbs, James Bilakovics, and Michael Nerenberg

Pleiotrophin stimulates fibroblasts and endothe- lial and epithelial cells and is expressed in human cancer. Wenjing Fang, Nicola Hartmann, David T. Chow, Anna Tate Riegel, and Anton Welktein

Interferon-induced Mx proteins form oligomers and contain a putative leucine zipper. Krister Me- len, Tapani Ronni, Barbara Broni, Robert M . Krug, Carl-Henrik von Bonsdorff, and Ilkka Julkunen

The redox-controlled light-harvesting chloro- phyll a/b protein kinase. Deactivation by substi- tuted quinones. Deborah Frid, Alma Gal, Walter Oett- meier, Gunter Hauska, Sigrid Berger, and Itzhak Ohad

Tumor necrosis factor stimulates multiple serine/ threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extra- cellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway. Jo- han Van Lint, Patrizia Agostinis, Veronique Vande- voorde, Guy Haegeman, Walter Fiers, Wilfried Mer- levede, and Jackie R. Vandenheede

Brain proline-directed protein kinase is a neu- rofilament kinase which displays high sequence homology to ~34"~"'. John Lew, Robert J. Winkfein, Hemant K. Paudel, and Jerry H. Wang

A novel nonmuscle a-actinin. Purification and characterization of chicken lung a-actinin. Mi- chihiro Imamura and Tomoh Masaki

Selective expression of mitogen-inducible cy- clooxygenase in macrophages stimulated with li- popolysaccharide. So0 H. Lee, Emmanuel Soyoola, Prithiva Chanmugam, Suzanne Hart, Wenqin Sun, Hua Zhong, Shuenn Liou, Daniel Simmons, and Daniel Hwang

Functional integrins from normal and glycosyl- ation-deficient baby hamster kidney cells. Ter- minal processing of asparagine-linked oligosac- charides is not correlated with fibronectin-bind- ing activity. Tamami Koyama and R. Colin Hughes

V

25945 Substrate specificity of myosin light chain kinases. B. Paul Herring, Patricia J . ~ l ~ h e r , and James T. Stull

25951 Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies. Manuel M. S6nchez del Pino, Richard A, Hawkins, and Darryl R. Peterson

25958 Insulin-dependent formation of a complex con- taining an 86-kDa subunit of phosphatidylin~i- to1 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1. Kazuyoshi Yonezawa, Hiroo Ueda, Kenta Hara, Kazuyuki Nishida, Akifumi Ando, Ah in Chavanieu, Hiroshi M a ~ ~ a ~ Kozui Shii, Koichi Yokono, Yasuhisa Fukui, Bernard Calas, Florin Grigo- rescu, Ritu Dhand, Ivan Gout, Masayuki Otsu, Michael D. Waterfield, and Masato Kasuga

25966 Phosphorylation-dependent regulation of phos- pholipase A2 by G-proteins and Ca2+ in HL60 granulocytes. Mingzhao Xing and Rafael Mattera

25976 Ph~phory~at ion of annexin I1 tetramer by pro- tein kinase C inhibits aggregation of lipid vesi- cles by the protein. Sharon Anne Johnstone, Ismail Hubaishy, and David Morton Waisman

25982 Transforming growth factor-B up-regulates low density lipoprotein receptor-mediated choles- terol metabolism in vascular smooth muscle cells. Andrew C. Nicho~on and David F. Hajjar

25988 Mechanism and fidelity of HIV reverse tran- scriptase. Warren M. Kati, Kenneth A. Johnson, L. Fred Jerva, and Karen S. Anderson

25998 Functional analysis at the Cys'06 residue of the retinoblastoma protein. Robert A. Kratzke, Gregory A. Otterson, Albert Y. Lin, Eiji Shimizu, Nadia Alex- androva, Maria Zajac-Kaye, Jonathan M. Horowitz, and Frederic J . Kaye

26004 Impaired tetramer assembly of variant medium- chain acyl-coenzyme G dehydrogenase with a glutamate or aspartate substitution for lysine 304 causing instability of the protein. Ichiro Yok- ota, Takahiko Saijo, Jerry Vockley, and Kay Tanaka

26011 Characterization of the human pleiotrophin gene. Promoter region and chromosomal local- ization. Yue-Sheng Li, Ruth M. Hoffman, Michelle M. Le Beau, Rafael Espinosa III, Nancy A. Jenkins, Debra J. Gilbert, Neat G. ~ o ~ l a n d , and Thomas F. Deuel

26017 Cross-talk between tyrosine kinase and G-pro- tein-linked receptors. Phosphorylation of B2-ad- renergic receptors in response to insulin. John R. Hadcock, J . David Port, Marina S. Gelmun, and Craig C. Malbon

26023 Differential regulation of T-cell receptor proc- essing and surface expression affected by CDIB, an alternatively spliced product of the CD~{/T gene locus. Linda K. Clayton, Andrew C. Diener, Adam Lerner, Albert G. D. Tse, Shigeo Koyasu, and Ellis L. Reinherz

26031 Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. Keith A. Houck, David W. Leung, Ann M. Rowland, Jane Winer, and ~apoleone Ferrara

26038 Sequence analysis, tissue distribution, and ex- pression of rat cathepsin S . Suzana Petanceska and L a ~ h m i Devi

26044

26050

26056

26062

26070

26078

26085

26091

26097

26104

26110

26121

26128

26134

26142

26150

The cyclic peptide synthetase catalyzing HC- toxin production in the filamentous fungus Cock- liobolus carbonum is encoded by a 15.7-kilobase open reading frame. John 5'. Scott-Craig, Daniel G. Panaccione, Jean-Alain Pocard, and Jonathan D. Walton Evidence for a structurally homologous Rh-like polypeptide in Rhnull erythrocytes. Jerome Connor, Menashe Bar-Eli, Karen D. Gillum, and Alan J . Schroit

Phospholamban expressed in slow-twitch and chronically stimulated fast-twitch muscles min- imally affects calcium affinity of sarcoplasmic reticulum CaZ*-ATPase. F. Norman Briggs, K. Francis Lee, Andrew W. Wechsler, and Larry R. Jones

Reconstitution and partial purification of the gli- benclamide-sensitive, ATP-dependent K+ chan- nel from rat liver and beef heart mitochondria. Petr Paucek Galina M i r o ~ v ~ Fakhri Mahdi, Andrew D. Beavis, Gebretateos WoMegiorgis, and Keith D. Garlid Selective expression of trypsin fusion genes in acinar cells of the pancreas and stomach of trans- genic mice. Brian P. Davis, Robert E. Hammer, Albee Messing, and Raymond J . MacDonald

Influence of specific y-carboxyglutamic acid res- idues on the integrity of the c ~ c i u m - d e ~ n d e n t conformation of human protein C. Li Zhang and Francis J . Castellino Molecular cloning of a homeobox transcription factor from adult aortic smooth muscle. Chan- drashekhar V. Patel, David H. Gorski, David F. &Page, John Lincecum, and Kenneth Walsh Inhibition of smooth muscle myosin's activity and assembly by an anti-rod monoclonal anti- body. Arie Horowitz and Kathleen M. Trybus

Identification of amino acid residues at the inter- face of a bacteriophage T4 regA protein-nucleic acid complex. Kevin R. Webster, Sarah Keill, William Konigsberg, Kenneth R. Williams, and Eleanor K. Spicer

The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives. Alireza R. Rezaie and Charles T. Esmon

Role of the membrane surface in the activation of human coagulation factor X. Sriram Krishnas- wamy, Kenneth A. Field, Thomas S. Edgington, James H. Morrissey, and Kenneth G. Mann

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quies- cent Swiss 3T3 fibroblasts. Ana Olivera, Nancy E. Buckiey, and Sarah Spiegel

Rates of carbamylation of specific lysyl residues in bovine cY-crystallins. Wen Qin, Jean €3. Smith, and David L. Smith

Tumor necrosis factor-a! down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity. Veli-Matti KcWri, Yue Qiu Chen, M u h a m m ~ M. Bashir, Joel Rosenbtoom, and Jouni Uitto Partial purification of the cystic fibrosis trans-

gaard and M~chael J. Webh membrane conductance regulator. Lynda S. Osted-

Lys-plasminogen is a significant intermediate in the activation of Glu-plasminogen during fibrin- olysis in vitro. James C. Fredenburgh and Michael E. Nesheim

VI

26157 1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligo- saccharides in bovine capillary endothelial cells. Mai Nguyen, Judah Folkman, and Joyce Bischff

26166 Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Ef- fects of mutations in the potential proteolytic cleavage site on processing and ligand binding. Melanie R. Mark, Nathalie A. Lokker, Thomas F. Zion- check, Elizabeth A. Luis, and Paul J. Godowski

26172 Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plas- minogen activator-inhibitor complexes and lac- toferrin, an inhibitor of chylomicron remnant clearance. Thomas E. Willnow, Joseph L. Goldstein, Kim Orth, Michael S. Brown, and Joachim Herz

26181 A novel family of cell surface receptors with tyrosine kinase-like domain. Piotr Masiakowski and Robert D. Carroll

26191 Characterization of F-pilin as an inner mem- brane component of Escherichia coli K12. Wil- liam D. Paiua, Trudy Grossman, and Philip M. Siluerman

ADDITIONS AND CORRECTIONS 26198 Molecular cloning and sequence analysis of

smooth muscle calponin. Vol. 266 (1991) 13284- 13288. Katsuhito Takahashi and Bernard0 Na- dal-Ginard

26198 Molecular cloning, expression, and characteriza- tion of the cDNA for the rat hepatic squalene synthase. Vol. 267 (1992) 21368-21374. Timo- thy L. McKenzie, Guojian Jiang, Juerg R. Straubhaar, Deanna G. Conrad, and Ishaiahu Shechter

26199 Thermodynamic and kinetic studies on the mech- anism of binding of methylumbelliferyl glyco- sides to jacalin. Vol. 267 (1992) 8909-8918. Dipti Gupta, N. V. S. A. V. Prasad Rao, Kamal Deep Puri, Khushi L. Matta, and Auadhesha Surolia

26200 Biochemical evidence for the presence of an amiloride binding protein in adult alveolar type I1 pneumocytes. Vol. 267 (1992) 18498-18504. Youngsuk Oh, Sadis Matalon, Thomas R. Kleyman, and Dale J . Benos

26201 Cumulative author index. Numbers 1 through

26237 Keyword index. 36.

GENERAL INFORMATION

your subscription agent or contact: THE JOURNAL OF BIOLOGICAL CHEMISTRY, This publication is auailable on CD-ROM. Inquire about availability through

428 EAST PRESTON STREET, BALTIMORE, MD 21202, U S A . Minireoiews are reprinted in January of the succeeding year in a Minireuiew Compendium.

ASBMB Office, 9650 Rockullle Pike, Bethesda, MD 20814, U.S.A. Compendia for 1988 through 1991 are auailable through the ASBMB office:

Submit all manuscripts in triplicate to Editor, The Journal of Biological Chemistry 9650 Rockville Pike Bethesda, MD 20814, U.S.A.

the author(s) will pay a charge per page. Current page charges may he obtained Accepted manuscripts will he published with the implicit understanding that

by contacting the JBC Office. Under exceptional circumstances, when no source

submission, for a grant-in-aid to Chairman, Publications Committee, Ameri- of grant or other support exists, the author(s) may apply, at the time of

can Society for Biochemistry and Molecular Biology, Inc., 9650 Rockville Pike, Bethesda, MD 20814. All such applications must he countersigned by an

charges. appropriate institutional official stating that no funds are available for page

“Instructions to Authors,” or of the “Editorial Policy and Practices,” or for Queries on matters of general editorial policy, requests for reprints of the

permission to reproduce any part of a previously published article should he directed to the Journal Editorial Office in Bethesda, telephone 301-530-7150.

The Journal of Biological Chemistry publishes papers on a broad range of topics of interest to biochemists. The views expressed are those of the author(s) and not of The Journal of Biological Chemistry or the American Society for Biochemistry and Molecular Biology.

for Biochemistry and Molecular Biology, Inc. Reprographic copying beyond The Journal of Biological Chemistry is copyrighted by the American Society

that permitted hy Sections 107 or 108 of the U.S. Copyright Law is allowed, provided that the $2.50 per-copy fee is paid through the Copyright Clearance Center, 27 Congress Street, Salem, MA 01970. For those organizations that have been granted photocopy license by CCC, a separate system of payment has been arranged. The fee code for users of the Transactional Reporting Service is: 0021-9258/93/$2.50. 8 Printed on acid-free paper effective with

subsequent republication requires permission of the copyright owner. Requests Volume 254, Issue No. 1 (1979). Reproduction of any portion of an article for

should he made in writing to the American Society for Biochemistry and Molecular Biology, Inc., Attn.: Editorial Office, 9650 Rockville Pike, Bethesda, MD 20814, and should include a statement of intended use as well as explicit specifications of the material to he reproduced.

copies to: THE JOURNAL OF BIOLOGICAL CHEMISTRY, 428 EAST PRESTON Address all correspondence and orders relative to subscriptions and hack

tions are entered on a calendar year bas s only. Requests for termination of STREET, BALTIMORE, MD 21202, U.S.A., telephone 410-528-4255. Suhscrip-

subscriptions will he honored with proportional refunds less a $10 cancellation charge. Allow at least six weeks for address changes. Claims for replacement copies must he received within four months of the issue date.

Vol. 267, No. 36 The Journal of Biological Chemistry December 25, 1992

25621

25759

25810

25939

-25628

-25640

025648

25685

25709

25722

25744

25748

CONTENTS Arranged by

MINIREVIEW

Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins. Lawrence Chan

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Rabbit skeletal muscle glycogenin. Molecular cloning and production of fully functional pro- tein in Escherichia coli. Emil Viskupic, Youjia Cao, Weiming Zhang, Christine Cheng, Anna A. De- Paoli-Roach, and Peter J . Roach

Investigation of the lectin-like binding domains in pertussis toxin using synthetic peptide se- quences. Identification of a sialic acid binding site in the S2 subunit of the toxin. Louis D. Heerze, Pele C. S. Chong, and Glen D. Armstrong

Functional integrins from normal and glycosyl- ation-deficient baby hamster kidney cells. Ter- minal processing of asparagine-linked oligosac- charides is not correlated with fibronectin-bind- ing activity. Tamami Koyama and R. Colin Hughes

CELL BIOLOGY AND METABOLISM

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. Rony Seger, Dalia Seger, Fred J. Lozeman, Natalie G. Ahn, Lee M. Graves, Jean S. Campbell, Lowell Ericsson, Maria Harrylock, A m y M. Jensen, and Edwin G. Krebs

Calcium-triggered fusion of exocytotic granules requires proteins in only one membrane. Steven S. Vogel, Leonid V. Chernomordik, and Joshua Zimmerberg

An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis. Edit Tarcsa, Noemi Kedei, Vilmos Thom- azy, and Laszlo Fesus

2”Deoxy-GTP in the microtubule cytoskeleton of neuronal cells cultured with nerve growth factor. James M. Angelastro and Daniel L. Purich

Post-translational processing of rac p21s is im- portant both for their interaction with the GDP/ GTP exchange proteins and for their activation of NADPH oxidase. Satoshi Ando, Kozo Kaibuchi, Takuya Sasaki, Kunihiko Hiraoka, Takayuki Nishi- yama, Takakazu Mizuno, Makoto Asada, Hiroyuki Nu- noi, Ichiro Matsuda, Yoshiharu Matsuura, Paul Po- lakis, Frank McCormick, and Yoshimi Takai

Tetrahydrobiopterin synthesis. An absolute re- quirement for cytokine-induced nitric oxide gen- eration by vascular smooth muscle. Steven s. Gross and Roberto Levi

Fibronectin receptor modulates cyclin-depend- ent kinase activity. B. Erhan Symington

Dopamine D2 receptor stimulation of Na+/H+ ex- change assessed by quantification of extracellu- lar acidification. Kim A. Neve, Michael R. Kozlowski, and Mary P. Rosser

Subject Categories

25764 The low density lipoprotein receptor-related protein/az-macroglobulin receptor binds and me- diates catabolism of bovine milk lipoprotein lip- ase. David A. Chappell, Glenna L. Fry, Michelle A. Waknitz, Per-Henrik Iverius, Suzanne E. Williams, and Dudley K. Strickland

25776 Identification of a Mg2+- and guanyl nucleotide- dependent glucagon receptor cycle by use of per- meabilized canine hepatocytes. Steven R. Post, Hi- roomi Miyazaki, and Howard S. Tager

25798 Activation of phospholipase C by al-adrenergic receptors is mediated by the a subunits of Gq family. Dianqing Wu, Arieh Katz, Chang-Ho Lee, and Melvin I. Simon

25803 Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix. David Moscatelli

25864 Calcium fluxes in T lymphocytes. Emmanuel Don- nadieu, Georges Bismuth, and Alain Trautmann

25889 Pleiotrophin stimulates fibroblasts and endothe- lial and epithelial cells and is expressed in human cancer. Wenjing Fang, Nicola Hartmann, David T. Chow, Anna Tate Riegel, and Anton Wellstein

25934 Selective expression of mitogen-inducible cy- clooxygenase in macrophages stimulated with li- popolysaccharide. So0 H. Lee, Emmanuel Soyoola, Prithiva Chanmugam, Suzanne Hart, Wenqin Sun, Hua Zhong, Shuenn Liou, Daniel Simmons, and Daniel Hwang

25958 Insulin-dependent formation of a complex con- taining an 85-kDa subunit of phosphatidylinosi- to1 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1. Kazuyoshi Yonezawa, Hiroo Ueda, Kenta Hara, Kazuyuki Nishida, Akifumi Ando, Alain Chavanieu, Hiroshi Matsuba, Kozui Shii, Koichi Yokono, Yasuhisa Fukui, Bernard Calas, Florin Grigo- rescu, Ritu Dhand, Ivan Gout, Masayuki Otsu, Michael D. Waterfield, and Masato Kasuga

25966 Phosphorylation-dependent regulation of phos- pholipase A2 by G-proteins and Ca2+ in HL60 granulocytes. Mingzhao Xing and Rafael Mattera

25982 Transforming growth factor+ up-regulates low density lipoprotein receptor-mediated choles- terol metabolism in vascular smooth muscle cells. Andrew C. Nicholson and David P. Hajjar

26017 Cross-talk between tyrosine kinase and G-pro- tein-linked receptors. Phosphorylation of &ad- renergic receptors in response to insulin. John R. Hadcock, J . David Port, Marina S. Gelman, and Craig C. Malbon

26031 Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. Keith A. Houck, David W. Leung, A n n M. Rowland, Jane Winer, and Napoleone Ferrara

26038 Sequence analysis, tissue distribution, and ex- pression of rat cathepsin S. Suzana Petanceska and Lakshmi Devi

26050 Evidence for a structurally homologous Rh-like polypeptide in Rh,,ll erythrocytes. Jerome Connor, Menashe Bar-Eli, Karen D. Gillum, and Alan J . Schroit

Indicates a Communication

vii

viii

26121

26134

26157

26172

-25672

25754

25822

25848

25856

25916

25922

26110

025660

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quies- cent Swiss 3T3 fibroblasts. Ana Olivera, Nancy E. Buckley, and Sarah Spiegel

Tumor necrosis factor-a down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity. Veli-Matti Kahari, Yue Qiu Chen, Muhammad M. Bashir, Joel Rosenbloom, and Jouni Uitto

1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligo- saccharides in bovine capillary endothelial cells. Mai Nguyen, Judah Folkman, and Joyce Bischoff

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plas- minogen activator-inhibitor complexes and lac- toferrin, an inhibitor of chylomicron remnant clearance. Thomas E. Willnow, Joseph L. Goldstein, Kim Orth, Michael S. Brown, and Joachim Herz

ENZYMOLOGY

A newly synthesized protein interacts with GroES on the surface of chaperonin GroEL. Elena S. Bochkareua and Alexander S. Girshuich

Site-directed mutagenesis of tyrosine hydroxyl- ase. Role of serine 40 in catalysis. Jing Wu, David Filer, Arnold J . Fr iedhf f , and Menek Goldstein

Catalytic properties of streptococcal NADH oxi- dase containing artificial flavins. S. Ashrafuddin Ahmed and A1 Claiborne

p-Hydroxyphenylacetate-3-hydroxylase. A two- protein component enzyme. Usha Arunachalam, Vincent Massey, and C. S. Vaidyanathm

Structural requirements for transformation of substrates by the S-adenosyl-L-methionine: A24(26)-sterol methyltransferase. Inhibition by analogs of the transition state coordinate. Giselle G. Janssen and W. David Nes

Tumor necrosis factor stimulates multiple serine/ threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extra- cellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway. Jo- han Van Lint, Patrizia Agostinis, Veronique Vande- voorde, Guy Haegeman, Walter Fiers, Wilfried Mer- levede, and Jackie R. Vandenheede

Brain proline-directed protein kinase is a neu- rofilament kinase which displays high sequence homology to p34cdc2. John Lew, Robert J. Winkfein, Hemant K. Paudel, and Jerry H. Wang

Role of the membrane surface in the activation of human coagulation factor X. Sriram Krishnas- wamy, Kenneth A. Field, Thomas S. Edgington, James H. Morrissey, and Kenneth G. Mann

MEMBRANES AND BIOENERGETICS Function of the a182y2S y-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. Stephun Kel- lenberger, Pari Malherbe, and Erwin Sigel

25690 Heterologous expression, purification, and bio- chemistry of the oligomycin sensitivity confer- ring protein (OSCP) from yeast. Arindam Mukho- padhyay, Xue-qiong Zhou, Misook Uh, and David M. Muller

25714

25730

25734

25739

25768

25792

25816

25908

25951

26056

26062

26200

Characterization of chlorophyll a/b proteins of photosystem I from Chlamydomonas reinhard- tii. Roberto Bassi, Su Y i n Soen, Gerhard Frank, Her- bert Zuber, and Jean-David Rochaix

Aspartic acid 85 in bacteriorhodopsin functions both as proton acceptor and negative counterion to the Schiff base. Sriram Subramaniam, Duncan A. Greenhalgh, and H. Gobind Khorana

Effect of introducing different carboxylate-con- taining side chains at position 86 on chromo- phore formation and proton transport in bacte- riorhodopsin. Duncan A. Greenhalgh, Sriram Subra- maniam, Ulrike Alexiev, HaraM Otto, Maarten P. Heyn, and H. Gobind Khorana

CrATP-induced Ca2+ occlusion in mutants of the Ca2+-ATPase of sarcoplasmic reticulum. Bente Vilsen and Jens Peter Andersen

Construction of a chimeric ArsA-ArsB protein for overexpression of the oxyanion-translocating ATPase. Dexian Dou, Joshua B. Owolabi, Saibal Dey, and Barry P. Rosen

Structural and functional characterization of band 3 from Southeast Asian ovalocytes. Ryuichi Moriyama, Hiroshi Ideguchi, Christian R. Lombardo, Heidi M. Van Dort, and Philip S. Low

Structural organization of proteins on the oxi- dizing side of photosystem 11. Two molecules of the 33-kDa manganese-stabilizing proteins per reaction center. Qiang X u and Terry M. Bricker

The redox-controlled light-harvesting chloro- phyll alb protein kinase. Deactivation by substi- tuted quinones. Deborah Frid, Alma Gal, Walter Oett- meier, Gunter Hauska, Sigrid Berger, and Itzhak Ohad

Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies. Manuel M. Sanchez del Pino, Richard A. Hawkins, and Darryl R. Peterson

Phospholamban expressed in slow-twitch and chronically stimulated fast-twitch muscles min- imally affects calcium affinity of sarcoplasmic reticulum Ca2+-ATPase. F. Norman Briggs, K. Francis Lee, Andrew W. Wechsler, and Larry R. Jones

Reconstitution and partial purification of the gli- benclamide-sensitive, ATP-dependent K+ chan- nel from rat liver and beef heart mitochondria. Petr Paucek, Galina Mironova, Fakhri Mahdi, Andrew D. Beauis, Gebretateos Woldegwrgis, and Keith D. Garlid

Biochemical evidence for the presence of an amiloride binding protein in adult alveolar type I1 pneumocytes. Vol. 267 (1992) 18498-18604. Youngsuk Oh, Sadis Matalon, Thomas R. Kleyman, and Dale J . Benos

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

-25636 A single nucleotide deletion in the skeletal mus- cle-specific calcium channel transcript of mus- cular dysgenesis (mdg) mice. Nirupa Chaudhari

e25644 Visible light-inducible photolyase gene from the goldfish Carassius auratus. Shinji Yasuhira and Akira Yasui

025652 Cloning and expression of the essential gene for guanylate kinase from yeast. Manfred Konrad

Indicates a Communication

ix

25676

25703

25186

25881

25988

25998

26004

26011

26023

26044

26070

26085

26097

26166

Purification and characterization of DNA topo- isomerase IV in Escherichia coli. Jun-ichi Kato, Hideho Suzuki, and Hideo Ikeda

Two isoforms of the thyrotropin-releasing hor- mone receptor generated by alternative splicing have indistinguishable functional properties. Pi- lar de la pe&, Luis M. Delgado, Donato del Camino, and Francisco Burros

Thyroid hormone-induced gene expression changes in the developing frog limb. Leonard Buckbinder and Donald D. Brown

Human T-cell leukemia virus type I tax transfor- mation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo. I sm Kitajimn, Toshiya Shinohara, Tani Minor, Lisa Bibbs, James Bilakovics, and Michael Nerenberg

Mechanism and fidelity of HIV reverse tran- scriptase. Warren M. Kati, Kenneth A. Johnson, L. Fred Jerva, and Karen S. Anderson

Functional analysis at the CYS'~'' residue of the retinoblastoma protein. Robert A. Kratzke, Gregory A. Otterson, Albert Y. Lin, Eiji Shimizu, Nadia Alex- androva, Maria Zajac-Kaye, Jonathan M. Horowitz, and Frederic J . Kaye

Impaired tetramer assembly of variant medium- chain acyl-coenzyme A dehydrogenase with a glutamate or aspartate substitution for lysine 304 causing instability of the protein. Ichiro Yok- ota, Takahiko Saijo, Jerry Vockley, and Kay Tanaka

Characterization of the human pleiotrophin gene. Promoter region and chromosomal local- ization. Yue-Sheng Li, Ruth M. Hoffman, Michelle M. Le Beau, Rafael Espinosa 111, Nancy A. Jenkins, Debra J . Gilbert, Neal G. Copeland, and Thomas F. Dew1

Differential regulation of T-cell receptor proc- essing and surface expression affected by CD30, an alternatively spliced product of the CD3{/q gene locus. Linda K. Clayton, Andrew C. Diener, Adam Lerner, Albert G. D. Tse, Shigeo Koyasu, and Ellis L. Reinherz

The cyclic peptide synthetase catalyzing HC- toxin production in the filamentous fungus Coch- liobolus carbonum is encoded by a 15.7-kilobase open reading frame. John S. Scott-Craig, Daniel G. Pannccione, Jean-Alain Pocard, and Jonathan D. Walton

Selective expression of trypsin fusion genes in acinar cells of the pancreas and stomach of trans- genic mice. Brian P. Davis, Robert E. Hammer, Albee Messing, and Raymond J . MacDonald

Molecular cloning of a homeobox transcription factor from adult aortic smooth muscle. Chan- drashekhur V. Patel, David H. Gorski, David F. LePage, John Lincecum, and Kenneth Wakh

Identification of amino acid residues at the inter- face of a bacteriophage T4 regA protein-nucleic acid complex. Kevin R. Webster, Sarah Keill, William Konigsberg, Kenneth R. Williams, and Eleanor K. Spicer

Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Ef- fects of mutations in the potential proteolytic cleavage site on processing and ligand binding. Melanie R. Mark, Nathalie A. Lokker, Thomas F. Zion- check, Elizabeth A. Luis, and Paul J . Godowski

26181

26198

e25625

~25632

-25656

-25664

*25668

25697

25830

25839

25873

25898

25927

25945

25976

26078

A novel family of cell surface receptors with tyrosine kinase-like domain. Piotr Masiakowski and Robert D. Carroll

Molecular cloning, expression, and characteriza- tion of the cDNA for the rat hepatic squalene synthase. Vol. 267 (1992) 21368-21374. Timo- thy L. McKenzie, Guojian Jiang, Juerg R. Straubhaar, Deanna G. Conrad, and Zshaiahu Shechter

PROTEIN CHEMISTRY AND STRUCTURE Protein control of iron-sulfur cluster redox po- tentials. Ralf Langen, Gerard M. Jensen, Uwe Jacob, Philip J . Stephens, and Arieh Warshel

Immunochemical localization of a region of chap- eronin-60 important for productive interaction with chaperonin-10. Drusilla L. Burns, Martin Kes- sel, Juan L. Arciniega, Arthur Karpas, and Jeanine Gould-Kostka Conversion of the proximal histidine ligand to glutamine restores activity to an inactive mutant of cytochrome c peroxidase. Kalidip Choudhury, Munirathinam Sundaramoorthy, J . Matthew Mauro, and Thomas L. Poulos

Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.

D. Strader Tung Ming Fong, Ruey-Ruey C. Huang, and Catherine

Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. Tung Ming Fong, Hong Yu, and Cath- erine D. Strader

Characterization of receptors for thyrotropin- releasing hormone-receptors potentiating pep- tide on rat anterior pituitary membranes. Ali Ladram, Marc Bulant, and Pierre Nicolas

The conformation of apolipoprotein A-I in dis- coidal and spherical recombinant high density lipoprotein particles. "C NMR studies of lysine ionization behavior. Daniel L. Sparks, Michael C. Phillips, and Sissel Lund-Katz

The charge and structural stability of apolipo- protein A-I in discoidal and spherical recombi- nant high density lipoprotein particles. Daniel L. Sparks, Sissel Lund-Katz, and Michael C. Phillips Kallistatin: a novel human tissue kallikrein in- hibitor. Purification, characterization, and re- active center sequence. Gary X. Zhou, Lee Chao, and Julie Chao

Interferon-induced Mx proteins form oligomers and contain a putative leucine zipper. Krister Me- En, Tapani Ronni, Barbara Broni, Robert M. Krug, Carl-Henrik von Bonsdorff, and Ilkka Julkunen

A novel nonmuscle a-actinin. Purification and characterization of chicken lung a-actinin. Mi- chihiro Imamura and Tomoh Masaki

Substrate specificity of myosin light chain kinases. B. Paul Herring, Patricia J . Gallagher, and James T. Stull Phosphorylation of annexin I1 tetramer by pro- tein kinase C inhibits aggregation of lipid vesi- cles by the protein. Sharon Anne Johnstone, Zsmail Hubaishy, and David Morton Waisman

Influence of specific y-carboxyglutamic acid res- idues on the integrity of the calcium-dependent conformation of human protein C. Li Zhang and Francis J . Castellino

Indicates a Communication

X

26091 Inhibition of smooth muscle myosin's activity 26150 Lys-plasminogen is a significant intermediate in and assembly by an anti-rod monoclonal anti- the activation of Glu-plasminogen during fibrin- body. Arie Horowitz and Kathleen M. Trybus E. Nesheim

olysis in vitro. James C. Fredenburgh and Michael

26104 The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives. Alireza R. Rezaie and Charles T. Esmon

26128 Rates of carbamylation of specific lysyl residues in bovine a-crystallins. W e n Qin, Jean B. Smith, and David L. Smith

26142 Partial purification of the cystic fibrosis trans- membrane conductance regulator. Lynda S. Osted- guard and Michael J. Welsh

26191 Characterization of F-pilin as an inner mem- brane component of Escherichia coli K12. Wil- liam D. Paiua, Trudy Grossman, and Philip M. Silverman

26198 Molecular cloning and sequence analysis of smooth muscle calponin. Vol. 266 (1991) 13284- 13288. Katsuhito Takahashi and Bernardo Na- dal-Ginard

26199 Thermodynamic and kinetic studies on the mech-

sides to jacalin. Vol. 267 (1992) 8909-8918. anism of binding of methylumbelliferyl glyco-

Dipti Gupta, N . V. S. A. V. Prasad Rao, Kamal Deep Puri, Khushi L. Matta, and Avadhesha Surolia

Agostinis, Patrizia, 25916 Ahmed, S. Ashrafuddin,

Ahn, Natalie G., 25628 Alexandrova, Nadia, 25998 Alexiev, Ulrike, 25734 Andersen, Jens Peter, 25739 Anderson, Karen S., 25988 Ando, Akifumi, 25958 Ando, Satoshi, 25709 Angelastro, James M., 25685 Arciniega, Juan L., 25632 Armstrong, Glen D., 25810 Arunachalam, Usha, 25848 Asada, Makoto, 25709 Bar-Eli, Menashe, 26050 Barros, Francisco, 25703 Bashir, Muhammad M.,

Bassi, Roberto, 25714 Beavis, Andrew D., 26062 Benos, Dale J., 26200 Berger, Sigrid, 25908 Bibbs, Lisa, 25881 Bilakovics, James, 25881 Bischoff, Joyce, 26157 Bismuth, Georges, 25864 Bochkareva, Elena S., 25672 Bricker, Terry M., 25816 Briggs, F. Norman, 26056 Broni, Barbara, 25898 Brown, Donald D., 25786 Brown, Michael S., 26172 Buckbinder, Leonard, 25786 Buckley, Nancy E., 26121 Bulant, Marc, 25697 Burns, Drusilla L., 25632 Calas, Bernard, 25958 Campbell, Jean S., 25628 Cao, Youjia, 25759 Carroll, Robert D., 26181 Castellino, Francis J., 26078 Chan, Lawrence, 25621 Chanmugam, Prithiva, 25934 Chao, Julie, 25873

25822

26134

Chao, Lee, 25873 Chappell, David A., 25764 Chaudhari, Nirupa, 25636 Chavanieu. Alain. 25958 Chen, Yue'Qiu, 26134

Chernomordik, Leonid V., Cheng, Christine, 25759

Chong, Pele C. S., 25810 Choudhury, Kalidip, 25656 Chow, David T., 25889 Claiborne, AI, 25822

25640

Clayton, Linda K., 26023 Connor, Jerome, 26050 Conrad, Deanna G., 26198 Copeland, Neal G., 26011

Davis, Brian P., 26070 de la Pefia, Pilar, 25703 del Camino, Donato, 25703 Delgado, Luis M., 25703 DePaoli-Roach, Anna A.,

Deuel, Thomas F., 26011 Devi, Lakshmi, 26038 Dey, Saibal, 25768 Dhand, Ritu, 25958 Diener, Andrew C., 26023 Donnadieu, Emmanuel,

Dou, Dexian, 25768

25759

25864

Edgington, Thomas S., 26110 Ericsson, Lowell, 25628 Esmon, Charles T., 26104 Espinosa, Rafael, 111, 26011

Fang, Wenjing, 25889 Ferrara, Napoleone, 26031 Fesus, Laszlo, 25648 Field, Kenneth A,, 26110 Fiers, Walter, 25916 Filer, David, 25754 Folkman, Judah, 26157 Fong, Tung Ming, 25664,

Frank, Gerhard, 25714 Fredenburgh, James C.,

Frid, Deborah, 25908 Friedhoff, Arnold J., 25754 Fry, Glenna L., 25764 Fukui, Yasuhisa, 25958

Gal, Alma, 25908 Gallagher, Patricia J., 25945 Garlid, Keith D., 26062 Gelman, Marina S., 26017 Gilbert, Debra J., 26011 Gillum, Karen D., 26050 Girshovich, Alexander S..

25668

26150

25672 Godowski, Paul J., 26166 Goldstein, Joseph L., 26172 Goldstein. Menek. 25754 Gorski, David H.,'26085 Gould-Kostka, Jeanine,

Gout, Ivan, 25958 Graves. Lee M.. 25628

25632

Greenhalgh, Duncan A., 25730,25734

AUTHOR INDEX

Grigorescu, Florin, 25958 Gross, Steven S., 25722 Grossman, Trudy, 26191 Gupta, Dipti, 26199

Hadcock, John R., 26017 Haegeman, Guy, 25916 Hajjar, David P., 25982

Hara, Kenta, 25958 Hammer, Robert E., 26070

Harrylock, Maria, 25628 Hart, Suzanne, 25934 Hartmann, Nicola, 25889 Hauska, Gunter, 25908 Hawkins, Richard A,, 25951 Heerze, Louis D., 25810 Herring, B. Paul, 25945 Herz, Joachim, 26172 Heyn, Maarten P., 25734 Hiraoka, Kunihiko, 25709 Hoffman, Ruth M., 26011 Horowitz, Arie, 26091 Horowitz, Jonathan M.,

Houck, Keith A., 26031 Huang, Ruey-Ruey C., 25664 Hubaishy, Ismail, 25976 Hughes, R. Colin, 25939 Hwang, Daniel, 25934

Ideguchi, Hiroshi, 25792 Ikeda, Hideo, 25676 Imamura, Michihiro, 25927 Iverius, Per-Henrik, 25764

Jacob, Uwe, 25625 Janssen, Giselle G., 25856 Jenkins, Nancy A,, 26011 Jensen, Amy M., 25628 Jensen, Gerard M., 25625 Jerva, L. Fred, 25988 Jiang, Guojian, 26198 Johnson, Kenneth A., 25988 Johnstone, Sharon Anne,

Jones, Larry R., 26056 Julkunen, Ilkka, 25898

Kahari, Veli-Matti, 26134 Kaibuchi, Kozo, 25709 Karpas, Arthur, 25632 Kasuga, Masato, 25958 Kati, Warren M., 25988 Kato, Jun-ichi, 25676 Katz, Arieh, 25798 Kaye, Frederic J., 25998 Kedei, Noemi, 25648 Keill, Sarah, 26097 Kellenberger, Stephan, 25660 Kessel, Martin, 25632

25998

25976

Khorana, H. Gobind, 25730,

Kitajima, Isao, 25881 Kleyman, Thomas R., 26200 Konigsberg, William, 26097 Konrad, Manfred, 25652 Koyama, Tamami, 25939 Koyasu, Shigeo, 26023 Kozlowski, Michael R., 25748 Kratzke, Robert A., 25998 Krebs, Edwin G., 25628 Krishnaswamy, Sriram,

Krug, Robert M., 25898 Ladram, Ah, 25697 Langen, Ralf, 25625 Le Beau, Michelle M., 26011 Lee, Chang-Ho, 25798 Lee, K. Francis, 26056 Lee, So0 H., 25934 LePage, David F., 26085 Lerner, Adam, 26023 Leung, David W., 26031 Levi, Roberto, 25722 Lew, John, 25922 Li, Yue-Sheng, 26011 Lin, Albert Y., 25998 Lincecum, John, 26085 Liou, Shuenn, 25934 Lokker, Nathalie A., 26166 Lombardo, Christian R.,

Low, Philip S., 25792 Lozeman, Fred J., 25628 Luis, Elizabeth A., 26166 Lund-Katz, Sissel, 25830,

MacDonald, Raymond J.,

Mahdi, Fakhri, 26062 Malbon, Craig C., 26017 Malherbe, Pari, 25660 Mann, Kenneth G., 26110 Mark, Melanie R., 26166 Masaki, Tomoh, 25927 Masiakowski, Piotr, 26181 Massey, Vincent, 25848 Matalon, Sadis, 26200 Matsuba, Hiroshi, 25958 Matsuda, Ichiro, 25709 Matsuura, Yoshiharu, 25709 Matta, Khushi L., 26199 Mattera, Rafael, 25966 Mauro, J. Matthew, 25656 McCormick, Frank, 25709 McKenzie, Timothy L., 26198 MelBn, Krister, 25898

25734

26110

25792

25839

26070

Merlevede, Wilfried, 25916

Minor, Tani, 25881 Messing, Albee, 26070

Mironova, Galina, 26062 Miyazaki, Hiroomi, 25776

Moriyama, Ryuichi, 25792 Mizuno, Takakazu, 25709

Morrissey, James H., 26110 Moscatelli, David, 25803 Mueller, David M., 25690 Mukhopadhyay, Arindam,

Nadal-Ginard, Bernardo,

Nerenberg, Michael, 25881 Nes, W. David, 25856 Nesheim, Michael E., 26150 Neve, Kim A., 25748 Nguyen, Mai, 26157 Nicholson, Andrew C., 25982 Nicolas, Pierre, 25697 Nishida, Kazuyuki, 25958 Nishiyama, Takayuki, 25709 Nunoi, Hiroyuki, 25709 Oettmeier, Walter, 25908 Oh, Youngsuk, 26200 Ohad, Itzhak, 25908 Olivera, Ana, 26121 Orth, Kim, 26172 Ostedgaard, Lynda S., 26142 Otsu, Masayuki, 25958 Otterson, Gregory A., 25998 Otto, Harald, 25734 Owolabi, Joshua B., 25768 Paiva, William D., 26191

Patel, Chandrashekhar V., Panaccione, Daniel G., 26044

Paucek, Petr, 26062 Paudel, Hemant K., 25922 Petanceska, Suzana, 26038 Peterson, Darryl R., 25951 Phillips, Michael C., 25830,

Pocard, Jean-Alain, 26044 Polakis, Paul, 25709 Port, J. David, 26017 Post, Steven R., 25776 Poulos, Thomas L., 25656 Puri, Kamal Deep, 26199 Purich, Daniel L., 25685 gin, Wen, 26128 Rao, N. V. S. A. V. Prasad,

Reinherz, Ellis L., 26023 Rezaie, Alireza R., 26104

25690

26198

26085

25839

26199