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ASAHI NEO’S Confidential / Internal Use Only

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Page 1: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

ASAHI NEO’S

Confidential / Internal Use Only

Page 2: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

2Confidential / Internal Use Only

ASAHI NEO’SContents:

Property of ASAHI NEO’S PTCA Guidewire FamilyStructureCoating over the metal

Product Line-upComparison ASAHI NEO’S vs. ACS Products (structure/ performance)

Soft typeCTO typeSupport type and Others

Tip Stiffness Comparison

Page 3: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

3Confidential / Internal Use Only

ASAHI NEO’SProperty of ASAHI NEO’S PTCA GUIDEWIRE Family ①

■ Structure

One-piece Core Wire

・High-strength stainless steel core wire.Unique taper design enables excellent torque response and steerability performance.

Jointless Spring Coil

・Our unique technology for jointless spring coil made of two different metals provides high torque response and good slides with devices.

Page 4: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

4Confidential / Internal Use Only

ASAHI NEO’SProperty of ASAHI NEO’S PTCA GUIDEWIRE Family ②■ Coating over the metal

Medical grade silicon coating Fluororesin coating

Stable against various chemicals.Low friction.Good resistance against high and low temperature. Usable at a wide range of temperature.Chemically stable, elution-free against any materials which lead to the human body hazard. Superficially inactive. No negative influence to human tissue or blood.

Chemically stable, and highly bio-compatible with least bio-reaction.Heat and cold resistant. Less physical changes against heat. Durable against various sterilization methods.Specific superficial property. High water repellency, and less coagulation and sticking of blood.Low friction. (not as good as fluororesin but sufficiently lubricious)

Page 5: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

5Confidential / Internal Use Only

ASAHI NEO’SASAHI NEO’S PTCA Guide Wire Line-up

Support

Flex

ibili

ty

More

MoreLess

LightAG145000Radio-opacity 3cmDiameter 0.014inchLength 175cm

Improved lubricity and good tip shape memory with our unique core design. Excellent torque response. This wire has a flexible tip and can be used as a first choice wire for almost all procedures.(Tip load 0.5G)

Flex

ibili

ty

Support

More

MoreLess

SoftAG141000Radio-opacity 3cmDiameter 0.014inchLength 175cm This is a first choice guidewire with high torque response and excellent

steerability because of the unique core property.(Tip load 0.7G)

Flex

ibili

ty

Support

More

MoreLess

IntermediateAG142000Radio-opacity 3cmDiameter 0.014inchLength 175cm This is a guidewire with a good balance of tip flexibility and support performance.

(Tip load 3.0G)

Flex

ibili

ty

Support

More

MoreLess

StandardAG143000Radio-opacity 3cmDiameter 0.014inchLength 175cm Improved tip stiffness with our unique core taper design.(Tip load 6.5G)

Page 6: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

6Confidential / Internal Use Only

ASAHI NEO’SMiracle Series Applying the structure which further improves torque performance for CTO use.The tip part has the structure which is difficult to be trapped by the lesions.

Flex

ibili

ty

Support

More

MoreLess

Miracle3AG14M050Radio-opacity 11cmDiameter 0.014inchLength 175cm

(Tip load 3.0G)

Flex

ibili

ty

Support

More

MoreLess

Miracle4.5AG14M045Radio-opacity 11cmDiameter 0.014inchLength 175cm

(Tip load 4.5G)

Flex

ibili

ty

Support

More

MoreLess

Miracle6AG14M060Radio-opacity 11cmDiameter 0.014inchLength 175cm

(Tip load 6.0G)

Flex

ibili

ty

Support

More

MoreLow

Miracle12AG14M070Radio-opacity 11cmDiameter 0.014inchLength 175cm (Tip load 12.0G)

Page 7: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

7Confidential / Internal Use Only

ASAHI NEO’S

Flex

ibili

ty

Support

More

MoreLess

This wire is developed for CTO use. Higher penetration ability than Miracles. Diameter of tip coil is tapered to 0.009 inch (φ0.23 mm). (Tip load 9.0G)

CONQUESTAG143090Radio-opacity 20cmDiameter 0.014inchLength 175cm

Flex

ibili

ty

Support

More

MoreLess

Grand SlamAG141002Radio-opacity 4cmDiameter 0.014inchLength 175cm In spite of its flexible tip, the core is also designed to provide strong support when

approaching the tortuous lesions. (Tip load 0.7G)

Flex

ibili

ty

Support

More

MoreLess

Marker WireAG141010Radio-opacity 3cmDiameter 0.014inchLength 175cm

Same level of tip stiffness as SOFT. It has ten markers starting after 50 mm from the tip to scale lesions and position devices. (Tip load 0.7G)

Insert the proximalend of guidewireExtension

AG149000Diameter 0.014inchLength 150cm

The material of the inserting part( tube part) is Ni-Ti alloy.★Note: This wire has different connection structure from ACS DOC. ACS DOC cannot

be applied to ASAHI NEO’S.

Page 8: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

8Confidential / Internal Use Only

A

Flexible tip by using shaping ribbon. (Tip load 0.4G)

ASAHI NEO’S Family H Family

Structural ComparisonASAHI NEO’S vs. A

Light

SoftB

C

D

Core-To-Tip structure. Its stiffness is middle between A andB.(Tip load 0.7G)

Flexible tip by using shaping ribbon.(Tip load 0.4G)

*先端荷重データは朝日インテック社測定値

ASAHI NEO’S( ASAHI INTECC Lab Test)

Improved lubricity and tip shape memory with our unique core design. Excellent torque response. This wire has the flexible tip and can be used as a first choice wire for almost all procedures.(Tip load 0.5G)

This is a first choice guidewire with high torque response and excellent steerability because of the unique core property.(Tip load 0.7G)

Higher support performance than B(Tip load 0.5G)

Page 9: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

9Confidential / Internal Use Only

ASAHI NEO’S Performance ComparisonASAHI NEO’S vs.A ( ASAHI INTECC Lab Test)

0.7

0.50.4

0.50.4

0.0

0.2

0.4

0.6

0.8

1.0

SOFT LIGHT A B C

Tip load[gf]

Test Method

GW

■Tip Stiffness

Page 10: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

10Confidential / Internal Use Only

ASAHI NEO’S■Torque Response Comparison (Soft type)  

( ASAHI INTECC Lab Test)

090

180270360450540630720

0 90 180 270 360 450 540 630 720Rotational angle (°)

Dis

tal t

ip re

spon

se (°

)

Ideal Soft B A LIGHT C

R25R30R25 R25

Inner Dia.φ0.4mm L=300mm PE Tube

GW

Test Method

Proximal : Counter clockwise torque

Page 11: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

11Confidential / Internal Use Only

ASAHI NEO’S■Tip Bent Resistance -Tip part- (Soft type)

0

0.1

0.2

0.3

0.4

0.5

0.6

50 60 70 80 90 100 110

Distance from tip (mm)

Ben

t Res

ista

nce

(gf・

C㎡

/cm

) A

B

Soft

Light

GW

Test Method

( ASAHI INTECC Lab Test)

Page 12: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

12Confidential / Internal Use Only

ASAHI NEO’S Family H Family

CONQUEST

A

D

Structural ComparisonASAHI NEO’S vs. A (INT-CTO type)

This is a guidewire with a good balance of tip flexibility and support performance.(Tip load 3.0G)

Applying the structure which further improves torque performancefor CTO use. The tip part has the structure which is difficult to be trapped by the lesions. (Tip load 3.0G)

This wire is developed for CTO use. Diameter of tip coil is tapered to 0.009 inch (φ0.23 mm). (Tip load 9.0G)

( ASAHI INTECC Lab Test)

ASAHI NEO’S

Intermediate

Good controllability and torque response with Core-To-Tip Structure (Tip load 2.0G)

BMiracle 3

Suitable to CTO. High pushability and support performance (Tip load 5.0G)

CMiracle 6

(Tip load 6.0G) Improved trackability by its thicker distal core and longer taper length than H.(Tip load 8.0G)

For CTO use. Tip diameter is 0.010inch.(Tip load 3.5G)

Page 13: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

13Confidential / Internal Use Only

ASAHI NEO’SPerformance Comparison

ASAHI NEO’S vs. A (CTO type)( ASAHI INTECC Lab Test)

4.56

12

98

53.5

0.0

2.0

4.0

6.0

8.0

10.0

12.0

Miracle 4.5 Miracle 6 Miracle12 Conquest A B C

■Tip stiffnessTip load

[gf]

Test Method

GW

Page 14: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

14Confidential / Internal Use Only

090

180270360450540630720

0 90 180 270 360 450 540 630 720Rotational angle (°)

Dis

tal t

ip re

spon

se (°

)

Ideal Miracle 6 C Conquest

R25R30

R25 R25

Inner Dia.φ0.4mm L=300mmPE Tube

GW

Test Method

ASAHI NEO’S

Proximal : Counter clockwise torque( ASAHI INTECC Lab Test)

■Torque Response Comparison (CTO type)          

Page 15: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

15Confidential / Internal Use Only

ASAHI NEO’S■Tip Bent Resistance -Tip part- (CTO type)

0

0.1

0.2

0.3

0.4

0.5

50 60 70 80 90 100 110

Distance from tip (mm)

Ben

t res

ista

nce

(gf・

C㎡

/cm

) CONQUEST

C

Miracle 6

GW

Test Method

( ASAHI INTECC Lab Test)

Page 16: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

16Confidential / Internal Use Only

ASAHI NEO’S■Trap Resistance -Load Test- (CTO type)

0 2,000 4,000 6,000 8,000 10,000 12,000Load (gf)

A

Miracle 3

Miracle 6

Miracle12

Test Method

GW Tip

( ASAHI INTECC Lab Test)

Page 17: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

17Confidential / Internal Use Only

ASAHI NEO’S Family H Family

Structural ComparisonASAHI NEO’S vs. A (Support type and others)

Its core is designed to provide strong support when approaching the tortuous lesions. Comparing to S’Port, this wire is more flexible. (Tip load 0.7G)

・Same level of tip stiffness as SOFT. It has ten markers starting after 50 mm from the tip to scale lesions and position devices. ・Markers are soldered in the coil with same/ less outer diameter than the coil, so that the resistance against PTCA balloon catheter is small.・The coil with markers provide higher stiffness than SOFT, so that this wire can stretch the tortuous vessel and enables good support for device delivery.(Tip load 0.7G)

ASAHI NEO’S( ASAHI INTECC Lab Test)

AGrand Slam

HS is enabled by eliminating the middle coil and making the core diameter larger. This wire is suitable for delivering devices as DCA. (Tip load 0.7G)

Marker Wire

Page 18: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

18Confidential / Internal Use Only

ASAHI NEO’S Performance ComparisonASAHI NEO’S vs. A (Support type) ( ASAHI INTECC Lab Test)

0.7 0.7

0.0

0.2

0.4

0.6

0.8

1.0

Grand Slam A

Tip load[gf] GW

■Tip Stiffness

Page 19: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

19Confidential / Internal Use Only

ASAHI NEO’S■Tip Bent Resistance -Tip part- (Support type)

0

0.5

1

1.5

2

50 60 70 80 90 100 110Distance from tip (mm)

Ben

t res

ista

nce

(gf ・

C㎡

/cm

)

Grand Slam

A

GW

Test Method

( ASAHI INTECC Lab Test)

Page 20: No Slide Title Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G

20Confidential / Internal Use Only

Guide Wire Tip Stiffness Comparison

GW

*ASAHI Lab Test Method

ASAHI NEO’S

ACS Floppy II, Balance 0.4G ASAHI NEO’S Light 0.5G ACS BMW 0.5G SciMed Choice Plus Floppy 0.6G ASAHI NEO’S Soft 0.7G ASAHI NEO’S Marker Wire 0.7G ASAHI NEO’S Grand Slam 0.7G ACS Traverse 0.7G ACS S’Port 0.7G Cordis Reflex Soft 0.8G Invatec Skipper Floppy 1.05G Invatec Skipper Floppy Support 1.1G ACS Intermediate 2.0G Invatec Skipper Intermediate 2.4G SciMed Platinum Plus 2.5G ASAHI NEO’S Miracle 3 3.0G ASAHI NEO’S Intermediate 3.0G Invatec Skipper Standard 3.4G ACS Cross-It 3.5G Terumo Cross Wire 4.0G ASAHI NEO’S Miracle 4.5 4.5G ACS Standard 5.0G ASAHI NEO’S Miracle 6 6.0G ASAHI NEO’S Standard 6.5G ACS Sting 8.0G ASAHI NEO’S Conquest 9.0G ASAHI NEO’S Miracle 12 12.0G

Pipe

Electronic Balance

10 mm

Test MethodBuckling load is defined as tip load.

(The distance from the lower end of the pipe to the upper side of the electronic balance is 10 mm.)

Tip loads of various guidewires