NIHR Programme Grants for Applied Research

Professor Adrian GrantProgramme Director

NIHR Dementia Research Workshop

14 January 2011

Programme Grants

• Support programmes of research rather than individual studies

• Individual awards for a maximum of £2m over up to five years (average of no more than £400k per year)

• Funding is made to an NHS Organisation in England working in collaboration with appropriate academic partners

• Two-stage assessment process

• Applications and post-award processes managed by team at the NIHR Central Commissioning Facility (NIHR CCF)

Background

Programme Grants

• Support top quality, collaborative, multidisciplinary teams

• ‘Downstream’, applied research

• Collection of inter-related research activities

• Coherent ‘stream’ of work, where the whole is greater than sum of the individual parts

• Often presented as workpackages, subdivided into discrete activities

Purpose

Programme Grants

• Dementia care in the communityProf Steve Iliffe, Central & North West London NHS Foundation Trust

• Support at home through psychological and social interventionsProf Martin Orrell, North East London NHS Foundation Trust

• Optimizing care in care homesProf Clive Ballard, Oxfordshire & Buckinghamshire Mental Health NHS

Foundation Trust

• Managing challenging behaviour in dementiaProf Esme Moniz-Cook, Humber Mental Health Teaching NHS Trust

• Preventing acute confusional illnessProf John Young, Bradford Teaching Hospitals NHS Foundation Trust

Some currently funded programmes:

Programme Grants

• Track record and appropriate mix of skills

• Relevance to priorities and needs of the NHS

• Likelihood of significant benefit to patients and the NHS within 3-5 years of programme’s end

• Quality of the proposed research

• Value for money

Patient and Public Involvement given particular attention

Selection criteria

Programme Grants

• Fuller details are on the website:

www.pgfar.nihr.ac.uk

• Enquires are welcomed:

The Programme Grants stand in the market place

E-mail: programme.grants@nihr-ccf.org.uk

Telephone: 020 8843 8039

Address: NIHR CCFGrange House15 Church StreetTwickenham, TW1 3NL

Further information

NIHR Research for Patient Benefit

Professor David ArmstrongProgramme Director

NIHR Dementia Research Workshop

14 January 2011

The RfPB Programme

• Response-mode funding programme with a budget of £25m per year

• Project grants may be: • Up to 36 months in duration • Up to £250k

• Three competitions per year• National Programme with ten

Regional Funding Committees• Open to researchers in the NHS in

England

The RfPB Programme

• Supports high quality investigator-led research projects which have a clear trajectory into patient benefit

• Includes qualitative or quantitative research which:– Studies the way the NHS services are provided and

used– Evaluates whether interventions are effective and

provide value for money– Supports pilot or feasibility studies leading to major

applications to other NIHR funding streams

The Application Process

• One stage application process

• Preliminary scrutiny and administrative sift

• External peer and lay review

• Full assessment by one of ten regional funding committees

• Final ratification

• Notification of outcome

The Scrutiny Stage

Three questions will be asked:

• Is the proposal likely to lead to patient benefit?

• Is the presentation and/or methods appropriate for the research question?

• Is the application form completed according to the instructions described in the guidance?

BLOOD

CANCER

CARDIOVASCULAR

CONGENITAL DISORDERS

EAR

EYE

INFECTION

INFLAMMATORY

INJURIES

MENTAL HEALTH

METABOLIC AND ENDOCRINE

MUSCULOSKELETAL

NEUROLOGICAL

ORAL AND GASTRO

OTHER

RENAL AND UROGENITAL

REPRODUCTIVE

RESPIRATORY

SKIN

STROKE

GENERIC HEALTHRELEVANCE

Research for Patient BenefitSpend across health category(2009-2010)

Generic Health Relevance

15%

Mental Health 19%Reproductive

8%

Cancer 7%

Oral & Gastro 7% Neurological

6%

Stroke 6%

Research for Patient Benefit

• Essentially will use existing processes (Scrutiny Committee, scientific and lay review, Regional Funding Committee appraisal)

• Will alert all Regional Committees of the Call and advise them of the strategic need to fund applications in this area, subject to quality thresholds

• Will participate with other Programmes in cross-referring applications

Dementia call

• For more information, visit

www.rfpb.nihr.ac.uk

• Or call the RfPB helpline

0208 843 8057

NIHR Evaluation Trials and Studies Programmes

Professor Tom Walley, CBEDirector: NIHR Evaluation Trials and Studies

NIHR Dementia Research Workshop

14 January 2011

Basic Research

National Institutefor Health Research

This pathway covers the full range of interventions - pharmaceuticals, biologicals, biotechnologies, procedures, therapies and practices - for the full range of health and health care delivery - prevention, detection, diagnosis, prognosis, treatment, care.

Patient Safety and QualityResearch Centres

Research for Patient Benefit

Programme Grants forApplied Research

Health Technology Assessment

Invention for Innovation

Primary Care Trusts Healthcare Commissioning

NHS Providers Patient Care

Research for Innovation,Speculation & Creativity

National Institute for Health & Clinical Excellence Guidance on Health & Healthcare

NHS Institute for Innovation & Improvement Support for the NHS

NHS Purchasing & Supplies Agency Centre for Evidence-based Purchasing

Service Delivery & Organisation

Collabs for Ldrshp in Appl Hlth Res and Care

Ctr for Reviews & Dissemination, Cochrane, TARs

NHS Evidence Access to Evidence

Development Pathway FundingMRC

Biomedical Research Units

Biomedical Research Centres

Public Health Research

Health Services Research

Strategic Health Authorities Duty of Innovation

Efficacy & Mechanism Evaluation

INVENTION EVALUATION ADOPTION DIFFUSION

NIHR Evaluation, Trials and Studies (NETS) programmes

NETSCC: Established: 2008

Health Services

Research

Established: 2008

Public Health

Research

Established: 2008

Health Technology

Assessment

Established: 1993

Service Delivery

& Organisation

Established: 1999

Efficacy and

Mechanism

Evaluation

Funded by the MRC

Managed by NIHR

Established: 2008

Efficacy and Mechanism Evaluation programme

Researcher-ledResearcher-led

Types of Research

Primary Research addressing efficacy +/- mechanism

Who defines the question?

Researcher

Frequency Per year

Continuous with 3 submission deadlines

• Purpose and RemitThe EME programme is aimed at supporting ‘science driven’ studies with an expectation of substantial health gain.

• The EME programme works seamlessly with and sits between MRC programmes and the HTA programme

NIHR Health Technology Assessment programme

• Purpose and Remit

To deliver information about the effectiveness, costs and broader impact of healthcare treatments and tests for those who plan, provide or receive care in the NHS.

Types of Research

Specific technologyassessment

Primary researchFeasibility & pilotEvidence synthesis

Who defines the question?

NICE

Researcher

Frequency Per year

Direct referral toOn-contract teams

Primary researchEvidence synthesis

Theme from HTAprogrammeQuestion from researcher

Continuous with4 closing dates

Researcher LedResearcher Led

Primary researchFeasibility & pilotEvidence synthesis

HTA programme 4 calls

Clinicalevaluation

Clinicalevaluation

Themed CallsThemed Calls 1 call

NICE GuidanceNICE Guidance

CommissionedCommissioned

HTA Studies currently underway in dementia• Reminiscence groups for people with dementia and their family

care-givers

Professor R Woods, University of Wales

2007-11 £1,536,391

• HTA study of antidepressants for depression in dementia (HTA-SADD)

Professor S Banerjee

The Institute of Psychiatry, 2006-11 £2,210,588

• Individual Cognitive Stimulation Therapy for dementia (iCST Trial)

Professor Martin Orrell, UCL,

2010-14 £1,213,646

• Effectiveness and cost effectiveness of Collaborative cARE for people with DEMentia in primary care (CARE-DEM trial)

Professor S Iliffe, UCL

2010-15 £2,315,251

• The START (STrAtegies for RelaTives) study: to determine the effectiveness of a manual based coping strategy programme in promoting the mental health of carers of people with dementia

Professor G Livingston UCL

2009-13 £1,521,781

HTA Studies currently underway in dementia

NIHR Service Delivery and Organisation Programme

• Purpose and Remit

Produces research about the organisation and delivery of healthcare for NHS leaders and decision-makers, commissioners, providers of health care, partner organisations such as local authorities and the voluntary sector, and for users of health care. This evidence is intended to improve practice in relation to the organisation and delivery of healthcare.

CommissionedCommissioned

Researcher-ledResearcher-led

Types of Research

Primary researchEvidence synthesis

Primary researchEvidence synthesisEmpirical studies

Who defines the question?

Researcher

SDO programmePriority AreasPriority Areas

SDO StudiesSDO Studies

Primary researchEvidence synthesisEvaluations

NHSSDO programmeResearcher

NHS EvaluationsNHS Evaluations

• Better mental health care for older people in general hospitals

Professor J Gladman, Nottingham

2008-11 £473,487

SDO Studies currently underway in dementia

NIHR Public Health Research programme

• Purpose and Remit

The PHR programme evaluates public health interventions, providing new knowledge on the benefits, costs, acceptability and wider impacts of non-NHS interventions intended to improve the health of the public and reduce inequalities in health.

The scope of the programme is multi-disciplinary and broad covering a range of public health interventions.

CommissionedCommissioned

Researcher-ledResearcher-led

Types of Research

Non-NHSPrimary researchEvidence synthesis

Non-NHSPrimary researchEvidence synthesis

Who defines the question?

Researcher

PHR programme

Frequency Per year

Continuous with3 closing dates

As required

NIHR Health Services Research programme

• Purpose and RemitThe HSR programme funds research to improve the quality, effectiveness and accessibility of the NHS.

The HSR programme addresses the three dimensions of quality currently of central concern to the NHS: patient safety, patient experience and effectiveness of care.

Types of Research

Any studydesign

Who defines the question?

Researcher

Frequency Per year

Twice yearlyResearcher-ledResearcher-led

NETS as a system

Facilitating researchers,

speeding review

Transfers between NETS

programmes

Active collaboration between

programmes

Directors' meetings

Joint calls

Meeting with networks

KeeleKeele Support for CTUs

25 (in England) now

supported by HTA

programme

“pump-priming”

• Major new opportunity for funding research into dementia– NETS programmes focused on projects with

national reach– Multicentred– Trials and other designs

(Engaging with CTUs)

For further information, please visit:

www.nihr.ac.uk/research/Pages/Dementia.aspx

NIHR Dementia Research Workshop

14 January 2011

National Institute for Health ResearchDementia Research Workshop

14 January 2011