Clinical Pharmacology Nifedipine lowers BP but has minimal effects on aldosterone

It has been proposed that 1n addition to their effects on the vascular system. calctum antagonists have an aldosterone mhtbttmg act1on and would therefore be of parttcular beneftt in the treatment of hypertension secondary to pnmary aldosteronism However, in 7 patients with idiopathic aldosteronism and 8 pat1ents with aldosterone-producmg adenoma. although BP was reduced by both ntfedtpme acute (10mg) and chrontc (20mg btd) admin1strat1on. 1t was only in the patients wtth 1diopath1c aldosteronism during chrontc therapy that plasma aldosterone was stgntftcantly reduced Carpene G Rocco S Opocher G Mantero F Acute and chronrc effect

of nrfedrprne rn prrmary aldosteronrsm Clrnrcal and Experrmental

Hypertensron A 11 1263·1272 Jul 1989 ''"'

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