nicotin replacement therapy
DESCRIPTION
prevent withdrawal symptoms of TOBACOTRANSCRIPT
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Introduction smoking
Smoke contents- 4000 chemicals
- 400 toxic - 43 known cancer
causing
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Contents of cigarette smoke
Acetone Cyanide Aluminum DDT/Dieldrin Ammonia Ethenol Arsenic Formaldehyde Benzene Hydrogen cyanide Butane Lead Cadmium Methanol Carbon monoxide Nicotine Carbon dioxide Tar Chloroform Vinyl Chloride
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Nicotine withdrawal Symptoms
• Tension
• Drowsiness
• Lack of concentration
• Irritability
Nicotine addiction Nicotine increases several neurotransmitters like dopamine These neurotransmitters cause the euphoria & relaxation to brain
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Types of NRT
Nicotine Medications - Nicotine patches
- Nicotine gum
- Nicotine lozenge
- Nicotine oral inhalers
- Nicotine nasal spray
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By nicotine agonists
- acetyl choline - choline - epibatidine
- lobeline - varenicline
By nicotine antagonists
- Bupropion -
mecamylamine - 18-methoxy coronaridie
Non-Nicotine Medications
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Nicotine medicationNicotine medication
Nicotine patchesNicotine patches
Use: -Apply to clean skin area (upper trunk/ arms)-24 or 16 hour dosing
Dosing:
14-21mg/patch
Length of Treatment: -Up to 12 weeks
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side effects
Drowsiness, hallucination Skin irritation Allergic reaction
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Nicotine gum Use: Chew and park Slow, buccal
absorption Dosing: 2-4mg/dayLength of Treatment 8-10 weeks
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Side effects
High amount nicotine produce irritation
Prolonged usage may cause ediction
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Nicotine Lozenge
These are nicotine sublingual tablets
Nicotine is absorbed through lining of mouth
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Nicotine Nasal spray/inhaler
This are aerosols contain nicotine
They are absorbed through lining of the nose and through lungs
They show quick onset of action
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Side effect
Nose and throat irritation
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Varenicline Partial agonist Action at 42 nicotine receptor Blocks nicotine from binding to
receptor Releases lower amounts of
dopamine
Non –nicotine medication
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Dose
Treatment with Varenicline begins one week before the quit date.
0.5-1mg every day
Adverse effects Nausea Head ache Difficulty to sleep Vomiting Constipation
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Bupropion
It is an α3β4 nicotinic antagonist Bupropion is a dopamine and
norepinephrine reuptake inhibitor
Start 7-10 days prior to quit dateDose150-300mg every dayContinue 7-12 weeks or longer
17
Dose
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Adverse effects hypertension
Insomnia
Dryness of mouth
Seizures
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CONCLUSION NRT is being provided to assist tobacco
users to become tobacco free.
NRT is not a treatment in itself, but is intended to complement the other assessments and treatments provided.
Pharmacotherapy works and is relatively safe and more effective.
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Thank youThank you