new chapter mission statement · 2020. 9. 11. · groups of students were able to question graduate...
TRANSCRIPT
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June 2020 Issue No. 47 Frederic Moulin, Editor
CHAPTER MISSION STATEMENT 1 MESSAGES FROM THE NCAC-SOT EXECUTIVE BOARD MEMBERS
The President, Narayana Garimella 2 The Students Message Kristal Rychlik, Emily Illingworth and Emmanuel Woode 3 The Treasurer’s Report, Laine Peyton Myers 4 The Website Coordinator, Jennifer Tanir 5 The Newsletter Editor, Frederic Moulin 5
EXECUTIVE BOARD CONTACT LIST 6 MEET OUR NEW OFFICERS Gopala Krishna 7 Patrick Crittenden 7 Laine Peyton Myers 8 Emmanuel Woode 8 GOODBYE FROM OUR OUTGOING OFFICERS 9 NCAC-SOT MEMBERSHIP Members list 10 Membership form 15 NCAC-SOT SPRING SYMPOSIUM 16 NCAC OUTREACH ACTIVITIES 18 BERN SCHWETZ AWARD 19
MEMBERS ACCOMPLISHMENTS 20
CHAPTER MISSION STATEMENT
The National Capital Area Chapter of the Society of Toxicology (NCAC-SOT) was established to provide a regional focus for scientists of all disciplines interested in toxicology. The Chapter acts to:
• Sponsor and co-sponsor symposia on current issues in toxicology. • Provide annual awards to an outstanding student and postdoctoral scholars in toxicology to assist in attending the annual meeting of the SOT. • Maintain communication with the National SOT regarding current toxicology and regulatory concerns. • Sponsor Regional Chapter events at the SOT Annual Meetings.
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MESSAGES FROM THE NCAC-SOT EXECUTIVE BOARD MEMBERS
President’s Message
Dear NCAC-SOT Members:
We take this opportunity to thank NCAC-SOT’s officers of 2019-2020 term and to wel-
come new officers of 2020-2021 term. Also, we welcome new members of NCAC-SOT.
Together we all are grateful to organizations and personnel dedicated in promoting and
protecting public health, especially during the spread of COVID-19 pandemic.
As global health and health-sciences became great concerns of focus during these times,
we are organizing a half-day spring-2020 scientific symposium on 25th June, 2020.
This WebEx virtual symposium is intended to invite and facilitate global-attendees and
to value the time and efforts of national and international speakers and organizers.
Next generation tools, technologies and surrogate endpoints in toxicological assessments is the title of this
symposium. Applications of novel and existing tools, technologies, assessments and their combinations have
the potential to identify and characterize toxicity and support the selection of safer products and therapeutic
procedures. Also, they are expected to bridge data gaps, predict toxicity at the molecular level, and minimize
animal and clinical studies. These tools include but are not limited to cells, proteins, microorganisms, chemi-
cals, pharmacodynamics, endpoints, in-silico predictions, and two or more of their hybrid influences. An ex-
ample of a hybrid tool is the integration of imaging and bio-analytical methodologies. In summary, the pur-
pose of this symposium is to (1) review key biological and exposure characteristics that may impact the evalu-
ation of toxicology and risk assessments, (2) discuss current and future toxicology and safety scopes, and (3)
identify potential gaps and future tools and technologies. Speakers from industry, academia, NGOs, and testing
laboratories are presenting in this symposium.
Toxicologists, health scientists and all interested health, science and technology personnel are cordially invited
to attend this Spring 2020 WebEx Symposium of the National Capital Area Chapter of the Society of Toxicol-
ogy (NCAC-SOT). The symposium, Next Generation Tools, Technologies and Surrogate Endpoints in Toxi-
cological Assessments, will be held 8:30 AM – 1:00 PM ET on Thursday, June 25, 2020 through Society of
Toxicology’s WebEx platform.
Agenda, Details, and Registration Information of the Symposium:
https://www.toxicology.org/groups/rc/ncac/events.asp
Online Registration
Thank you.
Sincerely,
Narayana Garimella, PhD. MS, M.Tech.
NCAC-SOT President
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Student Representative’s Message Greetings NCAC Student and Postdoc Members,
We hope this newsletter finds you healthy and well.
While we won’t be able to see each other in person, NCAC will hold a virtual symposium
this spring (June 25). We want to extend an invitation to our student and postdoc members.
We encourage you to attend this year’s spring symposium because it’s important during this
time especially to stay sharp and focused. Attending the meeting will allow you to stay con-
nected and continue networking, to keep your knowledge fresh as we all step away from the
bench for a while, and to share the results you have and receive constructive feedback from
colleagues outside your immediate network. If we can do these things while we’re stuck at
home, we will be in a great place to “hit the ground running” when our workplaces resume
normal activities.
If you’re feeling stressed about COVID-19 and adapting to working from home, know that
you aren’t alone. We understand the pressure graduate students and postdocs are facing dur-
ing this difficult time, and we want to provide you with several resources to remind you and
encourage you to, first and foremost, take care of yourself.
Free mental health resources:
• Youper (This AI-powered app will have a conversation with you to help talk you
through tough moments)
• Moodpath (Moodpath checks in on you three times a day to see how you’re doing and
tracks your mood over time, helping you identify triggers and providing resources to
address them)
• Headspace (This is a free mindfulness and meditation app that provides helpful re-
sources for newcomers to mindfulness and customizable meditations for whatever
amount of time you want)
Free physical health resources:
• Fitness Blender (This app creates a unique and personalized sequence of exercises for the user based on
your preferences and what you need that day)
• Down Dog (This yoga app and all related apps are currently free from the developer. They create a unique
and personalized sequence of exercises for the user based on your preferences and what you need that day)
From all of us to you, please stay safe during this unprecedented time and take care of yourselves!
Sincerely,
Kristal, Emily and Emmanuel
NCAC-SOT Councilors and Student Representatives
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NCAC Treasurer’s Report
Greetings to all the NCAC-SOT members from your new Treasurer. I hope that all
is well given the circumstances.
First off, I want to thank the past Treasurer (Dr. Charlie Thompson) for his amaz-
ing work as NCAC-SOT Treasurer. NCAC-SOT greatly appreciates the work that
he did over the years. I hope that I can fill his shoes.
As you can see from the tabulated report (below), we are in good shape financially.
We will have final numbers for 2020 when the FY is concluded in June but we
don’t expect any major changes. We have positive cash flow for FY 2020 and
spring expenses were low due to the cancellation of the SOT Annual Meeting.
We do not yet have final information on how the changes at SOT due to the hardship of cancelling the Annual
Meeting will affect the Regional Chapters.
Recent updates are somewhat reassuring for Regional Chapters as well as SOT as a whole. In the President’s
Message (see Toxchange - June 3, 2020), he states that SOT is not in as bad a shape as was previously predict-
ed from the cancellation “… good news is that those expenses are far less than the worst-case scenario we
were facing in mid-March”. This does not mean that the SOT Regional Chapters may not see some effects of
the financial hardship at SOT. But it does give hope that the hardship isn’t as bad as previously expected.
I look forward to a productive 2020. Stay safe and healthy everyone.
Laine Peyton Myers
NCAC-SOT Treasurer
NCAC Financials (from HQ): 1 July 2019 through 30 April 2020
Income Amount ($)
• Donations --
• Dues 4575.00
• Registration (Spring) --
• Registration (Fall) --
• Total Income 4575.00
Expense
• K-12 Outreach --
• Meeting (Spring – plaques) -460.15
• Meeting (Fall – speaker travel) -659.59
• Meeting (Reception) --
• Misc./Other (t-shirts) --
• Service Charge --
• Total Expense -1120.00
Net Cash Flow 3455.00
Closing Check Acct Balance 15, 801.04
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Website Coordinator’s Message Dear NCAC-SOT Members,
As the Councilor and Website Coordinator, I invite you to learn more about NCAC-SOT
through our website. For our upcoming Virtual Symposium on June 25, 2020, you can find
the registration link and the latest agenda on the events page. Recordings and slides from
past symposia are available too.
The officers page lists the current NCAC officers and you can get to know the new officers
(Vice President, Secretary, Treasurer, Student Representative) by reading the new officers’
bios.
The NCAC newsletters page is another great resource for learning about the chapter and its members.
If you have any suggestions for improvements to the NCAC-SOT website, please contact me and I’ll see what
I can do!
Best,
Jennifer Y. Tanir, Ph.D.
NCAC-SOT Councilor – Website Coordinator
Newsletter Editor’s Message Dear NCAC-SOT Members,
Welcome to the 2020 SARS-CoV-2 edition of the newsletter. Like so many lives
upended across the world by the sudden arrival of the new coronavirus, our spring
publication loss all relevance with the cancellation of the 2020 SOT annual meeting.
The decision was not an easy one and for many days we waited, hoping against all
odds to see you all at the Fifth, overlooking the Anaheim skyline. In the end, the
SOT council made the decision to cancel the meeting, and in retrospect this deci-
sion probably protected those like me who are not so young, not so thin, a little stressed and with a single X
chromosome. We retreated into the safety of our homes to weather the pandemic and plan our come-back.
During the past four months I have had to learn, like many of you I am sure, the intricacies of Zoom and We-
bEx, how to look lively on videoconferences and how to present and discuss scientific data when the audience
is just a set of tiny pictures, oddly pixelated by delays in data transmission. For me, it was a steep learning ex-
perience.
Fortunately we are finally back. With this newsletter, and the return of our spring symposium, the NCAC is
moving into virtual space. I encourage all of you to experience our new webinar format on June 25th and re-
connect with your colleagues in the DMV area. I have been locked down into a dank Maryland basement for
much longer than I cared for, and I am very excited for an opportunity to engage with all of you again. Our
colleagues at the FDA are working hard to deliver vaccines and new therapies for Covid-19, but until those are
validated and readily available, Sars-cov-2 will continue to define our new “normal”. I wish you all a great
virtual summer, and look forward to seeing you on the 25th… with or without delays in transmission.
Frederic Moulin, DVM, PhD, DABT
NCAC-SOT Newsletter Editor
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NCAC-SOT EXECUTIVE BOARD MEMBERS CONTACT LIST President: Narayana Garimella, PhD, MS
U.S. Food and Drug Administration
Vice-president: Gopala Krishna, PhD, MBA, DABT, ATS
Parexel International
Treasurer: Laine Peyton Myers, PhD, DABT
U.S. Food and Drug Administration
Secretary: Patrick Crittenden, PhD
U.S. Food and Drug Administration
Councilors: Jennifer Tanir, PhD
Website Coordinator
ToxServices LLC
Rosie Sneed, DVM, PhD
Student Liaison
University of the District of Columbia
Frederic Moulin
Newsletter Editor
U.S. Food and Drug Administration
Postdoctoral Kristal Rychlik, PhD
Representative: Johns Hopkins University
Graduate Emily Illingworth, BS
Student Johns Hopkins University
Representative: [email protected]
Graduate Emmanuel Woode, MSc, BS
Student University of Maryland Eastern Shore
Vice-Representative [email protected]
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NCAC-SOT WELCOMES OUR NEW OFFICERS VICE PRESIDENT Gopala Krishna, Ph.D., M.B.A., D.A.B.T., A.T.S.
Dr. Krishna is a Principal Consultant at Parexel International, where he serves as the Regulatory Affairs & Nonclinical Leader/Expert in drug development. As a member of PAREXEL Consulting's Regulatory & Access Team, he has worked collaboratively with a Team of highly experienced professionals from Industry, FDA, EMA and other global health authority experience. Dr. Krishna enjoys the opportunity to collaboratively work with a variety of global clients and products in an advisory role; finding tailored solutions to individual needs and executing them on behalf of clients for global regulatory submissions such as IND/IMPD/NDA/BLA/MAA and assist clients with global regulatory/health authority filings & Face to Face (F2F) meetings; getting products to patients for a win-win—
with a "patient-client" centric-approach—cost-effectively; using applicable accelerated regulatory pathways, Orphan Drug Designations, rare diseases, and a variety of other strategies, as applicable. He also supports a dedicated Team of Business Development Professionals, conducts workshops (including making a case for de-sired label), makes targeted presentations at scientific meetings and continues to learn and advance profession-ally. Previously, for over 30 years he has a proven track record at large & small pharma companies: Pfizer, Abbott Labs, Guilford/MGI, Enzon and Supernus as: Senior Scientist, Director & Vice President; contributed to bring-ing products (e.g., Lipitor, Neurontin, Lyrica, Omnicef, Humira, Oncaspar, Adagen, Nipent, Oxtellar XR, Trokendi XR), to the global market. Dr. Krishna received his PhD degree in Genetic Toxicology/Developmental Biology from West Virginia University in 1984. Dr. Krishna has authored ~70 publications, book chapters and 85 abstracts/ presentations/blogs. SECRETARY Patrick Crittenden, Ph.D.
Dr. Patrick Crittenden is a Toxicologist at the Food and Drug Administration in the Center for Food Safety and Applied Nutrition, where he reviews pre-market notifica-tions for the Division of Food Contact Substances. In this position, he assesses the safety of indirect food additives (i.e., packaging materials) by evaluating their potential for genotoxicity, carcinogenicity, and systemic toxicity. Dr. Crittenden has had a diverse career in science including experience as a waste fuels chemist for a private contract lab and as a biochemical technician in a government ag-riculture research laboratory. He has several years of experience as a study director for a contract research laboratory, where he was responsible for conducting preclinical and environmental toxicology studies for regulatory submissions. Prior to working with the
FDA, Dr. Crittenden was a professor of biology responsible for teaching courses including anatomy and physi-ology, cellular physiology, immunology, neurobiology, and toxicology. Dr. Crittenden received his Bachelor of Science in Chemistry and Microbiology from Mississippi University for Women. Subsequently, he obtained a Master of Science in Biological Sciences from Mississippi State Uni-versity with a focus in immunotoxicology, and a Doctor of Philosophy from Mississippi State University in Environmental Toxicology with a focus in neuroimmunotoxicology. He has published 6 peer-reviewed re-search papers, 3 as the first author. Dr. Crittenden has been a member of SOT since 1993 and is currently an Associate member of the society.
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TREASURER Laine Peyton Myers, Ph.D., D.A.B.T.
Dr. Myers is a Master Pharmacology/Toxicology drug reviewer for antiviral prod-
ucts at the US Food and Drug Administration. Dr. Myers received his PhD in im-
munotoxicology from LSU Health Sciences Center in 2003. He was a postdoctoral
fellow at NIOSH from 2003–2006 and later joined the US FDA as a Pharmacolo-
gy/Toxicology drug reviewer in 2006. Dr. Myers has experience in multiple thera-
peutic areas, including: antivirals, oncology, and reproductive/bone products.
Dr. Myers has served on multiple US FDA Pharm/Tox subcommittees and as chair
of the CDER Immunotoxicology Subcommittee. He also serves in several profes-
sional Societies and is the Past-President of the Immunotoxicology Specialty Section in the Society of Toxicol-
ogy (SOT) and the past chair of the SOT Membership Committee. He is currently serving as Co-Chair of the
Awards Committee for the American College of Toxicology (ACT). Dr. Myers has served on multiple other
working groups and committees for professional societies (SOT and ACT) as well as nonprofit scientific or-
ganizations (the Drug Information Association, the Pharmaceutical Users Software Exchange, and the Health
and Environmental Sciences Institute).
At the FDA, he serves as an expert on the “animal rule” for bioterrorism products as well as nonclinical immu-
notoxicology assessments at the US FDA. Dr. Myers has received multiple awards for his work at the Agency
during his tenure. His most recent approval of the world’s first therapeutic treatment of human variola virus
(smallpox) using animal efficacy data earned his group the prestigious US Health and Human Services Secre-
tary’s Award for Distinguished Service in May of 2019.
STUDENT REPRESENTATIVE Emmanuel Woode, M.S.
Mr. Emmanuel Woode is a Regulatory Affairs Specialist at the National Institutes of
Health, where he provides high-level current Good Manufacturing Practice (cGMP) con-
sultative support to the Clinical Center’s Pharmacy Department, Department of Transfu-
sion Medicine (DTM), Department of Laboratory Medicine (DLM), Positron Emission To-
mography (PET) Department, the Nuclear Medicine Department, and National Cancer In-
stitute (NCI) Surgery Branch.
Mr. Emmanuel Woode received his master’s degree in Regulatory Science from Johns
Hopkins in 2014 and is currently a first year PhD student at the University of Maryland
Eastern Shore. Mr. Woode holds a bachelor’s degree in Chemistry from the University of the District of Co-
lumbia.
Mr. Emmanuel Woode is the Co-Chair of NIH’s cGMP Advisory Committee Group and the executive secre-
tary to the NIH’s Environmental Monitoring Advisory Committee. Mr. Emmanuel Woode was recipient of
two (2) NIH Clinical Center CEO Awards in 2019.
Mr. Woode firmly believes in SOT’s vision to facilitate the scientific and professional development of its stu-
dent body via networking, scientific programs, and other SOT activities.
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GOODBYE FROM OUR OUTGOING OFFICERS
Margarett Whittaker, NCAC-SOT Past President
Over the past three months, there has been an immense change in the way that most NCAC
-SOT toxicologists practice toxicology. The impromptu transition to virtual work environ-
ments has triggered a tectonic shift in ways that many of us engage and contribute as toxi-
cologists. For myself, I’d like to share with you ways I’ve coped over the past three
months (both professionally and personally) and hope these items give you inspiration:
Attend the SOT virtual meeting: SOT has been presenting Scientific Sessions and Con-
tinuing Education (CE) courses that were originally planned for presentation in Ana-
heim. These courses run until are scheduled until at least the end of June. SOT’s CE
courses are cost-effective (only $150/course, even if you weren’t registered to attend the Anaheim meeting)
and are a great way to maintain your skill set and CV. Check out the Virtual meeting page to see the schedule
of sessions and CE courses: https://www.toxicology.org/events/am/AM2020/program.asp
Read Phillip Wexler’s Toxicology in Antiquity: While stuck at home, I’ve re-discovered the joy of reading
printed books, and treated myself to Toxicology in Antiquity (Elsevier Press, 2nd edition, available in print and
e-edition). The book colorfully describes and illustrates instances of poisoning, toxins, and toxics throughout
history, ranging from poisoning in ancient Greece and Rome, chemical warfare over time, and ancient man-
made sources of pollution. In the book’s Foreword remarks, author and well-known National Library Medi-
cine Information Scientist Phillip Wexler sagely points out that modern toxicologists have a lot of learn about
the past, in that toxicity can affect people anywhere, in any society, at any level, for many years, without any-
one being aware of it.
I am sure that COVID-19 will continue to challenge many of us working in our capacity as toxicologists. Vic-
tor Hugo said that “Great perils have this beauty, that they bring to light the fraternity of strangers.” I have
enjoyed meeting many NCAC-SOT members as part of my tenure as NCAC-SOT President and appreciated
the opportunity to serve our community. As we navigate living and working in a post-COVID-19 world, I
wish health to each of you and your families.
Meg Whittaker
Sarah Attreed, NCAC-SOT Past Student Representative
Hi all, Sarah here. It has been a privilege serving the National Capital Area Chapter and the wider SOT com-
munity for the past two years. I recently defended my thesis back on March 13th and, as of May 1st, I will be
a postdoctoral ORISE Fellow at the USDA on Plum Island in New York. There I will be developing and per-
forming immunological testing of vaccines against high consequence animal pathogens. I
am wishing the whole chapter community the best and know I am leaving fellow trainees
in good hands with Kristal, Emily and Emmanuel.
Sarah Attreed
Note from the Editor: We wish Sarah a wonderful time
on Plum Island. From our personal experience, she
will have no difficulty achieving social distancing at
her new duty station.
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Current NCAC-SOT Members
The NCAC-SOT Executive Board considers useful to publish the membership roster in each newsletter. As of June 2020, the Chapter members are listed below (First Name, Last Name, Institution):
Valerie H Adams US Army Public Health Center
Felix K Adatsi PreTrial Services Agency
Chinedu Ahuchaogu University of Maryland Eastern Shore
Devon K Andres LMI supporting JPEO-CBD Medical Countermeasures Sys-tems
Jay M Ansell Personal Care Products Council
Louise Assem Copper Alliance
Jennifer Greenlaw Ator ToxServices LLC
Sarah Attreed Johns Hopkins University
Michael A Babich US Consumer Product Safety Commission
Melissa Ann Badding Exponent Inc
Cheryl B Bast Keller and Heckman LLP
Ilona Gabriela Bebenek US FDA
Nancy B Beck US EPA
Richard A Becker American Chemistry Council
Adrienne T Black
Kenneth T Bogen ktbogen.com
Gary P Bond US FDA-CDER
Mohammed Bourdi NIH-NCATS
Ivan J Boyer Keller and Heckman LLP
Megan Boylan ToxServices LLC
Chad Nicholas Brocker US FDA
Deborah E Burgin US EPA
Jessica Aimee Camacho FDA
Joy A Cavagnaro Access BIO LC
Tracy Chen US FDA
Xinrong Chen US Consumer Product Safety Commission
Connie L Chen Health and Environmental Sciences Institute
Paola Chrysostomou Alexa Research & Engineering
Chrissy J Cochran US FDA
Joseph F Contrera Computational Toxicology Services LLC
Erdem Coskun National Institute of Standards and Technology
Gertrude-Emilia Costin Institute for In Vitro Sciences
Patrick Lee Crittenden US FDA
Lara Iza Dahora Virginia Tech
Danica Elizabeth DeGroot US FDA
Pedro L Del Valle US FDA-CDER
Paul DeLeo Integral Consulting Inc
Jose Francisco Delgado-Jimenez National Cancer Institute
John M DeSesso Exponent Inc
Laxmikant S Deshpande Virginia Commonwealth University
Deacqunita Laquade Diggs US FDA
Albert H Donnay Donnay Detoxicology LLC
Kimberly D Ehman Altria Client Services Inc
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Marion F Ehrich Virginia-Maryland College of Veterinary Medicine
Michelle R Embry Health and Environmental Sciences Institute
Neeraja (Neera) Kondapi Erraguntla American Chemistry Council
Louan C Fisher Toxicology Regulatory Services
Suzanne Compton Fitzpatrick US FDA
Thomas J Flynn Retired
Dana Michelle Freeman Johns Hopkins University
Joan D Garey Reproductive Toxicology Center
Narayana Garimella NCAC SOT
Philip Gatti US FDA
Lee E Geiger Geiger Toxicology Consulting
Chandramallika (Molly)
Ghosh US FDA
Peter L Goering US FDA
Emily Golden Johns Hopkins University
Sidney Green Howard University
James C Griffiths Council for Responsible Nutrition
Karen L Hamernik US EPA
Molly E Harmon US Environmental Protection Agency
Wafa A Harrouk US FDA-CDER-OND
Kristina M Hatlelid US Consumer Product Safety Commission
Esther M Haugabrooks Physicians Committee for Responsible Medicine
Jessica Hawes US FDA
Tala R Henry US EPA Office of Prevention Pesticides & Toxic Substances
Thomas Hill US FDA Center for Tobacco Products
Andrea R Hindman American Association for the Advancement of Science
Colette Susan Hodes US EPA-OLEM
Helena Therese Hogberg Johns Hopkins Bloomberg School of Public Health
Alan M Hood US FDA
Eric Pendleton Hooker US Consumer Product Safety Commission
Keith Alan Hostetler Toxicology Regulatory Services
Terry Hrubec Via College of Osteopathic Medicine Virginia Campus
Annette R Iannucci Occupational Safety and Health Administration
Emily Illingworth Johns Hopkins Bloomberg School of Public Health
William Andrew Irwin US EPA
Seshadri Iyengar Bayer
Sandra Ann James-Yi
David Alan Jett NIH Countermeasures Against Chemical Threats (CounterACT) Research Program
Zoe C Johnson University of Maryland Eastern Shore
Pramod S Joshi Supernus Pharmaceuticals Inc
Harriet W Kamendi Kariah Healthcare Solutions LLC
Jueichuan (Connie)
Kang US FDA
Athena Marie Keene Afton Chemical Corporation
James H Kim American Cleaning Institute
Marquea D King USDA ARS
Elaine Valerie Knight NIH-NCI
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Charles J Kokoski US FDA
Gopala Krishna Parexel International
Francis H Kruszewski American Cleaning Institute
Rohan Kulkarni MilliporeSigma
Susan A Laessig NIH ECHO
Amy Lavin Williams Exponent Inc
Emily May Lent Army Public Health Center
Jonathan A Leshin US FDA
Yizhong Liu FDA
Anne Elizabeth Loccisano Exponent Inc
Linda Loretz Personal Care Products Council
James T MacGregor Toxicology Consulting Services
Emily F Madden United States Pharmacopeia
Michael S Madejczyk WRAIR
Susan Makris US EPA-ORD
Nikki Maples-Reynolds Waterborne Environmental Inc
Laura C Markley US FDA
Joanna M Matheson US Consumer Product Safety Commission
Abigail McEwen Cardno ChemRisk
Timothy J McGovern US FDA
Colleen Elizabeth McLoughlin Scivera
Lauren M Mihalcik Amgen Inc
Beth E Mileson Technology Sciences Group Inc
Frederic J Moulin US FDA
Jorge Gerardo Muñiz Ortiz US EPA
Brian James Mulhern SciLucent LLC
Laine Peyton Myers US FDA
Gopakumar Nair Supernus Pharmaceuticals Inc
Arvind K N Nandedkar Howard University
April P Neal-Kluever Office of Management and Budget
Alexander Khoa Nguyen North Carolina State University
Tyler Nicholas Exponent
Simone Nicholson AstraZeneca
Andrey I Nikiforov Toxicology Regulatory Services
Berk Oktem US FDA
Teresa De Jesus Palacios- Hernandez US FDA
Ju Young Park Food and Drug Administration
Jin-Young Park U.S. FDA
Leslie E Patton Technology Sciences Group Inc
Geoffrey W Patton US FDA
Syril D Pettit Health and Environmental Sciences Institute
Martin B Phillips US EPA
Jennifer B Pierson Health and Environmental Sciences Institute
Anne M Pilaro US FDA
Caroline Lucia Pinto US FDA-ORISE
Karen L Porter PointCross Life Sciences
Carsten Prasse Johns Hopkins University
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Kathleen C Raffaele US EPA
Deepa B Rao StageBio
Jennifer L Rayner SRC
Gunda Reddy Army Public Health Center
Emily N Reinke Army Public Health Center
Ana C Ribeiro Virginia Commonwealth University
Alicia Carolyn Richards SRC
Paul L Roney Biomedical Advanced Research and Development Authority
Laurie E Roszell Army Public Health Center
Tinashe B Ruwona W.L. Gore & Associates Inc.
Patricia C Ryan AstraZeneca
Kristal A Rychlik Johns Hopkins Bloomberg School of Public Health
Jessica P Ryman-Rasmussen American Petroleum Institute
Louis J Scarano US EPA
Anthony R Scialli Scialli Consulting LLC
Sumitra Sengupta Johns Hopkins University
Fenna Sille Johns Hopkins Bloomberg School of Public Health
Om V Singh TSG Consulting
Amy M Skinner US FDA
Shelby Skoog US FDA
Deborah C Smegal US FDA
Donna C Smith Altria Client Services Inc
Rosie A Sneed University of the District of Columbia
Babasaheb Sonawane TRACS LLC
Martin Luther Stephens Johns Hopkins Bloomberg School of Public Health
Stephan T Stern Leidos Biomedical Research Inc
Anneliese Striz US FDA
Dale E Strother ToxSolve LLC
Evi B Struble US FDA
Jennifer Y Tanir ToxServices LLC
Sheryse Taylor National Cancer Institute
Sean Taylor Verto Solutions
Richard Dean Thomas Intercet Ltd
D Charles Thompson US FDA
Christopher Kirk Thompson Virginia Tech
Scott Thurmond US FDA-CFSAN
Vy P Tran Johns Hopkins Bloomberg School of Public Health
Richard Troast Troast Environmental Consulting Alexandra Eliza-beth Turley US FDA
Lorraine Evelyn Twerdok Twerdok Consulting LLC
Vipin Tyagi University College of Medical Sciences Delhi University
René Viñas Coca-Cola Company The
Bingxuan Wang ToxServices LLC
Zemin Wang US FDA
Ronald LeRoy Wange US FDA
Zhengxi Wei National Institutes of Health
Darmood Wei US FDA
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Kimberly Wise White
Margaret H Whittaker ToxServices LLC
Dionne Williams Delaware State University
Gary W Wolfe Gary Wolfe Toxicology LLC
Elissa Li-Yee Wong US FDA Emmanuel Kings-ley Woode ORSC
Linnzi Wright CCDC Chemical Biological Center
Charis Wynn
Menghang Xia NIH
NCAC-SOT MEMBERSHIP Did you remember to renew both your SOT and NCAC memberships this year? Annual membership fees for NCAC-SOT remain unchanged this year and are only $25 for regular memberships and $10 for full-time stu-dents. These fees are used to fund our symposium each year and to support a myriad of student activities, in-cluding student awards, travel supplements, and K-12 outreach. If you have not yet renewed your regional Chapter membership, please do so today! You can do that online or by mail using the membership application form on the next page.
NCAC-SOT 2019 ACTIVITIES
Fall Meeting Report
October 2019 seems so far away now… a time when we could come together on the NIH Bethesda Campus
without face masks, social distancing and the fear of Sars-Cov-2. In fact on the 24 of October, the NCAC
chapter of the SOT met in the Lister Hill Auditorium of the National Library of Medicine for a lively discus-
sion on safety considerations for the development of devices and drugs. I am fairly confident that none of us
realized at that time that we would not see each other again for almost a year. Here are a few pictures of the
event to remind you of happier days.
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MEMBERSHIP APPLICATION
Please check the most appropriate responses:
Please complete the information above and send with a check, money order or credit card (payable to National Capital Area Chapter SOT, no POs) to the address below. The NCAC SOT will review your application, and you will be notified within 30 days. Those not accepted will receive a full refund. Current RC members: please do not use this form since your renewal dues are billed annually through SOT.
Payment Type: Money Order______ Check ______ Credit Card ______
Credit Card # _______________________________________ Exp date ________
Name on Card ______________________________________
Signature
Please send completed form with payment to:
Society of Toxicology, ATTN: Ashley Black 1821 Michael Faraday Drive, Suite 300 Reston, VA 20190
Name: ______________________________________________________
Affiliation: ______________________________________________________
Address ______________________________________________________
City: ______________________________________________________
State: _____ Zip Code: ____________
Area Code: ______ Phone: _________________FAX:____________________
E-mail: ______________________________________________________
Membership Type ______ Full Member ($25) ______ Student ($10)
SOT Member
Yes
No
Highest Degree Attained
A.S. M.P.H.
B.A. M.S.
B.S. M.A.
D.V.M. Ph.D.
D.V.M./Ph.D. Sc.D.
M.D. V.M.D.
M.D./Ph.D. V.M.D./Ph.D.
Type of Affiliation
Academia
Consulting
Contract Lab
Government
Industry- Chemical/Petroleum
Industry- Pharmaceutical
Industry- Other
Other- _________________________
16
Spring Virtual Symposium by National Capital Area Chapter of the Society of Toxicology (NCAC-SOT)
Title: Next Generation Tools, Technologies and Surrogate Endpoints in
Toxicological Assessments
When: Thursday, June 25th, 2020 (8:30am-1:00pm)
Where: WebEx - Society of Toxicology
The Chapter-wide NCAC is holding a local scientific and virtual research symposium to discuss current and
future tools, technological improvements and surrogate endpoints in the field of toxicology and allied regulato-
ry sciences. Both nonclinical toxicology and its clinical manifestation are influenced by genetic, transcriptom-
ic, proteomic and metabolomic considerations, as well as environmental settings and lifestyle factors. Next
generation tools, technologies and surrogates have the potential to identify and characterize toxicity and sup-
port the selection of safer products and therapeutic procedures. Herein, we aim to present scientific and tech-
nological tools that will enhance our ability to characterize toxicity in the upcoming decade. These tools in-
clude but are not limited to cells, proteins, microorganisms, chemicals, pharmacodynamics, endpoints, in-silico
predictions, and two or more of their hybrid influences. An example of a hybrid tool is the integration of imag-
ing and bio-analytical methodologies. Next generation tools, technologies, and surrogates are expected to
bridge data gaps, predict toxicity at the molecular level, and minimize animal and clinical studies.
The purpose of this symposium is to (1) review key biological and exposure characteristics that may impact
the evaluation of toxicology and risk assessments, (2) discuss current and future toxicology and safety scopes,
and (3) identify potential gaps and future tools and technologies.
About the NCAC-SOT: The National Capital Area Chapter of the Society of Toxicology (NCAC-SOT) pro-
vides a regional focus for scientists of all disciplines interested in toxicology. The Chapter acts to:
• Sponsor and co-sponsor symposia on current issues in toxicology.
• Provide an annual award to an outstanding student in toxicology to assist in attending the Annual Meeting
of the SOT.
• Sponsor Regional Chapter events at the SOT Annual Meetings.
https://www.toxicology.org/groups/rc/ncac/
2020 NCAC-SOT Spring Symposium Logistics:
When: Thursday, June 25th, 2020, 8:30 AM – 01:00 PM
Where: WebEx –Virtual Session through Society of Toxicology (URL/Link will be provided upon registration)
WebEx Registration (free of charge): https://aim-hq.webex.com/aim-hq/onstage/g.php?
MTID=e7018e674a96dc4b3ff7abeb654e9c1e0
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Time Topic Spe aker
8:30 – 8:45 am Joining WebEx NCAC-SOT, Speakers, Attendees
8:45 – 9:00 am Welcome/Introduction/Opening Narayana Garimella, Ph.D., NCAC-SOT President
9:00 – 9:30 am Modeling Delays in Chemotherapy In-duced Hematological Toxicities
Wojciech Krzyzanski Ph.D., University of Buffalo
9:30 – 9:40 am On the Services and Accomplishments of Renowned Toxicologist Dr. Bern Schwetz
Margaret Whittaker, Ph.D., M.P.H., CBi-ol., F.R.S.B., E.R.T., D.A.B.T., ToxServices LLC & NCAC-SOT
9:40 – 10:10 am Insights into the Role of a Synuclein as an Epigenetic Mediator in Environmen-tal Parkinson’s Disease
Dana Freeman, John Hopkins University
10:10 – 10:40 am
21st Century Cures Act: A Boon to the Waiting Patient – A Safety Perspective on the Opportunities and Challenges in Drug Development
Gopala Krishna, Ph.D., Parexel Interna-tional & NCAC-SOT
10:40 – 11:05 am Break
11:05 – 11:35 am Novel BSEP and MDR3 Inhibition As-says for Investigating Drug-Induced Liver Toxicity
Kan He, Ph.D., Biotranex
11:35 am – 12:05 pm Data Science for Life Science: In the post COVID-era. Avik Pal, Ph.D., CliniOps
12:05 – 12:35 pm Toxicological Assessment of Prebiotics Prabhakar Bhoite, M.V.Sc., D.A.B.T., Syngene International Limited
12:35 – 12:50 pm Q & A Session with Presenters Panel Members
2020 NCAC-SOT Spring Symposium Agenda and Speaker List:
The presentations and speakers are listed in the table below:
18
NCAC OUTREACH ACTIVITIES
Reaching out to undergraduates in a time of pandemic.
NCAC continues to be involved with undergraduates in our area and beyond, through participation in two
SOT-sponsored programs called ToxScholar and the Undergraduate Diversity Program (UDP).
As ToxScholars, our president, Margaret Whittaker, our treasurer Charlie Thompson and myself (Fred Mou-
lin) returned to the campus of Trinity Washington University in October 2019 to talk about drug discovery,
toxicology and careers in general and share pizzas with the students of Dr. Shizuka Hsieh. It pains me to admit
that while I was the speaker of the day, the real star of the show was Margaret. All those young women were
glued to her every words and had so many career and life questions for her. All was not lost for Charlie and I
though, as Margaret doing most of the talking allowed us a much more thorough sampling of the pizzas on dis-
play. I have included below a couple of pictures of our visit.
The Undergraduate Diversity and Undergraduate Education programs were both devastated by the cancelling
of the annual meeting. Our undergraduate student guests were suddenly told to cancel hotel reservations and
flight, postpone their returns to campus and stay home. For many seniors, attendance and poster presentations
at SOT are essential elements of a successful graduate school application. All of those opportunities suddenly
vanished with the onset of the quarantine.
To compensate, the Committee for Diversity Initiatives created the Virtual Undergraduate Diversity Program.
The science talks planned for our Anaheim event were recorded and made available on the SOT web site. In
May, Dr. Marquea King presented the first webinar of the series titled “Introduction to Toxicology” which was
followed by a live Q&A session with all the presenters of the scientific lectures. This event was followed, two
weeks later by another virtual meeting titled “The ins and outs of Graduate School in Toxicology” where
groups of students were able to question graduate school advisors and graduate students moderators in multi-
ple “breakout rooms”. For the final webinar in early June, 12 of the Pfizer SOT Undergraduate Travel Award
recipients gave five-minute presentations of the
research that would have been featured during a
poster session at the 2020 SOT Annual Meeting
followed by 5 minutes of questions. The audi-
ence included students from the Undergraduate
Diversity Program, undergraduate meeting reg-
istrants, research mentors and guests from the
speakers. The sessions were remarkably well
attended, lively and fun for all the participants. I
enjoyed them immensely. The new look of SOT UDP
19
Bern Schwetz (retired) is a nationally recognized expert in reproductive and developmental toxicology. Dr.
Schwetz served as President of the National Capital Area Chapter (NCAC) of the Society of Toxicology
(SOT) from 2000-2001. Since 2004, in Dr. Schwetz’s honor, the NCAC-SOT provides travel awards to help
promising early career research scientists attend the SOT annual meeting.
The NCAC-SOT is delighted to present the following 2020 Bern Schwetz Travel Award winner:
2020 National Capital Area Chapter Bern Schwetz Travel Award Winners
Bern Schwetz Graduate Student Travel Award
Dana Freeman is a graduate student at the Bloomberg School of Public
Health at Johns Hopkins University and a past student representative of
the NCAC-SOT. She was awarded first place for her abstract entitled
“Human Allele-Specific Methylated Regions Have Increased Resilience
to Rotenone Exposure in α-Synuclein Knockdown Neurons.”
Alas, because of the quarantine, we were unable to celebrate Dana’s achievement as she deserved, but I am
including a picture from the desk of our past president showing the award and prize that we sent to Dana to let
you all know that NCAC did honor its commitment.
We all look forward to celebrating Dana’s success at a later time, when pesky viruses finally allow us to have
fun together again. Fortunately, I was able to catch Dana last year at the NCAC reception in Baltimore.
20
MEMBERS ACCOMPLISHMENTS
The NCAC-SOT likes to acknowledge the accomplishments of its members and celebrate their successes.
AWARDS
We would like to congratulate our long-time NCAC-SOT and AGT Member,
Dr. Sidney Green of Howard University, for his 2020 SOT founder award. This
award, recognizes a Full, Emeritus, or Retired Full member who has demonstrat-
ed outstanding leadership in fostering the role of toxicological sciences in safety
decision-making through the development and/or application of state-of-the-art
approaches that elucidate, with a high degree of confidence, the distinctions for
humans between safe and unsafe levels of exposures to chemical and physical
agents. Through his more than 50 years as a practicing toxicologist, Dr. Green
has made major contributions to academia, industry, and government.
Dr. Green joined the US Food and Drug Administration (US FDA) as a pharma-
cologist in 1965, after spending several years in industry. He received his PhD in
biochemical pharmacology from Howard University in 1972. Through various
roles at the FDA— most recently as Director of the Division of Toxicological
Research—Dr. Green ensured that appropriate scientific information was available to establish safe versus un-
safe exposure levels for chemical and physical agents that humans encounter daily. His efforts as the Agency’s
chief spokesperson in the area of alternative tests contributed significantly to the establishment of the Inter-
agency Regulatory Alternatives Group, which set the stage for the Interagency Coordinating Committee on the
Validation of Alternative Methods.
Dr. Green’s contributions to safety decision-making continued through his role at the US Environmental Pro-
tection Agency (US EPA), where he served as Chief of the Toxic Effects Branch, Health Review Division, in
the Office of Toxic Substances. In this role, he represented US EPA on many Organisation for Economic Co-
operation and Development (OECD) scientific panels developing toxicological guidelines for the testing of
materials. He also chaired the US EPA GeneTox Committee, the charge of which was to review the status of
most of the methods used in genetic toxicology.
Joining Covance Inc. as Director of the Department of Toxicology in 1995, Dr. Green was charged with en-
suring the appropriateness of studies in multispecies for generating data to support safety-of-use requirements
for designated products as part of the premarket approval process. Then, in 1998, Dr. Green joined Howard
University College of Medicine as an Adjunct Associate Professor of pharmacology, a position he continues
to hold.
Dr. Green also served on the National Academy of Sciences Committee on Toxicity Testing, which 2007 pub-
lication of Toxicity Testing in the 21st Century: A Vision and a Strategy, has been instrumental in changing
the approach of toxicologists to safety evaluation. In addition, Dr. Green has authored more than 70 publica-
tions, primarily on topics involving genetic toxicology, short-term test methodology, and policy issues asso-
ciated with alternatives to animal testing.
Dr. Green has been actively involved in SOT since 1974 in appointed, elected, and volunteer capacities. His
service includes positions on Council, as Chair of the Membership Committee, and as President of several
Component Groups. In addition to service to SOT, Dr. Green is a Past President of the American College of
Toxicology, Association of Government Toxicologists, and Academy of Toxicological Sciences.