new advances of bio- medical ultrasound...
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NEW ADVANCES OF BIO-MEDICAL ULTRASOUND
IMAGING IN HUST
Mingyue DingDepartment of Bio-medical Engineering, School of Life
Science and TechnologyHuazhong University of Science and Technology
Wuhan, ChinaJune 26, 2015
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Outlines
Introduction to MUL2D array-based 3D US ImagingUltrasound Computed Tomography for
Breast ImagingTarget Nano-particles Agent for US
Molecular Imaging High Frequency US Fused Scanning
Probe Microscopy
Introduction to MUL
Medical Ultrasound Laboratory (MUL was founded in 2006 as part of “Image Processing and Intelligent Control” Key Laboratory of The Ministry of Education of China, HUST. The goal of MUL lab isExplore the theory and principles in bio-medical ultrasound imaging, educate outstanding engineers oriented to application and become one of the most important ultrasound imaging research facilities in the world.Upgrade to a national lab within 5-10 years.
Longhui Wang, [email protected] Mingyue Ding, Professor
Ming Yuchi, Associate [email protected]
Xuming Zhang, Associate Professor [email protected]
Wenguang Hou, Associate Professor
Faculty in MUL
Yu Yuan, Associate [email protected]
Photo not available
MUL members in Sept. 2010
3D ultrasound imaging system for urological diseases diagnosis & therapy
Urological organs
Pre-planning
Surgery navigation
Image registration & fusion
Surgery toolsTracking & localization
2D probe basedimaging24 ×240.6mm ×0.6 mm×0.6mm25f/s
Prostrate
Automatic path planning
2D probe design and fabrication
48×48 probe maskElements & connection
Row-Column addressing simulation
32*32 row-column addressing8*8 probe fully connection
Proto-type 3D imaging system
2D array probe & 3D imaging system
Off-line reconstruction 240 X 560 X 116
2D array probe & 3D imaging system
2D array probe based 3D imaging
On line real time 3D US imaging
3D image of board
SoftVue-Breast UCT for breast imaging
UCT imaging with three different image components
Ring probe one transmission, the rest receiving
C(x, y)
The other element transmission
C(x, y)
Linear probe one transmissionthe another receiving
C(x, y)
Transmission from different angle
C(x, y)
Comparison of X-ray and US projection
x
yr
Space domain
Xray CT UCT
Ring transducer for breast imaging system
UCT based on 2 linear arrays
UCT with two linear array probes
Transmit part Capture part
Hardware system of UCT for 3D breast imaging system
Transmission signal
Echo signal received in system
Diagnosis results of breast cancer
Correct rate UCT >85% mammogram 55%
Comparison of proto-type and 1st
generation system
Fusion image from 3 US components
Comparison between UCT and MRI
Comparison between UCT and mammogram
Fusion of tumor
Target Nano-particles Agent for early liver diagnosis
Nano-particles
Targeted nanoparticles
4. Image reconstruction3. In vivo metabolizing
of Nano-particles
1. Mutual effect between Nano-particles and
tumor cells
2. In vitro metabolizingof Nano-particles
5. Data mining
Bio-marker More than 12 SCI papers published!
In vitro experiments
Experimental setup for in vitro 2D B-mode image
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Micro-bubble
Target-nanoparticles
Evaluate:--imaging--Liver perfusion--TIC
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In vivo experiments
GE logiq7
Wistar rat
In vivo experiments
SonoVue
Nanobubble
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The rat liver ultrasound image before (a) and 10s after (b) injection of the targeted nanobubbles
(a) (b)
In vivo experiments
Proto-type system for 3D imaging
SonixTouch US data acquisition system
Simens Acuson 512
Schematic structure of SPAM
f0
Laser
Specimen
Ultrasound image
Morphological image
fs
Photo diode Signal magnification & demodulation
Envelop signal
detection US fusion module
Signal fusion
Main controllerof SPM
Transduce
High Frequency Ultrasound Fused Scanning Probe Microscopy
Interference
High frequency
cantilever High frequency transducer
Nano-probe
High frequency transducer
Multi-frequency
Resolution 50nm
Proto-type HFUF SPM system
Experiments
DVD, NVD and specimens
DVD Blue DROM NVDSpecimens piled off are 0.60mm 1.12mm 0.62mm respectively.
Structures of DVD and BD
m×7 m of DVD
Morphological image Ultrasound imageMeasured five strips is 3725nm and the ground truth is 3700nm with a error rate of 0.6%.
26 m×26 m of DVD
Morphological image Ultrasound imageMeasurement of 10 strips is 7337nm with the ground truth of 7400nm the error rate is 0.8%
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Phantom designed for ultrasound image resolution measurement
Silicon wafer without gold particles
Morphological image Ultrasound image
Silicon wafer with god particles
Morphological image Ultrasound image
The same specimen moved to the left
Morphological image Ultrasound image
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Thanks!