Neu 200Molecular Mechanisms of Plasticity

Biochemical Basis of LTP

Calcium activation of CaM kinases

Calcium activation of CaMKII

LTP is reduced in Thr286A mutant mice

LTP-induced changes in AMPA currents

Glycine induces potentiation

Glycine increases surface GluR1

Phosphorylation of GluR1 by LTP

GluR1 phosphorylation at S831

S831 phosphorylation of GluR1is required for glycine-induced potentiation

Model of AMPA-R regulation

Evidence for GluR1 insertion at synapses

CaMKII effect on synaptic responses

Effect of S831A, S845A on LTP

Generation of S831/845- mice

Plasticity in S831/845- mice

Role of GluR1 trafficking in fear conditioning: Physiology of GluR1 transfected neurons in Amygdala

Expression of GluR1-C inhibits plasticity in Amygdala

Expression of GluR1-C inhibits fear conditioning

Biochemical Basis of LTP

Spatial learning induces gene expression

Calcium regulation of gene expression

CaM Kinase IV activates CREB

CaM Kinase IV phosphorylates CREB

LTP in dnCKIV mice

dnCaMKIV suppresses fear conditioning

Spatial learning in dnCKIV mice