nervous system augmentationexicon.website/uploads/editor/omaintec2019... · electrochemical...
TRANSCRIPT
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Hasan Al-NashashBiomedical Engineering Graduate Program
American University of Sharjah, UAE
Nervous System Augmentation
Biomedical and Clinical Engineering Forum, bioclinic 5 Dubai, November 20, 2019
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Neuroengineering Research Group
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Cortical Source Imaging Using EEG
Severity Assessment of Spinal Cord Injury
Flexible Implantable Electrodes
Cognitive Vigilance Assessment and Enhancement
Quantitative Assessment of Brain Injury
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Nerve Injury
Traumatic injury Spinal cord injury
Peripheral nerve injury which results in nerve-muscle and related limb functions
Other forms of neuromuscular function loss which may result from disorders such as multiple sclerosis or neuropathy, or injury to nerves affecting the bladder or prostate and related sexual dysfunctions
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Research Challenges in Nerve Injury
Assessment of injury level
Subjective tests
Objective tests
Therapy/Augmentation
Functional electrical stimulation
Brain computer interface for artificial prostheses control
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Basso, Beattie and Bresnahan (BBB) score
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Open-field test
(Score ranges from 0-21)
It consists of assessments of:
oHindlimb joint movements
oTrunk positions
oPaw placement
oStepping
oCoordination
oToe clearance
oPaw & tail positioning
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Spinal Cord Injury
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SSEPElectrical response of the nervous system to a sensory stimulus, recorded from the somatosensory cortex
Measures the integrity and conductivity of the sensory pathways through spinal cord
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Week 7 Postinjury SEP signals obtained from a rat in the 25 mm injury group
20 40 60 80
-10000
-5000
0
5000
Left Forelimb
Rig
ht
Hem
isphere
Am
p.
( V
)Time (msec)
0 50 100
-2
-1
0
1
x 104 Right Forelimb
Left
Hem
isphere
Am
p.
( V
)
Time (msec)
0 50 100-4000
-2000
0
2000Left Hindlimb
Rig
ht
Hem
isphere
Am
p.
( V
)
Time (msec)
0 50 100-4000
-2000
0
2000
4000Right Hindlimb
Left
Hem
isphere
Am
p.
( V
)
Time (msec)
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Spectral Coherence Measure
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Peripheral Nerve Injuries-Muscle Atrophy
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Muscle atrophy due to damage of PNS connection to muscles
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Peripheral Nerve InjuryImplantable electrodes for restoring motor function after peripheral nerve injuries
Market demands integrated designs for restoring sensory and motor function after nerve injuries
Electrical stimulation therapy helps to restore limb muscle function, sensory feedback and reduce the risk of muscle hypotrophy.
Simultaneous recording of the desired nerve Electroneurograph (ENG)
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Proximal
Peripheral nerve
Distal
Peripheral nerve
Muscle
groups
Damaged
Site
Neural recorders
Spike detectors
Stimul pulse Gens
Biphasic curr O/P
Recording
electrodes
Stimulation electrodes
Bionic Neural Link System
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Bioelectrodes
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Interface between the biological tissue and the electronic
system:
Sense/measure the bioelectrical signals within the body
Deliver stimulation signal from the instrumentation system to the target
tissue (nerve/muscle)
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Bioelectrodes Materials
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Inert metal electrodes:
Platinum
Gold Iridium
Silver
Platinum-iridium
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Bioelectrodes Materials
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Polymer-based electrodes with modification:
PEDOT
Polyimide (PI)
Polyaniline (PANi)
Polythiophene (PTh)
Polypyrrole (PPy)
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Grand Challenge
Current implantable electrodes are metal-based
Limitations:
Mechanical Mismatch
Foreign Body Response
High Cost
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Proposed Novel SolutionDESIGN REQUIREMENTS
Low Cost
Flexible
Conductive
Biocompatible
MATERIALS
Polymer + Metal + Mixing Assistant
Materials:
Silicone Polymer
Titanium (IV) Oxide
Glycerol
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Methodology: Material
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Prepared Sample
Silicone Polymer (polysiloxanes)
Metal Powder
Glycerol
Material Characterization
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Methodology: Sample Preparation
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Teflon mold (left) electrode sample prepared (right)
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Electrochemical Properties
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Potentiostat SetupEquivalent Randle’s Circuit
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Electrochemical Properties
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Material Specimen Rs (KΩ) Z at 1KHz
PEDOT:PSS Thin film 2.23 [7] 2.54 [7]
Ultrathin parylene C coated platinum
Needle-shaped 359 [8] 21,000 [8]
Platinum Thin film 2.96 [7] -
Gold Thin film 10 [9] 17.2 [9]
Literature values for electrochemical properties of conductive polymers and metal electrodes
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Ratio Testing with TiO2
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Si:TiO2:Gl
Sample
70:15:15 50:30:20
Bulk Impedance
(kΩ)
Impedance at 1
kHz (MΩ)
Bulk Impedance
(kΩ)
Impedance at 1
kHz (kΩ)
Sample 1 17.2 1.48 4.25 78.2
Sample 2 7.62 1.14 3.55 24.2
Sample 3 17.5 1.51 4.38 105
Average 8.96 ± 0.799 1.37 ± 0.206 4.06 ± 0.448 69.0 ± 41.0
EIS testing results for 3 samples of 15% TiO2 and 3 samples of 30% TiO2
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Methodology: Mechanical Characterization
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Mechanical Testing Results
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Modulus of Elasticity = 6.63 MPa
Elongation = 266%
y = 6.6269x - 1.4903
0
0.5
1
1.5
2
2.5
0 0.5 1 1.5
Ten
sile
Str
ain
(M
Pa)
Tensile Strain (mm/mm)
Stress-strain curve for a sample of 30% TiO2, 50% silicone and 20% glycerol
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Mechanical Testing Results
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Material SpecimenModulus of
Elasticity (MPa)Elongation%
PEDOT:PSS Cast film 1.8×10³ [57] 4.3 [58]
PI Thin film 6×10³ [59] <10% [59]
Platinum Thin film 140×10³ [60] 35 [60]
Gold Thin film 69.1×10³ [60] -
This Work Rectangular shape 4.519 ± 1.154 266 ± 27.1
Comparison of mechanical testing results for 30% TiO2 samples with conventional materials
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Vigilance Decrement and Enhancement
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Vigilance
Vehicle Driving
Airport screening
Diagnostic Medical
Screening
Air traffic
Monitoring surveillance
camera
Classroom settings
Vigilance could be define as the sustained attention to a particular stimulus over a prolonged period of time.
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GRAND CHALLENGE
Extreme high or low cognitive workload in active applications which require vigilance can lead to reduction in cognitive efficiency.
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Methods for Cognitive Enhancement
TRADITIONALEducation and learning
Mental training and encoding strategies
Meditation and yoga
Martial arts, sports and exercise
Caffeine and nicotine
Diet and herbal extracts
CONTEMPORARYPharmaceuticals
Psychological interventions
Molecular and gene therapy
Transcranial magnetic stimulation
Electrical stimulation
Gaming/Challenge integration
Tactile and rhythmic haptic
Audio (Music, Binaural Beats)
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Challenging Noise – 20 Minutes
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Results – EEG PSD, n=12
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Human Brain Senses and Waves
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p<0.05
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Binaural Auditory Beats (BBs)
When two auditory stimuli of different frequencies are presented to each ear, binaural beats are perceived by the listener.
The binaural beat frequency is equal to the difference between the frequencies applied to each ear.
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Objective
Develop a novel computerized vigilance test
Explore the effectiveness of BBs in vigilance enhancement
Identify useful frequencies
Investigate the vigilance permanence with time
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Proposed Binaural beats (BBs)The Carrier frequency is set to: [250 Hz]
BBs are presented at:
[4 Hz, correspond to EEG Theta rhythm]
[10 Hz, correspond to EEG Alpha rhythm]
[16 Hz correspond to EEG Beta rhythm]
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Data CollectionSign the informed consent form approved by the AUS IRB
Subject data: survey, data sheet
Epworth sleepiness scale test (ESS)
Short Stress State Questionnaire (SSSQ)
NASA TLX questionnaire
Reaction time
Response accuracy
Eye tracking variables
EEG
ECG
EOG
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Assessment Methods
Power spectrum analysis
Functional connectivity
Brain Source localization
Data fusion
Machine learning
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Results
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EEG connectivity network
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Average weighted directed connectivity network for (a) Vigilance, (b) Enhancement. Red indicates high connectivity strength
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Thank You
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