nd international meeting on childhood tb...university and baltipa, and with penta-id. a lithuanian...

Final report for 2nd International Meeting on Childhood TB Course Dates: 21st – 23rd March 2018 Venue: Crowne Plaza Hotel, Vilnius, Lithuania Website: https://www.ptbnetvilnius2018.com/ Organising Committee: Dr Folke Brinkmann, Dr Inga Ivaskeviciene, Miss Charlotte Male, Dr Ezia Maria Ruga, Dr James Seddon, Dr Marc Tebruegge, Dr Anna Turkova, Prof Vytautas Usonis, Dr Steve Welch. Contact details: Steve Welch – Education and Training Lead pTBnet Email: [email protected] Tel: +44 121 424 0823 Charlotte Male – Coordinator Email: [email protected] Tel: +447754463904 Fees/Sponsorship: Non-commercial sponsorship was provided by ESPID, PENTA-ID, and the Yusuf and Farida Hamied Foundation. Commercial sponsors were Cepheid, who had no input into the content of the programme. Partners: The meeting was organised in partnership with local hosts the Faculty of Medicine, Vilnius University and BALTIPA, and with PENTA-ID. A Lithuanian company, Top Session, was hired for logistical arrangements and website support. As an ESPID funded course, the Crowd Comms application was used to facilitate communication, programme updates, polling and feedback throughout the course. Financial information - Cost for Delegates The following registration fee was applied to participants: • Reduced fee*: Early Bird Euro 50 / Late Fee: Euro 60 • Trainees and nurses: Early Bird Euro 100 / Late fee Euro 120 • ESPID member: Early Bird Euro 200 / Late fee Euro 240 • Non-ESPID member: Early Bird Euro 300 / Late fee Euro 360

Registration included: Participation in the 2.5 days symposium (including 3 lunches and 2 dinners) in Vilnius, delegate packs, access to downloadable presentations.

pTBnet Background and the 2nd International Meeting on Childhood TB pTBnet is an international network of more than 200 clinicians and researchers. pTBnet was founded in 2009 and promotes clinically oriented research in the field of childhood tuberculosis by sharing and developing ideas and research protocols. The aims of the network are: • to enhance the understanding of the paediatric aspects of active and latent tuberculosis • to facilitate collaborative research studies on childhood TB in Europe • to provide expert opinion through excellence in science and teaching • to harmonise healthcare delivery/approaches within Europe • to establish an evidence base for diagnosis and treatment of TB in children

The first International Meeting on Childhood Tuberculosis was organised by pTBnet in Padova, Italy in March 2013. This meeting was pivotal in bringing together experts in many aspects of paediatric TB and was attended by over 100 delegates from across the globe. The feedback was very positive, and several projects emerged as a result of the meeting including multicentre clinical research and database projects, and also clinical activities such as interactive online case discussions. There has been considerable progress in research, drug development and programme delivery in paediatric TB since 2013. The 2nd conference provided updates on this progress, and its planned to established the meeting as a regular event. Themes included: Towards zero death - tackling childhood TB in Europe and abroad Clinical course of childhood TB New insights into an old disease – from basic science to new diagnostics MDR TB – a new threat The meeting specifically aimed to bring together clinicians from high tuberculosis-incidence countries in Eastern Europe and the countries of the former Soviet Union, and from Western Europe. Vilnius was chosen as a venue to facilitate this, and reduced registration and travel and accommodation bursaries were provided. In total 13 bursaries were awarded: 10 full bursaries (covering registration, travel, accommodation and networking dinner) were given to delegates from Ukraine (9) and Poland (1) and a further 3 delegates, 2 from Lithiuania and 1 from an NGO in the USA had their fees waived. Social Media networking The social media platforms will support ongoing networking for those who attended the meeting, and for others who have an interest in research, epidemiology, clinical practice and programme delivery in this field. The platforms will also be used for promotion of upcoming events and the planned 3rd International Meeting on Childhood TB in 2019/2020. www.facebook.com/ptbnetgroup/ #ptbnet2018 www.twitter.com/ptbnetgroup/ #ptbnet2018 Also: www.facebook.com/TBnet

Appendix 1: Final Programme

Photographs by Valeriu Istrati

Day 1: Wednesday 21st March 2018

08:30-12:30 pTBnet Business Meeting pTBnet Members

11:30-13:30 Conference Registration and lunch Session 1: Towards zero death - tackling childhood TB in Europe and beyond Chairs: Dr Steve Welch & Dr Inga Ivaskeviciene 13:30-13:50 Welcome and introduction

Dr Steve Welch Prof. Vytautas Usonis

13:50-14:30 Epidemiology in Europe with special focus on MDR Dr Senia Rosales-Klintz

14:30-15:00 End TB: strategies in Eastern European countries Prof Andrei Mariandyshev

15:00-15:30 Coffee Chairs: Prof. Vytautas Usonis & Dr Anna Turkova 15:30-16:00 The importance of PK studies for programmes

Prof Helen McIlleron

16:00-16:30 TB in special population – refugees in Europe Dr Folke Brinkmann

16:30-17:15 Clinical Cases Dr Ulrich von Both

17:15

Summary of day

Day 2: Thursday 22nd March 2018 Session 2: Clinical course of childhood TB Chairs: Dr Suzanne Anderson & Dr Steve Welch 08:30-09:00

Invited lecture: History of TB Dr John Innes

09:00-09:30 News on prevention – vaccine trials Dr Helen Fletcher

09:30-10:00 Biomarkers for predicting progression from latent to active TB

Dr Hazel Dockrell

10:00-10:30 Immune response to TB in children; immune evasion and novel molecular insights

Dr Ulrich von Both

10:30-11:00 Coffee Chairs: Dr Folke Brinkmann & Dr Steve Welch 11:00-11:30 Double trouble – TB and HIV coinfection Dr Steve Welch

11:30-12:00 TB Meningitis - what’s new? Dr Anna Turkova

12:00-12:30 Debate: MDR Regimens for children should always include an injectable agent.

For: Dr James Seddon Against: Dr Steve Welch

12:30-13:30 Lunch Session 3: New insights into an old disease Chairs: Dr James Seddon & Prof Andrei Mariandyshev 13:30-14:00 Pathogen–based TB diagnostics

Dr Carlos Perez-Velez

14:00-14:30 Immune–based TB diagnostics

Dr Nicole Ritz

14:30-15:00 Clinical Cases Dr Inga Ivaskeviciene & Jonuskaite Dovile

15:00 -15:30 Coffee Chairs: Dr James Seddon & Dr Nicole Ritz 15:30-16:00

Practicalities of recruiting in research Dr Suzanne Anderson

16:00-17:00 Roundtable – Future research and trials Prof Diana Gibb Dr Nicole Ritz Prof Andrei Mariandyshev Dr Suzanne Anderson Dr Begoña Santiago Dr Angela Crook Dr James Seddon

17:00-17:10

Summary of the day

Day 3: Friday 23rd March 2018 Session 4: MDR TB – a new threat Chairs: Dr Folke Brinkmann & Dr Begoña Santiago 08:30-09:00

How do children with MDR TB live - short sequences from hospitals/outpatient units in different countries

Mr Valeriu Istrati

09:00-09:30

Microbiology with focus on whole genome sequencing Dr Grace Smith

09:30-10:00

Biology of drug resistance Dr Claudio Köser

10:00-10:30

Diagnostic and clinical management of drug resistant TB

Dr James Seddon

10:30-11:00 Coffee 11:00-11:45

Treatment options of drug resistant TB – trial update and new drugs

Dr Tony Garcia-Prats (Video Conference)

11:45-12:15 Clinical Cases Dr Anna Turkova & Dr Steve Welch

12:15-12:45 Experiences with the introduction of new drugs and strategies in KNCV supported countries

Dr Gunta Dravniece

12:45-13:45 Lunch Session 5: Practical management in the 21st century Chairs: Dr Steve Welch 13:45-14:15 Compliance and Video Observed Therapy Dr Joe Hall

14:15-14:45 TB apps – any use? Dr Christian Herzmann

14:45-15:15 Debate: Microbiology samples should always be sent

before starting treatment for TB disease in children For: Dr Grace Smith Against: Dr Folke Brinkmann

15:15 Summary of day and conference Dr Steve Welch Dr Folke Brinkmann Dr Inga Ivaskeviciene

Appendix 2: Meeting Evaluation

1) Epidemiology in Europe with special focus on MDR Presentation ratings

• Content: 217/260 (Average: 4/5) • Clarity and delivery: 210/260 (Average: 4/5)

2) End TB: Strategies in Eastern European Countries

Presentation ratings • Content: 205/260 (Average: 4/5) • Clarity and delivery: 187/260 (Average: 3.5/5)

3) The importance of PK studies for programmes

Presentation ratings • Content: 231/255 (Average: 4.5/5) • Clarity and delivery: 223/255 (Average: 4.5/5)

4) TB in special populations - refugees in Europe


5) Clinical Cases - Day 1


6) Invited lecture: History of TB

Presentation ratings • Content: 212/240 (Average: 4.5/5) • Clarity and delivery: 226/240 (Average: 5/5)

7) News on prevention - vaccine trials


8) Biomarkers for predicting progression from latent to active TB


9) Immune response to TB in children; immune evasion & novel molecular insights

Presentation ratings • Content: 202/245 (Average: 4/5) • Clarity and delivery: 197/245 (Average: 4/5)

10) Double trouble - TB & HIV coinfection


11) TB meningitis - what's new?


12) Debate: MDR TB regimens for children should always include an injectable agent


13) Pathogen-based TB diagnostics


14) Immune-based TB diagnostics




16) Practicalities of recruiting in research


17) Round table


18) How do children with MDR TB live - short sequences from hospitals/outpatient units in

different countries Presentation ratings

• Content: 137/165 (Average: 4/5) • Clarity and delivery: 143/165 (Average: 4.5/5)

19) Microbiology with focus on whole genome sequencing


20) Biology of drug resistance


21) Diagnostic and clinical management of drug resistant TB


22) Treatment options of drug resistant TB - trial update and new drugs


23) Experiences with the introduction of new drugs and strategies in KNCV supported countries

Presentation ratings • Content: 140/165 (Average: 4/5) • Clarity and delivery: 147/165 (Average: 4.5/5)



25) Compliance and Video Observed Therapy


26) TB apps - any use?

Presentation Ratings • Content: 125/160 (Average: 4/5) • Clarity and delivery: 130/160 (Average: 4/5)

27) Debate: Microbiology samples should always be sent before starting treatment for TB disease

in children Presentation Ratings

• Content: 120/140 (Average: 4/5) • Clarity and delivery: 112/140 (Average: 4/5)

2nd International Meeting on Childhood TB participant comments “Great event, good speakers, useful information” “I feel so happy to listen to wonderful experts. Every presentation is very important and is prepared with love. Many thanks for good organisation and possibility to stay three days with childhood TB...” “Excellent meeting Wealth of knowledge shared Good organisation” “From TB history up to future. Many thanks.” “Thanks for a nice Meeting. Interesting lectures, very good speakers.” “Many thanks for the wonderful congress. A lot of useful information. Very interesting communication with colleagues.” “Great meeting, great people! Thanks much” “Excellent reports, interesting clinical cases, professional speakers, communication with colleagues, beautiful Vilnius! Thank so much the organizing committee, the management of ptbnet for the great conference! Thank you for attention to the problem of childhood TB! We wait for a new meeting!” “Great presentations on PK/PD issues, on critical concentrations and mutations, on clinical trials for kids. Many thanks. Looking forward for follow up actions and regular updates. Suggest cross fertilization with “adult” meetings and documents.” “I thought that the meeting was excellent. I’ve been to lots of TB meetings over the years and this was one of the best. The speakers were all top-quality and the audience was very interested and engaged. A sense of common purpose was everywhere. And the organisation was great.”

Appendix 3: 2nd International Meeting on Childhood TB Participants No Name Surname Country

1 David Aguilera-Alonso Spain 2 Francesca Wanda Basile Italy 3 Robin Basu Roy United Kingdom 4 Yvonne Beuvink United Kingdom 5 Olga Bilogortseva Ukraine 6 Matthias Bogyi Austria 7 Arleta Bublevič Lithuania 8 Mithilesh Bharadwaj Burra Ukraine 9 Charlotte Buxbaum Sweden

10 Janet Cairns United Kingdom 11 Vira Chechenieva Ukraine 12 James Cottam United States 13 Angela Crook United Kingdom 14 Saulius Čaplinskas Lithuania 15 Irma Čaplinskienė Lithuania 16 Natalija Dobrova Lithuania 17 Nadiia Drebot Ukraine 18 María Espiau Spain 19 Lola Falcon Spain 20 Laura Ferreras Antolin United Kingdom 21 Nataliya Gabrovska Bulgaria 22 Devasena Gnanashanmugam United States 23 Florian Goetzinger Austria 24 David Gomez Pastrana Spain 25 Paulius Gradeckas Lithuania 26 Eugenijus Griška Lithuania 27 Edita Hansted Lithuania 28 Norbert Heinrich Germany 29 Inis Hormann United States 30 Danutė Jadzevičienė Lithuania 31 Bashir Jan muhammad United Kingdom 32 Renata Jezukevičienė Lithuania 33

Monika Kapitančukė Lithuania 34 Hanna Kaur United Kingdom 35 Christina Kavouridou Sweden 36 Alexey Kazakov Russia 37 Satu Kekomaki Finland 38 Nataliia Kolisnyk Ukraine

39 Joana Korabliovienė Lithuania 40 Kristian Korns United States 41 Karsten Kötz Sweden 42 Zhanna Kryvasheyeva Belarus 43 Renate Krueger Germany 44 Vaida Kudirkienė Lithuania 45 Elena Kulinisch Ukraine 46 Kristen LeBeau United Kingdom 47 Giedra Leviniene Lithuania 48 Gintare Liakaite Lithuania 49 Clemens Mädel Austria 50 Nick Makwana United Kingdom 51

Andrii Mamotenko Ukraine 52 Elke Maritz Germany 53 Andrea Martin Nalda Spain 54 Lindsay McKenna United States 55 Meena Middleton United Kingdom 56 Valdonė Misevičienė Lithuania 57 Françoise Mouchet Belgium 58 Kadri Muoni Estonia 59 Lounis Nacer Belgium 60 Ronelle Naidoo United Kingdom 61 Airida Narkutė Lithuania 62 Laima Naskauskiene Lithuania 63 Olaf Neth Spain 64 Antoni Noguera-Julian Spain 65 Laura Olbrich Germany 66 Raa Orentaite Lithuania 67 Bozena Paskevic Lithuania 68 Maria Beatriz Perez Gorricho Spain 69 Tomas Perez-Porcuna Spain 70 Silvi Plado Estonia 71 Anja Pouslen Denmark 72 Nicole Ritz Switzerland 73 Rima Sabaliene Lithuania 74 Eeva Salo Finland 75 Karen Scott United Kingdom 76 Yana Sheremeta Ukraine 77 Geeke Sieben Germany 78 Paas Siiri Estonia 79 Rinn Song United Kingdom 80 Antoni Soriano-Arandes Spain

81 Stanislav Spavsky Ukraine 82 Indrė Stacevičienė Lithuania 83 Elena Suciliene Lithuania 84 Rita Šopienė Lithuania 85 Edita Tamulaitiene Lithuania 86 Vinisha Tekwani Ukraine 87 Margaret Thomason United Kingdom 88 Yanis Tolstov Germany 89 Maria Tsolia Greece 90 Ulle Uustalu Estonia 91 Laimutė Vaidelienė Lithuania 92 Sai Krishna raghu vamsi Varahabhatla Ukraine 93 Laima Vasiliauskaite Lithuania 94 Svetlana Velizarova Bulgaria 95 Anna Vidal Spain 96 Claire Watterson United Kingdom 97 Elizabeth Whittaker United Kingdom 98 Lenka Widner Austria 99 Amanda Williams United Kingdom

100 Galina Zagrebnevienė Lithuania 101 Andrzej Załęski Poland 102 Anna Zschocke Austria 103 Steve Welch UK 104 Senia Rosales-Klintz Sweden 105 Andrei Mariandyshev Russia 106 Helen McIlleron South Africa 107 Folke Brinkmann Germany 108 Ulrich Von Both Germany 109 John Innes UK 110 Helen Fletcher UK 111 Hazel Dockrell UK 112 Anna Turkova UK 113 James Seddon South Africa 114 Tony Garcia-Pratts South Africa 115 Valeriu Istrati Moldova 116 Grace Smith UK 117 Claudio Köser UK 118 Christian Herzmann Germany 119 Charlotte Male UK 120 Carlos Perez USA 121 Joe Hall UK 122 Gunta Dravniece Netherlands

123 Diana Gibb UK 124 Suzanne Anderson UK 125 Vytautas Usonis Lithuania 126 Inga Ivaškevičienė Lithuania

Appendix 4: Summary of income and expenditure

IN Euros Delegate fees 13750 Non-commercial sponsorship ESPID 10000 PENTA 16514 BALTIPA (from donation by Hameid foundation) 6612 Commercial sponsorship Cepheid 8037 Total 54913.00 OUT Euros Paid via Top Session Logistics Conference facilities 6640 Printing 1420 Delegate kits 1695 Catering 10210 Speaker & bursary travel & accommodation* 12409 Dinner & social event 3060 IT & comms 1742 Miscellaneous 50 Logistics company fee 8330 Subtotal 45556.00 Paid directly (see attached breakdown) Planning visit September 2016 1009.01 Planning visit November 2017 1369.51 Speaker travel expenses* 6457.58 Miscellaneous 520.29 Subtotal 9356.39 Total 54912.39

*majority of speaker travel arranged and paid directly by TopSession, some speakers paid own travel and reimbursed directly.

nd international meeting on childhood tb...university and baltipa, and with penta-id. a lithuanian...

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