nc a&t state university made history
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NC A&T State University Made History. NOW…..THE REST OF MY STORY. KNOWN FACTS……..MUST BECOME REALITY :. Partnership (small or big) must transcends all boundaries True Partnership takes place at the intellectual level (Performance level and Wavelength) – PASSION DRIVES THEM - PowerPoint PPT PresentationTRANSCRIPT
NSF-ERC for Revolutionizing Metallic Biomaterials
Press Release 08-174
NSF Launches Third Generation of Engineering Research Centers with Awards Totaling $92.5 Million
Five new centers will pursue innovations in biorenewable chemicals, green energy systems, communications networks, medical implants and smart lighting.
Jagnnathan "Jag" Sankar, Distinguished Professor of Mechanical Engineering at North Carolina A&T State University, will lead NSF ERC research to create "smart" implants for craniofacial, dental, orthopedic and cardiovascular interventions.
http://www.nsf.gov/news/news_images.jsp?cntn_id=112313&org=NSF
NC A&T State University Made History
NOW…..THE REST OF MY STORY KNOWN FACTS……..MUST BECOME REALITY:
Partnership (small or big) must transcends all boundaries
True Partnership takes place at the intellectual level (Performance level and Wavelength) – PASSION DRIVES THEM
Sacrifices at all levels…….Leaders in the trust sense Nothing comes EASY.… it has to Be Earned
Intangibles and Luck will help - for those in the High level performance and partnership zone
NSF-ERC for Revolutionizing Metallic Biomaterials
Center for Advanced Materials and Smart Structures (CAMSS) - Foundation for the ERC
NSF-CREST1997-2008
NSF-NSEC(2004 -
NSF-NIRT(2005- 10)
DoD-CNN(2003 – 2011)
Other NSF, AFRL, ONR, NASA-NIA
Others
Four (4) National Broad-based Advanced, Nano Centers
•Leveraging and Strategic Resources Sharing
•Maximum output for each $ spent•Innovative thinking that cuts across areas
RECENT competitive Programs WON:NSF-US/Europe
Collaboration, NSF-MRIs, Various NSF-SBIRs,STTR,
NSF- NUE (2), DoD-Nanolithography, DoD-DURIP
High Profile Broad Based Materials Activities over 20 years
NSF-ERC for Revolutionizing Metallic Biomaterials
NCAT Facilities: A Foundation for Partnership and Innovation Ecosystem
• Pulsed Laser Deposition Facility• Fuel Cell Processing Laboratory• Coatings Synthesis Laboratory• Bio/Polymer Laboratory• Composite Processing Laboratory• Materials Processing and Sample Preparation Laboratory• Microscopy and Surface Analysis Facility• Electron Microscopy Laboratory• Computation and Visualization Lab• Nanoindentation Facility• Mechanical Testing /High-Temperature Testing Facility• Structural Health Monitoring Research Laboratory• X-ray Diffraction Facility• Physical Property Measurement Lab• Catalysis Facility• Electronic Materials Laboratory • Magnetron Deposition Facility • Direct Write Nano-Fludics Analysis Facility• Micro-Raman facility• Clean Room with Ink Jet, High Speed Camera and
Nanolithography• Bioengineering ERC General facility• FSEM, AFM, Nano CT
Interconnected Labs
Facility,Research,
knowledge without
boundaries
REST OF MY STORY
CENTER Ethics lay a strong foundation for its growth and true partnership
- it is adaptable to innovative technologies
and education
Partnership is Ready to Contribute
with Customer Focus
OTHER ingredient for true partnership:
“Quality (track record)”
“Strong on deadlines and deliverables”ERC Faculty ACROSS
PARTNER INSITUTIONS – T Function
National Science Foundation – Gen 3
“THIS GREW OUT OF OUR RELATIONSHIP AND TRACK STRENGTH”
Engineering Research Centerfor
“Revolutionizing Metallic Biomaterials”
Deputy Director (Pitt)
Deputy Director (UC)
Education & Outreach Director (NCAT)
Global Site
Coordinator (MHH)
Executive Director
(Pitt)
Mark SchulzBill Wagner Devdas Pai Frank Witte Harvey Borovetz
Malformations
National Priority to become the Global Leader
Complex fractures of the Tibia and Femur: Need for Resorbable Fixation
Plates, Pins and Screws
TRAUMA Medical spending: Close to $250 billionTotal knee replacement surgeries increased by 85% in the recent years.
% mini plate surgeries led to infection 64% of Ti plate fixations need to be removed due to complications, infections, painstents are difficult to remove and additional stents must be inserted (elicit an immune response that can lead to the growth of scar tissue and the formation of blood clots)
Value of regenerative implants, Degradable metal anchors, screws, plates, stents and drug eluting
stents, staples, sutures, sternal wires, and meshesPRICELESS
Cleft Lip
will create biodegradable metals with the promise that new kinds of implants can adapt to the human body and eventually dissolve when no longer needed, eliminating multiple surgery and reduce health care costs
“Imagine Implants with their own intelligence that adapt to biological changes of the patient and are automatically eliminated from the body after healing”
Before After
ACL Screw Development Strategic Plan“Partnership both Inside and from Outside”
Alloy Design & Development
Xu (NCAT)Kumta (Pitt)Shanov(UC)
Biomechanics & In-vitro
FunctionalityWoo & Kim (Pitt)
Toxicology & Functional
BiocompatibilityDong (UC)
Barchowsky (Pitt)
Screw Design & Manufacture
Woo, McMahon, Tei & Kim(Pitt)
Schulz & Yin (UC)Kumta (Pitt)Xu (NCAT)
Surface TreatmentYun & Yarmolenko (NCAT)
Vanooij (Ecosil LLC) Shanov (UC)
Material Characterization
Schulz & Yin (UC)Xu (NCAT)
Controlled Drug Release
Wagner (Pitt)
Alloy Corrosion & Degradation
Yun (NCAT)Dong (UC)
IndustryJ&J Depuy Mitek
Alonzo CookGary McAlistar
Orthopedic SurgeonsPatrick McMahon
Marc Philippon, Richard Steadman,James Bradley, Frank Witte
Matteo Tei (Resident)
Design Objectives(ERC Team)
Clinical Trials
J&J Depuy Mitek
Industry
In-Vivo Animal Models
Woo & Kim McMahon & Tei
(Pitt)
E & O Partnership Strategic Plan
ACL Fixation Screw Medical System
• In-vitro ACL reconstruction using bone-patellar tendon-bone (BPTB) graft• Graft fixation using interference screws
– Mg-based screws (Mg & AZ31 alloy ); Titanium screws as control
Commercial Titanium
Screw
Screws
Mg Screw
Minimal degradation 6 wk post-implant
Interference Screw
NCAT Veterinarian and Animal Surgeon – Getting trained at Pitt
Bioreactor Development at NCAT with Pitt Partnership
Alcian Blue Stain Glycosaminoglycans
Ex Vivo Models For Biologic and Mechanical EvaluationConfidential
Toxicology Pixley (UC)
Functional Biocompatibility
Sfeir, Gilbert, Cui (UPitt)
In vivo Models
Witte (MHH) Dong (UC)
Clinical
Trials
Industry
Characterization Schulz (UC)
Yun (NCAT)
ProcessingShanov (UC) Yun (NCAT)Kumta (UPitt)
AlloysXu (NCAT)
Kumta (UPitt)
Strategic Plan for Biosensors
Sensor designHeineman (UC)Kumta (UPitt)
RESIDUE OF TRUE PARTNERSHIPRMB - Materials Database for Medical Devices - MD2
Key world leaders have accepted our requests to be a part of this materials database collection system and now with ASM- International
Workshop at the FDA+ Multiple Global Biometallic Materials Conferences
http://erc.ncat.edu/biodegradablemetals
NCAT- Bioengineering Program BS, MS – ongoing and Ph.D on its way- History in Making
Gatchell, Linsenmeier, CoC, 2/07
Accredited
Total UG Programs
NCAT
FIRST HBCU AMONG THESE 80+ PROGRAMS!
Dr. Borovetz and Pitt- Bioengineering Program – an Integral part of the development activities
Development of an Innovative, Globally Competitive Research, Education and Diverse Engineering Workforce
Development of an Innovative, Globally Competitive Research, Education and Diverse Engineering Workforce
Academic Programs
Academic Programs
Educational Outreach
Educational Outreach
Technical Dissemination
Technical Dissemination
Economic DevelopmentEconomic
Development
Frontier/Transformational
Scientific Research
Frontier/Transformational
Scientific Research
BS, MS and Ph.D in Bioengineering
BS, MS and Ph.D in Bioengineering
InnovationInnovation
EntrepreneurshipEntrepreneurship
Innovate “R” with Partners
Innovate “R” with Partners
SBIR/ STTRSBIR/ STTR
“D” with Local/Partner Companies
“D” with Local/Partner Companies
SeminarsSeminars
ConferencesSymposia
ConferencesSymposia
Distance Learning
Distance Learning
PublicationsPublications
REU/ LS-AMP/OPT-ED
REU/ LS-AMP/OPT-ED
K-14K-14
ConferencesSymposia
ConferencesSymposia
Teaching the Teacher/RET
Teaching the Teacher/RET
Spin-off Companies
Spin-off Companies
ERC Impact via Effective PartnershipFully - Integrated Management
Hitachi
“One Team ....One Dream”
CSAB
Johnson & Johnson
Em2 Machine Inc