Title : Nanoscale human

interventions to enhance bioavailability of Curcumin

in the treatment of Alzheimer's disease

By: Kushali

Jain.D

M.pharma

Introduction Alzheimer’s disease is the commonest

progressive neurodegenerative disorder of elderly population, characterized by memory dysfunction, spatial and temporal disorientation and impairment of judgment clinically.

In Alzheimer’s disease, a peptide referred as amyloid beta aggregates (oligomers), and accumulates in the brain to form deposits called as amyloid plaques.

Curcumin Turmeric (Curcuma longa) is an amazing ingredient with a rich traditional history as a dietary spice and herbal supplement in ancient china and India.

This characteristic yellow colored spice, derived from the rhizome of the plant (C. longa), is a member of Zingiberaceae family and is widely cultivated in India and Southeast Asia.

Benefits of curcumin

Epidemiological studies Various studies and research results indicate a lower incidence and prevalence of AD in India The prevalence of AD among adults aged 70-79 years in India is 4.4 times less than that of adults aged 70-79 years in the United States. Researchers investigated the association between the curry consumption and cognitive level in Asians between 60 and 93 years of age. The study found that those who occasionally ate curry (less than once a month) and often (more than once a month) performed better on a standard test mini mental state examination (MMSE) of cognitive function than those who ate curry never or rarely

Mechanism of Alzheimer's disease and role of Curcumin

Cleavage

STRESS, INJURY

Protective mechanism

α- secretase β- secretase

40 amino acid Cleavage (42-amino acidgroups)

A-β fibril plaques(intracellular)

Cont…..

Curcumin

Evert insidious evolution

It helps macrophages to clear amyloid-β plaques found in AD

Curcumin has shown

1. Anti inflammatory property2. Anti-oxidant property

Oxidative damage

Inflammation

β –Amyloid plaques in Brain

Intracellular aggregates

Synaptic loss,

Neuron dysfunction

Dementia

Uses of Nano technology

Curcumin Vs Nanocurcumin

Free Curcumin

Poorly dispersible in waterReduced Bioavailability

Nanocurcumin

Dispersible in water Sustained drug release

kinetics Improved Bioavailability Improved cellular uptake

Nano robot Drug delivery system

Nanorobotics is emerging field of a nanotechnologyNanorobot skeleton Made up

Carbon and its tool kit ContainMedicine cavity

Consist ofMedicine, Micro camera, payload, Capacitor

As nano robot have special sensor which detect target molecule in Human body

Used in treatment ofVarious disease which include Cancer ,Diabetes,

Alzheimer's etc.

ConclusionBased on the above details this novel Nano Curcumin may have great potential for AD therapy and can be a reference for future studies on formulation of drugs using Nano technology. 

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