† This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

CLINICALLY-TESTED I/O SKIN MOISTURIZER

HIGHLY EFFECTIVE, LOW DAILY DOSE

FROM CORN OR RICE , GLUTEN-FREE. †

MY SECRET

MY SKIN

MY LIFE

innoVactiv inc. 265 2nd Street East, Rimouski (Quebec) G5L 9H3 Canada

T 418 721-2308 - F 418 721-2318 - info@innovactiv.com - www.innovactiv.com

ROLES OF SKIN CERAMIDESAging induces many changes in the appearance, composition and structure of the skin. One of the most striking changes in aging skin is a GRADUAL LOSS OF CERAMIDE content, reducing its water-holding capacity and making it more susceptible to IRRITATION, PEELING and REDNESS.

Ceramides are the major constituent of skin lipids and are essential to prevent water loss from the outermost layer of skin surface. After secretion, ceramides are organized in thin lamellar sheets creating multiple lipophilic and hydrophilic barriers between corneocytes. This structural organization is critical to maintain a strong protection against external aggressors, pathogens and toxins.

Oral intake of ceramides offers the unique advantage of allowing the natural integration of ceramides in the desired lamellar structures. This natural replenishment is simply not possible when ceramides are used topically.

MYOCERAM™ BOOSTS ENDOGENOUS CERAMIDE PRODUCTION AND IMPROVES OVERALL BODILY SKIN BARRIER AND HYDRATION

M YO C E R A M ™ C P (C O R N ) M YO C E R A M ™ R P S ( R I C E )

300

200

100

0 1 2 3 1 2 3

Period (Weeks)

Incr

emen

tal r

atio

of

wat

er c

on

ten

t (%

)

400 P < 0.01

P < 0.05

Forearm Leg P < 0.01

P < 0.05

Control Myoceram™ CP 20 mgMyoceram™ CP 40 mg

60

40

20

0 1 2 3 1 2 3

Period (Weeks)

Incr

emen

tal r

atio

of

tran

sep

ider

mal

wat

er lo

ss (%

)

80 P < 0.05

P < 0.05

Forearm Leg

P < 0.05

P < 0.05

N=23

N=23

Ref.: Rinsho Byori, 55, 209-15 (2007)

Control Myoceram™ RPS 30 mg

+ 2

0

- 2

0 4 8 12 16

Period (Weeks)

Ch

ange

in T

EW

L

(g/m

2/h

)C

han

ge in

TE

WL

(g

/m2/h

)

**

** *

+ 1

- 1

Upper Back

P < 0.05

P < 0.01

P < 0.01

+ 2

0

- 2

0 4 8 12 16

Period (Weeks)

**

*

*

+ 1

- 1

MYOCERAM™ INTAKE WASH OUT

Cheek

- 4 *

- 3

P < 0.01

P < 0.05

P < 0.05

N=123

N=123

Ref.: Jpn Pharmacol Ther, 41, 1051-9 (2013)

Myoceram™ is a trademark of Nippon Flour Mills Co., Ltd.

Human clinical trials show MYOCERAM™ from rice and from corn can sustain optimal skin barrier function.