Material And Methods

Patient identification and recruitmentPatient

identification and recruitment

Sample of Patient receiving statin

Age ≥ 18 years

Increase CPK > 4*ULN

Extraction of DNA

Blood sample 5ml

Saliva sample 3ml

Designing and synthesis of oligonucleotide primers

Primer 3 software

IDT , BLAST(USA)

PCR and Nucleotide

sequencing

Qiagen PCR

Biosystem 3130 XL genetic analyzer

Chromaslite program