Muscular Muscular DystrophyDystrophy

Evaluation of Mamsagni Evaluation of Mamsagni Rasayana [MGR] in Rasayana [MGR] in

55 Patients of55 Patients of

DMD, BMD & LGMDDMD, BMD & LGMD

Mukesh Jain, AMDS IndiaMukesh Jain, AMDS India

The Ayush Samiti Bhilai CGThe Ayush Samiti Bhilai CG

Muscular Muscular DystrophyDystrophy

• Incurable Genetic disease Incurable Genetic disease • The dysfunction of Vata & Dhatvagnis is the

main pathology. Muscle degeneration due to progressive diminishing of Mamsagni along with aggravation of Vata element.

• Symptoms & Signs: # Large calf muscles • # Walking on the toes• # Using the hands to rise from a sitting position,

called Gower's sign • # Progressive muscle deterioration, starting

with the muscles nearest the hips • # Curvature of the spine # Enlargement of the

heart muscle • # intellectual impairment # Breathing Difficulty.

Muscular DystrophyMuscular Dystrophy

Mamsagat Vata VyadhiMamsagat Vata Vyadhi

Treatment, Help & Treatment, Help & MonitoringMonitoring

• The major goal of early treatment is to The major goal of early treatment is to keep the ability to walk as long as possible.keep the ability to walk as long as possible.

• Pawan Muktasana, Stretching exercises Pawan Muktasana, Stretching exercises and using braces at night help avoid the and using braces at night help avoid the tightening of tendons.tightening of tendons.

• Surgery can be used to release tight Surgery can be used to release tight tendons. tendons.

• Mamsagni Rasayana is promising molecule. Mamsagni Rasayana is promising molecule. It is an ayurvedic dietary supplement and is It is an ayurvedic dietary supplement and is safe and superior than Prednisone for long safe and superior than Prednisone for long term management of muscular dystrophies.term management of muscular dystrophies.

Ayurvedic TreatmentAyurvedic Treatment

• Panch Karma & Rasayana Panch Karma & Rasayana treatments have shown promising treatments have shown promising protective effects on NMD.protective effects on NMD.

• These therapies and remedies These therapies and remedies help in the regeneration of dhatus help in the regeneration of dhatus because they are capable to because they are capable to balance the Doshas and Agnis.balance the Doshas and Agnis.

• TMP Swedana procedure is effective to stabilize Vata dominant Sarcolemmal membrane defect.

Care through Research Care through Research Clinic BhilaiClinic Bhilai

• AMDS IndiaAMDS India

• Study involving Study involving Mamsagni Mamsagni Rasayana Rasayana along with TMP along with TMP & Yogic & Yogic SupportSupport yielded yielded mixed results in 55 mixed results in 55 boys of DMD, BMD boys of DMD, BMD & LGMD& LGMD

. . Over 100 cases of Muscular Over 100 cases of Muscular dystrophies were enrolled at dystrophies were enrolled at Panch Karma Clinic of Central Panch Karma Clinic of Central Medical Institute, Bhilai Medical Institute, Bhilai

& treated during March 1999 & & treated during March 1999 & Sep 2004. Sep 2004.

28 28 DMD , DMD , 1919 BMD BMD 88 LMGD boys LMGD boys

All the Dystrophy boys were All the Dystrophy boys were subjected to 2 weeks Panch karma subjected to 2 weeks Panch karma procedures before administration procedures before administration of oral Mamsagni Rasayana along of oral Mamsagni Rasayana along with Yogic support for 6 months.with Yogic support for 6 months.

Observation & Results: Observation & Results:

• It was observed that degeneration of It was observed that degeneration of muscle fibers were arrested after 6 muscle fibers were arrested after 6 weeks of administration of Mamsagni weeks of administration of Mamsagni Rasayana. This was presumed on the Rasayana. This was presumed on the basis of reduced CK level in blood and basis of reduced CK level in blood and functional improvement such as functional improvement such as

• (i) Weight loss, (ii) Decrease in walking difficulty and (iii) Decrease in the severity of contractures and scoliosis. However DMD boys have shown very slow progress.

RESULT ANALYSIS :RESULT ANALYSIS : DMDDMD

((BARTHEL -SANJEEVAN SCALEBARTHEL -SANJEEVAN SCALE))

• MARKED RELIEF MARKED RELIEF 42%42%

• MODERATE MODERATE 21%21%

• MILD RELIEF MILD RELIEF 36.8%36.8%

RESULT ANALYSISRESULT ANALYSIS

0

10

20

30

40

50

60

6 Weeks 12 Weeks 18 Weeks 24 Weeks

DMDBMDLGMD

Average ObservationsAverage Observations

Improvement in Functional Ability Improvement in Functional Ability visible after 6 weeks of visible after 6 weeks of Administration of MGRAdministration of MGR

Presumption : Reduced CPK level, Presumption : Reduced CPK level, weight loss, Decrease in Walking weight loss, Decrease in Walking difficulty.difficulty.

Decrease in the Severity of Decrease in the Severity of Contractures and Scoliosis.Contractures and Scoliosis.

Average Decrement in 24 Average Decrement in 24 WeeksWeeks

45% -2.8 Kg. -2800 (IU) 10%

SEV

ER

ITY

WT

LO

SS

BLO

OD

C

K

CO

NTR

AC

TU

RE

Quality of Life Quality of Life ImprovementImprovement

FU

NC

TIO

NA

L

EN

DU

RA

NC

E

SE

LF

CO

NF

IDE

NC

E

40%

60%

90%

A Case Of DMDA Case Of DMD

PATIENT BEFORE TREATMENT

PATIENT AFTER TREATMENT

EFFECT OF TMP IN DMDEFFECT OF TMP IN DMD

BEFORE REATMENT

AFTER TREATMENT

Effect of Mamsagni Effect of Mamsagni RasayanaRasayana

BEFORE TREATMENT AFTER TREATMENT

Functional Improvement in Functional Improvement in a DMD a DMD

BEFORE TREATMENT

AFTER 12 WEEKS

Improvement in DMD BoyImprovement in DMD Boy

BEFORE TREATMENT

AFTER TREATMENT