muscle structure and physiology j. rosenbluth, april 2012
DESCRIPTION
MUSCLE STRUCTURE AND PHYSIOLOGY J. Rosenbluth, April 2012. MUSCLE. Skeletal muscle fibers Contraction mechanism Excitation-contraction coupling Gross properties of skeletal muscle Pathology/Clinical examples. Myofibrils. Skeletal muscle band pattern. - PowerPoint PPT PresentationTRANSCRIPT
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MUSCLE STRUCTURE AND PHYSIOLOGY
J. Rosenbluth, April 2012
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MUSCLE• Skeletal muscle fibers
– Contraction mechanism– Excitation-contraction coupling
• Gross properties of skeletal muscle
• Pathology/Clinical examples
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Myofibrils
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Skeletal muscle band pattern
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Double “antiparallel” array of myofilamnts (H.E.Huxley)
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Sliding filament model
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Myosin filament formation
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Low-angle X-ray diffraction of skeletal muscle (meridional pattern)
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Decorated F-actin
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Antiparallel array of myofilaments
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Double hexagonal array (vertebrate skeletal muscle)
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Crossbridge position during relaxation (top) vs contraction (bottom)
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Cross-bridge Cycle
– Attached
– Released
– Cocked
– Force generating
– Attached
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Triads (amphibian)
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Skeletal muscle triad (amphibian)
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Triad structure
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Actin filament with Tr and Tm
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Tropomyosin movement
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Pennate Muscles
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Length-TensionRelationship
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Load-Velocity Relationship
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Twitch vs Tetanic Tension
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Fiber types (cat gastrocnemius)
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Twitch contraction times
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Skeletal Muscle Fatigue
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“Winging”(facio-scapulo-humeral dystrophy)
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“Pseudohypertrophy” (Duchenne dystrophy)
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Charcot-Marie-Tooth disease
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Spinal muscular atrophy
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