multipurpose prevention technologies what are they & why do we need them? [presenter name,...
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Multipurpose Prevention TechnologiesWhat are they & why do we need them?[Presenter name, degree, affiliation][Event title]
[Date]
Multipurpose Prevention Technologies for Reproductive Health
What do women want and need?
Every year. . . 80 million unintended pregnancies 358,000 women die from pregnancy- related complications
2.5 million people infected with HIV 340 million new gonorrhea, syphilis, trichomonas infections
250,000 deaths from cervical cancer 16 % (15-49) have genital herpes (HSV-2)
products that… Prevent pregnancy,
HIV/AIDS & STIs at the same time
Ensure women’s privacy and safety
Are affordable & easily available
Are designed by women for their specific needs & preferences
Imagine
Multipurpose Prevention Technologies
The Challenge
50 years of contraceptive advances
Sheldon SegalFirst long term
drug delivery deviceNorplant
;Female-controlled MPTs
Female Condom
SILCS Diaphragm
Women’s Condom
Currently available MPTs
Female Condom Male Condom
Emerging MPTs
Drug combinations
Multipurpose vaccines
Drug/device combinations
Bacterial therapeutics
Nanoparticals
Potential Delivery Mechanisms for MPTs Devices
SILCS Diaphragm Women’s Condom
Vaginal Rings Drug release rates differ by ring type Matrix rings vs. Reservoir rings Release rates differ in-vitro from in-vivo
Vaginal Tablet Combining different class ART
Vaginal Film Nontoxic to cells and flora, fast dissolution
Multipurpose Vaccines: the future Today: Single purpose vaccines (HPV &
HBV) are commercially available Next 2 decades: Dual-purpose vaccines
that prevent transmission of HSV, HIV, Gonorrhea, Chlamydia, Trichomonas or other STIs
Contraceptive vaccines not likely
Collaboration, advocacy, & research to advance MPTs
Initiative on MPTs: Partner Organizations
MPTs in the Pipeline
Mapping Matrix: www.cami-health.org
CAMI Activities MPT Think Tank (May 2011) Target Product Profile working groups (May – Oct
2011) ARHP Conference (September 2011) APHA Conference (October 2011) International MPT Symposium, DC (November
2011) International MPT Symposium, London (January
2012) Microbicides 2012 Conference, Sydney (April 2012) NEXT STEPS
Future directions and priorities
Support and coordinate novel approaches for multi-disciplinary collaboration
Facilitate funding for research & development
Expand global and US support Refine priority Product Profiles Assist with clarifying the regulatory
pathways
Questions?www.cami-health.orgwww.arhp.orgwww.phi.org