MU Innovation & Commercialization

R.V. Duncan, Ph.D.Vice Chancellor for Research

Professor of Physics February 27, 2012

http://research.missouri.edu

MU Research and TT ‘By the Numbers’ • FY2010 Research, Instruction and Public Service, and

Academic Enterprise External Awards: – Research: $178.0 million (Total @ MU: $238.5M) – External Instruction / Public Service: $105.7 Million– Academic Enterprise: $222.0 Million – Totals over $500M per year in FY12!

• MU’s research funding rank at 87 has increased by 11 places from 2005 to 2009 (NSF Table 24) UM System is in the upper quarter of 160 universities in licensing revenues

MU Licenses and Options FY2011 to date

Technology Commercialization • Licensing revenues grew from $4.7M in FY07 to a high of $10.1M in

FY09, then to $7.4M in FY11. These market-exposed revenues show large fluctuations, as do our fee-for-service activities.

• Licensing revenues total almost $70M from over $1B in gross sales by companies that have licensed MU technology

• Licensing deals expand to take equity, and to secure ‘footprint’ (plant location) commitments in Missouri

• Missouri Life Sciences Business Incubator at MU

• ‘Shovel Ready’ Technology Park at Discovery Ridge

• Jake Halliday, Executive Director of MIC / Incubator

• Centennial Investors

MURR Evolving CompetenciesFDA-approvable cGMP and GLP Programs

1,000+ shipments year to 11 countries of 34 different radioisotopes for pharmaceuticals, & a cyclotron operated under a public/private partnership.

Pharmaceutical Research

25-year history of successful and innovative pharmaceutical research, including the development of:• CeretecTM (with 99mTc), a diagnostic used to

evaluate cerebral blood flow in patients.• Quadramet® (with 153Sm), a therapeutic for treatment of pain

associated with metastatic bone cancer.• TheraSphere® (with 90Y), a glass microsphere

used to treat patients with inoperable liver cancer.• Zegerid ®, an antacid and not a radio-pharmaceutical, is by

far our most successful drug, generating $40M in licensing revenues & half-billion dollars + in total sales

• Future: major new collaborations on drug development on MU’s campus, and in the KC area

Savage River Farms

FinancingInnovation

Commercialization

RoyaltyEquityFollow on ResearchLocal Investment

Organovo and Organ Printing

Invented by Professor Gabor Forgacs at MU, Keith Murphy isCEO http://www.organovo.com/

Marketed throughand

Now, Modern Meadows!!

The Economist Magazine

On the Horizon

• Shasun NBI, LLC attracts millions of dollars from Chennai, India to create high-end drug development jobs in Missouri. Very Promising!

• At last year’s R&D Advisory Board Meeting, VC Martin Sanders teamed with MU Associate Professor John Viator to create a company that detects blood-borne pathogens photo-acoustically. Viator Technologies, Inc.

• Proposed system under development to produce 150M gallons / year of butanol from woody biomass along major river valleys in the USA

• HLB Horizons, LLC , EternoGen, & more!

Coulter Foundation Support

Second Round Partner Institutions (2011)Columbia UniversityJohns Hopkins UniversityUniversity of LouisvilleUniversity of MissouriUniversity of PittsburghUniversity of Southern California

First Round Partner Institutions (2005)Boston UniversityCase Western Reserve UniversityDrexel UniversityDuke UniversityGeorgia Tech/Emory UniversityStanford UniversityUniversity of MichiganUniversity of VirginiaUniversity of WashingtonUniversity of Wisconsin

Sidney Kimmel Institute for Nuclear Renaissance (SKINR) at MU

$5.5 Million gift, plus equipment Five-year duration

SKINR’s objective is to determine the physical origin of the anomalous heat effect.

“I chose MU for this important gift because it is a comprehensive university, experienced in using its deep scientific research capacity across many fields with its firm commitment to serve the public good.”

IDEXX Buys MU RADIL

On Monday, November 7, 2011, MU sold its fee-for service animal diagnostics lab, called RADIL, to world leader IDEXX Corporation for $43M. Steve Wyatt was the Deal Lead.

Student Entrepreneurial Programs

Collaboration, Leadership, and Innovation for Missouri Business

Luis Jimenez, student president of CLIMB, started EternoGen

Student Angel Investment Network and Course, and other student entrepreneurial programs within the Business School

Reynolds Journalism Institute, Engineering, and Student Competitions

Over $50K in ‘pitch competition’ seed money (CLIMB, REDI, Missouri Technology Expo) and students own their IP

MU received on of three student entrepreneurial seed grants from Kauffman Foundation in 2010

Path Forward?

Much more inter-institutional collaboration, especially regionally, but also (inter)nationally

More innovation on how to manage and advance innovation -- Teaming and strategic alignment & relationship building with industry

More of an entrepreneurial spirit in everything that we do at MU, esp. student mentoring and engagement

Much less fear and bureaucracy, and more caution,systematic implementation, and determination

Discovery is Disruptive!

If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance.

Orville Wright