mri of the locus coeruleus and substantia nigra dr timothy rittman academic foundation year 2
TRANSCRIPT
![Page 1: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/1.jpg)
MRI of the locus coeruleus MRI of the locus coeruleus and substantia nigraand substantia nigra
Dr Timothy RittmanDr Timothy Rittman
Academic Foundation Year 2Academic Foundation Year 2
![Page 2: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/2.jpg)
Locus coeruleusLocus coeruleusSubstantia nigraSubstantia nigra
![Page 3: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/3.jpg)
Imaging of SNImaging of SN
![Page 4: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/4.jpg)
Sasaki et alSasaki et al
![Page 5: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/5.jpg)
Effect of MT and SPIREffect of MT and SPIR
![Page 6: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/6.jpg)
Magnetisation transferMagnetisation transfer
NeuromelaninNeuromelanin Macromolecules = short T2*Macromolecules = short T2* Off resonance radiofrequency pulseOff resonance radiofrequency pulse Transfer of energy from macromoleculesTransfer of energy from macromolecules
waterwater ?iron?iron
SPIRSPIR presaturation pulsepresaturation pulse hidden MT effecthidden MT effect
![Page 7: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/7.jpg)
MethodMethod
T1 MRIT1 MRI Repetition time 757msRepetition time 757ms Echo time 9.1msEcho time 9.1ms Voxel size = 0.47x0.47x2.75mmVoxel size = 0.47x0.47x2.75mm33
SPIRSPIR 7 healthy volunteers7 healthy volunteers MT not possible due to SAR limitsMT not possible due to SAR limits
![Page 8: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/8.jpg)
Results - Substantia nigraResults - Substantia nigra
![Page 9: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/9.jpg)
Results - Locus coeruleusResults - Locus coeruleus
![Page 10: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/10.jpg)
ConclusionConclusion
The substantia nigra and locus coeruleus The substantia nigra and locus coeruleus are visible using T1 weighted imaging with are visible using T1 weighted imaging with SPIRSPIR
Most likely due to an MT effectMost likely due to an MT effect Sequence is sensitive to neuromelaninSequence is sensitive to neuromelanin Specificity remains to be testedSpecificity remains to be tested
![Page 11: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/11.jpg)
![Page 12: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/12.jpg)
![Page 13: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/13.jpg)
![Page 14: MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2](https://reader036.vdocuments.site/reader036/viewer/2022062312/5515d055550346dd6f8b45d4/html5/thumbnails/14.jpg)
Thanks to…Thanks to…
Prof AuerProf Auer All in Academic RadiologyAll in Academic Radiology All at Sir Peter Mansfield Magnetic All at Sir Peter Mansfield Magnetic
Resonance CentreResonance Centre Prof Mahida and Prof HawkeyProf Mahida and Prof Hawkey